| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0958666 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0672941 |
| ACTG1 | actin gamma 1 | 0.0669388 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0500776 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0475408 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0469836 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0462686 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0453642 |
| INSR | insulin receptor | 0.0441797 |
| S100P | S100 calcium binding protein P | 0.0432123 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0383779 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0378589 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0377109 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0363454 |
| NTN4 | netrin 4 | 0.0351027 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0350016 |
| RPS3 | ribosomal protein S3 | 0.0343549 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0327671 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0304279 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0284255 |
| DSPP | dentin sialophosphoprotein | 0.0282697 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0281348 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0274978 |
| HSPA8 | heat shock 70kDa protein 8 | 0.027052 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0260781 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0250263 |
| JAK1 | Janus kinase 1 | 0.0239783 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0235332 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0234586 |
| SQSTM1 | sequestosome 1 | 0.0233975 |
| MLPH | melanophilin | 0.0231039 |
| KIF1A | kinesin family member 1A | 0.0219797 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0216222 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0215294 |
| SP100 | SP100 nuclear antigen | 0.0210208 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0202096 |
| KLHL24 | kelch-like family member 24 | 0.0202025 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0188492 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0185966 |
| RGS6 | regulator of G-protein signaling 6 | 0.0184603 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0178069 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0176143 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0174384 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0163486 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0160743 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0155235 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0154111 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0153272 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0150317 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0149584 |
| TENM2 | teneurin transmembrane protein 2 | 0.0148092 |
| MED13L | mediator complex subunit 13-like | 0.0145675 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0145088 |
| MAPK4 | mitogen-activated protein kinase 4 | 0.0145023 |
| TUFT1 | tuftelin 1 | 0.0144437 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0143074 |
| MBOAT1 | membrane bound O-acyltransferase domain containing 1 | 0.0143035 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0142652 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0142517 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0142279 |
| KRT18 | keratin 18, type I | 0.0141617 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0133884 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0133149 |
| CENPF | centromere protein F, 350/400kDa | 0.0131865 |
| DUSP16 | dual specificity phosphatase 16 | 0.0131168 |
| NEK7 | NIMA-related kinase 7 | 0.013066 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0129309 |
| RGS7 | regulator of G-protein signaling 7 | 0.0128842 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.012689 |
| GOLGB1 | golgin B1 | 0.0126813 |
| SMYD3 | SET and MYND domain containing 3 | 0.0125609 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0125328 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0124835 |
| TPR | translocated promoter region, nuclear basket protein | 0.0123637 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0121129 |
| CTTN | cortactin | 0.012047 |
| VCL | vinculin | 0.0120436 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0119392 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0119101 |
| MSI2 | musashi RNA-binding protein 2 | 0.0117966 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0117481 |
| TOX3 | TOX high mobility group box family member 3 | 0.0116307 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0115834 |
| ARRB1 | arrestin, beta 1 | 0.0115806 |
| FMNL2 | formin-like 2 | 0.0114168 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0114111 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0113468 |
| SEPTIN9 | septin 9 | 0.0112928 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0111815 |
| INTS6 | integrator complex subunit 6 | 0.0110549 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0110164 |
| CAPN8 | calpain 8 | 0.0109782 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0109725 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0109616 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0108744 |
| PDE10A | phosphodiesterase 10A | 0.0107806 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0107753 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0107544 |
| PCM1 | pericentriolar material 1 | 0.0107313 |
| APP | amyloid beta (A4) precursor protein | 0.0106755 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.250383 |
| RPL19 | ribosomal protein L19 | -0.187318 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.155808 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.135627 |
| ASPH | aspartate beta-hydroxylase | -0.0884338 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0871649 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0776194 |
| TMSB10 | thymosin beta 10 | -0.0764718 |
| ACACA | acetyl-CoA carboxylase alpha | -0.075195 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0717487 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0665416 |
| S100A9 | S100 calcium binding protein A9 | -0.0638877 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0622088 |
| S100A8 | S100 calcium binding protein A8 | -0.0525828 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0505705 |
| MT2A | metallothionein 2A | -0.0505687 |
| OSMR | oncostatin M receptor | -0.0456931 |
| RPL35A | ribosomal protein L35a | -0.0454904 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0449372 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0431734 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0421481 |
| PTMA | prothymosin, alpha | -0.0408941 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0380473 |
| TMEM165 | transmembrane protein 165 | -0.0367216 |
| NDRG1 | N-myc downstream regulated 1 | -0.0365136 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0361798 |
| PGK1 | phosphoglycerate kinase 1 | -0.0356209 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0354813 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0353018 |
| CCND1 | cyclin D1 | -0.0351993 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0350864 |
| S100A14 | S100 calcium binding protein A14 | -0.0341155 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0334815 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0327866 |
| RPL35 | ribosomal protein L35 | -0.0325425 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0317291 |
| TMEM123 | transmembrane protein 123 | -0.0312971 |
| RPS6 | ribosomal protein S6 | -0.031104 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0304001 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0297332 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0297037 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.029266 |
| PFN1 | profilin 1 | -0.0292392 |
| ENO1 | enolase 1, (alpha) | -0.0292287 |
| ANXA2 | annexin A2 | -0.0288658 |
| CCNI | cyclin I | -0.0288168 |
| DTNA | dystrobrevin, alpha | -0.0287498 |
| RPS19 | ribosomal protein S19 | -0.0284466 |
| RPL8 | ribosomal protein L8 | -0.0283496 |
| TXNRD1 | thioredoxin reductase 1 | -0.028242 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0281134 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0278435 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0276751 |
| RPLP1 | ribosomal protein, large, P1 | -0.0275993 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0275852 |
| S100A6 | S100 calcium binding protein A6 | -0.0272842 |
| RPL32 | ribosomal protein L32 | -0.027268 |
| GNAS | GNAS complex locus | -0.0269986 |
| FADS2 | fatty acid desaturase 2 | -0.0269723 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0264357 |
| LDHA | lactate dehydrogenase A | -0.0263255 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0263026 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0262156 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | -0.025101 |
| TMSB4X | thymosin beta 4, X-linked | -0.0245163 |
| RPL27A | ribosomal protein L27a | -0.0242147 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0241009 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0238772 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0236035 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0226599 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0224705 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0222267 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0220868 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0217906 |
| PKM | pyruvate kinase, muscle | -0.0216202 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0210787 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0210296 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0209505 |
| SERF2 | small EDRK-rich factor 2 | -0.020875 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.020687 |
| RRBP1 | ribosome binding protein 1 | -0.0204704 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -0.0203508 |
| FASN | fatty acid synthase | -0.0203129 |
| ZNF217 | zinc finger protein 217 | -0.0202603 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0202508 |
| CDK12 | cyclin-dependent kinase 12 | -0.02024 |
| KRT19 | keratin 19, type I | -0.0202368 |
| HLA-C | major histocompatibility complex, class I, C | -0.0201902 |
| RPL30 | ribosomal protein L30 | -0.0201564 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0201313 |
| POTEF | POTE ankyrin domain family, member F | -0.0201059 |
| AREG | amphiregulin | -0.0200778 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0200022 |
| BBX | bobby sox homolog (Drosophila) | -0.0196694 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0196643 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0196608 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0196358 |
| NF1 | neurofibromin 1 | -0.0195649 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0195302 |
| TPI1 | triosephosphate isomerase 1 | -0.0194926 |
