| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.118203 |
| MCL1 | myeloid cell leukemia 1 | 0.11088 |
| ACTG1 | actin gamma 1 | 0.0969681 |
| NRG1 | neuregulin 1 | 0.095567 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0904256 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.085172 |
| KIF26B | kinesin family member 26B | 0.0826593 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0743113 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0694154 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0690532 |
| NBEA | neurobeachin | 0.0683386 |
| INHBA | inhibin, beta A | 0.0644211 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0620216 |
| RORA | RAR-related orphan receptor A | 0.0596819 |
| GPC6 | glypican 6 | 0.0581146 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0573519 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.0563764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0555337 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0512601 |
| SMYD3 | SET and MYND domain containing 3 | 0.0510859 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0488586 |
| SNTG1 | syntrophin, gamma 1 | 0.0475397 |
| PTCHD4 | patched domain containing 4 | 0.0474503 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0473802 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0468672 |
| CPE | carboxypeptidase E | 0.0467447 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0462392 |
| FGF14 | fibroblast growth factor 14 | 0.0423402 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0417918 |
| SVIL | supervillin | 0.0407809 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0394961 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0380613 |
| EGR1 | early growth response 1 | 0.0379063 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0375896 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0375547 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0371862 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0364546 |
| TOX | thymocyte selection-associated high mobility group box | 0.0352578 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0349816 |
| ZFHX3 | zinc finger homeobox 3 | 0.0347912 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0345728 |
| CDK13 | cyclin-dependent kinase 13 | 0.0345458 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0344925 |
| TOP1 | topoisomerase (DNA) I | 0.0340643 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.033939 |
| SP100 | SP100 nuclear antigen | 0.0338257 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0334377 |
| ASPH | aspartate beta-hydroxylase | 0.0332373 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0328562 |
| CNTNAP5 | contactin associated protein-like 5 | 0.0326149 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0317995 |
| ENO1 | enolase 1, (alpha) | 0.0316623 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0313568 |
| DENND4A | DENN/MADD domain containing 4A | 0.030966 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0309347 |
| NCKAP5 | NCK-associated protein 5 | 0.0308876 |
| CHGB | chromogranin B | 0.0307358 |
| HOMER1 | homer scaffolding protein 1 | 0.0305999 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.0304911 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0304776 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.030426 |
| SETX | senataxin | 0.0300863 |
| NANOS1 | nanos homolog 1 (Drosophila) | 0.0300177 |
| PAEP | progestagen-associated endometrial protein | 0.0297822 |
| RGS7 | regulator of G-protein signaling 7 | 0.029638 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0296161 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | 0.0292525 |
| LSAMP | limbic system-associated membrane protein | 0.0290691 |
| ARFGEF3 | ARFGEF family member 3 | 0.0290534 |
| EGFR | epidermal growth factor receptor | 0.0288605 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0287837 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0285889 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.028549 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0280821 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0278918 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0277146 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0277082 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | 0.0276618 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | 0.0275137 |
| CNKSR3 | CNKSR family member 3 | 0.0272953 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0263188 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0263165 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0262437 |
| TUSC3 | tumor suppressor candidate 3 | 0.0258666 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0258439 |
| NAV2 | neuron navigator 2 | 0.0256687 |
| SCG2 | secretogranin II | 0.0255989 |
| NF1 | neurofibromin 1 | 0.0253945 |
| VMP1 | vacuole membrane protein 1 | 0.0249358 |
| SIK2 | salt-inducible kinase 2 | 0.0242401 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0241693 |
| ZNF804A | zinc finger protein 804A | 0.024117 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0240829 |
| RNF144A | ring finger protein 144A | 0.0240545 |
| RGS17 | regulator of G-protein signaling 17 | 0.0238729 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0237756 |
| GPATCH2L | G patch domain containing 2-like | 0.0235581 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0233572 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.023348 |
| TCF12 | transcription factor 12 | 0.023182 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM1 | teneurin transmembrane protein 1 | -0.205079 |
| PTMA | prothymosin, alpha | -0.14131 |
| CENPF | centromere protein F, 350/400kDa | -0.137577 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.117106 |
| PDE10A | phosphodiesterase 10A | -0.112107 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0979048 |
| PEG10 | paternally expressed 10 | -0.0794788 |
| CALCA | calcitonin-related polypeptide alpha | -0.0586086 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0576562 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0573059 |
| MKI67 | marker of proliferation Ki-67 | -0.0549484 |
| XPO1 | exportin 1 | -0.0512909 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0496438 |
| CCDC88A | coiled-coil domain containing 88A | -0.0475346 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0469749 |
| ZNF292 | zinc finger protein 292 | -0.0465911 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0462646 |
| MATR3 | matrin 3 | -0.0449153 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0440929 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0439136 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0438129 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0420553 |
| RPL26 | ribosomal protein L26 | -0.0406551 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -0.0393593 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0355562 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0354223 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0352542 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.035184 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.034692 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0341056 |
| TPX2 | TPX2, microtubule-associated | -0.0340814 |
| HMGB2 | high mobility group box 2 | -0.0339013 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0337151 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0336727 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0332013 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.033124 |
| AURKA | aurora kinase A | -0.0329486 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0328658 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0323254 |
| RAD21 | RAD21 homolog (S. pombe) | -0.031932 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0317767 |
| ESRRG | estrogen-related receptor gamma | -0.0312538 |
| ECT2 | epithelial cell transforming 2 | -0.0305546 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0304464 |
| CDCA2 | cell division cycle associated 2 | -0.0302435 |
| PBK | PDZ binding kinase | -0.030079 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0294094 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0293971 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0290619 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0288928 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0283603 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0282573 |
| TTK | TTK protein kinase | -0.0280897 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0280282 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0278383 |
| FTL | ferritin, light polypeptide | -0.0277926 |
| NFIA | nuclear factor I/A | -0.0272232 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0271554 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0268817 |
| RTN4 | reticulon 4 | -0.0268606 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.026696 |
| KANTR | KDM5C adjacent non-coding transcript | -0.026617 |
| NRXN1 | neurexin 1 | -0.0265934 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0265042 |
| STMN1 | stathmin 1 | -0.0264385 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0264309 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0264195 |
| TXNIP | thioredoxin interacting protein | -0.0259738 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0259029 |
| LIFR | leukemia inhibitory factor receptor alpha | -0.0256823 |
| RPS6 | ribosomal protein S6 | -0.0256104 |
| RPL37A | ribosomal protein L37a | -0.025413 |
| PGK1 | phosphoglycerate kinase 1 | -0.0252643 |
| SGO2 | shugoshin 2 | -0.0251544 |
| ANLN | anillin, actin binding protein | -0.0250538 |
| PDS5B | PDS5 cohesin associated factor B | -0.0250318 |
| PHIP | pleckstrin homology domain interacting protein | -0.0248465 |
| CEP152 | centrosomal protein 152kDa | -0.0248092 |
| CA8 | carbonic anhydrase VIII | -0.0243706 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0243645 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0239721 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0235683 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0235189 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0234575 |
| CDK8 | cyclin-dependent kinase 8 | -0.0231778 |
| NCAM1 | neural cell adhesion molecule 1 | -0.0231277 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0231266 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0229395 |
| NKTR | natural killer cell triggering receptor | -0.0226968 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0226907 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0225689 |
| FOXN3 | forkhead box N3 | -0.0225663 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0224662 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -0.0223228 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0222987 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0222207 |
| PCM1 | pericentriolar material 1 | -0.0220685 |
| KIF2C | kinesin family member 2C | -0.0220344 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0219122 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.021838 |
