4EGI-1_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP1 insulin-like growth factor binding protein 1 0.139033
AKAP12 A kinase (PRKA) anchor protein 12 0.0792198
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0708009
PDLIM5 PDZ and LIM domain 5 0.053922
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0450002
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0441144
EEF2 eukaryotic translation elongation factor 2 0.0436053
MBNL2 muscleblind-like splicing regulator 2 0.0382742
GMDS GDP-mannose 4,6-dehydratase 0.0349582
IGF2 insulin-like growth factor 2 0.0344366
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0339691
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0295616
GCLC glutamate-cysteine ligase, catalytic subunit 0.0266359
CTSB cathepsin B 0.0257878
MBNL1 muscleblind-like splicing regulator 1 0.0248792
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0240315
ASPH aspartate beta-hydroxylase 0.0234509
KYNU kynureninase 0.0220787
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0213385
TNS1 tensin 1 0.0201779
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0195912
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.018929
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0189241
FOXP1 forkhead box P1 0.0188961
SVIL supervillin 0.0186906
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0184843
GRB10 growth factor receptor-bound protein 10 0.0178567
PAWR PRKC, apoptosis, WT1, regulator 0.0175856
EGFR epidermal growth factor receptor 0.0174395
FAM107B family with sequence similarity 107, member B 0.0171381
RPL3 ribosomal protein L3 0.0168201
INTS6 integrator complex subunit 6 0.0164688
DSPP dentin sialophosphoprotein 0.0163163
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0162457
AKAP9 A kinase (PRKA) anchor protein 9 0.0158965
SORBS1 sorbin and SH3 domain containing 1 0.0158429
HPCAL1 hippocalcin-like 1 0.015645
LPP LIM domain containing preferred translocation partner in lipoma 0.0153614
PDE4D phosphodiesterase 4D, cAMP-specific 0.0153167
PALLD palladin, cytoskeletal associated protein 0.0153028
RAB3B RAB3B, member RAS oncogene family 0.0152204
LMO7 LIM domain 7 0.0151175
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0145837
RAI14 retinoic acid induced 14 0.0143522
ACTG1 actin gamma 1 0.0141559
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0141008
HSPA8 heat shock 70kDa protein 8 0.0140388
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0138773
SQSTM1 sequestosome 1 0.0137809
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0135034
ZNF804A zinc finger protein 804A 0.0129613
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0129451
ITGA6 integrin, alpha 6 0.012893
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0127879
TMED2 transmembrane emp24 domain trafficking protein 2 0.0127607
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0126758
COPA coatomer protein complex, subunit alpha 0.012643
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0126355
GSK3B glycogen synthase kinase 3 beta 0.0125442
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0125362
RBM19 RNA binding motif protein 19 0.0123525
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0122177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0121516
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0121309
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0121274
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0120525
MACF1 microtubule-actin crosslinking factor 1 0.012036
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0120348
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0119665
GK glycerol kinase 0.0117059
RPS7 ribosomal protein S7 0.0115986
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0114108
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0112881
FAT1 FAT atypical cadherin 1 0.0111779
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0111694
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0111557
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0111142
CAPRIN2 caprin family member 2 0.0110997
APP amyloid beta (A4) precursor protein 0.0110902
TRIO trio Rho guanine nucleotide exchange factor 0.0110835
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0110727
ANXA2 annexin A2 0.0108645
DTNA dystrobrevin, alpha 0.0106018
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0105927
SOD2 superoxide dismutase 2, mitochondrial 0.0105598
ARHGAP26 Rho GTPase activating protein 26 0.0105399
RSU1 Ras suppressor protein 1 0.0105197
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0104963
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0102113
STK39 serine threonine kinase 39 0.0101772
SND1 staphylococcal nuclease and tudor domain containing 1 0.0101032
PMM2 phosphomannomutase 2 0.0100944
BRD2 bromodomain containing 2 0.0100199
SERBP1 SERPINE1 mRNA binding protein 1 0.0100148
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.00999312
PGM3 phosphoglucomutase 3 0.00997046
