4EGI-1_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

189 genes differentially expressed following the 4EGI-1_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.180597
PABPC1 poly(A) binding protein, cytoplasmic 1 0.130729
EGFR epidermal growth factor receptor 0.113319
VIM vimentin 0.111188
FTH1 ferritin, heavy polypeptide 1 0.105423
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.103602
FN1 fibronectin 1 0.0892334
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0851786
KRT18 keratin 18, type I 0.0850491
JMJD1C jumonji domain containing 1C 0.0810744
KTN1 kinectin 1 (kinesin receptor) 0.0753167
AKAP13 A kinase (PRKA) anchor protein 13 0.0714406
RPS6 ribosomal protein S6 0.0702075
FTL ferritin, light polypeptide 0.0698164
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0690257
ACTG1 actin gamma 1 0.0688282
SDK1 sidekick cell adhesion molecule 1 0.0671896
BAIAP2L1 BAI1-associated protein 2-like 1 0.0654261
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0649305
PTK2 protein tyrosine kinase 2 0.0648939
SBF2 SET binding factor 2 0.0606903
HMGA1 high mobility group AT-hook 1 0.0605565
AHNAK AHNAK nucleoprotein 0.0580948
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0577122
HELZ helicase with zinc finger 0.0567836
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0555278
APLP2 amyloid beta (A4) precursor-like protein 2 0.0553291
ZSWIM6 zinc finger, SWIM-type containing 6 0.0546742
PKN2 protein kinase N2 0.0535636
RPL26 ribosomal protein L26 0.0531841
MSI2 musashi RNA-binding protein 2 0.0505654
EML4 echinoderm microtubule associated protein like 4 0.0502188
SENP6 SUMO1/sentrin specific peptidase 6 0.0491045
GOLGA4 golgin A4 0.0468577
RPL35A ribosomal protein L35a 0.0460691
FMNL2 formin-like 2 0.0452715
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0449307
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0415433
ZNF638 zinc finger protein 638 0.039713
RPLP0 ribosomal protein, large, P0 0.0397115
TPT1 tumor protein, translationally-controlled 1 0.0394653
BIRC6 baculoviral IAP repeat containing 6 0.0383422
TPM4 tropomyosin 4 0.0382934
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0382347
NCOA3 nuclear receptor coactivator 3 0.0379901
EGR1 early growth response 1 0.0377538
RPLP1 ribosomal protein, large, P1 0.0376907
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0371776
AKAP9 A kinase (PRKA) anchor protein 9 0.0362855
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.034982
DSPP dentin sialophosphoprotein 0.0337389
EEF2 eukaryotic translation elongation factor 2 0.0336483
NDRG1 N-myc downstream regulated 1 0.0328749
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0328363
RPLP2 ribosomal protein, large, P2 0.0321124
TTC3 tetratricopeptide repeat domain 3 0.0321014
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0319454
SLTM SAFB-like, transcription modulator 0.0316984
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0312565
ARHGAP32 Rho GTPase activating protein 32 0.0300721
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0298751
EXOC4 exocyst complex component 4 0.0294781
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0293074
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0291716
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.028807
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0283623
SEC31A SEC31 homolog A (S. cerevisiae) 0.0265821
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0255855
FNDC3B fibronectin type III domain containing 3B 0.0248432
PRRC2C proline-rich coiled-coil 2C 0.0243335
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0239978
ASPH aspartate beta-hydroxylase 0.0232645
NAMPT nicotinamide phosphoribosyltransferase 0.0213465
ENO1 enolase 1, (alpha) 0.0211455
RPL32 ribosomal protein L32 0.0210078
RPS3 ribosomal protein S3 0.0184419
RPS24 ribosomal protein S24 0.0178886
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0164058
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0163484
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0158984
PDE4D phosphodiesterase 4D, cAMP-specific 0.0153228
GLIS3 GLIS family zinc finger 3 0.0151524
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0135653
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0133236
RPS8 ribosomal protein S8 0.0132859
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0129106
MYO1E myosin IE 0.0128959
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0128144
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0112888
RPL7A ribosomal protein L7a 0.0103304
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00783151
MAP4 microtubule-associated protein 4 0.00756469
