4EGI-1_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 4EGI-1_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0804431
EGFR epidermal growth factor receptor 0.0492886
ZEB1 zinc finger E-box binding homeobox 1 0.0408931
PDGFC platelet derived growth factor C 0.0368783
ADAM10 ADAM metallopeptidase domain 10 0.0311904
ZNF608 zinc finger protein 608 0.0276946
ZFAND3 zinc finger, AN1-type domain 3 0.0258551
SOX6 SRY (sex determining region Y)-box 6 0.0254436
ANXA1 annexin A1 0.0253303
NCEH1 neutral cholesterol ester hydrolase 1 0.0241122
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.022459
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0222465
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0216179
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0209795
TSC22D1 TSC22 domain family, member 1 0.0208247
HSPA8 heat shock 70kDa protein 8 0.020275
LOXL3 lysyl oxidase-like 3 0.0194688
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0181532
MEF2A myocyte enhancer factor 2A 0.0172883
EZR ezrin 0.017155
EPS8 epidermal growth factor receptor pathway substrate 8 0.0167925
EIF4A2 eukaryotic translation initiation factor 4A2 0.016705
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.015926
MYOF myoferlin 0.0156751
EEF2 eukaryotic translation elongation factor 2 0.0154788
MACROD2 MACRO domain containing 2 0.0150355
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0149388
PICALM phosphatidylinositol binding clathrin assembly protein 0.0147526
PLPP3 phospholipid phosphatase 3 0.0146866
DUSP4 dual specificity phosphatase 4 0.014666
TMEM65 transmembrane protein 65 0.0146567
ATP9B ATPase, class II, type 9B 0.014629
SGMS2 sphingomyelin synthase 2 0.0144555
ARID1A AT rich interactive domain 1A (SWI-like) 0.0138355
LMCD1 LIM and cysteine-rich domains 1 0.0137986
YAP1 Yes-associated protein 1 0.0136585
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0132862
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.012635
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0125638
NBAS neuroblastoma amplified sequence 0.012474
EXT1 exostosin glycosyltransferase 1 0.0123961
HDAC9 histone deacetylase 9 0.0123748
PDE4B phosphodiesterase 4B, cAMP-specific 0.012261
SAMD4A sterile alpha motif domain containing 4A 0.0122351
PLK2 polo-like kinase 2 0.0122347
USP24 ubiquitin specific peptidase 24 0.012227
EIF4B eukaryotic translation initiation factor 4B 0.0121023
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.011755
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0115603
LRRC7 leucine rich repeat containing 7 0.0115433
BMP2K BMP2 inducible kinase 0.0115103
ANK2 ankyrin 2, neuronal 0.0114907
CCNL1 cyclin L1 0.0109696
JMJD1C jumonji domain containing 1C 0.0104342
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0103625
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0103125
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0102984
EP300 E1A binding protein p300 0.0102536
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0102342
ATOSA atos homolog A 0.0100981
EML4 echinoderm microtubule associated protein like 4 0.0100452
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.00996137
UHMK1 U2AF homology motif (UHM) kinase 1 0.00974253
UBQLN1 ubiquilin 1 0.00970879
RPL3 ribosomal protein L3 0.00955696
DSCAM Down syndrome cell adhesion molecule 0.00954858
PTBP2 polypyrimidine tract binding protein 2 0.00950295
WAC WW domain containing adaptor with coiled-coil 0.00947474
MBNL2 muscleblind-like splicing regulator 2 0.00947374
TGFBR3 transforming growth factor, beta receptor III 0.00945574
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0094536
TRERF1 transcriptional regulating factor 1 0.00943863
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.00942513
SGMS1 sphingomyelin synthase 1 0.00939944
RBMS2 RNA binding motif, single stranded interacting protein 2 0.00936922
TACC2 transforming, acidic coiled-coil containing protein 2 0.00933362
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.00932957
CREB5 cAMP responsive element binding protein 5 0.00931488
CRY1 cryptochrome circadian clock 1 0.00928559
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00926502
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.00923521
USP47 ubiquitin specific peptidase 47 0.00918843
KDM6A lysine (K)-specific demethylase 6A 0.0090935
WDR43 WD repeat domain 43 0.0089288
ECPAS Ecm29 proteasome adaptor and scaffold 0.00890862
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0088296
ADAM9 ADAM metallopeptidase domain 9 0.00882678
ZNF292 zinc finger protein 292 0.0086579
TBC1D5 TBC1 domain family, member 5 0.00861575
FRMD6 FERM domain containing 6 0.00860963
HABP4 hyaluronan binding protein 4 0.0085984
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.00855986
PCGF5 polycomb group ring finger 5 0.00854593
TSC22D2 TSC22 domain family, member 2 0.00854069
