4EGI-1_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) 0.136629
LMO7 LIM domain 7 0.115938
MBNL2 muscleblind-like splicing regulator 2 0.103982
FNDC3B fibronectin type III domain containing 3B 0.0901923
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0740644
EZR ezrin 0.0697976
ATXN1 ataxin 1 0.0681946
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0666331
LPP LIM domain containing preferred translocation partner in lipoma 0.0665529
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0662258
PDLIM5 PDZ and LIM domain 5 0.0649383
MYOF myoferlin 0.064534
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0642711
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0629873
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0629344
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0602646
EMP1 epithelial membrane protein 1 0.0591906
BCL2L1 BCL2-like 1 0.0589871
PTPRK protein tyrosine phosphatase, receptor type, K 0.0575049
VEGFA vascular endothelial growth factor A 0.0572725
VMP1 vacuole membrane protein 1 0.0565545
MYO1E myosin IE 0.0529435
MBNL1 muscleblind-like splicing regulator 1 0.0528636
DSPP dentin sialophosphoprotein 0.0518594
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0502854
SEPTIN9 septin 9 0.0491571
TJP1 tight junction protein 1 0.0481795
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0478695
AKAP13 A kinase (PRKA) anchor protein 13 0.0477165
MYH9 myosin, heavy chain 9, non-muscle 0.047315
EXT1 exostosin glycosyltransferase 1 0.0466968
VCL vinculin 0.0454988
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0446463
BACE2 beta-site APP-cleaving enzyme 2 0.0436955
NUPR1 nuclear protein, transcriptional regulator, 1 0.0435498
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0430957
TMC5 transmembrane channel-like 5 0.0430875
FRMD5 FERM domain containing 5 0.0427966
RUNX1 runt-related transcription factor 1 0.0425598
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0425266
DOCK5 dedicator of cytokinesis 5 0.0425021
FTH1 ferritin, heavy polypeptide 1 0.0424208
ZSWIM6 zinc finger, SWIM-type containing 6 0.0407247
POF1B premature ovarian failure, 1B 0.0403023
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0381962
EXOC4 exocyst complex component 4 0.0373265
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0371816
NCEH1 neutral cholesterol ester hydrolase 1 0.0367011
CDK6 cyclin-dependent kinase 6 0.0358436
BTBD9 BTB (POZ) domain containing 9 0.0357829
ANXA11 annexin A11 0.0357234
SH3RF1 SH3 domain containing ring finger 1 0.0355559
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0354572
FAT1 FAT atypical cadherin 1 0.0354129
NDRG1 N-myc downstream regulated 1 0.0352636
GMDS GDP-mannose 4,6-dehydratase 0.0349295
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0348659
KLHL29 kelch-like family member 29 0.0345003
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0344671
ZBTB20 zinc finger and BTB domain containing 20 0.0342193
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0342166
INTS6 integrator complex subunit 6 0.0331265
COBL cordon-bleu WH2 repeat protein 0.032897
ANXA1 annexin A1 0.0328691
CADPS2 Ca++-dependent secretion activator 2 0.0328264
RNF213 ring finger protein 213 0.0324198
FOXO3 forkhead box O3 0.0321537
SNX9 sorting nexin 9 0.0320913
ARHGAP32 Rho GTPase activating protein 32 0.0320536
HSPA8 heat shock 70kDa protein 8 0.0317933
KRT8 keratin 8, type II 0.0317686
PLEC plectin 0.0316402
C6ORF132 chromosome 6 open reading frame 132 0.0315519
CATSPERB catsper channel auxiliary subunit beta 0.0315466
MPRIP myosin phosphatase Rho interacting protein 0.0315076
AKAP9 A kinase (PRKA) anchor protein 9 0.0314989
ANXA3 annexin A3 0.0311724
GOLGB1 golgin B1 0.0307885
LCN2 lipocalin 2 0.0302715
CLDN4 claudin 4 0.0300149
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0298535
NCOA7 nuclear receptor coactivator 7 0.0297877
WWC1 WW and C2 domain containing 1 0.0297703
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0297131
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0296597
RAD51B RAD51 paralog B 0.029088
MYO1D myosin ID 0.0290841
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0284417
DST dystonin 0.0284252
SLC38A2 solute carrier family 38, member 2 0.0283055
IL1RAP interleukin 1 receptor accessory protein 0.0282943
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0280799
BCAS3 breast carcinoma amplified sequence 3 0.0280625
MACROD2 MACRO domain containing 2 0.0280592
FNIP1 folliculin interacting protein 1 0.0278581
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0275132
BAIAP2L1 BAI1-associated protein 2-like 1 0.0273138
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272304
SHB Src homology 2 domain containing adaptor protein B 0.0270217
HKDC1 hexokinase domain containing 1 0.0270187

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.150327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140329
TMSB10 thymosin beta 10 -0.0925587
