| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 4EGI-1_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.201519 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.149564 |
| EXT1 | exostosin glycosyltransferase 1 | 0.110114 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0841803 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0832353 |
| EFNA5 | ephrin-A5 | 0.0655102 |
| LAMC2 | laminin, gamma 2 | 0.0609787 |
| LMO7 | LIM domain 7 | 0.0606001 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0599025 |
| FBXO32 | F-box protein 32 | 0.0595295 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0549942 |
| ERBIN | erbb2 interacting protein | 0.0495383 |
| DSPP | dentin sialophosphoprotein | 0.0491831 |
| GOLGB1 | golgin B1 | 0.0485533 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0477657 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0457637 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.045717 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0456094 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0443753 |
| NAV2 | neuron navigator 2 | 0.0443208 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0442466 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0428442 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0417644 |
| ACTG1 | actin gamma 1 | 0.0417593 |
| MYO5B | myosin VB | 0.0415125 |
| VGLL3 | vestigial-like family member 3 | 0.0413851 |
| FNIP1 | folliculin interacting protein 1 | 0.0402979 |
| MYO1E | myosin IE | 0.040117 |
| SVIL | supervillin | 0.0396597 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.0394419 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0390979 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0376025 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.0370548 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0369862 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0368696 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0364561 |
| MYO6 | myosin VI | 0.0353447 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0347908 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0344865 |
| ATXN1 | ataxin 1 | 0.0344772 |
| RBM47 | RNA binding motif protein 47 | 0.0337867 |
| EGFR | epidermal growth factor receptor | 0.033611 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0330811 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0328387 |
| ETV6 | ets variant 6 | 0.0324707 |
| DTNA | dystrobrevin, alpha | 0.0317871 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0313545 |
| OCLN | occludin | 0.0310314 |
| INTS6 | integrator complex subunit 6 | 0.0305917 |
| VMP1 | vacuole membrane protein 1 | 0.0305874 |
| RAI14 | retinoic acid induced 14 | 0.030452 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0304034 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0302304 |
| EGR1 | early growth response 1 | 0.0299964 |
| VCL | vinculin | 0.029965 |
| USP53 | ubiquitin specific peptidase 53 | 0.0294295 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0294268 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.029375 |
| ANO6 | anoctamin 6 | 0.0292793 |
| SMAD3 | SMAD family member 3 | 0.0288758 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0284492 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0282604 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0282394 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0280136 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0279808 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0279646 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0277052 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0273558 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0264777 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0258442 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0255841 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0254971 |
| PLEC | plectin | 0.0254143 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0254109 |
| NTN4 | netrin 4 | 0.0246351 |
| HDAC9 | histone deacetylase 9 | 0.0240101 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0239435 |
| VEGFA | vascular endothelial growth factor A | 0.0238184 |
| CDK13 | cyclin-dependent kinase 13 | 0.0237364 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0236644 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0235561 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0233039 |
| CTBP2 | C-terminal binding protein 2 | 0.0232814 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0226965 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0226873 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0226738 |
| DUSP10 | dual specificity phosphatase 10 | 0.0225445 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.02244 |
| RAD51B | RAD51 paralog B | 0.0223024 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0222044 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0221318 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0220963 |
| TJP1 | tight junction protein 1 | 0.021723 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0215727 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.0213562 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0211194 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0209104 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0208822 |
| DSG2 | desmoglein 2 | 0.0207537 |
| FHIT | fragile histidine triad | 0.0200193 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.147743 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.135277 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.130866 |
| PTMA | prothymosin, alpha | -0.110731 |
| NDRG1 | N-myc downstream regulated 1 | -0.0983395 |
| TMSB10 | thymosin beta 10 | -0.0901463 |
| S100A6 | S100 calcium binding protein A6 | -0.0865981 |
| FTL | ferritin, light polypeptide | -0.0855718 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0759631 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0614448 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0585811 |
| HMGA1 | high mobility group AT-hook 1 | -0.058163 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0575182 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0528933 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0520774 |
| FN1 | fibronectin 1 | -0.0511526 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.049413 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0468301 |
| POTEF | POTE ankyrin domain family, member F | -0.0460079 |
| TFG | TRK-fused gene | -0.0459925 |
| FAM162A | family with sequence similarity 162, member A | -0.0446452 |
| PGK1 | phosphoglycerate kinase 1 | -0.0426551 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0426493 |
| RNF145 | ring finger protein 145 | -0.0425431 |
| ASPH | aspartate beta-hydroxylase | -0.04237 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.040294 |
| FAM13A | family with sequence similarity 13, member A | -0.0397682 |
| MT2A | metallothionein 2A | -0.0392384 |
| S100A10 | S100 calcium binding protein A10 | -0.0386634 |
| RPL35A | ribosomal protein L35a | -0.038606 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0385768 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0375823 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.036578 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0361704 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0358995 |
| RPLP1 | ribosomal protein, large, P1 | -0.034573 |
| USP3 | ubiquitin specific peptidase 3 | -0.0340674 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0328693 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0326217 |
| GNAS | GNAS complex locus | -0.0321997 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0295873 |
| RPS6 | ribosomal protein S6 | -0.0295596 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0294896 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0294011 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0291891 |
| G0S2 | G0/G1 switch 2 | -0.0291624 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0285578 |
| RPL34 | ribosomal protein L34 | -0.028328 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0282639 |
| RBM39 | RNA binding motif protein 39 | -0.0278274 |
| HMGB2 | high mobility group box 2 | -0.0276129 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0275496 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0271974 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0268054 |
| RPS19 | ribosomal protein S19 | -0.0266744 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0263498 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0256564 |
| SEPTIN7 | septin 7 | -0.0250775 |
| TMEM123 | transmembrane protein 123 | -0.0250055 |
| TXNRD1 | thioredoxin reductase 1 | -0.0249257 |
| QKI | QKI, KH domain containing, RNA binding | -0.0247797 |
| RLF | rearranged L-myc fusion | -0.0247338 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0246999 |
| MATR3 | matrin 3 | -0.024037 |
| RTN4 | reticulon 4 | -0.023977 |
| TMEM263 | transmembrane protein 263 | -0.0237989 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0233662 |
| FOSL1 | FOS-like antigen 1 | -0.0233634 |
| RBM25 | RNA binding motif protein 25 | -0.0233183 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0232294 |
| PKM | pyruvate kinase, muscle | -0.0232216 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0232115 |
| LDHA | lactate dehydrogenase A | -0.023201 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0231804 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0230584 |
| RHEB | Ras homolog enriched in brain | -0.0228863 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0228128 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0228125 |
| EPCAM | epithelial cell adhesion molecule | -0.0227833 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0226255 |
| RPL8 | ribosomal protein L8 | -0.0224204 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0223341 |
| DEK | DEK proto-oncogene | -0.02228 |
| TOP1 | topoisomerase (DNA) I | -0.0222 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0219825 |
| FAM3C | family with sequence similarity 3, member C | -0.0216423 |
| DSTN | destrin (actin depolymerizing factor) | -0.0215881 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0214737 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0214088 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0213963 |
| RPS23 | ribosomal protein S23 | -0.0213383 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.021213 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0211902 |
| RPLP0 | ribosomal protein, large, P0 | -0.020855 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0207715 |
| CDK17 | cyclin-dependent kinase 17 | -0.020713 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0207045 |
| AREG | amphiregulin | -0.0206598 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.020585 |
| RPL11 | ribosomal protein L11 | -0.0205574 |