CHD1 chromodomain helicase DNA binding protein 1 0.00700258
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00580003
SOS1 son of sevenless homolog 1 (Drosophila) 0.00398548
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00364828
LOXL2 lysyl oxidase-like 2 0.00211234
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.00200735
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00119245
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 6.85097E-4

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.149457
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.14005
PDE10A phosphodiesterase 10A -0.13792
LDHA lactate dehydrogenase A -0.117025
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110205
NUP58 nucleoporin 58 -0.103627
PARD3 par-3 family cell polarity regulator -0.0862911
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0818629
SMYD3 SET and MYND domain containing 3 -0.0805815
RTN4 reticulon 4 -0.0776078
ANXA2 annexin A2 -0.077472
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.076869
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0740777
RLF rearranged L-myc fusion -0.071234
RPL23 ribosomal protein L23 -0.0709409
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.067692
HMGA2 high mobility group AT-hook 2 -0.0670743
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0656179
RPS25 ribosomal protein S25 -0.0654477
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0641351
CDH13 cadherin 13 -0.0620259
PKM pyruvate kinase, muscle -0.0561029
ACTN4 actinin, alpha 4 -0.0555295
DST dystonin -0.0545317
TRIO trio Rho guanine nucleotide exchange factor -0.0525535
PSD3 pleckstrin and Sec7 domain containing 3 -0.05222
COL5A1 collagen, type V, alpha 1 -0.0519245
ADAM10 ADAM metallopeptidase domain 10 -0.0518183
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0487777
GPC6 glypican 6 -0.0486894
LAMB3 laminin, beta 3 -0.0477207
TMSB10 thymosin beta 10 -0.0475256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0471064
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0468607
EXT1 exostosin glycosyltransferase 1 -0.0457897
RPS27A ribosomal protein S27a -0.0457546
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0441435
WAC WW domain containing adaptor with coiled-coil -0.0439807
RPS19 ribosomal protein S19 -0.0413656
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0402236
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0397612
RPS12 ribosomal protein S12 -0.0351509
MYH9 myosin, heavy chain 9, non-muscle -0.0344056
VCL vinculin -0.0340534
CNKSR3 CNKSR family member 3 -0.0336459
FLNB filamin B, beta -0.0321037
PGK1 phosphoglycerate kinase 1 -0.0319071
UBC ubiquitin C -0.0314254
ZBTB20 zinc finger and BTB domain containing 20 -0.0312483
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0305523
NAV2 neuron navigator 2 -0.0302535
RPL31 ribosomal protein L31 -0.0292385
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0274343
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0267911
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0252194
SRPK2 SRSF protein kinase 2 -0.0236591
FRYL FRY-like -0.0229414
MCL1 myeloid cell leukemia 1 -0.0222299
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0204035
IGFBP3 insulin-like growth factor binding protein 3 -0.0199789
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0199108
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0193179
EFNA5 ephrin-A5 -0.0188636
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0185015
MYO10 myosin X -0.0176274
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0171654
STC1 stanniocalcin 1 -0.0158489
MT2A metallothionein 2A -0.0148704
HDLBP high density lipoprotein binding protein -0.0144673
SETD5 SET domain containing 5 -0.0137481
SEPTIN2 septin 2 -0.0137219
CCNI cyclin I -0.0112518
DOCK4 dedicator of cytokinesis 4 -0.00998086
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.00973584
EIF5B eukaryotic translation initiation factor 5B -0.00966058
PUM1 pumilio RNA-binding family member 1 -0.00937084
KMT2A lysine (K)-specific methyltransferase 2A -0.0083544
RAD51B RAD51 paralog B -0.00825857
FUS FUS RNA binding protein -0.00757244
KMT2C lysine (K)-specific methyltransferase 2C -0.00732601
CANX calnexin -0.00604144
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.00509067
KIF5B kinesin family member 5B -0.00442581
ZNF292 zinc finger protein 292 -0.0040597
LRMDA leucine rich melanocyte differentiation associated -0.00298656
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00204701
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.00188858
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.00187952
NALF1 NALCN channel auxiliary factor 1 -2.33232E-4