4EGI-1_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.186357
FN1 fibronectin 1 0.0851691
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0847948
HDAC9 histone deacetylase 9 0.0725407
MT2A metallothionein 2A 0.0645294
MMP12 matrix metallopeptidase 12 0.0551137
BACE2 beta-site APP-cleaving enzyme 2 0.0538434
SDK1 sidekick cell adhesion molecule 1 0.0463989
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0463001
CEMIP cell migration inducing protein, hyaluronan binding 0.0462008
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0449106
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0444656
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0438904
B2M beta-2-microglobulin 0.0427505
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0421699
SLC39A11 solute carrier family 39, member 11 0.0409394
FAM13A family with sequence similarity 13, member A 0.0406752
HMGA2 high mobility group AT-hook 2 0.0406561
FNIP1 folliculin interacting protein 1 0.0393087
DTNA dystrobrevin, alpha 0.0389626
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0375015
FGF13 fibroblast growth factor 13 0.0359374
COL6A3 collagen, type VI, alpha 3 0.0349957
IGFBP3 insulin-like growth factor binding protein 3 0.034881
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336826
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0315498
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0297297
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0292402
MACF1 microtubule-actin crosslinking factor 1 0.0289899
P4HB prolyl 4-hydroxylase, beta polypeptide 0.02836
VEGFA vascular endothelial growth factor A 0.0283257
FAM219A family with sequence similarity 219, member A 0.0265386
DOCK5 dedicator of cytokinesis 5 0.026454
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0263135
HIP1 huntingtin interacting protein 1 0.0262152
NLGN1 neuroligin 1 0.0261058
PRKG1 protein kinase, cGMP-dependent, type I 0.0258888
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0257148
HILPDA hypoxia inducible lipid droplet-associated 0.0256426
CLEC1B C-type lectin domain family 1, member B 0.0250521
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.024984
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0249513
MAST4 microtubule associated serine/threonine kinase family member 4 0.0244477
DGKI diacylglycerol kinase, iota 0.0240833
AUTS2 autism susceptibility candidate 2 0.0237096
C1S complement component 1, s subcomponent 0.023147
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0231254
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0228406
YEATS2 YEATS domain containing 2 0.0225985
NRXN3 neurexin 3 0.0225436
ARHGAP22 Rho GTPase activating protein 22 0.0225207
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0221884
NAV2 neuron navigator 2 0.0221058
ADGRB3 adhesion G protein-coupled receptor B3 0.0220395
OXR1 oxidation resistance 1 0.0217612
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0208253
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0206915
HELZ helicase with zinc finger 0.0205204
RIMS2 regulating synaptic membrane exocytosis 2 0.020436
ENO2 enolase 2 (gamma, neuronal) 0.019994
PTPRD protein tyrosine phosphatase, receptor type, D 0.0197536
MYO1B myosin IB 0.0195464
ZNF638 zinc finger protein 638 0.0193575
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0190823
PIAS2 protein inhibitor of activated STAT, 2 0.0190094
WWOX WW domain containing oxidoreductase 0.0187737
APP amyloid beta (A4) precursor protein 0.0183743
WLS wntless Wnt ligand secretion mediator 0.0183128
AKAP12 A kinase (PRKA) anchor protein 12 0.0182423
EEF2 eukaryotic translation elongation factor 2 0.0182328
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0182263
TM4SF19 transmembrane 4 L six family member 19 0.0180625
NCOR2 nuclear receptor corepressor 2 0.0179335
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0177916
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0175894
MCTP1 multiple C2 domains, transmembrane 1 0.0173985
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0173712
COL6A1 collagen, type VI, alpha 1 0.0172994
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0172238
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0171133
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0170082
STS steroid sulfatase (microsomal), isozyme S 0.0169946
GJA1 gap junction protein, alpha 1, 43kDa 0.0169909
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.016826
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0166871
AFF1 AF4/FMR2 family, member 1 0.0166833
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.0166014
C3 complement component 3 0.0165222
GPC5 glypican 5 0.0163898
SCAPER S-phase cyclin A-associated protein in the ER 0.0161995
SFTPA2 surfactant protein A2 0.0159843
PRR16 proline rich 16 0.01596
PCBP2 poly(rC) binding protein 2 0.0157483
MYLK myosin light chain kinase 0.0157468
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0157207
ZBTB1 zinc finger and BTB domain containing 1 0.0155542
