| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.104855 |
| KRT18 | keratin 18, type I | 0.0615704 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0555196 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0507415 |
| INTS6 | integrator complex subunit 6 | 0.0435285 |
| KRT8 | keratin 8, type II | 0.0386659 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0383817 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0370628 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0368583 |
| LRRC23 | leucine rich repeat containing 23 | 0.0358613 |
| RACK1 | receptor for activated C kinase 1 | 0.0347319 |
| RPS8 | ribosomal protein S8 | 0.0333561 |
| EGR1 | early growth response 1 | 0.0291187 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0268236 |
| RPS12 | ribosomal protein S12 | 0.0247808 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0241184 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0225924 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0225097 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0221603 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0214853 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0210876 |
| EGFR | epidermal growth factor receptor | 0.0208282 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0204412 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0200174 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0195 |
| GPC5 | glypican 5 | 0.0193339 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0191713 |
| TGFB1 | transforming growth factor, beta 1 | 0.0187725 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0187045 |
| RCC1 | regulator of chromosome condensation 1 | 0.0180416 |
| CTSB | cathepsin B | 0.0177809 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.017457 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0170167 |
| VIM | vimentin | 0.0168651 |
| RPS27 | ribosomal protein S27 | 0.0167697 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0166235 |
| ACTG1 | actin gamma 1 | 0.0166069 |
| RPS3 | ribosomal protein S3 | 0.0163068 |
| SQSTM1 | sequestosome 1 | 0.0161515 |
| EFNB2 | ephrin-B2 | 0.0159808 |
| RPL37 | ribosomal protein L37 | 0.0159685 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0155886 |
| RPL31 | ribosomal protein L31 | 0.0154926 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0153271 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0152812 |
| KLHL29 | kelch-like family member 29 | 0.0152396 |
| HLA-E | major histocompatibility complex, class I, E | 0.0150791 |
| B2M | beta-2-microglobulin | 0.0150758 |
| MACROD2 | MACRO domain containing 2 | 0.0150016 |
| RPL38 | ribosomal protein L38 | 0.0149834 |
| SFTPA2 | surfactant protein A2 | 0.0149089 |
| DST | dystonin | 0.0148953 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0148243 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0144666 |
| CD44 | CD44 molecule (Indian blood group) | 0.0144555 |
| RPL3 | ribosomal protein L3 | 0.0144249 |
| RPL12 | ribosomal protein L12 | 0.0144002 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0142444 |
| ABHD5 | abhydrolase domain containing 5 | 0.0142161 |
| FBXO32 | F-box protein 32 | 0.0141892 |
| CALR | calreticulin | 0.0140825 |
| HLA-B | major histocompatibility complex, class I, B | 0.0140525 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0140097 |
| NAV2 | neuron navigator 2 | 0.0140059 |
| TRIM72 | tripartite motif containing 72, E3 ubiquitin protein ligase | 0.013873 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0138211 |
| RPL23 | ribosomal protein L23 | 0.0129394 |
| FMNL2 | formin-like 2 | 0.0129326 |
| FNIP1 | folliculin interacting protein 1 | 0.0128891 |
| RPL26 | ribosomal protein L26 | 0.0128818 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0128798 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0128533 |
| FN1 | fibronectin 1 | 0.0128018 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0126054 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0125887 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0125303 |
| ABLIM2 | actin binding LIM protein family, member 2 | 0.0124059 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0123705 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0122164 |
| GTF2B | general transcription factor IIB | 0.0121838 |
| POU2F2 | POU class 2 homeobox 2 | 0.0121537 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0120364 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0120023 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0119519 |
| HOMER1 | homer scaffolding protein 1 | 0.0119304 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0119259 |
| NABP1 | nucleic acid binding protein 1 | 0.0118563 |
| PLEC | plectin | 0.0118446 |
| ANXA5 | annexin A5 | 0.0117505 |
| RPL14 | ribosomal protein L14 | 0.0116741 |
| FAM53C | family with sequence similarity 53, member C | 0.0116636 |
| SEPTIN11 | septin 11 | 0.0116609 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0116529 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0114227 |
| CDH13 | cadherin 13 | 0.0112865 |
| RPS15A | ribosomal protein S15a | 0.0112679 |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 | 0.0110862 |
| RPL5 | ribosomal protein L5 | 0.0110223 |
| MYLIP | myosin regulatory light chain interacting protein | 0.0109955 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.01098 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.334586 |
| PTMA | prothymosin, alpha | -0.222142 |
