4EGI-1 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5717952
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Genes

199 proteins with high or low expression in 4EGI-1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
KLHL23 kelch-like family member 23 1.66
HHEX hematopoietically expressed homeobox 0.83
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.76
ADGRF1 adhesion G protein-coupled receptor F1 0.74
HIPK1 homeodomain interacting protein kinase 1 0.69
ADPRH ADP-ribosylarginine hydrolase 0.64
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.64
RUNX2 runt-related transcription factor 2 0.61
KIF26A kinesin family member 26A 0.58
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.56
SPTBN5 spectrin, beta, non-erythrocytic 5 0.56
FOSL1 FOS-like antigen 1 0.52
RGPD2 RANBP2-like and GRIP domain containing 2 0.5
ASB8 ankyrin repeat and SOCS box containing 8 0.49
TMEM168 transmembrane protein 168 0.49
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.47
GDA guanine deaminase 0.45
ZNF28 zinc finger protein 28 0.44
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.44
ULK1 unc-51 like autophagy activating kinase 1 0.43
SMIM26 small integral membrane protein 26 0.43
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.42
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.42
LMTK2 lemur tyrosine kinase 2 0.42
ALDOA aldolase A, fructose-bisphosphate 0.41
SMAD3 SMAD family member 3 0.41
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.41
PON3 paraoxonase 3 0.41
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.4
RXRG retinoid X receptor, gamma 0.39
ARHGAP23 Rho GTPase activating protein 23 0.39
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 0.39
CPA4 carboxypeptidase A4 0.39
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.38
SON SON DNA binding protein 0.38
MEAK7 MTOR associated protein, eak-7 homolog 0.38
PGBD2 piggyBac transposable element derived 2 0.38
PLXNB1 plexin B1 0.37
STC2 stanniocalcin 2 0.36
BCAR3 breast cancer anti-estrogen resistance 3 0.36
GDF15 growth differentiation factor 15 0.36
FASTK Fas-activated serine/threonine kinase 0.36
IREB2 iron-responsive element binding protein 2 0.36
ICOSLG inducible T-cell co-stimulator ligand 0.35
CDK6 cyclin-dependent kinase 6 0.35
DNAL4 dynein, axonemal, light chain 4 0.35
SLC38A7 solute carrier family 38, member 7 0.35
CCDC85B coiled-coil domain containing 85B 0.34
RGPD8 RANBP2-like and GRIP domain containing 8 0.34
DONSON downstream neighbor of SON 0.34
CCNE2 cyclin E2 0.34
DEPDC1 DEP domain containing 1 0.34
RGN regucalcin 0.34
MNX1 motor neuron and pancreas homeobox 1 0.34
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.33
F3 coagulation factor III (thromboplastin, tissue factor) 0.33
KLF4 Kruppel-like factor 4 (gut) 0.33
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 0.33
GPR179 G protein-coupled receptor 179 0.32
SNX19 sorting nexin 19 0.32
OSBP2 oxysterol binding protein 2 0.32
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.32
ASB7 ankyrin repeat and SOCS box containing 7 0.32
UHMK1 U2AF homology motif (UHM) kinase 1 0.32
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.32
YAE1 YAE1 maturation factor of ABCE1 0.31
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 0.31
MAST3 microtubule associated serine/threonine kinase 3 0.31
ATP9B ATPase, class II, type 9B 0.31
GAS6 growth arrest-specific 6 0.31
PRELID3B PRELI domain containing 3B 0.3
ZNF397 zinc finger protein 397 0.3
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 0.3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.3
MLPH melanophilin 0.3
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.3
DIPK1A divergent protein kinase domain 1A 0.3
SGO1 shugoshin 1 0.29
FRK fyn-related Src family tyrosine kinase 0.29
HELB helicase (DNA) B 0.29
CECR2 cat eye syndrome chromosome region, candidate 2 0.29
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.29
OPHN1 oligophrenin 1 0.29
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.29
ENO1 enolase 1, (alpha) 0.29
ZBTB49 zinc finger and BTB domain containing 49 0.29
ZNF324 zinc finger protein 324 0.29
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.29
PARP9 poly (ADP-ribose) polymerase family, member 9 0.29
AZIN1 antizyme inhibitor 1 0.28
C11ORF68 chromosome 11 open reading frame 68 0.28
NRBP2 nuclear receptor binding protein 2 0.28
RBMS2 RNA binding motif, single stranded interacting protein 2 0.28
DMWD dystrophia myotonica, WD repeat containing 0.28
LZTS1 leucine zipper, putative tumor suppressor 1 0.28
C2CD4C C2 calcium-dependent domain containing 4C 0.27
CENPM centromere protein M 0.27
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 0.27
CCND3 cyclin D3 0.27