CLMP CXADR-like membrane protein 0.0152967
CHRM3 cholinergic receptor, muscarinic 3 0.0152349
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0151737
KAT6B K(lysine) acetyltransferase 6B 0.015033

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.181215
CXCL8 chemokine (C-X-C motif) ligand 8 -0.162083
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.144941
MAP1B microtubule-associated protein 1B -0.098813
FNDC3B fibronectin type III domain containing 3B -0.0930584
GARS1 glycyl-tRNA synthetase 1 -0.0836381
RTN4 reticulon 4 -0.0802903
NAMPT nicotinamide phosphoribosyltransferase -0.0768328
TNNC1 troponin C type 1 (slow) -0.0738643
ANKRD11 ankyrin repeat domain 11 -0.0735805
KYNU kynureninase -0.0699941
TXNRD1 thioredoxin reductase 1 -0.0686297
DGKD diacylglycerol kinase, delta 130kDa -0.0678236
INHBA inhibin, beta A -0.0654068
CANX calnexin -0.063854
AHNAK AHNAK nucleoprotein -0.0625593
ATP13A3 ATPase type 13A3 -0.0559203
ZFAND3 zinc finger, AN1-type domain 3 -0.0545936
TPM4 tropomyosin 4 -0.0545378
STK17A serine/threonine kinase 17a -0.0506675
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0502214
SBF2 SET binding factor 2 -0.0500236
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0498007
DST dystonin -0.0493609
LDHA lactate dehydrogenase A -0.0488234
LRRC49 leucine rich repeat containing 49 -0.0477402
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0476202
ANKRD28 ankyrin repeat domain 28 -0.0475567
EXT1 exostosin glycosyltransferase 1 -0.047238
ACTN4 actinin, alpha 4 -0.0457961
LMAN1 lectin, mannose-binding, 1 -0.0453781
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0450993
CADM1 cell adhesion molecule 1 -0.0441363
VCL vinculin -0.0432
GLIS3 GLIS family zinc finger 3 -0.0428167
TMSB10 thymosin beta 10 -0.0427725
BIRC6 baculoviral IAP repeat containing 6 -0.0424033
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0414672
SLC38A2 solute carrier family 38, member 2 -0.0411445
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0401564
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0390877
MAP4 microtubule-associated protein 4 -0.0388799
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0387317
OSMR oncostatin M receptor -0.0381184
RRBP1 ribosome binding protein 1 -0.037233
SMAD3 SMAD family member 3 -0.0370985
SCFD2 sec1 family domain containing 2 -0.036996
COG5 component of oligomeric golgi complex 5 -0.0366996
SH3KBP1 SH3-domain kinase binding protein 1 -0.0358995
RNF216 ring finger protein 216 -0.0351823
ANKRD17 ankyrin repeat domain 17 -0.0335724
CREB5 cAMP responsive element binding protein 5 -0.0333126
FAM20C family with sequence similarity 20, member C -0.0328454
CLINT1 clathrin interactor 1 -0.0321501
ATXN1 ataxin 1 -0.0321431
SLC38A1 solute carrier family 38, member 1 -0.0319083
NIPBL Nipped-B homolog (Drosophila) -0.03179
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0317149
FBXL17 F-box and leucine-rich repeat protein 17 -0.0314042
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0312725
NABP1 nucleic acid binding protein 1 -0.0310534
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0310489
ANXA2 annexin A2 -0.0303876
IARS1 isoleucyl-tRNA synthetase 1 -0.0302647
SQSTM1 sequestosome 1 -0.0298307
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0292452
CLTC clathrin, heavy chain (Hc) -0.0291202
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0290386
TM9SF3 transmembrane 9 superfamily member 3 -0.0289777
PTPRG protein tyrosine phosphatase, receptor type, G -0.0289581
WWTR1 WW domain containing transcription regulator 1 -0.0287977
PGK1 phosphoglycerate kinase 1 -0.0286589
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0286569
CARS1 cysteinyl-tRNA synthetase 1 -0.0283482
DLG1 discs, large homolog 1 (Drosophila) -0.0282968
PDLIM5 PDZ and LIM domain 5 -0.0282304
SPAG9 sperm associated antigen 9 -0.0280964
TUBB tubulin, beta class I -0.0278293
TNPO1 transportin 1 -0.0278278
COPB1 coatomer protein complex, subunit beta 1 -0.0277759
GCC2 GRIP and coiled-coil domain containing 2 -0.0270682
PTCHD4 patched domain containing 4 -0.026946
TNRC18 trinucleotide repeat containing 18 -0.0267189
FTL ferritin, light polypeptide -0.0266954
USP15 ubiquitin specific peptidase 15 -0.0263272
VMP1 vacuole membrane protein 1 -0.0262956
TTC3 tetratricopeptide repeat domain 3 -0.0262949
TMEM41B transmembrane protein 41B -0.0262102
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.025738
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0253548
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0252223
TJP1 tight junction protein 1 -0.025063
SEC24D SEC24 family member D -0.0250004
MB21D2 Mab-21 domain containing 2 -0.0249168
TRA2A transformer 2 alpha homolog (Drosophila) -0.0247229
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0246737
ERLEC1 endoplasmic reticulum lectin 1 -0.0246233
RBM39 RNA binding motif protein 39 -0.0244382
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0244173
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.02438