| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 5-Azacytidine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 5-Azacytidine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.326352 |
| C3 | complement component 3 | 0.215278 |
| DSPP | dentin sialophosphoprotein | 0.214614 |
| ENO1 | enolase 1, (alpha) | 0.166145 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.153605 |
| TF | transferrin | 0.137773 |
| SLC38A2 | solute carrier family 38, member 2 | 0.123459 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.12236 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.105508 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0893788 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0811734 |
| RPS12 | ribosomal protein S12 | 0.0780533 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0775467 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0670864 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0644194 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0620754 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0617013 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0611761 |
| SDC4 | syndecan 4 | 0.0606723 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0600976 |
| RPL41 | ribosomal protein L41 | 0.0533871 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0524206 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0506799 |
| RPS3 | ribosomal protein S3 | 0.0485106 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0481204 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0471194 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0459139 |
| AHSG | alpha-2-HS-glycoprotein | 0.0450418 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0420529 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0413396 |
| VMP1 | vacuole membrane protein 1 | 0.0409828 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0384376 |
| CANX | calnexin | 0.0383551 |
| RPL4 | ribosomal protein L4 | 0.0380862 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0377471 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0374849 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.03735 |
| FAM107B | family with sequence similarity 107, member B | 0.0367927 |
| LDHA | lactate dehydrogenase A | 0.0360396 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0357273 |
| DIAPH1 | diaphanous-related formin 1 | 0.0349704 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0345126 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0343714 |
| BRD4 | bromodomain containing 4 | 0.034264 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0340097 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0339848 |
| CPE | carboxypeptidase E | 0.0329352 |
| RPL37A | ribosomal protein L37a | 0.0322858 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0321531 |
| YTHDC1 | YTH domain containing 1 | 0.0319814 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0318293 |
| VCL | vinculin | 0.0317974 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0316323 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0313126 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.031248 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0310988 |
| MCL1 | myeloid cell leukemia 1 | 0.0307439 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0301139 |
| JUN | jun proto-oncogene | 0.0298507 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0296086 |
| WDR43 | WD repeat domain 43 | 0.029359 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0293484 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0292024 |
| SELENOP | selenoprotein P | 0.0290397 |
| SFTPA2 | surfactant protein A2 | 0.0288392 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0288372 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.028336 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0277109 |
| TNS1 | tensin 1 | 0.027549 |
| XPOT | exportin, tRNA | 0.0274379 |
| VEGFA | vascular endothelial growth factor A | 0.0273649 |
| PHF3 | PHD finger protein 3 | 0.0272276 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0271264 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0269895 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0269804 |
| GPC3 | glypican 3 | 0.0269793 |
| CALR | calreticulin | 0.0269189 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0267328 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0267098 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0267077 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.026565 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0262793 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0261782 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0260228 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.025282 |
| SMAD3 | SMAD family member 3 | 0.025192 |
| SDC2 | syndecan 2 | 0.0250245 |
| SSR1 | signal sequence receptor, alpha | 0.0245554 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0244997 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0244599 |
| JAK1 | Janus kinase 1 | 0.0244552 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0244081 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0243623 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0242042 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0241879 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0240295 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.023903 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0238763 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0237164 |
| ZNF644 | zinc finger protein 644 | 0.0236221 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.271854 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.128218 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.108727 |
| GPC6 | glypican 6 | -0.100311 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0778256 |
| FN1 | fibronectin 1 | -0.076537 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0657493 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0531226 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.048917 |
| APOB | apolipoprotein B | -0.0465486 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0452728 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0432507 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0429093 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0428918 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0422827 |
| NDRG1 | N-myc downstream regulated 1 | -0.0418841 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0418802 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0408006 |
| APOA2 | apolipoprotein A-II | -0.0403449 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0397311 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0395456 |
| RPS24 | ribosomal protein S24 | -0.0391892 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0390749 |
| DTNA | dystrobrevin, alpha | -0.0376458 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0373646 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0365711 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0362799 |
| A2M | alpha-2-macroglobulin | -0.0355774 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0347934 |
| CRLS1 | cardiolipin synthase 1 | -0.0344897 |
| TMSB10 | thymosin beta 10 | -0.0338228 |
| PTCHD4 | patched domain containing 4 | -0.0329288 |
| OSMR | oncostatin M receptor | -0.0328997 |
| FAM135A | family with sequence similarity 135, member A | -0.0301162 |
| RPL23 | ribosomal protein L23 | -0.0289345 |
| GNAS | GNAS complex locus | -0.0284574 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0283173 |
| ATP10A | ATPase, class V, type 10A | -0.0282957 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0279273 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0278749 |
| KRT18 | keratin 18, type I | -0.0272028 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0263047 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0262327 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.026125 |
| MT2A | metallothionein 2A | -0.0259596 |
| GSE1 | Gse1 coiled-coil protein | -0.0253183 |
| TMEM123 | transmembrane protein 123 | -0.025197 |
| HMGA1 | high mobility group AT-hook 1 | -0.0248928 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0244035 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0241427 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0229904 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.022683 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0223743 |
| ATXN1 | ataxin 1 | -0.0221474 |
| SETD5 | SET domain containing 5 | -0.0221094 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0220239 |
| ACTN4 | actinin, alpha 4 | -0.0220114 |
| RPS19 | ribosomal protein S19 | -0.0215784 |
| RNF145 | ring finger protein 145 | -0.0215597 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0212895 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0204182 |
| WDR45B | WD repeat domain 45B | -0.0202623 |
| CDK6 | cyclin-dependent kinase 6 | -0.0201247 |
| RPS8 | ribosomal protein S8 | -0.020081 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0197503 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0196734 |
| RPL35A | ribosomal protein L35a | -0.0196315 |
| HMGA2 | high mobility group AT-hook 2 | -0.0195525 |
| RRBP1 | ribosome binding protein 1 | -0.0194862 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0193737 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0189804 |
| SYN3 | synapsin III | -0.0189192 |
| FTL | ferritin, light polypeptide | -0.0186178 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0183132 |
| PLPP3 | phospholipid phosphatase 3 | -0.0183062 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0181692 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0179203 |
| FRMD5 | FERM domain containing 5 | -0.0178018 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.017625 |
| H1-0 | H1.0 linker histone | -0.0175158 |
| RPS15 | ribosomal protein S15 | -0.0174751 |
| FMNL2 | formin-like 2 | -0.0173878 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0173874 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0173511 |
| RPL28 | ribosomal protein L28 | -0.0172784 |
| RUNX1 | runt-related transcription factor 1 | -0.0170808 |
| PLIN2 | perilipin 2 | -0.0168436 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0168078 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0166987 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0164447 |
| FHIT | fragile histidine triad | -0.0162531 |
| HNRNPLL | heterogeneous nuclear ribonucleoprotein L-like | -0.0161792 |
| ZFR | zinc finger RNA binding protein | -0.0161394 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0159104 |
| TMEM51 | transmembrane protein 51 | -0.015853 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0156466 |
| PCNX1 | pecanex 1 | -0.0156289 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0155878 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0155825 |
| STK39 | serine threonine kinase 39 | -0.0155716 |
