4EGI-1_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.240151
CXCL8 chemokine (C-X-C motif) ligand 8 0.147821
VEGFA vascular endothelial growth factor A 0.143614
PABPC1 poly(A) binding protein, cytoplasmic 1 0.10849
NAV2 neuron navigator 2 0.0907433
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0810355
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0805667
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0766754
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0765082
FNDC3B fibronectin type III domain containing 3B 0.072541
PTK2 protein tyrosine kinase 2 0.0696496
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0651052
CD44 CD44 molecule (Indian blood group) 0.0625497
EEF2 eukaryotic translation elongation factor 2 0.0600865
TRIO trio Rho guanine nucleotide exchange factor 0.0522357
RICTOR RPTOR independent companion of MTOR, complex 2 0.0496842
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0474757
HMGA2 high mobility group AT-hook 2 0.0415966
MYH9 myosin, heavy chain 9, non-muscle 0.0405945
PLSCR1 phospholipid scramblase 1 0.0388205
RASA2 RAS p21 protein activator 2 0.0381722
B2M beta-2-microglobulin 0.0372056
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0369469
ECE1 endothelin converting enzyme 1 0.0360606
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0355704
SOD2 superoxide dismutase 2, mitochondrial 0.034673
ARRDC3 arrestin domain containing 3 0.034252
SMAD3 SMAD family member 3 0.0322324
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0318346
UBC ubiquitin C 0.0314635
STAT1 signal transducer and activator of transcription 1, 91kDa 0.03142
LPP LIM domain containing preferred translocation partner in lipoma 0.0305561
FMNL2 formin-like 2 0.028834
WWTR1 WW domain containing transcription regulator 1 0.0286451
PLEC plectin 0.0285747
TNIP1 TNFAIP3 interacting protein 1 0.0283206
ZFAND3 zinc finger, AN1-type domain 3 0.0280975
SP100 SP100 nuclear antigen 0.0272743
SBF2 SET binding factor 2 0.0271453
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0270112
DOCK5 dedicator of cytokinesis 5 0.0269234
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0263933
SVIL supervillin 0.0262004
SFPQ splicing factor proline/glutamine-rich 0.0261374
NRP1 neuropilin 1 0.025443
NOTCH2 notch 2 0.0249582
FOSL1 FOS-like antigen 1 0.0247649
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0245466
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0244617
COPA coatomer protein complex, subunit alpha 0.0243034
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0241652
ZFPM2 zinc finger protein, FOG family member 2 0.0239668
CCNL1 cyclin L1 0.0238195
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0232041
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0231183
ALCAM activated leukocyte cell adhesion molecule 0.0227811
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0226992
HSPA8 heat shock 70kDa protein 8 0.022685
CSDE1 cold shock domain containing E1, RNA-binding 0.0226561
MLF1 myeloid leukemia factor 1 0.022225
COG5 component of oligomeric golgi complex 5 0.0222206
PTBP2 polypyrimidine tract binding protein 2 0.0221348
AKAP9 A kinase (PRKA) anchor protein 9 0.0220372
GOLGA4 golgin A4 0.0219543
PITPNB phosphatidylinositol transfer protein, beta 0.0219341
GRB10 growth factor receptor-bound protein 10 0.0218336
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0217275
VMP1 vacuole membrane protein 1 0.0211767
MSN moesin 0.0211348
HIPK2 homeodomain interacting protein kinase 2 0.0208703
MAML2 mastermind-like 2 (Drosophila) 0.0207142
ANKH ANKH inorganic pyrophosphate transport regulator 0.0206749
DPYSL3 dihydropyrimidinase-like 3 0.0204876
RPL3 ribosomal protein L3 0.0204784
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.020092
KMT2E lysine (K)-specific methyltransferase 2E 0.0200771
IL6ST interleukin 6 signal transducer 0.0198085
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0197622
FAF1 Fas (TNFRSF6) associated factor 1 0.0197148
ZNF148 zinc finger protein 148 0.0196857
DOCK7 dedicator of cytokinesis 7 0.0195413
MYO9B myosin IXB 0.019531
PICALM phosphatidylinositol binding clathrin assembly protein 0.0195141
SHB Src homology 2 domain containing adaptor protein B 0.0193757
NRIP1 nuclear receptor interacting protein 1 0.0193126
ADAR adenosine deaminase, RNA-specific 0.0192911
OPTN optineurin 0.0191796
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0191699
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0190786
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0190346
TMEM165 transmembrane protein 165 0.0188757
PCM1 pericentriolar material 1 0.0188557
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0188438
AXL AXL receptor tyrosine kinase 0.0188068
STK24 serine/threonine kinase 24 0.0186986
TNS1 tensin 1 0.0186715
MED13L mediator complex subunit 13-like 0.0185756
RNF145 ring finger protein 145 0.0185585