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00850823
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.00846734
MAPK1 mitogen-activated protein kinase 1 0.00837761
LRP12 low density lipoprotein receptor-related protein 12 0.00836597
QKI QKI, KH domain containing, RNA binding 0.0083503
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00833047

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.252507
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158113
TPT1 tumor protein, translationally-controlled 1 -0.121983
RPS6 ribosomal protein S6 -0.0963405
RPS8 ribosomal protein S8 -0.0940018
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.091157
RPL35A ribosomal protein L35a -0.0766693
RPL26 ribosomal protein L26 -0.0740618
RPL31 ribosomal protein L31 -0.0651044
RPL37A ribosomal protein L37a -0.0634729
RPLP1 ribosomal protein, large, P1 -0.0633096
RPL9 ribosomal protein L9 -0.0628589
NAP1L1 nucleosome assembly protein 1-like 1 -0.0592752
RPS12 ribosomal protein S12 -0.0586201
ACTG1 actin gamma 1 -0.0585794
RPS3 ribosomal protein S3 -0.0582868
RPS23 ribosomal protein S23 -0.0578546
RPLP2 ribosomal protein, large, P2 -0.0572579
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0572125
RPL36 ribosomal protein L36 -0.0536739
RPL34 ribosomal protein L34 -0.0528858
RPS19 ribosomal protein S19 -0.0523073
RPL11 ribosomal protein L11 -0.0515334
RPL12 ribosomal protein L12 -0.0514808
FOXP1 forkhead box P1 -0.0494072
RPL23 ribosomal protein L23 -0.0480987
RPS27A ribosomal protein S27a -0.0476347
RPS25 ribosomal protein S25 -0.0455959
HSPB1 heat shock 27kDa protein 1 -0.0446671
TMSB10 thymosin beta 10 -0.043952
MKI67 marker of proliferation Ki-67 -0.0417808
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0410918
CENPF centromere protein F, 350/400kDa -0.0405042
RPL19 ribosomal protein L19 -0.0399944
NAV2 neuron navigator 2 -0.0393436
RPL32 ribosomal protein L32 -0.0384195
RPS24 ribosomal protein S24 -0.0381493
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0379864
RPL7A ribosomal protein L7a -0.0376034
RPS13 ribosomal protein S13 -0.0373227
B2M beta-2-microglobulin -0.0370385
PFN1 profilin 1 -0.0369899
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0364642
RPS29 ribosomal protein S29 -0.035982
SMC4 structural maintenance of chromosomes 4 -0.0355254
RPL28 ribosomal protein L28 -0.0350655
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.034801
RPS21 ribosomal protein S21 -0.0346045
RPS27 ribosomal protein S27 -0.0344263
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0341741
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0337902
S100A6 S100 calcium binding protein A6 -0.0337709
RPLP0 ribosomal protein, large, P0 -0.0331849
RPS17 ribosomal protein S17 -0.0327839
PKM pyruvate kinase, muscle -0.0322674
RACK1 receptor for activated C kinase 1 -0.0307871
MT2A metallothionein 2A -0.0307717
VIM vimentin -0.0304627
RPL18 ribosomal protein L18 -0.029503
RPL13A ribosomal protein L13a -0.0294605
S100A10 S100 calcium binding protein A10 -0.0291512
DIAPH3 diaphanous-related formin 3 -0.0291017
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.029092
WSB1 WD repeat and SOCS box containing 1 -0.0290822
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0287758
RPS16 ribosomal protein S16 -0.0281782
GNAS GNAS complex locus -0.0280069
RPS11 ribosomal protein S11 -0.0279328
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0278622
BMP10 bone morphogenetic protein 10 -0.0275581
CCND1 cyclin D1 -0.0275302
SMC3 structural maintenance of chromosomes 3 -0.0274214
VCL vinculin -0.0270842
TPM4 tropomyosin 4 -0.026944
RPS14 ribosomal protein S14 -0.026442
PNISR PNN-interacting serine/arginine-rich protein -0.0259671
NBEA neurobeachin -0.0259613
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0258503
S100A9 S100 calcium binding protein A9 -0.0254412
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0247237
TPX2 TPX2, microtubule-associated -0.0246556
MYL12B myosin, light chain 12B, regulatory -0.0242372
RPS5 ribosomal protein S5 -0.024127
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0236536
FTL ferritin, light polypeptide -0.0235038
RPL36A ribosomal protein L36a -0.0232632
ASPH aspartate beta-hydroxylase -0.0231991
RPL5 ribosomal protein L5 -0.0230809
RPS15 ribosomal protein S15 -0.023021
RPL8 ribosomal protein L8 -0.0230072
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0227834
RPL30 ribosomal protein L30 -0.0226684
RPS10 ribosomal protein S10 -0.0220899
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0219664
LOC102724023 ES1 protein homolog, mitochondrial -0.0219207
POTEF POTE ankyrin domain family, member F -0.0217792
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0211013
S100A4 S100 calcium binding protein A4 -0.0209696
NACA nascent polypeptide-associated complex alpha subunit -0.020888
EIF1 eukaryotic translation initiation factor 1 -0.0201604