4EGI-1_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.158921
THSD4 thrombospondin, type I, domain containing 4 0.0972363
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0869694
NRIP1 nuclear receptor interacting protein 1 0.0771243
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.076094
EEF2 eukaryotic translation elongation factor 2 0.0725415
CEMIP cell migration inducing protein, hyaluronan binding 0.0649898
NAV2 neuron navigator 2 0.0512925
FTH1 ferritin, heavy polypeptide 1 0.0482958
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0482327
SOD2 superoxide dismutase 2, mitochondrial 0.0478776
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0475028
RICTOR RPTOR independent companion of MTOR, complex 2 0.0455125
USP47 ubiquitin specific peptidase 47 0.0440422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0440268
VIM vimentin 0.0432085
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0411604
LAMC2 laminin, gamma 2 0.040682
UBC ubiquitin C 0.0400151
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0368977
EIF1 eukaryotic translation initiation factor 1 0.0343552
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0341161
STC1 stanniocalcin 1 0.0333112
TKT transketolase 0.0328841
APP amyloid beta (A4) precursor protein 0.03283
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327622
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0325984
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0320797
PDZD8 PDZ domain containing 8 0.0315918
ARHGAP26 Rho GTPase activating protein 26 0.0314433
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0300546
PCM1 pericentriolar material 1 0.0300273
ELL2 elongation factor, RNA polymerase II, 2 0.0298107
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0294858
TNIP1 TNFAIP3 interacting protein 1 0.0293491
ELOVL7 ELOVL fatty acid elongase 7 0.0292717
MCTP1 multiple C2 domains, transmembrane 1 0.0291874
EFL1 elongation factor like GTPase 1 0.0291395
HSPA8 heat shock 70kDa protein 8 0.0285098
TAOK1 TAO kinase 1 0.0284221
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0280539
ETNK1 ethanolamine kinase 1 0.0277335
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0276378
KDM7A lysine (K)-specific demethylase 7A 0.0275231
DOCK4 dedicator of cytokinesis 4 0.0274996
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0274685
FNIP1 folliculin interacting protein 1 0.0268411
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0267475
BCL2L1 BCL2-like 1 0.0264136
ARHGAP5 Rho GTPase activating protein 5 0.0259502
ERBIN erbb2 interacting protein 0.0256634
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0256029
NPC1 Niemann-Pick disease, type C1 0.0253875
SMYD3 SET and MYND domain containing 3 0.024877
B2M beta-2-microglobulin 0.0247888
ANKRD17 ankyrin repeat domain 17 0.0238821
RHCG Rh family, C glycoprotein 0.0238278
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0236657
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0229504
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0224249
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0223736
CXCL8 chemokine (C-X-C motif) ligand 8 0.0223465
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0222778
EIF4B eukaryotic translation initiation factor 4B 0.0218953
RASA2 RAS p21 protein activator 2 0.021647
RPS2 ribosomal protein S2 0.0216278
MYO9A myosin IXA 0.0216077
IRAK2 interleukin-1 receptor-associated kinase 2 0.0209126
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0205234
EXOC6B exocyst complex component 6B 0.0205151
WWTR1 WW domain containing transcription regulator 1 0.0204455
HDLBP high density lipoprotein binding protein 0.0203293
PDLIM5 PDZ and LIM domain 5 0.0200635
RPS7 ribosomal protein S7 0.0199533
RPL4 ribosomal protein L4 0.0198384
RPLP0 ribosomal protein, large, P0 0.0197856
MAP2K1 mitogen-activated protein kinase kinase 1 0.0197514
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0196772
ARB2A ARB2 cotranscriptional regulator A 0.0195917
EIF4H eukaryotic translation initiation factor 4H 0.0195507
CD44 CD44 molecule (Indian blood group) 0.0194157
RANBP17 RAN binding protein 17 0.0193947
RPL3 ribosomal protein L3 0.0193872
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0192061
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0187483
BHLHE40 basic helix-loop-helix family, member e40 0.0186819
SSH1 slingshot protein phosphatase 1 0.0186094
S100A6 S100 calcium binding protein A6 0.0185984
SAMD5 sterile alpha motif domain containing 5 0.018589
MYO1D myosin ID 0.0185091
CSNK1G1 casein kinase 1, gamma 1 0.018489
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0181087
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0178081
JMJD1C jumonji domain containing 1C 0.0177458
NGLY1 N-glycanase 1 0.0175734
AKAP13 A kinase (PRKA) anchor protein 13 0.0174577
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0174203