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0867397
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0844851
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0806183
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0781763
S100A6 S100 calcium binding protein A6 -0.0772831
PTMA prothymosin, alpha -0.0756193
PDIA3 protein disulfide isomerase family A, member 3 -0.0627769
INSIG1 insulin induced gene 1 -0.0544903
S100A10 S100 calcium binding protein A10 -0.0537387
EPCAM epithelial cell adhesion molecule -0.0526258
RRBP1 ribosome binding protein 1 -0.0520513
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0513783
ACACA acetyl-CoA carboxylase alpha -0.0449242
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0440062
SMC4 structural maintenance of chromosomes 4 -0.0428443
FGFR2 fibroblast growth factor receptor 2 -0.0414111
H1-0 H1.0 linker histone -0.0413878
AGR2 anterior gradient 2 -0.040559
ANLN anillin, actin binding protein -0.0397031
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.037508
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0359489
LOC112694756 uncharaterized LOC112694756 -0.0358296
GPX2 glutathione peroxidase 2 -0.0336213
EIF1 eukaryotic translation initiation factor 1 -0.0334583
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0332804
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0324001
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.032131
RPLP1 ribosomal protein, large, P1 -0.0314745
GNAS GNAS complex locus -0.0313196
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0308378
KPNB1 karyopherin (importin) beta 1 -0.0300598
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0299624
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293641
DLG1 discs, large homolog 1 (Drosophila) -0.0293489
MKI67 marker of proliferation Ki-67 -0.0291089
RPL35A ribosomal protein L35a -0.0280833
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0279515
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0278516
GSTP1 glutathione S-transferase pi 1 -0.0275781
MSMO1 methylsterol monooxygenase 1 -0.0274273
WDR45B WD repeat domain 45B -0.0274096
ALDOC aldolase C, fructose-bisphosphate -0.0274062
HLA-E major histocompatibility complex, class I, E -0.0261995
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0260242
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0257205
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0256744
SREBF2 sterol regulatory element binding transcription factor 2 -0.0256375
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0243551
FDPS farnesyl diphosphate synthase -0.0243542
RAD21 RAD21 homolog (S. pombe) -0.0242933
S100A11 S100 calcium binding protein A11 -0.0241939
DIAPH3 diaphanous-related formin 3 -0.0240212
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.023581
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0230807
PDIA6 protein disulfide isomerase family A, member 6 -0.0229419
CD46 CD46 molecule, complement regulatory protein -0.0229045
HMGB1 high mobility group box 1 -0.0226607
XPO1 exportin 1 -0.0224508
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0223719
CD2AP CD2-associated protein -0.02219
LMAN1 lectin, mannose-binding, 1 -0.0221166
FASN fatty acid synthase -0.021973
LYZ lysozyme -0.0218302
CBX3 chromobox homolog 3 -0.021751
GARS1 glycyl-tRNA synthetase 1 -0.0216969
DEK DEK proto-oncogene -0.0212551
GRB2 growth factor receptor-bound protein 2 -0.0212011
HLA-A major histocompatibility complex, class I, A -0.0210816
WARS1 tryptophanyl-tRNA synthetase 1 -0.0210258
RPL11 ribosomal protein L11 -0.0209192
RBM25 RNA binding motif protein 25 -0.0208669
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0207628
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.0205261
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0204004
HMGA1 high mobility group AT-hook 1 -0.0202145
RAB1A RAB1A, member RAS oncogene family -0.0201121
H3-3B H3.3 histone B -0.0201103
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.020071
THOC2 THO complex 2 -0.0200076
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0198977
MYL12B myosin, light chain 12B, regulatory -0.0197763
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0197054
ATF5 activating transcription factor 5 -0.0196436
RPS21 ribosomal protein S21 -0.0196326
BIRC6 baculoviral IAP repeat containing 6 -0.0196063
HLA-C major histocompatibility complex, class I, C -0.0195655
TMEM123 transmembrane protein 123 -0.0194254
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0190797
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0189384
RPL8 ribosomal protein L8 -0.018817
CAMKMT calmodulin-lysine N-methyltransferase -0.0187204
KDM3A lysine (K)-specific demethylase 3A -0.0186591
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0185873
RPL23 ribosomal protein L23 -0.0185716
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0185393
PFN1 profilin 1 -0.0185073
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0183893