4EGI-1_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.122282
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0802659
LAMC2 laminin, gamma 2 0.0716971
B2M beta-2-microglobulin 0.0636291
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0595125
NRG3 neuregulin 3 0.0576319
ZSWIM6 zinc finger, SWIM-type containing 6 0.0557828
MYO1E myosin IE 0.054443
AHNAK2 AHNAK nucleoprotein 2 0.0469642
MACF1 microtubule-actin crosslinking factor 1 0.0457931
APP amyloid beta (A4) precursor protein 0.0455637
HDAC9 histone deacetylase 9 0.043423
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0421868
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.039977
SYNE2 spectrin repeat containing, nuclear envelope 2 0.039794
LPP LIM domain containing preferred translocation partner in lipoma 0.0387864
BACE2 beta-site APP-cleaving enzyme 2 0.0383652
DSPP dentin sialophosphoprotein 0.0374009
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0370065
EEF2 eukaryotic translation elongation factor 2 0.0336562
MT1E metallothionein 1E 0.0334315
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0334077
ARHGAP5 Rho GTPase activating protein 5 0.0331163
VEGFA vascular endothelial growth factor A 0.0328407
PPARD peroxisome proliferator-activated receptor delta 0.0327741
MX1 MX dynamin-like GTPase 1 0.0322077
SMAD3 SMAD family member 3 0.0314345
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0298767
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.028337
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0282552
LAMA4 laminin, alpha 4 0.0279737
TMC5 transmembrane channel-like 5 0.0276978
SVIL supervillin 0.0274969
ARHGAP26 Rho GTPase activating protein 26 0.0271092
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0270543
CMIP c-Maf inducing protein 0.027023
DTNA dystrobrevin, alpha 0.0269883
TGM2 transglutaminase 2 0.0267912
VMP1 vacuole membrane protein 1 0.0265556
APLP2 amyloid beta (A4) precursor-like protein 2 0.0264138
DOCK5 dedicator of cytokinesis 5 0.0263496
FNDC3B fibronectin type III domain containing 3B 0.0262476
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.026221
OPTN optineurin 0.0257899
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0257381
PLEC plectin 0.02565
ZBTB20 zinc finger and BTB domain containing 20 0.0253337
EXT1 exostosin glycosyltransferase 1 0.0253198
FNIP1 folliculin interacting protein 1 0.0250692
THSD4 thrombospondin, type I, domain containing 4 0.0250426
SEPTIN9 septin 9 0.0250242
ALCAM activated leukocyte cell adhesion molecule 0.0249452
RAI14 retinoic acid induced 14 0.0241326
MCL1 myeloid cell leukemia 1 0.0241203
MYO5B myosin VB 0.0239627
NABP1 nucleic acid binding protein 1 0.0237836
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0237318
GOLGB1 golgin B1 0.023343
RASAL2 RAS protein activator like 2 0.0228995
RPS12 ribosomal protein S12 0.0227245
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.022462
NAV2 neuron navigator 2 0.0224032
BCAR3 breast cancer anti-estrogen resistance 3 0.0221756
BPTF bromodomain PHD finger transcription factor 0.0220821
RPS2 ribosomal protein S2 0.021998
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.021964
CDCP1 CUB domain containing protein 1 0.0218
CSNK1A1 casein kinase 1, alpha 1 0.0216407
KTN1 kinectin 1 (kinesin receptor) 0.0215494
RNF213 ring finger protein 213 0.0215494
SGMS2 sphingomyelin synthase 2 0.0215137
RAD51B RAD51 paralog B 0.0211999
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0211158
ZC3H12C zinc finger CCCH-type containing 12C 0.0210881
RAB10 RAB10, member RAS oncogene family 0.0209966
SP100 SP100 nuclear antigen 0.0209876
MAST4 microtubule associated serine/threonine kinase family member 4 0.0209754
DST dystonin 0.0208169
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205749
WWTR1 WW domain containing transcription regulator 1 0.0205638
KIAA1217 KIAA1217 0.020403
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0202243
NALF1 NALCN channel auxiliary factor 1 0.0200791
BCL2L1 BCL2-like 1 0.0200698
EGFR epidermal growth factor receptor 0.0199048
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0198103
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.019785
PATJ PATJ crumbs cell polarity complex component 0.0196461
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0196088
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0195367
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.019336
PSEN1 presenilin 1 0.0192047
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0191764
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0190133
PABPC1 poly(A) binding protein, cytoplasmic 1 0.018915
SQSTM1 sequestosome 1 0.0186795
NTN4 netrin 4 0.0186255
INTS6 integrator complex subunit 6 0.0184744
GPATCH2L G patch domain containing 2-like 0.0184044
KLF5 Kruppel-like factor 5 (intestinal) 0.0183842

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.270269
TMSB10 thymosin beta 10 -0.174394
