4EGI-1_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 4EGI-1_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.211915
THSD4 thrombospondin, type I, domain containing 4 0.116567
GRAMD1B GRAM domain containing 1B 0.0853908
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0791847
MCL1 myeloid cell leukemia 1 0.0684494
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0652126
ERRFI1 ERBB receptor feedback inhibitor 1 0.056787
DOCK5 dedicator of cytokinesis 5 0.0538345
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0533141
OSMR oncostatin M receptor 0.0494205
PDE4D phosphodiesterase 4D, cAMP-specific 0.0477821
HMGA2 high mobility group AT-hook 2 0.0476629
IGF1R insulin-like growth factor 1 receptor 0.0473883
FMNL2 formin-like 2 0.046556
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0460938
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0454837
EXT1 exostosin glycosyltransferase 1 0.0438875
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0427351
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0416195
TPM3 tropomyosin 3 0.0412258
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0405472
RIMS2 regulating synaptic membrane exocytosis 2 0.0401955
EGFR epidermal growth factor receptor 0.0398194
EXOC4 exocyst complex component 4 0.0390467
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0389351
EEF2 eukaryotic translation elongation factor 2 0.0386642
AFF3 AF4/FMR2 family, member 3 0.0381061
ATP11A ATPase, class VI, type 11A 0.0373451
PDE10A phosphodiesterase 10A 0.0372221
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0366523
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0358557
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0348632
MACF1 microtubule-actin crosslinking factor 1 0.0341493
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0338416
TM4SF1 transmembrane 4 L six family member 1 0.0323539
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0320074
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0313189
SFPQ splicing factor proline/glutamine-rich 0.0311653
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.030208
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0292392
HOMER1 homer scaffolding protein 1 0.028501
SVIL supervillin 0.0281351
ELL2 elongation factor, RNA polymerase II, 2 0.0279609
PRKCE protein kinase C, epsilon 0.0277215
PDLIM5 PDZ and LIM domain 5 0.027207
ANO6 anoctamin 6 0.0269944
ZSWIM6 zinc finger, SWIM-type containing 6 0.0264882
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.026463
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0264452
CDK17 cyclin-dependent kinase 17 0.026312
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0259771
TRIP12 thyroid hormone receptor interactor 12 0.0257782
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0255114
RAD51B RAD51 paralog B 0.0241607
MMP12 matrix metallopeptidase 12 0.0240561
HSPA8 heat shock 70kDa protein 8 0.0236661
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0236649
TRIO trio Rho guanine nucleotide exchange factor 0.0236057
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0235482
ZFAND3 zinc finger, AN1-type domain 3 0.0234764
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0234617
DST dystonin 0.0233144
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0233095
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0227581
YAP1 Yes-associated protein 1 0.0222351
STC1 stanniocalcin 1 0.0221649
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0211894
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0209785
ATG7 autophagy related 7 0.0206258
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0204595
FNDC3B fibronectin type III domain containing 3B 0.0203986
CAPRIN2 caprin family member 2 0.0203946
NRG1 neuregulin 1 0.0200934
DIAPH2 diaphanous-related formin 2 0.0197623
LPP LIM domain containing preferred translocation partner in lipoma 0.0193497
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0192228
RICTOR RPTOR independent companion of MTOR, complex 2 0.0191782
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.019176
CDCP1 CUB domain containing protein 1 0.0191107
FBXL17 F-box and leucine-rich repeat protein 17 0.018982
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0187491
CCDC91 coiled-coil domain containing 91 0.0185356
ACTN1 actinin, alpha 1 0.0184949
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0182811
RABGAP1L RAB GTPase activating protein 1-like 0.0181504
RASAL2 RAS protein activator like 2 0.0181388
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0181304
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0179646
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0179411
RPL3 ribosomal protein L3 0.0179182
TTC28 tetratricopeptide repeat domain 28 0.0174524
WWOX WW domain containing oxidoreductase 0.017209
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0170743
SNX9 sorting nexin 9 0.0170017
DSPP dentin sialophosphoprotein 0.0168056