| DSCAM | Down syndrome cell adhesion molecule | -0.110973 |
| TMSB10 | thymosin beta 10 | -0.102025 |
| PRELID2 | PRELI domain containing 2 | -0.0998057 |
| FAT1 | FAT atypical cadherin 1 | -0.0890028 |
| TXNRD1 | thioredoxin reductase 1 | -0.0766054 |
| RAD51B | RAD51 paralog B | -0.0758226 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0671893 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0657399 |
| AHNAK | AHNAK nucleoprotein | -0.0644405 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0627794 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.062432 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0619234 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0615173 |
| RBM39 | RNA binding motif protein 39 | -0.0600433 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0599593 |
| MKI67 | marker of proliferation Ki-67 | -0.0593178 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.055634 |
| NF1 | neurofibromin 1 | -0.0550566 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0547461 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0546134 |
| SETD5 | SET domain containing 5 | -0.0545715 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0535426 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.05317 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0507474 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0505704 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0497705 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0490633 |
| MED13L | mediator complex subunit 13-like | -0.0484282 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0477087 |
| GOLGA4 | golgin A4 | -0.0474069 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0471196 |
| DIAPH3 | diaphanous-related formin 3 | -0.04638 |
| OGA | O-GlcNAcase | -0.0456507 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0455045 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.045023 |
| TENM3 | teneurin transmembrane protein 3 | -0.0443489 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0437132 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.043371 |
| ARF4 | ADP-ribosylation factor 4 | -0.0432768 |
| USP34 | ubiquitin specific peptidase 34 | -0.0430918 |
| PKM | pyruvate kinase, muscle | -0.0430161 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0425872 |
| CENPF | centromere protein F, 350/400kDa | -0.0425799 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0422376 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0421813 |
| KPNB1 | karyopherin (importin) beta 1 | -0.041552 |
| CDK19 | cyclin-dependent kinase 19 | -0.0415102 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0414779 |
| ZNF292 | zinc finger protein 292 | -0.0406362 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0403922 |
| PGK1 | phosphoglycerate kinase 1 | -0.0397871 |
| TPM4 | tropomyosin 4 | -0.0394103 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0393576 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0388166 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0388107 |
| HMGB2 | high mobility group box 2 | -0.038626 |
| HELZ | helicase with zinc finger | -0.0386171 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0385194 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0379897 |
| MATR3 | matrin 3 | -0.0375164 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.037492 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0374188 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0372483 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0370121 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0366582 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0361217 |
| RBM25 | RNA binding motif protein 25 | -0.0361183 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0359718 |
| VCL | vinculin | -0.0358142 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0356014 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0352413 |
| FDPS | farnesyl diphosphate synthase | -0.0351358 |
| VMP1 | vacuole membrane protein 1 | -0.0351185 |
| ZNF654 | zinc finger protein 654 | -0.0350016 |
| JMJD1C | jumonji domain containing 1C | -0.0348972 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0348924 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0348366 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0347825 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0346344 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0344236 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0343351 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0342896 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0342437 |
| TMEM41B | transmembrane protein 41B | -0.0342315 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0340815 |
| NDRG1 | N-myc downstream regulated 1 | -0.033965 |
| PFN1 | profilin 1 | -0.0337326 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0336962 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.03363 |
| PTK2 | protein tyrosine kinase 2 | -0.0333712 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0333646 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0332828 |
| MED13 | mediator complex subunit 13 | -0.033149 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0330249 |
| SHROOM3 | shroom family member 3 | -0.0330074 |
| NOP58 | NOP58 ribonucleoprotein | -0.0329007 |
| SON | SON DNA binding protein | -0.0326427 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0323843 |
