| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 4EGI-1_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.165909 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.159383 |
| NRG3 | neuregulin 3 | 0.152061 |
| FMN1 | formin 1 | 0.149827 |
| FNDC3B | fibronectin type III domain containing 3B | 0.138671 |
| DST | dystonin | 0.106037 |
| NAV2 | neuron navigator 2 | 0.101852 |
| FN1 | fibronectin 1 | 0.0978562 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0912012 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0870749 |
| SPAG9 | sperm associated antigen 9 | 0.0853028 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0808604 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0802828 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0775067 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0693684 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0684658 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0668363 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0661855 |
| LDHA | lactate dehydrogenase A | 0.0598821 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0574286 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0563073 |
| PGK1 | phosphoglycerate kinase 1 | 0.0556131 |
| CD44 | CD44 molecule (Indian blood group) | 0.0540473 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.052573 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0524124 |
| GOLGA4 | golgin A4 | 0.0498728 |
| MAP4 | microtubule-associated protein 4 | 0.0497924 |
| CENPF | centromere protein F, 350/400kDa | 0.049182 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0487114 |
| CANX | calnexin | 0.0486056 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0476033 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0475527 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0466907 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0463027 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0456425 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0451156 |
| ANGPTL4 | angiopoietin-like 4 | 0.044597 |
| GOLGB1 | golgin B1 | 0.043994 |
| CLTC | clathrin, heavy chain (Hc) | 0.0438819 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0429857 |
| B2M | beta-2-microglobulin | 0.0429826 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0427927 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0427298 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0426798 |
| ANXA2 | annexin A2 | 0.0425291 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0421815 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0420853 |
| HDAC9 | histone deacetylase 9 | 0.0420804 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.042052 |
| BBX | bobby sox homolog (Drosophila) | 0.0416967 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0413328 |
| ASPH | aspartate beta-hydroxylase | 0.041204 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0411372 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0409713 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0408585 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.040858 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0408254 |
| PKM | pyruvate kinase, muscle | 0.0394569 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0393893 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0386767 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0386453 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0381434 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0380662 |
| ANXA5 | annexin A5 | 0.0379231 |
| SQSTM1 | sequestosome 1 | 0.0378165 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0376727 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.0374154 |
| EP300 | E1A binding protein p300 | 0.0371666 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.036582 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0363912 |
| SFTPA2 | surfactant protein A2 | 0.0358968 |
| UBC | ubiquitin C | 0.035308 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0352456 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0350024 |
| PHF21A | PHD finger protein 21A | 0.0349723 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0347487 |
| ZNF697 | zinc finger protein 697 | 0.03457 |
| MKI67 | marker of proliferation Ki-67 | 0.0345441 |
| ENO1 | enolase 1, (alpha) | 0.0344336 |
| RUNX1 | runt-related transcription factor 1 | 0.0338025 |
| TRIM33 | tripartite motif containing 33 | 0.0337408 |
| NGLY1 | N-glycanase 1 | 0.0336274 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0335274 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0334283 |
| COG5 | component of oligomeric golgi complex 5 | 0.0333993 |
| CD109 | CD109 molecule | 0.0330379 |
| LSAMP | limbic system-associated membrane protein | 0.0328065 |
| PCBP3 | poly(rC) binding protein 3 | 0.0325337 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | 0.0324624 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0321659 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.0320121 |
| MORF4L2 | mortality factor 4 like 2 | 0.0319181 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0315162 |
| SETD5 | SET domain containing 5 | 0.0314882 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0312889 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0311848 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0309607 |
| TXNRD1 | thioredoxin reductase 1 | 0.0309287 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0309118 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0308651 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.0433184 |
