| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/12934390 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in 4mu8C relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | 1.26 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1.11 |
| FAM135B | family with sequence similarity 135, member B | 0.64 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | 0.64 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | 0.61 |
| MT2A | metallothionein 2A | 0.56 |
| USP27X | ubiquitin specific peptidase 27, X-linked | 0.55 |
| ITGA1 | integrin, alpha 1 | 0.48 |
| WWC2 | WW and C2 domain containing 2 | 0.47 |
| ELMO1 | engulfment and cell motility 1 | 0.47 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.47 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.44 |
| INVS | inversin | 0.44 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.43 |
| RMI2 | RecQ mediated genome instability 2 | 0.43 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | 0.43 |
| TNXB | tenascin XB | 0.43 |
| ALMS1 | Alstrom syndrome protein 1 | 0.42 |
| SET | SET nuclear proto-oncogene | 0.42 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.41 |
| DNAL4 | dynein, axonemal, light chain 4 | 0.41 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.41 |
| FBXL16 | F-box and leucine-rich repeat protein 16 | 0.4 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.4 |
| ATXN2 | ataxin 2 | 0.4 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.39 |
| JADE2 | jade family PHD finger 2 | 0.38 |
| POC1A | POC1 centriolar protein A | 0.37 |
| ZNF580 | zinc finger protein 580 | 0.37 |
| TP73 | tumor protein p73 | 0.37 |
| FRRS1 | ferric-chelate reductase 1 | 0.36 |
| CGNL1 | cingulin-like 1 | 0.34 |
| ZNF799 | zinc finger protein 799 | 0.34 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.34 |
| CST6 | cystatin E/M | 0.34 |
| ZC3H14 | zinc finger CCCH-type containing 14 | 0.33 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.33 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.33 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.32 |
| DCLRE1C | DNA cross-link repair 1C | 0.32 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.32 |
| ODC1 | ornithine decarboxylase 1 | 0.32 |
| ABLIM2 | actin binding LIM protein family, member 2 | 0.32 |
| ZBED8 | zinc finger, BED-type containing 8 | 0.32 |
| DCLRE1B | DNA cross-link repair 1B | 0.31 |
| CAPN15 | calpain 15 | 0.31 |
| GDA | guanine deaminase | 0.31 |
| FAM193A | family with sequence similarity 193, member A | 0.31 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.31 |
| CCDC77 | coiled-coil domain containing 77 | 0.3 |
| CHN1 | chimerin 1 | 0.3 |
| LGALSL | lectin, galactoside-binding-like | 0.3 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.3 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.3 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.3 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 0.3 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.3 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.3 |
| KLHL2 | kelch-like family member 2 | 0.3 |
| IL6ST | interleukin 6 signal transducer | 0.29 |
| CDK6 | cyclin-dependent kinase 6 | 0.29 |
| H3C1 | H3 clustered histone 1 | 0.29 |
| ZFP62 | ZFP62 zinc finger protein | 0.29 |
| RCAN3 | RCAN family member 3 | 0.29 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.29 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.28 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.28 |
| NDE1 | nudE neurodevelopment protein 1 | 0.28 |
| MRC2 | mannose receptor, C type 2 | 0.28 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.28 |
| RFX7 | regulatory factor X, 7 | 0.28 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.28 |
| MT1X | metallothionein 1X | 0.28 |
| SNTA1 | syntrophin, alpha 1 | 0.28 |
| KSR2 | kinase suppressor of ras 2 | 0.27 |
| SMAD3 | SMAD family member 3 | 0.27 |
| RNF145 | ring finger protein 145 | 0.27 |
| KCTD18 | potassium channel tetramerization domain containing 18 | 0.27 |
| RNF17 | ring finger protein 17 | 0.27 |
| ITGB5 | integrin, beta 5 | 0.27 |
| PEX1 | peroxisomal biogenesis factor 1 | 0.26 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | 0.26 |
| SP100 | SP100 nuclear antigen | 0.26 |
| ANTXR1 | anthrax toxin receptor 1 | 0.26 |
| NRM | nurim (nuclear envelope membrane protein) | 0.26 |
| RNF4 | ring finger protein 4 | 0.26 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.26 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.26 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.25 |
| B2M | beta-2-microglobulin | 0.25 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | 0.25 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | 0.25 |
| MLXIPL | MLX interacting protein-like | 0.25 |
| ATXN7L3B | ataxin 7-like 3B | 0.25 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.25 |
| SASH1 | SAM and SH3 domain containing 1 | 0.25 |
| PRR3 | proline rich 3 | 0.25 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.25 |
| SLC25A39 | solute carrier family 25, member 39 | 0.25 |
| KLHL24 | kelch-like family member 24 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SAT2 | spermidine/spermine N1-acetyltransferase family member 2 | -0.82 |
