| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD6 | FERM domain containing 6 | 0.217568 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.187253 |
| HDAC9 | histone deacetylase 9 | 0.161073 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.152312 |
| NAV3 | neuron navigator 3 | 0.150464 |
| ZNF438 | zinc finger protein 438 | 0.146205 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.13415 |
| EXT1 | exostosin glycosyltransferase 1 | 0.126805 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.124003 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.120281 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0950987 |
| FRMD4A | FERM domain containing 4A | 0.0930829 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0826186 |
| DGKI | diacylglycerol kinase, iota | 0.0808639 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0763027 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0742661 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0705503 |
| NAV2 | neuron navigator 2 | 0.0703866 |
| HMGA2 | high mobility group AT-hook 2 | 0.0698823 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0681409 |
| NABP1 | nucleic acid binding protein 1 | 0.0646011 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0627549 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0619562 |
| PARD3 | par-3 family cell polarity regulator | 0.0618202 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0600397 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.059933 |
| FLNB | filamin B, beta | 0.0593053 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0557176 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0547062 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0532737 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0526494 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0522008 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0520246 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0508964 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.049765 |
| DENND1A | DENN/MADD domain containing 1A | 0.0486248 |
| RUNX1 | runt-related transcription factor 1 | 0.0470718 |
| NDRG1 | N-myc downstream regulated 1 | 0.0464809 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0461639 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0438637 |
| MCL1 | myeloid cell leukemia 1 | 0.0436172 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0425806 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0417489 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0402871 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0396266 |
| RCOR1 | REST corepressor 1 | 0.0394512 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0388517 |
| INTS6 | integrator complex subunit 6 | 0.0383908 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0382655 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0381938 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.037542 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0374287 |
| JMJD1C | jumonji domain containing 1C | 0.0372434 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0367179 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.036493 |
| NEMP2 | nuclear envelope integral membrane protein 2 | 0.0359132 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0354517 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0346665 |
| GOLGA4 | golgin A4 | 0.034134 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0340393 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0340109 |
| FHIT | fragile histidine triad | 0.0330624 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0329463 |
| CAPRIN2 | caprin family member 2 | 0.0324013 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.032197 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0319591 |
| SETD5 | SET domain containing 5 | 0.0319013 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0309578 |
| CANX | calnexin | 0.0308699 |
| ENO1 | enolase 1, (alpha) | 0.0303535 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0294121 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0293874 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0293358 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.029335 |
| RAD51B | RAD51 paralog B | 0.0291071 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0289275 |
| BRD4 | bromodomain containing 4 | 0.0288629 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0287924 |
| FKBP15 | FK506 binding protein 15, 133kDa | 0.0284531 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0282576 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.028243 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0281181 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0280041 |
| ZNF292 | zinc finger protein 292 | 0.027918 |
| LAMB3 | laminin, beta 3 | 0.0278395 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0273795 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0268994 |
| BBX | bobby sox homolog (Drosophila) | 0.0267126 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0266142 |
| SET | SET nuclear proto-oncogene | 0.0259398 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0257507 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.025706 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0254114 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0253644 |
| PTK2 | protein tyrosine kinase 2 | 0.0252016 |
| RPL3 | ribosomal protein L3 | 0.0249447 |
| ZNF207 | zinc finger protein 207 | 0.0249255 |
| FNIP1 | folliculin interacting protein 1 | 0.0248678 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0245871 |