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0185106
COL6A3 collagen, type VI, alpha 3 0.0184831

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.283909
COL1A1 collagen, type I, alpha 1 -0.173488
TIMP3 TIMP metallopeptidase inhibitor 3 -0.162475
NDRG1 N-myc downstream regulated 1 -0.149846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.111602
PSD3 pleckstrin and Sec7 domain containing 3 -0.103387
COL1A2 collagen, type I, alpha 2 -0.0898514
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0711692
COL5A1 collagen, type V, alpha 1 -0.0678969
FBN1 fibrillin 1 -0.064798
MT2A metallothionein 2A -0.0599623
CANX calnexin -0.0580189
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0544565
IGFBP3 insulin-like growth factor binding protein 3 -0.0520836
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0490079
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0470359
TPT1 tumor protein, translationally-controlled 1 -0.0466439
ASPH aspartate beta-hydroxylase -0.0441664
CAVIN1 caveolae associated protein 1 -0.0435839
RPS8 ribosomal protein S8 -0.0413419
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0401277
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0393039
IER3 immediate early response 3 -0.03804
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0373235
ABI3BP ABI family, member 3 (NESH) binding protein -0.0369903
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0359671
LOX lysyl oxidase -0.0354448
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0337889
TPM4 tropomyosin 4 -0.032378
RPL35A ribosomal protein L35a -0.0322123
RRBP1 ribosome binding protein 1 -0.0321117
F3 coagulation factor III (thromboplastin, tissue factor) -0.0315241
PDE4D phosphodiesterase 4D, cAMP-specific -0.0306124
RPL37A ribosomal protein L37a -0.0302813
PRELID2 PRELI domain containing 2 -0.0300167
LOXL2 lysyl oxidase-like 2 -0.0286809
AHNAK AHNAK nucleoprotein -0.0286606
COL3A1 collagen, type III, alpha 1 -0.028371
INHBA inhibin, beta A -0.0282939
PALLD palladin, cytoskeletal associated protein -0.0282843
VCL vinculin -0.0274652
TGFBI transforming growth factor, beta-induced, 68kDa -0.0270673
SQSTM1 sequestosome 1 -0.0268884
FKBP10 FK506 binding protein 10, 65 kDa -0.0266594
HLA-B major histocompatibility complex, class I, B -0.0263941
TRPS1 trichorhinophalangeal syndrome I -0.0256755
PDLIM5 PDZ and LIM domain 5 -0.0252646
COL7A1 collagen, type VII, alpha 1 -0.025233
LMAN1 lectin, mannose-binding, 1 -0.0248887
RPS3 ribosomal protein S3 -0.0247608
RPS25 ribosomal protein S25 -0.0239684
EFNA5 ephrin-A5 -0.0238153
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0235555
TMSB10 thymosin beta 10 -0.0235191
TMEM263 transmembrane protein 263 -0.0230884
CADM1 cell adhesion molecule 1 -0.0227458
NABP1 nucleic acid binding protein 1 -0.0226161
CALD1 caldesmon 1 -0.0225142
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0216322
RPL26 ribosomal protein L26 -0.0213466
FBXL13 F-box and leucine-rich repeat protein 13 -0.0213353
ACTG1 actin gamma 1 -0.0211409
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0204308
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.020038
RPL31 ribosomal protein L31 -0.0198477
VDAC1 voltage-dependent anion channel 1 -0.0197929
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0196878
KCTD16 potassium channel tetramerization domain containing 16 -0.019585
ZMYND8 zinc finger, MYND-type containing 8 -0.0195803
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0195225
IARS1 isoleucyl-tRNA synthetase 1 -0.0194931
TTC3 tetratricopeptide repeat domain 3 -0.0194727
NPAS2 neuronal PAS domain protein 2 -0.0191744
SPDYA speedy/RINGO cell cycle regulator family member A -0.0190389
RPS24 ribosomal protein S24 -0.0188079
FTL ferritin, light polypeptide -0.0185822
RPS27A ribosomal protein S27a -0.0185128
RPL30 ribosomal protein L30 -0.0184836
GNAS GNAS complex locus -0.0184774
RPL9 ribosomal protein L9 -0.0183967
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0183453
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0181493
FSTL1 follistatin-like 1 -0.0181324
COL5A2 collagen, type V, alpha 2 -0.0181037
RTN3 reticulon 3 -0.0178604
DPYSL2 dihydropyrimidinase-like 2 -0.0177996
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0177517
PTMA prothymosin, alpha -0.0175822
CALU calumenin -0.0174137
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0173156
GARS1 glycyl-tRNA synthetase 1 -0.0172827
INTS6 integrator complex subunit 6 -0.0171966
OXR1 oxidation resistance 1 -0.0170686
RPL28 ribosomal protein L28 -0.0170661
GLIS3 GLIS family zinc finger 3 -0.0169597
PTPRF protein tyrosine phosphatase, receptor type, F -0.0168139
RBPMS RNA binding protein with multiple splicing -0.0167657
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0167103
INSIG1 insulin induced gene 1 -0.0166306
KDM3A lysine (K)-specific demethylase 3A -0.0164716