| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 4EGI-1_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.185989 |
| SLTM | SAFB-like, transcription modulator | 0.0727735 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0559139 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0514615 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0475758 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.035429 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.034773 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0293998 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0283124 |
| CES1 | carboxylesterase 1 | 0.0278213 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0256961 |
| STC1 | stanniocalcin 1 | 0.02454 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.024426 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0237815 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0237024 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0224454 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0223834 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0209891 |
| RAD51B | RAD51 paralog B | 0.0209854 |
| FNIP1 | folliculin interacting protein 1 | 0.0205164 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0204469 |
| SPAG9 | sperm associated antigen 9 | 0.019963 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0195299 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0193384 |
| CANX | calnexin | 0.0188552 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0185043 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.017263 |
| BMP6 | bone morphogenetic protein 6 | 0.0164977 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0163446 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.01546 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0153818 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0150832 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0149349 |
| HYOU1 | hypoxia up-regulated 1 | 0.0145995 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0144541 |
| ARRDC3 | arrestin domain containing 3 | 0.014214 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0138287 |
| HDAC9 | histone deacetylase 9 | 0.0123497 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0121855 |
| ATXN1 | ataxin 1 | 0.0121026 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0120479 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0119565 |
| SP100 | SP100 nuclear antigen | 0.0117653 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0117569 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0116853 |
| ZNF292 | zinc finger protein 292 | 0.0116807 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0115914 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0115804 |
| KIAA1217 | KIAA1217 | 0.0115765 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0114608 |
| SMAD3 | SMAD family member 3 | 0.0113257 |
| COPA | coatomer protein complex, subunit alpha | 0.0113188 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0111642 |
| UVRAG | UV radiation resistance associated | 0.0108931 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0107871 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0107257 |
| NGLY1 | N-glycanase 1 | 0.0106811 |
| PAPOLA | poly(A) polymerase alpha | 0.0106764 |
| CCNG2 | cyclin G2 | 0.01033 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0102931 |
| ANXA5 | annexin A5 | 0.0101939 |
| MYO5B | myosin VB | 0.0101273 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.010124 |
| GOLGB1 | golgin B1 | 0.00998434 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00997385 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.00993121 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.00991561 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.00986227 |
| SLC35F5 | solute carrier family 35, member F5 | 0.00969701 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.00958828 |
| LYST | lysosomal trafficking regulator | 0.00957165 |
| GPC5 | glypican 5 | 0.00951071 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.00936305 |
| RUNX1 | runt-related transcription factor 1 | 0.00934452 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.00933905 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0090926 |
| ITSN2 | intersectin 2 | 0.00895973 |
| PHF3 | PHD finger protein 3 | 0.00875098 |
| KIZ | kizuna centrosomal protein | 0.00868107 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.00851261 |
| ARCN1 | archain 1 | 0.00847741 |
| KLHL24 | kelch-like family member 24 | 0.0083902 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.00833374 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.00826583 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.008218 |
| HBP1 | HMG-box transcription factor 1 | 0.00820776 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0081824 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.00815935 |
| PRELID2 | PRELI domain containing 2 | 0.00812667 |
| DTNA | dystrobrevin, alpha | 0.00808702 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0080766 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.00793753 |
| CDCP1 | CUB domain containing protein 1 | 0.00780018 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0077613 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.00776103 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.00775429 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.00772993 |