low expression

Symbol Name Standardized Value
LMOD1 leiomodin 1 (smooth muscle) -2.47
AHR aryl hydrocarbon receptor -1.4
NTHL1 nth endonuclease III-like 1 (E. coli) -1.35
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -1.16
MUTYH mutY homolog -1.04
PPAT phosphoribosyl pyrophosphate amidotransferase -0.84
CISD3 CDGSH iron sulfur domain 3 -0.84
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -0.77
CIAO3 cytosolic iron-sulfur assembly component 3 -0.76
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -0.69
ANO8 anoctamin 8 -0.68
LSM11 LSM11, U7 small nuclear RNA associated -0.65
ZNF524 zinc finger protein 524 -0.64
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit -0.64
SGSH N-sulfoglucosamine sulfohydrolase -0.62
ELP3 elongator acetyltransferase complex subunit 3 -0.59
SMIM19 small integral membrane protein 19 -0.58
ENTR1 endosome associated trafficking regulator 1 -0.55
BBS9 Bardet-Biedl syndrome 9 -0.52
TMOD1 tropomodulin 1 -0.52
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.51
GATA2 GATA binding protein 2 -0.51
DPH1 diphthamide biosynthesis 1 -0.5
CD99 CD99 molecule -0.48
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.48
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene -0.48
ZNF431 zinc finger protein 431 -0.47
METTL17 methyltransferase like 17 -0.46
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -0.45
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.45
TESC tescalcin -0.45
ZNF57 zinc finger protein 57 -0.44
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.44
COL13A1 collagen, type XIII, alpha 1 -0.43
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) -0.43
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -0.43
MAP2K5 mitogen-activated protein kinase kinase 5 -0.42
FECH ferrochelatase -0.42
FBF1 Fas (TNFRSF6) binding factor 1 -0.4
CISD1 CDGSH iron sulfur domain 1 -0.4
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -0.4
GLRX5 glutaredoxin 5 -0.4
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -0.39
ZDHHC23 zinc finger, DHHC-type containing 23 -0.38
PWWP2B PWWP domain containing 2B -0.38
POLE polymerase (DNA directed), epsilon, catalytic subunit -0.38
JOSD1 Josephin domain containing 1 -0.38
HIPK2 homeodomain interacting protein kinase 2 -0.38
DUSP6 dual specificity phosphatase 6 -0.38
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.37
BCDIN3D BCDIN3 domain containing -0.37
CMC4 C-x(9)-C motif containing 4 -0.37
COL11A1 collagen, type XI, alpha 1 -0.37
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -0.36
JAG1 jagged 1 -0.36
KMT2B lysine (K)-specific methyltransferase 2B -0.35
MCRIP1 MAPK regulated corepressor interacting protein 1 -0.35
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -0.35
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.35
STYK1 serine/threonine/tyrosine kinase 1 -0.35
PROS1 protein S (alpha) -0.34
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.34
TSPAN3 tetraspanin 3 -0.34
MXRA7 matrix-remodelling associated 7 -0.34
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.34
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -0.34
ANKRD10 ankyrin repeat domain 10 -0.34
NKAPD1 NKAP domain containing 1 -0.33
SS18 synovial sarcoma translocation, chromosome 18 -0.33
SH3BP2 SH3-domain binding protein 2 -0.33
APOLTP apolipoprotein lipid transfer particle homolog -0.33
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -0.33
GPRC5B G protein-coupled receptor, class C, group 5, member B -0.33
CEP70 centrosomal protein 70kDa -0.33
DPH2 DPH2 homolog (S. cerevisiae) -0.32
TTC9 tetratricopeptide repeat domain 9 -0.32
FDX1 ferredoxin 1 -0.32
NCOR1 nuclear receptor corepressor 1 -0.32
CISD2 CDGSH iron sulfur domain 2 -0.31
N4BP2L2 NEDD4 binding protein 2-like 2 -0.31
TMSB10 thymosin beta 10 -0.31
CTHRC1 collagen triple helix repeat containing 1 -0.31
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.31
NF1 neurofibromin 1 -0.31
BANF1 barrier to autointegration factor 1 -0.3
CPPED1 calcineurin-like phosphoesterase domain containing 1 -0.3
AURKAIP1 aurora kinase A interacting protein 1 -0.3
LGALS1 lectin, galactoside-binding, soluble, 1 -0.3
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.3
TMEM173 transmembrane protein 173 -0.3
ERH enhancer of rudimentary homolog (Drosophila) -0.29
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.29
SLC25A39 solute carrier family 25, member 39 -0.29
MED10 mediator complex subunit 10 -0.29
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.29
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -0.29
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -0.28
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -0.28
DAD1 defender against cell death 1 -0.28
ELP2 elongator acetyltransferase complex subunit 2 -0.28