4EGI-1_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0955496
EEF2 eukaryotic translation elongation factor 2 0.0946089
FAT1 FAT atypical cadherin 1 0.0867082
EPS8 epidermal growth factor receptor pathway substrate 8 0.0794491
LMO7 LIM domain 7 0.0617434
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0553023
PTPRR protein tyrosine phosphatase, receptor type, R 0.051702
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0475257
EGFR epidermal growth factor receptor 0.0426882
BACE2 beta-site APP-cleaving enzyme 2 0.0396515
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.037189
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0331673
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0310502
RPL3 ribosomal protein L3 0.0304883
AKAP9 A kinase (PRKA) anchor protein 9 0.0295186
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0291591
CEMIP cell migration inducing protein, hyaluronan binding 0.0275346
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0266437
DSCAM Down syndrome cell adhesion molecule 0.0260131
TXNRD1 thioredoxin reductase 1 0.0259226
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0253078
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0236036
FOXP1 forkhead box P1 0.0232388
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0231865
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0230298
CCSER1 coiled-coil serine-rich protein 1 0.0228726
GOLGA4 golgin A4 0.0225552
SLTM SAFB-like, transcription modulator 0.0224439
PCBP2 poly(rC) binding protein 2 0.0223722
SHROOM3 shroom family member 3 0.0222583
EXT1 exostosin glycosyltransferase 1 0.0219863
COPA coatomer protein complex, subunit alpha 0.0215061
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0212171
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0208843
ZNF292 zinc finger protein 292 0.020458
JMY junction mediating and regulatory protein, p53 cofactor 0.0202883
SAMD5 sterile alpha motif domain containing 5 0.0201935
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0200742
DST dystonin 0.0190824
HSPA8 heat shock 70kDa protein 8 0.0189398
SFPQ splicing factor proline/glutamine-rich 0.0183915
BTBD9 BTB (POZ) domain containing 9 0.0183776
EIF4B eukaryotic translation initiation factor 4B 0.0182894
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0179954
KMT2C lysine (K)-specific methyltransferase 2C 0.0179419
UTRN utrophin 0.0177855
TCF12 transcription factor 12 0.017668
PTPRG protein tyrosine phosphatase, receptor type, G 0.0174829
GARS1 glycyl-tRNA synthetase 1 0.0171191
CADPS2 Ca++-dependent secretion activator 2 0.0171012
SEC31A SEC31 homolog A (S. cerevisiae) 0.0168542
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0166853
RNF145 ring finger protein 145 0.0166408
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0165297
ASPH aspartate beta-hydroxylase 0.016428
TBC1D15 TBC1 domain family, member 15 0.0163768
UBN2 ubinuclein 2 0.0163608
FTH1 ferritin, heavy polypeptide 1 0.0162491
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0162442
LGALS12 lectin, galactoside-binding, soluble, 12 0.0161518
ZNF638 zinc finger protein 638 0.0160387
ATXN1 ataxin 1 0.015806
TMF1 TATA element modulatory factor 1 0.0157211
RPS18 ribosomal protein S18 0.0155994
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0153641
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0149883
ERBIN erbb2 interacting protein 0.0148703
UBA6 ubiquitin-like modifier activating enzyme 6 0.014867
TBC1D5 TBC1 domain family, member 5 0.0148593
ITPRID2 ITPR interacting domain containing 2 0.0148464
KTN1 kinectin 1 (kinesin receptor) 0.0148204
SNX9 sorting nexin 9 0.014756
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0146761
FNIP1 folliculin interacting protein 1 0.0146234
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0144836
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0144774
FBXL17 F-box and leucine-rich repeat protein 17 0.0144632
ZFC3H1 zinc finger, C3H1-type containing 0.0144502
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0144063
PCM1 pericentriolar material 1 0.01435
SPON1 spondin 1, extracellular matrix protein 0.0142507
MON2 MON2 homolog (S. cerevisiae) 0.0142288
BBS9 Bardet-Biedl syndrome 9 0.0142075
TTC3 tetratricopeptide repeat domain 3 0.0142036
MACF1 microtubule-actin crosslinking factor 1 0.0141158
TMED2 transmembrane emp24 domain trafficking protein 2 0.0138981
CCPG1 cell cycle progression 1 0.0138336
COG5 component of oligomeric golgi complex 5 0.0135951
NEBL nebulette 0.0135805
CARD16 caspase recruitment domain family, member 16 0.0134866
MLEC malectin 0.0134399
PTEN phosphatase and tensin homolog 0.0133757
ZBTB20 zinc finger and BTB domain containing 20 0.0132567
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0132291
PICALM phosphatidylinositol binding clathrin assembly protein 0.0131879
