| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.134686 |
| LAMC2 | laminin, gamma 2 | 0.0958447 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.083521 |
| KYNU | kynureninase | 0.0820257 |
| EGFR | epidermal growth factor receptor | 0.0617069 |
| INTS6 | integrator complex subunit 6 | 0.0584991 |
| PHF3 | PHD finger protein 3 | 0.0576224 |
| VCL | vinculin | 0.0534831 |
| DTNA | dystrobrevin, alpha | 0.051411 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.048183 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0479182 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0473228 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.046412 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0452646 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0450199 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.044484 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0436291 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0411401 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.041068 |
| IL1RN | interleukin 1 receptor antagonist | 0.0408956 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0408098 |
| RND3 | Rho family GTPase 3 | 0.0405951 |
| NAV2 | neuron navigator 2 | 0.0405726 |
| NABP1 | nucleic acid binding protein 1 | 0.0405628 |
| FNIP1 | folliculin interacting protein 1 | 0.0404009 |
| EGR1 | early growth response 1 | 0.0403746 |
| MT2A | metallothionein 2A | 0.038891 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0382366 |
| LAMB3 | laminin, beta 3 | 0.0381417 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0381079 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0375665 |
| CDCP1 | CUB domain containing protein 1 | 0.0375585 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0373937 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0371063 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0370427 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0361547 |
| UBAP2 | ubiquitin associated protein 2 | 0.0351051 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0350983 |
| OCLN | occludin | 0.0350969 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0348541 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.034817 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0347666 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0346791 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0345695 |
| SP100 | SP100 nuclear antigen | 0.0333789 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0329289 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.0327743 |
| SEPTIN10 | septin 10 | 0.0327639 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0320161 |
| LAMA4 | laminin, alpha 4 | 0.0318524 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0318438 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0316846 |
| CREBBP | CREB binding protein | 0.0316429 |
| GOLGA4 | golgin A4 | 0.0315894 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0315089 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.031356 |
| CNKSR3 | CNKSR family member 3 | 0.0310568 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0310031 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0307091 |
| SMAD3 | SMAD family member 3 | 0.0305843 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0305217 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0305074 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0302302 |
| RBM47 | RNA binding motif protein 47 | 0.0299893 |
| KRT18 | keratin 18, type I | 0.0298699 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0297926 |
| SETD2 | SET domain containing 2 | 0.029511 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0293843 |
| ZFR | zinc finger RNA binding protein | 0.0293046 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0289833 |
| FRMD5 | FERM domain containing 5 | 0.028574 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0284958 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0282847 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0281083 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0280911 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0280709 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0279748 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0279413 |
| TYW1B | tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) | 0.027893 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0278253 |
| MORC3 | MORC family CW-type zinc finger 3 | 0.0277206 |
| ULK4 | unc-51 like kinase 4 | 0.0275292 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0273415 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0270543 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | 0.0262999 |
| ANO6 | anoctamin 6 | 0.0260334 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0259818 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0259396 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0258529 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.025683 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0256572 |
| ETV3 | ets variant 3 | 0.025655 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0256392 |
| BRD2 | bromodomain containing 2 | 0.0256065 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0253084 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0249577 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.0248805 |
| WWOX | WW domain containing oxidoreductase | 0.0244981 |
| JMJD1C | jumonji domain containing 1C | 0.0244477 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0243187 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.127296 |
| FN1 | fibronectin 1 | -0.125794 |
| GRB10 | growth factor receptor-bound protein 10 | -0.125527 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.111526 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0947851 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0941391 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0899017 |
| PTMA | prothymosin, alpha | -0.0817991 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0800812 |
| NDRG1 | N-myc downstream regulated 1 | -0.0744343 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0652936 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0638503 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0631571 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0587375 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0584747 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0573447 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0568939 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0559017 |
| RIOK3 | RIO kinase 3 | -0.0554995 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0538365 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0534842 |
| LMO7 | LIM domain 7 | -0.0534355 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0524236 |
| FAM13A | family with sequence similarity 13, member A | -0.0508369 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0505467 |
| POTEF | POTE ankyrin domain family, member F | -0.0474945 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0468813 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0467131 |
| RPL23 | ribosomal protein L23 | -0.0467081 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0465011 |
| FAM107B | family with sequence similarity 107, member B | -0.0464754 |
| VIM | vimentin | -0.0455256 |
| SRPK2 | SRSF protein kinase 2 | -0.0443961 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0431736 |
| PCBP2 | poly(rC) binding protein 2 | -0.0425088 |
| B2M | beta-2-microglobulin | -0.0418529 |
| ATOSA | atos homolog A | -0.0409864 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0407004 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0403062 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.039769 |
| TMSB10 | thymosin beta 10 | -0.0389286 |
| FMN1 | formin 1 | -0.038928 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0385831 |
| PTK2 | protein tyrosine kinase 2 | -0.038507 |
| CALR | calreticulin | -0.0383666 |
| HELZ | helicase with zinc finger | -0.0383472 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0380406 |
| TAOK3 | TAO kinase 3 | -0.0380358 |
| FDPS | farnesyl diphosphate synthase | -0.0377236 |
| CD2AP | CD2-associated protein | -0.0375324 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0374957 |
| GPC6 | glypican 6 | -0.0374523 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0374394 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0374137 |
| MYO6 | myosin VI | -0.0374085 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0371422 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0371232 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0367932 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0365844 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0362795 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0361562 |
| TPR | translocated promoter region, nuclear basket protein | -0.0359219 |
| LMTK2 | lemur tyrosine kinase 2 | -0.0358109 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0355575 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0355332 |
| LMNA | lamin A/C | -0.0354659 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0353715 |
| TMEM41B | transmembrane protein 41B | -0.0352665 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0349862 |
| WDR26 | WD repeat domain 26 | -0.0349549 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0346305 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0343955 |
| RREB1 | ras responsive element binding protein 1 | -0.0341961 |
| USP3 | ubiquitin specific peptidase 3 | -0.0339447 |
| MYOF | myoferlin | -0.0331676 |
| ATXN2 | ataxin 2 | -0.0330351 |
| FOXO3 | forkhead box O3 | -0.0329183 |
| RPL35A | ribosomal protein L35a | -0.0329069 |
| RCOR1 | REST corepressor 1 | -0.0328968 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0327177 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0323418 |
| CALD1 | caldesmon 1 | -0.0318779 |
| TOP1 | topoisomerase (DNA) I | -0.0317812 |
| BBX | bobby sox homolog (Drosophila) | -0.0314569 |
| S100A6 | S100 calcium binding protein A6 | -0.0313247 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0310277 |
| TAOK1 | TAO kinase 1 | -0.030984 |
| WASF2 | WAS protein family, member 2 | -0.0309284 |
| RPL37A | ribosomal protein L37a | -0.0309085 |
| ZNF638 | zinc finger protein 638 | -0.0308866 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0308781 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0307216 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0304755 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0304538 |
| USP15 | ubiquitin specific peptidase 15 | -0.030296 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0302641 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0296241 |
| ZNF207 | zinc finger protein 207 | -0.0294078 |
| RAB6A | RAB6A, member RAS oncogene family | -0.029372 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0291447 |
