| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.194016 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.101072 |
| NLGN1 | neuroligin 1 | 0.0927798 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0872656 |
| HMGA2 | high mobility group AT-hook 2 | 0.0835694 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0807136 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0770327 |
| YAP1 | Yes-associated protein 1 | 0.0707753 |
| RASAL2 | RAS protein activator like 2 | 0.0562274 |
| ASPH | aspartate beta-hydroxylase | 0.0555119 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0540344 |
| PCDH7 | protocadherin 7 | 0.0539298 |
| MMP12 | matrix metallopeptidase 12 | 0.0532798 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0519554 |
| JMJD1C | jumonji domain containing 1C | 0.0510539 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0509389 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0479533 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0453654 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0420952 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0401901 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0394311 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0376084 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0342668 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.033003 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0324885 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0315482 |
| IPO7 | importin 7 | 0.031522 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0313082 |
| VMP1 | vacuole membrane protein 1 | 0.0304257 |
| PDGFC | platelet derived growth factor C | 0.0298277 |
| DST | dystonin | 0.0279105 |
| ANXA1 | annexin A1 | 0.0277681 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0273161 |
| INTS6 | integrator complex subunit 6 | 0.0270342 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0270027 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0267262 |
| MGAT4C | MGAT4 family, member C | 0.0264444 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0258248 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0257513 |
| EHBP1 | EH domain binding protein 1 | 0.025205 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0250583 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0247031 |
| NEGR1 | neuronal growth regulator 1 | 0.0244558 |
| EDARADD | EDAR-associated death domain | 0.024014 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0235726 |
| TPM3 | tropomyosin 3 | 0.023107 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0230322 |
| PRDX1 | peroxiredoxin 1 | 0.022888 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0228251 |
| ACTG1 | actin gamma 1 | 0.0227658 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0225942 |
| BCHE | butyrylcholinesterase | 0.0225205 |
| YBX3 | Y box binding protein 3 | 0.0225031 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0219594 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0218047 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0216397 |
| CLTC | clathrin, heavy chain (Hc) | 0.0212887 |
| ZNF804A | zinc finger protein 804A | 0.0212221 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.020721 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.020532 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0204891 |
| USP53 | ubiquitin specific peptidase 53 | 0.0200275 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0193408 |
| DENND5A | DENN/MADD domain containing 5A | 0.0193316 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0191664 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0189475 |
| FAT1 | FAT atypical cadherin 1 | 0.0189124 |
| SETX | senataxin | 0.0186189 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0185593 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0183998 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.018241 |
| MYPN | myopalladin | 0.0178472 |
| DPYD | dihydropyrimidine dehydrogenase | 0.017837 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0174593 |
| PCDH9 | protocadherin 9 | 0.0172623 |
| HOMER1 | homer scaffolding protein 1 | 0.0170898 |
| RRM2 | ribonucleotide reductase M2 | 0.0169912 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0169844 |
| RPS2 | ribosomal protein S2 | 0.0169294 |
| EGFR | epidermal growth factor receptor | 0.0168483 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0166628 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0165976 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0163953 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0163492 |
| EPHA5 | EPH receptor A5 | 0.0163283 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0162151 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0159518 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0157518 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0157464 |
| RCOR1 | REST corepressor 1 | 0.0157076 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0153395 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0152661 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0151075 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0150827 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0149345 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0148688 |
| EZR | ezrin | 0.0148236 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0148051 |
| VIM | vimentin | 0.0148037 |
| CALR | calreticulin | 0.0146846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.111989 |
| PTMA | prothymosin, alpha | -0.0600957 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0478383 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0434615 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0430595 |
| FTL | ferritin, light polypeptide | -0.0371425 |
| RPL35A | ribosomal protein L35a | -0.0338252 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0315083 |
| AREG | amphiregulin | -0.0297322 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0276675 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0273313 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0272071 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.026825 |
| RPLP1 | ribosomal protein, large, P1 | -0.0264571 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0263963 |
| PFN1 | profilin 1 | -0.0263928 |
| PTMS | parathymosin | -0.0230267 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0228831 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0228818 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0224535 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0218878 |
| LDHB | lactate dehydrogenase B | -0.0216452 |
| KIF5B | kinesin family member 5B | -0.0212579 |
| RPS21 | ribosomal protein S21 | -0.0208315 |
| RPS19 | ribosomal protein S19 | -0.0208249 |
| HMGA1 | high mobility group AT-hook 1 | -0.0208195 |
| RPL8 | ribosomal protein L8 | -0.0202319 |
| GNAS | GNAS complex locus | -0.0194787 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0191847 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0188453 |
| RPL36 | ribosomal protein L36 | -0.0181311 |
| RPL19 | ribosomal protein L19 | -0.0179317 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0176109 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0174152 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0169811 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0169304 |
| THOC2 | THO complex 2 | -0.0168971 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0168803 |
| CLDN1 | claudin 1 | -0.0167896 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0165276 |
| RPS24 | ribosomal protein S24 | -0.0163546 |
| WDR43 | WD repeat domain 43 | -0.0155342 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0155303 |
| CBX3 | chromobox homolog 3 | -0.0153947 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0153936 |
| H1-0 | H1.0 linker histone | -0.0153861 |
| RPS6 | ribosomal protein S6 | -0.0153747 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.015326 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0152779 |
| SLC38A1 | solute carrier family 38, member 1 | -0.015246 |
| RPLP2 | ribosomal protein, large, P2 | -0.0151366 |
| RPL23 | ribosomal protein L23 | -0.0151149 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0148849 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0147034 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0145757 |
| RPS23 | ribosomal protein S23 | -0.0144649 |
| CCDC88A | coiled-coil domain containing 88A | -0.0144499 |
| RPL11 | ribosomal protein L11 | -0.014425 |
| S100A6 | S100 calcium binding protein A6 | -0.0142771 |
| RPS27A | ribosomal protein S27a | -0.0142448 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0142118 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0139443 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0137714 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0137387 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0137298 |
| MAP1B | microtubule-associated protein 1B | -0.0135485 |
| SYT1 | synaptotagmin I | -0.0135277 |
| XPO1 | exportin 1 | -0.0134975 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0134755 |
| ECT2 | epithelial cell transforming 2 | -0.0134697 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0134169 |
| CPOX | coproporphyrinogen oxidase | -0.013315 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0132857 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0132624 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0132312 |
| CENPE | centromere protein E, 312kDa | -0.0132194 |
| RPL37A | ribosomal protein L37a | -0.0132099 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.013169 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0131519 |
| CENPF | centromere protein F, 350/400kDa | -0.0129345 |
| RPL26 | ribosomal protein L26 | -0.0128669 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0128485 |
| KIF18B | kinesin family member 18B | -0.0128392 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.012689 |
| RBM27 | RNA binding motif protein 27 | -0.0126475 |
| STIL | SCL/TAL1 interrupting locus | -0.0126248 |
| RPS14 | ribosomal protein S14 | -0.0124869 |
| FAM162A | family with sequence similarity 162, member A | -0.0124644 |
| RPS16 | ribosomal protein S16 | -0.0124404 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0124395 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0123958 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0123263 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0122517 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0122188 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0122188 |
| R3HDM1 | R3H domain containing 1 | -0.0120971 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0120543 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.01202 |
| HLA-A | major histocompatibility complex, class I, A | -0.0119608 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0119578 |