PTMA prothymosin, alpha -0.168672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.152237
NAMPT nicotinamide phosphoribosyltransferase -0.124675
MT1X metallothionein 1X -0.12281
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11453
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112763
TSC22D2 TSC22 domain family, member 2 -0.0904441
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0901728
MMP7 matrix metallopeptidase 7 -0.0817092
WSB1 WD repeat and SOCS box containing 1 -0.0783883
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0733432
MT2A metallothionein 2A -0.0672502
FTL ferritin, light polypeptide -0.0671243
RBM39 RNA binding motif protein 39 -0.0670598
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0663503
NPEPPS aminopeptidase puromycin sensitive -0.0618296
FAM13A family with sequence similarity 13, member A -0.0580813
PGK1 phosphoglycerate kinase 1 -0.0574403
NDRG1 N-myc downstream regulated 1 -0.0574269
S100A6 S100 calcium binding protein A6 -0.0556358
FAM162A family with sequence similarity 162, member A -0.0525408
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0515752
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0507511
PDIA3 protein disulfide isomerase family A, member 3 -0.0500321
OGA O-GlcNAcase -0.0493987
CCNY cyclin Y -0.0484899
RTN4 reticulon 4 -0.047023
KDM3A lysine (K)-specific demethylase 3A -0.0457256
IER3 immediate early response 3 -0.0439525
USP3 ubiquitin specific peptidase 3 -0.0424421
H1-0 H1.0 linker histone -0.0421485
TOP1 topoisomerase (DNA) I -0.0394853
TPT1 tumor protein, translationally-controlled 1 -0.0391651
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0389562
F3 coagulation factor III (thromboplastin, tissue factor) -0.0385695
MEF2A myocyte enhancer factor 2A -0.0383551
KDM5B lysine (K)-specific demethylase 5B -0.0382192
FLNB filamin B, beta -0.0382096
UGCG UDP-glucose ceramide glucosyltransferase -0.0378711
ZNF292 zinc finger protein 292 -0.0371637
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0369619
RPLP1 ribosomal protein, large, P1 -0.036409
IGFBP3 insulin-like growth factor binding protein 3 -0.0359495
HILPDA hypoxia inducible lipid droplet-associated -0.0357674
SPAG9 sperm associated antigen 9 -0.0355953
CP ceruloplasmin (ferroxidase) -0.0354186
RAB6A RAB6A, member RAS oncogene family -0.0352785
RPL35A ribosomal protein L35a -0.0351087
RAB1A RAB1A, member RAS oncogene family -0.0344523
TFG TRK-fused gene -0.0338992
GNAS GNAS complex locus -0.0334461
CANX calnexin -0.0330216
TMSB4X thymosin beta 4, X-linked -0.0327927
GARS1 glycyl-tRNA synthetase 1 -0.032768
POTEF POTE ankyrin domain family, member F -0.0325168
MARCHF6 membrane associated ring-CH-type finger 6 -0.0324006
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0323821
TMEM123 transmembrane protein 123 -0.0319941
STRN3 striatin, calmodulin binding protein 3 -0.0319205
LY6E lymphocyte antigen 6 complex, locus E -0.0316196
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0312625
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0310198
CLINT1 clathrin interactor 1 -0.0307785
TM4SF1 transmembrane 4 L six family member 1 -0.0307683
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0303705
ADAM9 ADAM metallopeptidase domain 9 -0.0301044
PLAUR plasminogen activator, urokinase receptor -0.0298681
ELL2 elongation factor, RNA polymerase II, 2 -0.029599
PDIA6 protein disulfide isomerase family A, member 6 -0.0294047
SLC38A1 solute carrier family 38, member 1 -0.0293583
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0292904
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.029098
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0290951
TRA2A transformer 2 alpha homolog (Drosophila) -0.0289808
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0288381
HELZ helicase with zinc finger -0.0287568
C15ORF48 chromosome 15 open reading frame 48 -0.0286734
ANXA2 annexin A2 -0.0286057
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0283859
TMEM263 transmembrane protein 263 -0.0276649
INSIG1 insulin induced gene 1 -0.0276211
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0273274
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.027009
ASPH aspartate beta-hydroxylase -0.0267828
LMAN1 lectin, mannose-binding, 1 -0.0266179
RPS24 ribosomal protein S24 -0.0263964
RPS21 ribosomal protein S21 -0.0258007
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0258004
QKI QKI, KH domain containing, RNA binding -0.0254645
WDR45B WD repeat domain 45B -0.0254193
IFI16 interferon, gamma-inducible protein 16 -0.0252103
RLF rearranged L-myc fusion -0.0248999
KMT2E lysine (K)-specific methyltransferase 2E -0.0248819
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0247381
ZMYND8 zinc finger, MYND-type containing 8 -0.0245546
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0244558
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0243532
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0241607