| MT2A | metallothionein 2A | -0.040045 |
| RPS12 | ribosomal protein S12 | -0.0384831 |
| TMSB10 | thymosin beta 10 | -0.0308532 |
| RPL31 | ribosomal protein L31 | -0.0304426 |
| RPS8 | ribosomal protein S8 | -0.0265871 |
| RAD51B | RAD51 paralog B | -0.0261488 |
| RPL37A | ribosomal protein L37a | -0.0260402 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0259117 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0254809 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0240003 |
| IER3 | immediate early response 3 | -0.0221206 |
| RPL36 | ribosomal protein L36 | -0.0215837 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.021583 |
| C10ORF90 | chromosome 10 open reading frame 90 | -0.0214734 |
| NLGN1 | neuroligin 1 | -0.0213084 |
| RPS23 | ribosomal protein S23 | -0.0204482 |
| WWOX | WW domain containing oxidoreductase | -0.0199139 |
| RPL9 | ribosomal protein L9 | -0.0197806 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0190413 |
| RPS29 | ribosomal protein S29 | -0.0179499 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.0173659 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0173539 |
| RPS16 | ribosomal protein S16 | -0.0173359 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0169955 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.016927 |
| RPL26 | ribosomal protein L26 | -0.0167344 |
| RPLP2 | ribosomal protein, large, P2 | -0.0159659 |
| RPS3 | ribosomal protein S3 | -0.015957 |
| PYGB | phosphorylase, glycogen; brain | -0.0159421 |
| NOP56 | NOP56 ribonucleoprotein | -0.0158739 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0157878 |
| RPS15 | ribosomal protein S15 | -0.0154793 |
| PDE10A | phosphodiesterase 10A | -0.0154016 |
| RPS13 | ribosomal protein S13 | -0.0152148 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0151391 |
| HMGA1 | high mobility group AT-hook 1 | -0.0150874 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0150853 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0149993 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0149933 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0149788 |
| DHFR | dihydrofolate reductase | -0.0149586 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0148999 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.0147477 |
| TYR | tyrosinase | -0.0146645 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.014377 |
| RPL27 | ribosomal protein L27 | -0.0142432 |
| FTL | ferritin, light polypeptide | -0.0140622 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.0140003 |
| RACK1 | receptor for activated C kinase 1 | -0.0139148 |
| RPL37 | ribosomal protein L37 | -0.0138229 |
| RPL28 | ribosomal protein L28 | -0.0136748 |
| MELTF | melanotransferrin | -0.0136393 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0133001 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0132609 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.012885 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0127443 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0126561 |
| RPS25 | ribosomal protein S25 | -0.0126319 |
| RPS27A | ribosomal protein S27a | -0.0125227 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0124197 |
| RPL12 | ribosomal protein L12 | -0.0124126 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0124023 |
| RPL35A | ribosomal protein L35a | -0.0123336 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -0.0123242 |
| NAV3 | neuron navigator 3 | -0.0122795 |
| RPS11 | ribosomal protein S11 | -0.0121184 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -0.01208 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0120441 |
| DIS3L2 | DIS3 like 3'-5' exoribonuclease 2 | -0.0119275 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0117813 |
| EGFR | epidermal growth factor receptor | -0.0117406 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0116566 |
| CHRM3 | cholinergic receptor, muscarinic 3 | -0.0116469 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0115937 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0115592 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0115085 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0113964 |
| MTIF2 | mitochondrial translational initiation factor 2 | -0.0112805 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.0111306 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | -0.0111055 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0110349 |
| PLXND1 | plexin D1 | -0.0109775 |
| RPL38 | ribosomal protein L38 | -0.0106939 |
| APOD | apolipoprotein D | -0.0105415 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0105152 |
| PAGE5 | P antigen family, member 5 (prostate associated) | -0.0104574 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0103638 |
| IGF2 | insulin-like growth factor 2 | -0.0103024 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.0101333 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0100577 |
| SNRPD3 | small nuclear ribonucleoprotein D3 polypeptide 18kDa | -0.0100564 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | -0.0100531 |
| RPL19 | ribosomal protein L19 | -0.0100373 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.00998338 |
| MDN1 | MDN1, midasin homolog (yeast) | -0.00995329 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | -0.00986639 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.00986504 |
| PCNX4 | pecanex 4 | -0.00986023 |
| NFIA | nuclear factor I/A | -0.0098102 |