| ZNF445 | zinc finger protein 445 | -0.62 |
| C5 | complement component 5 | -0.62 |
| CCDC158 | coiled-coil domain containing 158 | -0.6 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.6 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.56 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.55 |
| FTL | ferritin, light polypeptide | -0.54 |
| RAB40C | RAB40C, member RAS oncogene family | -0.52 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.52 |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit | -0.52 |
| DISP1 | dispatched homolog 1 (Drosophila) | -0.51 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.49 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.47 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.43 |
| PKLR | pyruvate kinase, liver and RBC | -0.43 |
| THAP9 | THAP domain containing 9 | -0.42 |
| INHBA | inhibin, beta A | -0.42 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.42 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.41 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.41 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.4 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | -0.4 |
| FUNDC1 | FUN14 domain containing 1 | -0.4 |
| CTSL | cathepsin L | -0.4 |
| THBS2 | thrombospondin 2 | -0.39 |
| TP53 | tumor protein p53 | -0.39 |
| CD82 | CD82 molecule | -0.38 |
| ANGPTL4 | angiopoietin-like 4 | -0.38 |
| GRAMD2B | GRAM domain containing 2B | -0.37 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.37 |
| LIME1 | Lck interacting transmembrane adaptor 1 | -0.36 |
| PLAUR | plasminogen activator, urokinase receptor | -0.36 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.36 |
| CCDC57 | coiled-coil domain containing 57 | -0.36 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -0.35 |
| CLCN6 | chloride channel, voltage-sensitive 6 | -0.35 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.35 |
| AHR | aryl hydrocarbon receptor | -0.35 |
| SEC24D | SEC24 family member D | -0.35 |
| CERK | ceramide kinase | -0.35 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.35 |
| BRD9 | bromodomain containing 9 | -0.34 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.34 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.34 |
| ZNF440 | zinc finger protein 440 | -0.33 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.33 |
| HBA1 | hemoglobin, alpha 1 | -0.33 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.32 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -0.32 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | -0.32 |
| CORO2B | coronin, actin binding protein, 2B | -0.32 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.31 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.31 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.3 |
| TRAM1 | translocation associated membrane protein 1 | -0.3 |
| ZFP36 | ZFP36 ring finger protein | -0.3 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.3 |
| GPR180 | G protein-coupled receptor 180 | -0.29 |
| PER2 | period circadian clock 2 | -0.29 |
| SQSTM1 | sequestosome 1 | -0.29 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.28 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.28 |
| TDG | thymine-DNA glycosylase | -0.28 |
| FBXO46 | F-box protein 46 | -0.28 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.28 |
| CYBRD1 | cytochrome b reductase 1 | -0.28 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | -0.27 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | -0.27 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | -0.26 |
| RPGRIP1L | RPGRIP1-like | -0.26 |
| PTK2B | protein tyrosine kinase 2 beta | -0.26 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.26 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.25 |
| BOK | BCL2-related ovarian killer | -0.25 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.25 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.25 |
| TMEM39A | transmembrane protein 39A | -0.25 |
| GGT7 | gamma-glutamyltransferase 7 | -0.25 |
| F2 | coagulation factor II (thrombin) | -0.25 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.25 |
| MKX | mohawk homeobox | -0.25 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | -0.25 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.25 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.25 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.25 |
| C12ORF4 | chromosome 12 open reading frame 4 | -0.24 |
| LRP6 | low density lipoprotein receptor-related protein 6 | -0.24 |
| DPP4 | dipeptidyl-peptidase 4 | -0.24 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.24 |
| SESN2 | sestrin 2 | -0.24 |
| DNAH8 | dynein, axonemal, heavy chain 8 | -0.24 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.24 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.24 |
| ACVR1B | activin A receptor, type IB | -0.24 |
| HKDC1 | hexokinase domain containing 1 | -0.24 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.24 |
| ZNF669 | zinc finger protein 669 | -0.24 |
| CLK4 | CDC-like kinase 4 | -0.24 |