SHB Src homology 2 domain containing adaptor protein B 0.0167696
DOCK1 dedicator of cytokinesis 1 0.0165785
VMP1 vacuole membrane protein 1 0.0164131
KRT18 keratin 18, type I 0.0162074
ADAR adenosine deaminase, RNA-specific 0.0161484

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.292579
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.147841
PTMA prothymosin, alpha -0.125918
TMSB10 thymosin beta 10 -0.113005
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0921164
VIM vimentin -0.0762681
TFPI2 tissue factor pathway inhibitor 2 -0.0516621
RPL35A ribosomal protein L35a -0.0510915
RPS21 ribosomal protein S21 -0.0468859
RPLP1 ribosomal protein, large, P1 -0.046799
KDM3A lysine (K)-specific demethylase 3A -0.0462792
FTL ferritin, light polypeptide -0.045918
GOLGA4 golgin A4 -0.0458302
MYL12B myosin, light chain 12B, regulatory -0.0455928
EIF1 eukaryotic translation initiation factor 1 -0.0446497
GNAS GNAS complex locus -0.0441904
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0435971
RPL26 ribosomal protein L26 -0.0427223
RPL37A ribosomal protein L37a -0.0420314
TPI1 triosephosphate isomerase 1 -0.0408851
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0397291
RPL12 ribosomal protein L12 -0.039552
RPL37 ribosomal protein L37 -0.0386617
NAP1L1 nucleosome assembly protein 1-like 1 -0.0383741
RPS8 ribosomal protein S8 -0.0377007
RPLP0 ribosomal protein, large, P0 -0.0371044
KDM2A lysine (K)-specific demethylase 2A -0.0369058
PFN1 profilin 1 -0.0353592
MORF4L2 mortality factor 4 like 2 -0.0339688
WSB1 WD repeat and SOCS box containing 1 -0.0338652
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0338485
KPNB1 karyopherin (importin) beta 1 -0.0337938
RBM39 RNA binding motif protein 39 -0.0330969
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0329373
LMAN1 lectin, mannose-binding, 1 -0.0327328
BBX bobby sox homolog (Drosophila) -0.0323297
H1-0 H1.0 linker histone -0.031951
SRP72 signal recognition particle 72kDa -0.0317517
SMC4 structural maintenance of chromosomes 4 -0.0317063
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0315385
RPS27A ribosomal protein S27a -0.0313407
MKI67 marker of proliferation Ki-67 -0.0312852
CANX calnexin -0.0310394
MT2A metallothionein 2A -0.0309337
YBX1 Y box binding protein 1 -0.0308977
RPS19 ribosomal protein S19 -0.0308187
PHIP pleckstrin homology domain interacting protein -0.0307885
RPL8 ribosomal protein L8 -0.0306802
RPL36 ribosomal protein L36 -0.0305929
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0304349
RPS29 ribosomal protein S29 -0.0298689
OGA O-GlcNAcase -0.0296677
RPL32 ribosomal protein L32 -0.0295021
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.028879
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0283446
RPL19 ribosomal protein L19 -0.0280027
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0278725
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0277644
RPS3 ribosomal protein S3 -0.0275725
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0275574
RSF1 remodeling and spacing factor 1 -0.0272403
ATP5F1B ATP synthase F1 subunit beta -0.0267254
RPL23 ribosomal protein L23 -0.0266903
RPL31 ribosomal protein L31 -0.0266663
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0265095
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0263408
RBM25 RNA binding motif protein 25 -0.0262171
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0261826
RPL11 ribosomal protein L11 -0.0260222
GSTP1 glutathione S-transferase pi 1 -0.0259285
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0256048
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0255359
RPS27 ribosomal protein S27 -0.0252894
RPL34 ribosomal protein L34 -0.0252404
RAB1A RAB1A, member RAS oncogene family -0.0251215
TPX2 TPX2, microtubule-associated -0.0249543
CAVIN1 caveolae associated protein 1 -0.0248484
UBE2H ubiquitin-conjugating enzyme E2H -0.0248261
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0247993
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0246382
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.024587
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0245842
PGK1 phosphoglycerate kinase 1 -0.0244745
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0244013
CSDE1 cold shock domain containing E1, RNA-binding -0.0243669
RPLP2 ribosomal protein, large, P2 -0.0243601
SEPTIN7 septin 7 -0.0242498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0241352
RACK1 receptor for activated C kinase 1 -0.0236963
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.023536
NOP58 NOP58 ribonucleoprotein -0.0234425
PNISR PNN-interacting serine/arginine-rich protein -0.0233773
MIS18BP1 MIS18 binding protein 1 -0.0232129
LDHB lactate dehydrogenase B -0.023089
WDR45B WD repeat domain 45B -0.0230813
TPT1 tumor protein, translationally-controlled 1 -0.0230688
RPS15 ribosomal protein S15 -0.0230615
DEK DEK proto-oncogene -0.0230447
LRRC23 leucine rich repeat containing 23 -0.0230135
KMT2A lysine (K)-specific methyltransferase 2A -0.0228909