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.017383
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0173506
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0170931

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.267246
TMSB10 thymosin beta 10 -0.176235
NDRG1 N-myc downstream regulated 1 -0.151428
IGFBP3 insulin-like growth factor binding protein 3 -0.146521
PDE10A phosphodiesterase 10A -0.145482
IGFBP4 insulin-like growth factor binding protein 4 -0.100442
MAML3 mastermind-like 3 (Drosophila) -0.0994961
FTL ferritin, light polypeptide -0.0962108
AUTS2 autism susceptibility candidate 2 -0.0861634
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0775987
MT2A metallothionein 2A -0.0766794
FLNB filamin B, beta -0.0706925
EGFR epidermal growth factor receptor -0.0624771
PRKCA protein kinase C, alpha -0.0614173
GRB10 growth factor receptor-bound protein 10 -0.0595783
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0591138
ASPH aspartate beta-hydroxylase -0.0582557
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0582173
IGFBP1 insulin-like growth factor binding protein 1 -0.0565254
PTPRM protein tyrosine phosphatase, receptor type, M -0.0563633
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0556928
VCL vinculin -0.0540838
TPM1 tropomyosin 1 (alpha) -0.0533932
PTMA prothymosin, alpha -0.0520832
RPL37A ribosomal protein L37a -0.0519424
RNF213 ring finger protein 213 -0.051798
MYO1E myosin IE -0.0508276
TNS3 tensin 3 -0.050512
EFNA5 ephrin-A5 -0.0502868
CA12 carbonic anhydrase XII -0.0499742
CMIP c-Maf inducing protein -0.0496854
TJP1 tight junction protein 1 -0.0490663
IGSF11 immunoglobulin superfamily, member 11 -0.0467707
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0467452
ZBTB20 zinc finger and BTB domain containing 20 -0.0456296
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0455029
RIN2 Ras and Rab interactor 2 -0.0445129
ACTN4 actinin, alpha 4 -0.044415
NAP1L1 nucleosome assembly protein 1-like 1 -0.0441896
TPT1 tumor protein, translationally-controlled 1 -0.0430881
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424173
EGR1 early growth response 1 -0.0423485
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0414476
ACTG1 actin gamma 1 -0.0412138
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0402156
MT1X metallothionein 1X -0.0395889
LIMCH1 LIM and calponin homology domains 1 -0.0388813
AKR1C2 aldo-keto reductase family 1, member C2 -0.0382487
RRBP1 ribosome binding protein 1 -0.0380173
RPS29 ribosomal protein S29 -0.0376065
TBC1D22A TBC1 domain family, member 22A -0.0375059
PARD3 par-3 family cell polarity regulator -0.0366498
GLIS3 GLIS family zinc finger 3 -0.0364983
WSB1 WD repeat and SOCS box containing 1 -0.0359956
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0358639
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0358364
RPS19 ribosomal protein S19 -0.03538
ZMYND8 zinc finger, MYND-type containing 8 -0.0351919
RPS27A ribosomal protein S27a -0.0349401
TXNRD1 thioredoxin reductase 1 -0.0347065
FA2H fatty acid 2-hydroxylase -0.0344081
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0338908
LMNA lamin A/C -0.0335676
RPLP2 ribosomal protein, large, P2 -0.0329295
RPL13A ribosomal protein L13a -0.0325501
MYOF myoferlin -0.0322759
RPS8 ribosomal protein S8 -0.0322627
RPL31 ribosomal protein L31 -0.031809
ZFHX3 zinc finger homeobox 3 -0.0313081
PSD3 pleckstrin and Sec7 domain containing 3 -0.0312288
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0311275
SLC38A2 solute carrier family 38, member 2 -0.0311143
ANKRD11 ankyrin repeat domain 11 -0.0308525
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0307813
ANXA4 annexin A4 -0.0305467
EHBP1 EH domain binding protein 1 -0.0298617
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0294522
AHNAK AHNAK nucleoprotein -0.0289894
RPL26 ribosomal protein L26 -0.0287819
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0283437
RPLP1 ribosomal protein, large, P1 -0.0282155
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0281458
RPS12 ribosomal protein S12 -0.0281096
RPS24 ribosomal protein S24 -0.0277346
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0276877
FBXO11 F-box protein 11 -0.0276163
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0276084
SMAD3 SMAD family member 3 -0.0274723
TRIO trio Rho guanine nucleotide exchange factor -0.0270193
MAP1B microtubule-associated protein 1B -0.0269778
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0262683
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0261048
RPL28 ribosomal protein L28 -0.0259297
RPS3 ribosomal protein S3 -0.0259002
ITGB4 integrin, beta 4 -0.0254774
RPL11 ribosomal protein L11 -0.0254298
PFKP phosphofructokinase, platelet -0.0252603
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0251946
NCOA7 nuclear receptor coactivator 7 -0.0249618
RPL9 ribosomal protein L9 -0.0246711