| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 4EGI-1 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 4EGI-1_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT8 | keratin 8, type II | 0.139583 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.136373 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0859637 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0813572 |
| RPS12 | ribosomal protein S12 | 0.0698825 |
| B2M | beta-2-microglobulin | 0.0579225 |
| NEBL | nebulette | 0.053561 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0514541 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0513556 |
| RPS2 | ribosomal protein S2 | 0.0458762 |
| RPS3 | ribosomal protein S3 | 0.0399564 |
| DSPP | dentin sialophosphoprotein | 0.0390256 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0389597 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0354749 |
| BRD2 | bromodomain containing 2 | 0.0342104 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0336779 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0321315 |
| PCBP2 | poly(rC) binding protein 2 | 0.0317511 |
| VMP1 | vacuole membrane protein 1 | 0.0306421 |
| DIAPH1 | diaphanous-related formin 1 | 0.0306224 |
| RPL3 | ribosomal protein L3 | 0.0304688 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0299454 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0286046 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0283016 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0275265 |
| PARD3B | par-3 family cell polarity regulator beta | 0.027266 |
| TPM3 | tropomyosin 3 | 0.0266589 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0258967 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0256466 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0252388 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0251752 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0250904 |
| TRIM2 | tripartite motif containing 2 | 0.0247287 |
| CALR | calreticulin | 0.0246211 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0242129 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0240572 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0238234 |
| TXNIP | thioredoxin interacting protein | 0.0237036 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0234562 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0234141 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0229231 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0227778 |
| MYO5B | myosin VB | 0.022697 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0220903 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0220843 |
| SMYD3 | SET and MYND domain containing 3 | 0.0219507 |
| CCNL1 | cyclin L1 | 0.0219003 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0214692 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0214579 |
| NRP1 | neuropilin 1 | 0.0209763 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0209467 |
| SET | SET nuclear proto-oncogene | 0.0209326 |
| RPL21 | ribosomal protein L21 | 0.0205476 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0204503 |
| YAP1 | Yes-associated protein 1 | 0.0203943 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0202783 |
| CLDN4 | claudin 4 | 0.0196934 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0191756 |
| MKRN1 | makorin ring finger protein 1 | 0.0191093 |
| RACK1 | receptor for activated C kinase 1 | 0.0188418 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0186422 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0186001 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0182017 |
| DST | dystonin | 0.0179906 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0178574 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0178551 |
| RPS17 | ribosomal protein S17 | 0.0178169 |
| RBM33 | RNA binding motif protein 33 | 0.0174302 |
| NCKAP1 | NCK-associated protein 1 | 0.0171745 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.017157 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0171284 |
| RPL13A | ribosomal protein L13a | 0.0170978 |
| RPS7 | ribosomal protein S7 | 0.0169961 |
| RPL5 | ribosomal protein L5 | 0.0168641 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0168231 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0167978 |
| FHIT | fragile histidine triad | 0.0167494 |
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 0.0167018 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.01665 |
| NEK7 | NIMA-related kinase 7 | 0.0165673 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0164931 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0163479 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0163276 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0162831 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0162168 |
| ZNF207 | zinc finger protein 207 | 0.016195 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0161132 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0160913 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0159682 |
| ZNF277 | zinc finger protein 277 | 0.0159636 |
| PNN | pinin, desmosome associated protein | 0.0159252 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0159243 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0158035 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0158012 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0157188 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0157031 |
| ZNRF3 | zinc and ring finger 3 | 0.0155559 |
| RPS18 | ribosomal protein S18 | 0.01553 |
| EXT1 | exostosin glycosyltransferase 1 | 0.015464 |
| EXOC6B | exocyst complex component 6B | 0.0153928 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.350371 |
| TMSB10 | thymosin beta 10 | -0.148415 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144264 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.102134 |
| AHNAK | AHNAK nucleoprotein | -0.0931662 |
| GNAS | GNAS complex locus | -0.0831608 |
| CANX | calnexin | -0.0822044 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0764021 |
| IER3 | immediate early response 3 | -0.0758162 |
| TMEM123 | transmembrane protein 123 | -0.0720035 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0702744 |
| EPCAM | epithelial cell adhesion molecule | -0.069328 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0617899 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0614321 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0583561 |
| RPL35A | ribosomal protein L35a | -0.0574571 |
| RPLP1 | ribosomal protein, large, P1 | -0.0560507 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0551457 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0535365 |
| PGK1 | phosphoglycerate kinase 1 | -0.0512514 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0508768 |
| NFIA | nuclear factor I/A | -0.0502117 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0500795 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0482074 |
| H1-0 | H1.0 linker histone | -0.0477701 |
| CCND1 | cyclin D1 | -0.0471478 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0468488 |
| S100A6 | S100 calcium binding protein A6 | -0.0454271 |
| RPS21 | ribosomal protein S21 | -0.0427157 |
| ZNF217 | zinc finger protein 217 | -0.0422601 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0399115 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0395894 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0395407 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0394355 |
| VCL | vinculin | -0.0390663 |
| RPS24 | ribosomal protein S24 | -0.0380832 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0380594 |
| TOP1 | topoisomerase (DNA) I | -0.0375255 |
| NDRG1 | N-myc downstream regulated 1 | -0.0371888 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0359852 |
| S100A2 | S100 calcium binding protein A2 | -0.0355378 |
| CTSD | cathepsin D | -0.0354783 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.035102 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.034451 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0337334 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0334308 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0332476 |
| HDLBP | high density lipoprotein binding protein | -0.0329068 |
| HLA-A | major histocompatibility complex, class I, A | -0.0320466 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0316232 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0315556 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0314848 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0312838 |
| HM13 | histocompatibility (minor) 13 | -0.0312297 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0308825 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0305202 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0301659 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0299681 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0299107 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0298686 |
| TPM4 | tropomyosin 4 | -0.0296588 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0293165 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0290298 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0289143 |
| PERP | PERP, TP53 apoptosis effector | -0.0287033 |
| SDC4 | syndecan 4 | -0.0285792 |
| PKM | pyruvate kinase, muscle | -0.0284788 |
| RRBP1 | ribosome binding protein 1 | -0.0280079 |
| TES | testin LIM domain protein | -0.0279384 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0277851 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0277715 |
| EHF | ets homologous factor | -0.0271653 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0271626 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0268546 |
| CD2AP | CD2-associated protein | -0.026792 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0265524 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0264893 |
| FLNB | filamin B, beta | -0.0257604 |
| RBM39 | RNA binding motif protein 39 | -0.0256449 |
| LDHA | lactate dehydrogenase A | -0.0255895 |
| SERINC5 | serine incorporator 5 | -0.0255023 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0254679 |
| ACTN4 | actinin, alpha 4 | -0.025294 |
| BBX | bobby sox homolog (Drosophila) | -0.0252824 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0251217 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0244439 |
| PRELID2 | PRELI domain containing 2 | -0.0242787 |
| KLK10 | kallikrein-related peptidase 10 | -0.024266 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0240216 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0239156 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0238743 |
| EGR1 | early growth response 1 | -0.0235492 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0235257 |
| SETD5 | SET domain containing 5 | -0.0234806 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0232759 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0231865 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0231329 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0229737 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0228336 |
| EHBP1 | EH domain binding protein 1 | -0.0227452 |
