| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 4EGI-1_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.079361 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0594689 |
| RPS12 | ribosomal protein S12 | 0.0561112 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0524568 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0491125 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0450881 |
| MT1E | metallothionein 1E | 0.0334407 |
| RPL23 | ribosomal protein L23 | 0.0292645 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0292308 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0273908 |
| RPS2 | ribosomal protein S2 | 0.0268512 |
| MT2A | metallothionein 2A | 0.0266868 |
| CAPRIN2 | caprin family member 2 | 0.026012 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0255416 |
| UBC | ubiquitin C | 0.0255251 |
| KLF6 | Kruppel-like factor 6 | 0.0254294 |
| ANGPTL4 | angiopoietin-like 4 | 0.0252408 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0251702 |
| HSPA8 | heat shock 70kDa protein 8 | 0.02491 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0230214 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0228649 |
| MCL1 | myeloid cell leukemia 1 | 0.0225939 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0225088 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0221392 |
| B2M | beta-2-microglobulin | 0.0211704 |
| RPLP0 | ribosomal protein, large, P0 | 0.0209138 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0208466 |
| RPL5 | ribosomal protein L5 | 0.0207189 |
| RPL12 | ribosomal protein L12 | 0.0203661 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0198894 |
| BRD2 | bromodomain containing 2 | 0.019416 |
| SGMS2 | sphingomyelin synthase 2 | 0.0189952 |
| TXNRD1 | thioredoxin reductase 1 | 0.0188405 |
| TPM3 | tropomyosin 3 | 0.0183515 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0175061 |
| RUNX1 | runt-related transcription factor 1 | 0.0172293 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0169275 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0163597 |
| RPL3 | ribosomal protein L3 | 0.0162239 |
| IPO7 | importin 7 | 0.0159855 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0158196 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0156377 |
| PRDX1 | peroxiredoxin 1 | 0.0153672 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0152994 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0152143 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0150438 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0147419 |
| ARRDC3 | arrestin domain containing 3 | 0.014697 |
| HDAC9 | histone deacetylase 9 | 0.0145078 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0144661 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0143968 |
| RO60 | Ro60, Y RNA binding protein | 0.0143645 |
| SIK3 | SIK family kinase 3 | 0.0140445 |
| EREG | epiregulin | 0.0139324 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0138599 |
| RPS17 | ribosomal protein S17 | 0.0134441 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0131451 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0131341 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0130219 |
| RPS4X | ribosomal protein S4, X-linked | 0.0130164 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0129037 |
| ATF3 | activating transcription factor 3 | 0.0128712 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.012838 |
| NCKAP1 | NCK-associated protein 1 | 0.0128366 |
| IL6ST | interleukin 6 signal transducer | 0.0128242 |
| SEC24A | SEC24 family member A | 0.0125894 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.012283 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.012273 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0121984 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0121641 |
| HMOX1 | heme oxygenase 1 | 0.0121143 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0121109 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0120129 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0119804 |
| RPS3 | ribosomal protein S3 | 0.0119667 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0118886 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0117985 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0116957 |
| NAV2 | neuron navigator 2 | 0.0116299 |
| RB1 | retinoblastoma 1 | 0.0114646 |
| RPS18 | ribosomal protein S18 | 0.011453 |
| RPS13 | ribosomal protein S13 | 0.0114162 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0113567 |
| NUP58 | nucleoporin 58 | 0.0113388 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0112852 |
| RPL27A | ribosomal protein L27a | 0.0112743 |
| ASTN2 | astrotactin 2 | 0.0112096 |
| SYAP1 | synapse associated protein 1 | 0.0111413 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0111117 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0110667 |
| MT1X | metallothionein 1X | 0.0110338 |
| TAC4 | tachykinin 4 (hemokinin) | 0.011026 |
| DNAJA2 | DnaJ (Hsp40) homolog, subfamily A, member 2 | 0.0109627 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0109254 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0109148 |
| AREG | amphiregulin | 0.0107859 |
| RPS7 | ribosomal protein S7 | 0.0107789 |
| CENPF | centromere protein F, 350/400kDa | 0.0107739 |
| RCOR1 | REST corepressor 1 | 0.0107214 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0106275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.138912 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.126445 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107152 |
| TP63 | tumor protein p63 | -0.102533 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.101321 |
| CD44 | CD44 molecule (Indian blood group) | -0.0948956 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0814198 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0793235 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0769896 |
| TMSB10 | thymosin beta 10 | -0.0754193 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0715402 |
| CADM2 | cell adhesion molecule 2 | -0.0712649 |
| CANX | calnexin | -0.068491 |
| VIM | vimentin | -0.0684675 |
| EFNA5 | ephrin-A5 | -0.0682507 |
| EPHA4 | EPH receptor A4 | -0.0657901 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0614379 |
| EHBP1 | EH domain binding protein 1 | -0.0589723 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0541709 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0540002 |
| TMSB4X | thymosin beta 4, X-linked | -0.0539804 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0515606 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0515459 |
| TNS3 | tensin 3 | -0.04726 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0444144 |
| COL5A2 | collagen, type V, alpha 2 | -0.0438782 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0432926 |
| MYOF | myoferlin | -0.0404283 |
| PRELID2 | PRELI domain containing 2 | -0.0388957 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0384341 |
| VCL | vinculin | -0.0383628 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0375083 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0370821 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0362061 |
| RAI1 | retinoic acid induced 1 | -0.035612 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0355319 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0353757 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0353487 |
| RNF213 | ring finger protein 213 | -0.0345669 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0342712 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0338826 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0336553 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0332461 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0330493 |
| RAD51B | RAD51 paralog B | -0.0327805 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.03272 |
| PGK1 | phosphoglycerate kinase 1 | -0.0325874 |
| AHNAK | AHNAK nucleoprotein | -0.032564 |
| CAVIN1 | caveolae associated protein 1 | -0.0322613 |
| TMEM123 | transmembrane protein 123 | -0.0319949 |
| ZNF217 | zinc finger protein 217 | -0.0317049 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0293606 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0293346 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0293289 |
| SRGN | serglycin | -0.0290959 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0288927 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0286085 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0285444 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0282766 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0279273 |
| RAB27B | RAB27B, member RAS oncogene family | -0.027559 |
| RPL35A | ribosomal protein L35a | -0.0271571 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0269435 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0266217 |
| FUS | FUS RNA binding protein | -0.0265815 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0263414 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0262848 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0261343 |
| EXOC4 | exocyst complex component 4 | -0.0259419 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0256855 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0254168 |
| ECE1 | endothelin converting enzyme 1 | -0.0244302 |
| FNIP1 | folliculin interacting protein 1 | -0.0242988 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0242461 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0240075 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0238619 |
| DENND1A | DENN/MADD domain containing 1A | -0.023578 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0235278 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0233459 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0231252 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0228874 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0227809 |
| FBXO11 | F-box protein 11 | -0.0224513 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0224166 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.022407 |
| RPL37A | ribosomal protein L37a | -0.0217615 |
| RIGI | RNA sensor RIG-I | -0.0215057 |
| TFB1M | transcription factor B1, mitochondrial | -0.0214981 |
| EGFR | epidermal growth factor receptor | -0.0213506 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0213417 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0213332 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0210101 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0210027 |
| MAP4 | microtubule-associated protein 4 | -0.0209615 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.020921 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0209132 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0208598 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0207468 |
| ANXA1 | annexin A1 | -0.0205631 |
| RPL37 | ribosomal protein L37 | -0.0203178 |
