4EGI-1_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 4EGI-1 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 4EGI-1_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMC2 laminin, gamma 2 0.192634
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.163895
HMGA2 high mobility group AT-hook 2 0.156196
EEF2 eukaryotic translation elongation factor 2 0.150435
EGFR epidermal growth factor receptor 0.116787
EGR1 early growth response 1 0.102123
ANXA1 annexin A1 0.0935025
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0853915
HSPA8 heat shock 70kDa protein 8 0.0785834
SNX9 sorting nexin 9 0.0736426
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0674639
ACTG1 actin gamma 1 0.0655964
LAMA4 laminin, alpha 4 0.0647677
ITPKC inositol-trisphosphate 3-kinase C 0.0635049
LAMB3 laminin, beta 3 0.0600752
RCOR1 REST corepressor 1 0.0553999
EMP1 epithelial membrane protein 1 0.0545188
RPL3 ribosomal protein L3 0.0542494
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0537959
LMO7 LIM domain 7 0.0518544
DSPP dentin sialophosphoprotein 0.0498501
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0475387
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0464424
GPC5 glypican 5 0.0461677
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0425244
AKAP9 A kinase (PRKA) anchor protein 9 0.0412279
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0411443
BRD2 bromodomain containing 2 0.0409985
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0408787
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0408352
CLIP2 CAP-GLY domain containing linker protein 2 0.0400876
FTH1 ferritin, heavy polypeptide 1 0.0394408
PLAUR plasminogen activator, urokinase receptor 0.0380965
SGMS2 sphingomyelin synthase 2 0.0380185
POTEF POTE ankyrin domain family, member F 0.037538
NDRG1 N-myc downstream regulated 1 0.0374757
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0373573
OSBPL10 oxysterol binding protein-like 10 0.0370251
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0368749
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.03655
UBC ubiquitin C 0.0364432
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0363109
ZSWIM6 zinc finger, SWIM-type containing 6 0.0361687
CDCP1 CUB domain containing protein 1 0.0361659
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0357616
KLF5 Kruppel-like factor 5 (intestinal) 0.0347707
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0346899
EXT1 exostosin glycosyltransferase 1 0.0345932
FBXO11 F-box protein 11 0.0342354
MYO5B myosin VB 0.0340188
NUP50 nucleoporin 50kDa 0.0331545
CREB5 cAMP responsive element binding protein 5 0.0328395
USP9X ubiquitin specific peptidase 9, X-linked 0.0318442
RPS2 ribosomal protein S2 0.0307723
FHL2 four and a half LIM domains 2 0.0299047
KRT8 keratin 8, type II 0.0296018
ANXA2 annexin A2 0.0294139
EEF1G eukaryotic translation elongation factor 1 gamma 0.0290674
ABR active BCR-related 0.0288637
SEC31A SEC31 homolog A (S. cerevisiae) 0.0286484
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0285342
ABHD3 abhydrolase domain containing 3 0.0280506
GCLC glutamate-cysteine ligase, catalytic subunit 0.0279263
S100A6 S100 calcium binding protein A6 0.027348
RPS13 ribosomal protein S13 0.0272162
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0269493
ARHGAP42 Rho GTPase activating protein 42 0.0268582
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0267802
HM13 histocompatibility (minor) 13 0.0262562
DSG2 desmoglein 2 0.0261271
KLK10 kallikrein-related peptidase 10 0.0260623
IGFBP3 insulin-like growth factor binding protein 3 0.0259255
UGDH UDP-glucose 6-dehydrogenase 0.0258444
CDK13 cyclin-dependent kinase 13 0.0256752
JARID2 jumonji, AT rich interactive domain 2 0.0252466
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0252008
S100A10 S100 calcium binding protein A10 0.0248523
AKAP13 A kinase (PRKA) anchor protein 13 0.0247919
MACF1 microtubule-actin crosslinking factor 1 0.0242488
TPM4 tropomyosin 4 0.0241918
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0238853
DOCK5 dedicator of cytokinesis 5 0.0238348
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.023575
DSC3 desmocollin 3 0.0234303
VMP1 vacuole membrane protein 1 0.0231985
RPS17 ribosomal protein S17 0.0229342
NSD1 nuclear receptor binding SET domain protein 1 0.022621
HOMER1 homer scaffolding protein 1 0.0226006
SCFD1 sec1 family domain containing 1 0.0224819
RPL10A ribosomal protein L10a 0.0224217
FERMT1 fermitin family member 1 0.0223091
DCLK1 doublecortin-like kinase 1 0.022159
CALU calumenin 0.0220221
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0217649
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0216463
EIF1 eukaryotic translation initiation factor 1 0.0215917
DSCAM Down syndrome cell adhesion molecule 0.0215874
SRRM1 serine/arginine repetitive matrix 1 0.021542
ZNF106 zinc finger protein 106 0.0214141
SEPTIN9 septin 9 0.0212587

decreased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) -0.175389