| GPATCH2L | G patch domain containing 2-like | 0.00769533 |
| HMGA2 | high mobility group AT-hook 2 | 0.00766683 |
| ARFGEF3 | ARFGEF family member 3 | 0.00764375 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.119213 |
| ASPH | aspartate beta-hydroxylase | -0.110701 |
| TXNRD1 | thioredoxin reductase 1 | -0.0816091 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0762484 |
| LMO7 | LIM domain 7 | -0.0703072 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0628382 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0538954 |
| ACTG1 | actin gamma 1 | -0.0487893 |
| SCEL | sciellin | -0.0487688 |
| MT2A | metallothionein 2A | -0.0457296 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0411276 |
| S100A10 | S100 calcium binding protein A10 | -0.0399264 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0372336 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0369641 |
| LAMA4 | laminin, alpha 4 | -0.0355419 |
| ANXA2 | annexin A2 | -0.0352187 |
| PTMA | prothymosin, alpha | -0.0334792 |
| OSMR | oncostatin M receptor | -0.032541 |
| FTL | ferritin, light polypeptide | -0.0321931 |
| VCL | vinculin | -0.0316624 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0312207 |
| CST3 | cystatin C | -0.0307602 |
| EGR1 | early growth response 1 | -0.0305476 |
| RPL35A | ribosomal protein L35a | -0.0297214 |
| PKM | pyruvate kinase, muscle | -0.0294845 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0292416 |
| EFNA5 | ephrin-A5 | -0.0290971 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0290856 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0286429 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0278324 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0271428 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0266109 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0263186 |
| AREG | amphiregulin | -0.0262986 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0262233 |
| SEC61G | Sec61 gamma subunit | -0.0261504 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0260316 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0252228 |
| KRT7 | keratin 7, type II | -0.0251034 |
| CCND1 | cyclin D1 | -0.0247957 |
| RAB10 | RAB10, member RAS oncogene family | -0.024279 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0240587 |
| RPL37A | ribosomal protein L37a | -0.0240004 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0230439 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0229741 |
| FLNB | filamin B, beta | -0.0227712 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0227584 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0223091 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0221995 |
| KRT8 | keratin 8, type II | -0.0220459 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0220384 |
| PRKCA | protein kinase C, alpha | -0.0204766 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.020216 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0196129 |
| RPS24 | ribosomal protein S24 | -0.0193844 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0192289 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0186386 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0186235 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.018576 |
| LDHA | lactate dehydrogenase A | -0.018376 |
| RBM25 | RNA binding motif protein 25 | -0.0182763 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0181858 |
| LAMC2 | laminin, gamma 2 | -0.0181515 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0178384 |
| SLC38A2 | solute carrier family 38, member 2 | -0.017678 |
| CUX1 | cut-like homeobox 1 | -0.0175892 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0175295 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0175018 |
| RIN2 | Ras and Rab interactor 2 | -0.0174787 |
| RPS3 | ribosomal protein S3 | -0.0174765 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0174693 |
| RPS8 | ribosomal protein S8 | -0.0173286 |
| S100A6 | S100 calcium binding protein A6 | -0.0171663 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0171458 |
| S100A11 | S100 calcium binding protein A11 | -0.01709 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0170613 |
| POTEF | POTE ankyrin domain family, member F | -0.0170447 |
| RPS25 | ribosomal protein S25 | -0.0169058 |
| MYL12B | myosin, light chain 12B, regulatory | -0.01678 |
| TNS3 | tensin 3 | -0.0167064 |
| NABP1 | nucleic acid binding protein 1 | -0.0165113 |
| PCED1B | PC-esterase domain containing 1B | -0.016061 |
| S100P | S100 calcium binding protein P | -0.0158871 |
| KRT19 | keratin 19, type I | -0.0158827 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0157116 |
| CMIP | c-Maf inducing protein | -0.0156896 |
| PRDX1 | peroxiredoxin 1 | -0.0156349 |
| TJP1 | tight junction protein 1 | -0.0155126 |
| S100A9 | S100 calcium binding protein A9 | -0.0154765 |
| PGK1 | phosphoglycerate kinase 1 | -0.0153725 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0152428 |
| H1-0 | H1.0 linker histone | -0.0151297 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0150165 |
| SDC1 | syndecan 1 | -0.014913 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0147546 |
| IER3 | immediate early response 3 | -0.0147423 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0146763 |
| MCU | mitochondrial calcium uniporter | -0.014637 |
| RPS29 | ribosomal protein S29 | -0.0145721 |
| HLA-B | major histocompatibility complex, class I, B | -0.0144363 |