| FMNL2 | formin-like 2 | 0.0245026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0912774 |
| TXNRD1 | thioredoxin reductase 1 | -0.0633566 |
| STC1 | stanniocalcin 1 | -0.0628145 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.053634 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0504024 |
| FHL2 | four and a half LIM domains 2 | -0.0399809 |
| RPL12 | ribosomal protein L12 | -0.0363893 |
| MKI67 | marker of proliferation Ki-67 | -0.0361053 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0358066 |
| MT2A | metallothionein 2A | -0.0350977 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0350458 |
| RBM25 | RNA binding motif protein 25 | -0.0300986 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0280051 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0276232 |
| HLA-C | major histocompatibility complex, class I, C | -0.0264214 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0253506 |
| RIGI | RNA sensor RIG-I | -0.0248055 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.023998 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0237283 |
| RPL26 | ribosomal protein L26 | -0.0232863 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0228032 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0225314 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0224119 |
| PLSCR1 | phospholipid scramblase 1 | -0.0222287 |
| G0S2 | G0/G1 switch 2 | -0.0215295 |
| KLF10 | Kruppel-like factor 10 | -0.0214015 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0207808 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.020762 |
| MX1 | MX dynamin-like GTPase 1 | -0.0198014 |
| TEX10 | testis expressed 10 | -0.0197752 |
| SMYD3 | SET and MYND domain containing 3 | -0.0194603 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0193622 |
| RPLP2 | ribosomal protein, large, P2 | -0.0193391 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0192592 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0191995 |
| TDRD7 | tudor domain containing 7 | -0.0190913 |
| MTAP | methylthioadenosine phosphorylase | -0.0190275 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0187601 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0187293 |
| CDK17 | cyclin-dependent kinase 17 | -0.018153 |
| BCL2L1 | BCL2-like 1 | -0.0181408 |
| VCL | vinculin | -0.0178221 |
| EMP1 | epithelial membrane protein 1 | -0.0177517 |
| FANCI | Fanconi anemia, complementation group I | -0.017688 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.0175248 |
| MX2 | MX dynamin-like GTPase 2 | -0.0174703 |
| RPL36A | ribosomal protein L36a | -0.0174017 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0173115 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0171821 |
| CENPE | centromere protein E, 312kDa | -0.0170216 |
| NOP56 | NOP56 ribonucleoprotein | -0.0169066 |
| HELLS | helicase, lymphoid-specific | -0.0167225 |
| RPL19 | ribosomal protein L19 | -0.016647 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | -0.0165848 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0165434 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0161608 |
| SERPINA2 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) | -0.0161212 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0157551 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0156261 |
| CCND2 | cyclin D2 | -0.0156162 |
| RBL1 | retinoblastoma-like 1 | -0.0155124 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0154079 |
| TAF2 | TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa | -0.0152017 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0151584 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0151474 |
| ZHX3 | zinc fingers and homeoboxes 3 | -0.0151466 |
| CEP95 | centrosomal protein 95kDa | -0.0150576 |
| TOP1 | topoisomerase (DNA) I | -0.0150405 |
| SMC4 | structural maintenance of chromosomes 4 | -0.01494 |
| RASA3 | RAS p21 protein activator 3 | -0.0149081 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -0.0148098 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0147867 |
| KNL1 | kinetochore scaffold 1 | -0.0147312 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0147308 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0146248 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0145131 |
| NUP214 | nucleoporin 214kDa | -0.0144978 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0143694 |
| RBM26 | RNA binding motif protein 26 | -0.0143284 |
| THOC2 | THO complex 2 | -0.0142355 |
| CUL1 | cullin 1 | -0.0142324 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.014124 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0141148 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0140476 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0139962 |
| ZNHIT6 | zinc finger, HIT-type containing 6 | -0.0139024 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0139 |
| RPL32 | ribosomal protein L32 | -0.0136767 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | -0.0136445 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0136328 |
| RPL36AL | ribosomal protein L36a-like | -0.0135611 |
| KLHL8 | kelch-like family member 8 | -0.0134223 |
| DICER1 | dicer 1, ribonuclease type III | -0.0133821 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0133179 |
| NIN | ninein (GSK3B interacting protein) | -0.0131415 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.013121 |
| NEMF | nuclear export mediator factor | -0.0131098 |
| RPL36 | ribosomal protein L36 | -0.0131033 |
| GOLM1 | golgi membrane protein 1 | -0.0130725 |
| SRPK1 | SRSF protein kinase 1 | -0.0130502 |