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.00992724
PEAK1 pseudopodium-enriched atypical kinase 1 0.00988082
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00984079
ANXA5 annexin A5 0.0098369

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.234283
MT2A metallothionein 2A -0.16728
GPC3 glypican 3 -0.127869
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.123571
TPT1 tumor protein, translationally-controlled 1 -0.112949
RPL11 ribosomal protein L11 -0.105694
FN1 fibronectin 1 -0.0944318
RPLP1 ribosomal protein, large, P1 -0.0930697
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0812828
FBF1 Fas (TNFRSF6) binding factor 1 -0.0801298
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0761952
RPS6 ribosomal protein S6 -0.0741475
RPS24 ribosomal protein S24 -0.0731466
LRMDA leucine rich melanocyte differentiation associated -0.0677922
FTL ferritin, light polypeptide -0.0667926
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0653763
RPL35A ribosomal protein L35a -0.0637168
SLC38A2 solute carrier family 38, member 2 -0.063687
ZMYND8 zinc finger, MYND-type containing 8 -0.0620996
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0619009
RPS19 ribosomal protein S19 -0.0618596
GNAS GNAS complex locus -0.060612
EHBP1 EH domain binding protein 1 -0.060076
RPL37A ribosomal protein L37a -0.0600254
RPS21 ribosomal protein S21 -0.0582462
C3 complement component 3 -0.0549003
TMSB10 thymosin beta 10 -0.0548996
FNDC3B fibronectin type III domain containing 3B -0.0530015
TRIM26 tripartite motif containing 26 -0.0528935
RPL34 ribosomal protein L34 -0.0526424
GPC6 glypican 6 -0.052331
RPLP2 ribosomal protein, large, P2 -0.0496195
ELL2 elongation factor, RNA polymerase II, 2 -0.0488834
RPL23 ribosomal protein L23 -0.0488122
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0487239
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0481516
RBM39 RNA binding motif protein 39 -0.0479049
RPL26 ribosomal protein L26 -0.0476311
MAML2 mastermind-like 2 (Drosophila) -0.0468355
PDGFB platelet-derived growth factor beta polypeptide -0.0459388
SDC4 syndecan 4 -0.0457989
APOE apolipoprotein E -0.0456598
RRBP1 ribosome binding protein 1 -0.0446583
NPAS2 neuronal PAS domain protein 2 -0.0444967
MARCKS myristoylated alanine-rich protein kinase C substrate -0.044254
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0440852
NKD1 naked cuticle homolog 1 (Drosophila) -0.0438848
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0436145
ISG15 ISG15 ubiquitin-like modifier -0.0431287
PTCHD4 patched domain containing 4 -0.0421303
RPS27A ribosomal protein S27a -0.0419459
LOC112694756 uncharaterized LOC112694756 -0.0410308
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0408719
APOA2 apolipoprotein A-II -0.0373504
PTMA prothymosin, alpha -0.03696
EPAS1 endothelial PAS domain protein 1 -0.0366924
S100A9 S100 calcium binding protein A9 -0.0359916
RPS29 ribosomal protein S29 -0.0357106
APOB apolipoprotein B -0.0354
CPE carboxypeptidase E -0.0351706
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0351025
AMBP alpha-1-microglobulin/bikunin precursor -0.0347947
RPS23 ribosomal protein S23 -0.0347625
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0346092
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0345986
EGR1 early growth response 1 -0.0345324
JMJD1C jumonji domain containing 1C -0.0344393
TGFBI transforming growth factor, beta-induced, 68kDa -0.0343963
CFB complement factor B -0.0339512
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0336306
RPL31 ribosomal protein L31 -0.0335073
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0334514
RNF213 ring finger protein 213 -0.0333713
UGP2 UDP-glucose pyrophosphorylase 2 -0.0330454
RPS13 ribosomal protein S13 -0.0329589
RPS14 ribosomal protein S14 -0.0328022
RPL12 ribosomal protein L12 -0.0326209
TM4SF1 transmembrane 4 L six family member 1 -0.0322868
EML4 echinoderm microtubule associated protein like 4 -0.0322657
TM9SF3 transmembrane 9 superfamily member 3 -0.0321973
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0318257
APOC1 apolipoprotein C-I -0.0317972
RBM25 RNA binding motif protein 25 -0.0316666
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0310163
RPL32 ribosomal protein L32 -0.030636
RPS16 ribosomal protein S16 -0.0306341
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0302313
RAB1A RAB1A, member RAS oncogene family -0.0299245
AHSG alpha-2-HS-glycoprotein -0.0297399
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0296924
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0295766
DNAH17 dynein, axonemal, heavy chain 17 -0.0294484
VCL vinculin -0.0293111
APOA1 apolipoprotein A-I -0.02918
IER3 immediate early response 3 -0.0291698
RPS10 ribosomal protein S10 -0.029125
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0291068
SOS1 son of sevenless homolog 1 (Drosophila) -0.0289369
IFITM1 interferon induced transmembrane protein 1 -0.028818
RPL19 ribosomal protein L19 -0.0286901