RAD51B RAD51 paralog B -0.155442
PTMA prothymosin, alpha -0.135479
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.128928
FHIT fragile histidine triad -0.0905428
RBM25 RNA binding motif protein 25 -0.0729493
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0706919
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0691795
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0656827
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0649584
IER3 immediate early response 3 -0.0648651
OXR1 oxidation resistance 1 -0.0588264
TPT1 tumor protein, translationally-controlled 1 -0.0552861
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0540069
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0531098
GPHN gephyrin -0.0527673
TRA2A transformer 2 alpha homolog (Drosophila) -0.0524709
RPS24 ribosomal protein S24 -0.0508923
MTAP methylthioadenosine phosphorylase -0.0478372
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.047095
RUNX2 runt-related transcription factor 2 -0.0463079
PRELID2 PRELI domain containing 2 -0.0461341
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0447329
NT5DC3 5'-nucleotidase domain containing 3 -0.04317
SMYD3 SET and MYND domain containing 3 -0.043148
HDAC2 histone deacetylase 2 -0.0428308
OSBPL3 oxysterol binding protein-like 3 -0.0425193
CCSER1 coiled-coil serine-rich protein 1 -0.0425185
ZNRF3 zinc and ring finger 3 -0.0419036
RBM39 RNA binding motif protein 39 -0.0410301
EXOC4 exocyst complex component 4 -0.0409069
VCL vinculin -0.039996
GMDS GDP-mannose 4,6-dehydratase -0.0398105
ACTN4 actinin, alpha 4 -0.0394774
MSI2 musashi RNA-binding protein 2 -0.0381596
NAP1L1 nucleosome assembly protein 1-like 1 -0.038095
KDM3A lysine (K)-specific demethylase 3A -0.0377305
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0372281
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.037116
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0364603
TOP1 topoisomerase (DNA) I -0.0363309
TMSB10 thymosin beta 10 -0.0362133
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0359882
DENND1A DENN/MADD domain containing 1A -0.0351301
ZMYM2 zinc finger, MYM-type 2 -0.0349968
RNF43 ring finger protein 43 -0.0346133
RSRC1 arginine/serine-rich coiled-coil 1 -0.034375
TGFB2 transforming growth factor, beta 2 -0.0342671
CUX1 cut-like homeobox 1 -0.0342297
BBX bobby sox homolog (Drosophila) -0.0339819
KITLG KIT ligand -0.0337245
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0332117
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0330442
FNDC3B fibronectin type III domain containing 3B -0.0330101
AOPEP aminopeptidase O (putative) -0.033009
WDR43 WD repeat domain 43 -0.0329442
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.032562
PNISR PNN-interacting serine/arginine-rich protein -0.0325141
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0324507
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0316743
TJP1 tight junction protein 1 -0.031664
OGA O-GlcNAcase -0.0315587
PHIP pleckstrin homology domain interacting protein -0.0314409
R3HDM1 R3H domain containing 1 -0.0311988
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0311752
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0311569
MED13L mediator complex subunit 13-like -0.0310834
DIAPH2 diaphanous-related formin 2 -0.0309846
MIS18BP1 MIS18 binding protein 1 -0.0308542
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0304901
SKAP1 src kinase associated phosphoprotein 1 -0.0303503
TFRC transferrin receptor -0.0299987
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0294161
RPL37A ribosomal protein L37a -0.0293383
PHF14 PHD finger protein 14 -0.0292535
SMC4 structural maintenance of chromosomes 4 -0.0292177
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0290019
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.028854
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0287135
EWSR1 EWS RNA-binding protein 1 -0.0286472
NF1 neurofibromin 1 -0.0286021
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0285279
NFIA nuclear factor I/A -0.0283736
ACBD6 acyl-CoA binding domain containing 6 -0.0280224
PTBP2 polypyrimidine tract binding protein 2 -0.0278531
TUBB tubulin, beta class I -0.0270477
EIF5B eukaryotic translation initiation factor 5B -0.0270308
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0267062
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0266543
CENPF centromere protein F, 350/400kDa -0.0265248
NEK7 NIMA-related kinase 7 -0.0264247
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0263446
RSRC2 arginine/serine-rich coiled-coil 2 -0.0261938
MARCHF6 membrane associated ring-CH-type finger 6 -0.0259016
TNPO1 transportin 1 -0.0256571
PUM2 pumilio RNA-binding family member 2 -0.0256135
PARD3 par-3 family cell polarity regulator -0.025576
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0255584
FAR1 fatty acyl CoA reductase 1 -0.0254782
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0254173