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0131615
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0131362
RB1CC1 RB1-inducible coiled-coil 1 0.0131333
RAB6A RAB6A, member RAS oncogene family 0.0130625
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0130232

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.215111
RPLP1 ribosomal protein, large, P1 -0.097852
TMSB10 thymosin beta 10 -0.0948673
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0835403
ANXA2 annexin A2 -0.0795456
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0727215
RPL37A ribosomal protein L37a -0.0702798
RPL35A ribosomal protein L35a -0.0679918
RPL34 ribosomal protein L34 -0.0660317
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0657857
PDE4D phosphodiesterase 4D, cAMP-specific -0.0623097
HLA-B major histocompatibility complex, class I, B -0.0620807
RPLP2 ribosomal protein, large, P2 -0.0616434
RPS12 ribosomal protein S12 -0.0615998
RPS6 ribosomal protein S6 -0.0607681
PTMA prothymosin, alpha -0.0594894
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0589446
RPS19 ribosomal protein S19 -0.0568769
FLNB filamin B, beta -0.0565476
RPS8 ribosomal protein S8 -0.0562114
RPL26 ribosomal protein L26 -0.0560865
THSD4 thrombospondin, type I, domain containing 4 -0.0555684
RPL31 ribosomal protein L31 -0.0542377
RPS24 ribosomal protein S24 -0.0533884
GMDS GDP-mannose 4,6-dehydratase -0.049825
RPS25 ribosomal protein S25 -0.0486009
RPS23 ribosomal protein S23 -0.0478796
IFI6 interferon, alpha-inducible protein 6 -0.0472217
RIGI RNA sensor RIG-I -0.0467189
RPL9 ribosomal protein L9 -0.046292
RPS27A ribosomal protein S27a -0.0461242
MSI2 musashi RNA-binding protein 2 -0.0437806
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0436776
RPS29 ribosomal protein S29 -0.043503
ACTN4 actinin, alpha 4 -0.0430918
LAMB3 laminin, beta 3 -0.0429034
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0424554
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0419259
RPL11 ribosomal protein L11 -0.0408886
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.040036
F3 coagulation factor III (thromboplastin, tissue factor) -0.0390498
RPL36 ribosomal protein L36 -0.0379021
RPS21 ribosomal protein S21 -0.0378064
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0376578
NPSR1 neuropeptide S receptor 1 -0.036301
RPL19 ribosomal protein L19 -0.0361837
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0352679
RPS17 ribosomal protein S17 -0.0351929
ACTG1 actin gamma 1 -0.0349676
RPL37 ribosomal protein L37 -0.0337276
AOPEP aminopeptidase O (putative) -0.0335353
INTS6 integrator complex subunit 6 -0.033397
RPL12 ribosomal protein L12 -0.0331493
LAMA4 laminin, alpha 4 -0.0328283
MCU mitochondrial calcium uniporter -0.0324264
RPS13 ribosomal protein S13 -0.0321433
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0320817
VCL vinculin -0.0320036
RPS16 ribosomal protein S16 -0.0319785
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0318198
RPL30 ribosomal protein L30 -0.0311052
MYH14 myosin, heavy chain 14, non-muscle -0.030884
RPS3 ribosomal protein S3 -0.0299819
SP100 SP100 nuclear antigen -0.029925
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0298323
DSG3 desmoglein 3 -0.0296186
RPS11 ribosomal protein S11 -0.0295861
PALLD palladin, cytoskeletal associated protein -0.0293394
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0288378
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0287081
PKM pyruvate kinase, muscle -0.028178
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0280252
RPL23 ribosomal protein L23 -0.027746
FBXO11 F-box protein 11 -0.0273699
RPS15 ribosomal protein S15 -0.0262751
RBM25 RNA binding motif protein 25 -0.0261825
PSD3 pleckstrin and Sec7 domain containing 3 -0.025848
RPL36A ribosomal protein L36a -0.025768
RPS5 ribosomal protein S5 -0.0255636
RPL38 ribosomal protein L38 -0.0255452
RPL28 ribosomal protein L28 -0.025337
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0250476
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0248735
NT5C2 5'-nucleotidase, cytosolic II -0.0248556
PERP PERP, TP53 apoptosis effector -0.0246188
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0244216
C6ORF132 chromosome 6 open reading frame 132 -0.0243985
HLA-A major histocompatibility complex, class I, A -0.0241533
S100A10 S100 calcium binding protein A10 -0.0236942
CATSPERB catsper channel auxiliary subunit beta -0.0236486
IER3 immediate early response 3 -0.0236343
RRBP1 ribosome binding protein 1 -0.0233933
S100P S100 calcium binding protein P -0.0232462
MPRIP myosin phosphatase Rho interacting protein -0.0228034
RPS14 ribosomal protein S14 -0.0226891
ISG15 ISG15 ubiquitin-like modifier -0.0225113
RPL35 ribosomal protein L35 -0.0217149
RPL32 ribosomal protein L32 -0.0216978
RPL27A ribosomal protein L27a -0.0214358
RPL27 ribosomal protein L27 -0.0212251