| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 4EGI-1_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0881837 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0706536 |
| DOCK4 | dedicator of cytokinesis 4 | 0.069367 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0688736 |
| MT2A | metallothionein 2A | 0.0683799 |
| FMNL2 | formin-like 2 | 0.0674854 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0656155 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.061701 |
| MCL1 | myeloid cell leukemia 1 | 0.0611751 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0607345 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0578032 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0572611 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0565899 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0531017 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0510866 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0492929 |
| COPA | coatomer protein complex, subunit alpha | 0.0456352 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0454976 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0451236 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0441011 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0436017 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.042357 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0417973 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0404645 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0385174 |
| BMP6 | bone morphogenetic protein 6 | 0.0384504 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.03588 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0351769 |
| ATXN1 | ataxin 1 | 0.0332284 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0327266 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0324348 |
| ACTG1 | actin gamma 1 | 0.0319509 |
| EGFR | epidermal growth factor receptor | 0.0319325 |
| BRD2 | bromodomain containing 2 | 0.0311693 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0299187 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0298741 |
| NUMB | numb homolog (Drosophila) | 0.029542 |
| KIAA0319 | KIAA0319 | 0.0291251 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0279298 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.027724 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0272004 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0271252 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0267921 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0264286 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0263956 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0260502 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0258214 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0255857 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.0252922 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0249829 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0247147 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0241314 |
| LAMC2 | laminin, gamma 2 | 0.024033 |
| MYO1E | myosin IE | 0.0239545 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0238686 |
| MED13 | mediator complex subunit 13 | 0.0234407 |
| CCNL1 | cyclin L1 | 0.0233983 |
| KIF13A | kinesin family member 13A | 0.0233613 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0231667 |
| NDRG1 | N-myc downstream regulated 1 | 0.022893 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0226577 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0225379 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0225228 |
| CDK13 | cyclin-dependent kinase 13 | 0.0222112 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0222108 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.021863 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0217503 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0217091 |
| HMOX1 | heme oxygenase 1 | 0.0215559 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0213266 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0209341 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0209097 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0206767 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0205094 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0204857 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0204812 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0203079 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0202334 |
| GOLGA4 | golgin A4 | 0.0199452 |
| EXOC6B | exocyst complex component 6B | 0.0198878 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0197644 |
| OPTN | optineurin | 0.0194639 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0194582 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0194072 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0193678 |
| GOLGB1 | golgin B1 | 0.0191933 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0189702 |
| PCBP2 | poly(rC) binding protein 2 | 0.0188543 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0187568 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.018736 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0186793 |
| CD44 | CD44 molecule (Indian blood group) | 0.0185596 |
| SNX9 | sorting nexin 9 | 0.0183227 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0182994 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0182136 |
| CDCP1 | CUB domain containing protein 1 | 0.0181543 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0181436 |
| CMIP | c-Maf inducing protein | 0.0181408 |
| FERMT2 | fermitin family member 2 | 0.0181306 |
| FNIP1 | folliculin interacting protein 1 | 0.0180862 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.191473 |
| PM20D1 | peptidase M20 domain containing 1 | -0.167638 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.154718 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.142859 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.103934 |
| GRAMD1B | GRAM domain containing 1B | -0.101763 |
| TMSB10 | thymosin beta 10 | -0.0863807 |
| FGB | fibrinogen beta chain | -0.0711016 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0672002 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0646367 |
| PTMA | prothymosin, alpha | -0.0641189 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0586806 |
| ASPH | aspartate beta-hydroxylase | -0.0576065 |
| BICC1 | BicC family RNA binding protein 1 | -0.0554216 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.05331 |
| EFNA5 | ephrin-A5 | -0.0510244 |
| RAD21 | RAD21 homolog (S. pombe) | -0.048288 |
| RPS27A | ribosomal protein S27a | -0.0473684 |
| FTL | ferritin, light polypeptide | -0.0464751 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0457284 |
| HDAC9 | histone deacetylase 9 | -0.0435234 |
| CAVIN1 | caveolae associated protein 1 | -0.0431679 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0420505 |
| MKI67 | marker of proliferation Ki-67 | -0.0416344 |
| SLC38A2 | solute carrier family 38, member 2 | -0.041508 |
| NEGR1 | neuronal growth regulator 1 | -0.0412874 |
| ECT2 | epithelial cell transforming 2 | -0.0410208 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0392142 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0387513 |
| FGG | fibrinogen gamma chain | -0.0385229 |
| RPL19 | ribosomal protein L19 | -0.0382452 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0379802 |
| ENO1 | enolase 1, (alpha) | -0.0379039 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.036025 |
| RPL23 | ribosomal protein L23 | -0.0359191 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0353235 |
| RTN4 | reticulon 4 | -0.0348422 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0343373 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0340129 |
| THBS1 | thrombospondin 1 | -0.0337053 |
| DST | dystonin | -0.0336341 |
| AHR | aryl hydrocarbon receptor | -0.0335304 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0328178 |
| WDR43 | WD repeat domain 43 | -0.0327228 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0315797 |
| WWOX | WW domain containing oxidoreductase | -0.0311546 |
| TUBB | tubulin, beta class I | -0.031076 |
| ANLN | anillin, actin binding protein | -0.0309833 |
| AHNAK | AHNAK nucleoprotein | -0.0302276 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0301187 |
| CANX | calnexin | -0.0295189 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0291322 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.029045 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0290023 |
| RAD51B | RAD51 paralog B | -0.0285777 |
| RPL4 | ribosomal protein L4 | -0.0283884 |
| YBX1 | Y box binding protein 1 | -0.0282702 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0279987 |
| SRGN | serglycin | -0.0279495 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0277717 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0273575 |
| NHSL1 | NHS-like 1 | -0.0271407 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0270552 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0269297 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0269108 |
| CENPF | centromere protein F, 350/400kDa | -0.0265824 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0265292 |
| IER3 | immediate early response 3 | -0.0263486 |
| ANXA2 | annexin A2 | -0.0261952 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0260478 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0259031 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0257965 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0257176 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0256026 |
| USP3 | ubiquitin specific peptidase 3 | -0.025553 |
| ACACA | acetyl-CoA carboxylase alpha | -0.025469 |
| LAMB1 | laminin, beta 1 | -0.0254322 |
| TNPO1 | transportin 1 | -0.0253466 |
| RPS21 | ribosomal protein S21 | -0.0247699 |
| YBX3 | Y box binding protein 3 | -0.0243024 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.024252 |
| ZNF804A | zinc finger protein 804A | -0.0240456 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.023736 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.023702 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0236521 |
| RHEB | Ras homolog enriched in brain | -0.0236234 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0235637 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0235016 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0232584 |
| RPLP1 | ribosomal protein, large, P1 | -0.0231444 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0230636 |
| HMGB1 | high mobility group box 1 | -0.0229985 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0226051 |
| S100A6 | S100 calcium binding protein A6 | -0.0223959 |
| PFDN2 | prefoldin subunit 2 | -0.0222598 |
| NRG1 | neuregulin 1 | -0.022196 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0221734 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0221658 |
| ERBIN | erbb2 interacting protein | -0.0220846 |
| LDHB | lactate dehydrogenase B | -0.0219 |
