5-Azacytidine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Azacytidine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Azacytidine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0525099
KIAA1217 KIAA1217 0.0451418
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0443607
MBNL2 muscleblind-like splicing regulator 2 0.0433289
SMAD3 SMAD family member 3 0.0429342
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0421825
ENO1 enolase 1, (alpha) 0.0421514
APLP2 amyloid beta (A4) precursor-like protein 2 0.0418431
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0410672
MSN moesin 0.0399811
MEF2A myocyte enhancer factor 2A 0.0395146
SQLE squalene epoxidase 0.0389798
TPM3 tropomyosin 3 0.0381341
MYOF myoferlin 0.0381103
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0378952
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0376379
ARRDC3 arrestin domain containing 3 0.0375317
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0367836
FNDC3B fibronectin type III domain containing 3B 0.0366764
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0352988
GOLGA4 golgin A4 0.034942
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0345714
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0325895
ESYT2 extended synaptotagmin-like protein 2 0.0323715
BHLHE40 basic helix-loop-helix family, member e40 0.0320319
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0318214
KTN1 kinectin 1 (kinesin receptor) 0.0310247
SLK STE20-like kinase 0.0308833
CD44 CD44 molecule (Indian blood group) 0.0307698
AKAP13 A kinase (PRKA) anchor protein 13 0.0307331
SEPTIN9 septin 9 0.0304799
PICALM phosphatidylinositol binding clathrin assembly protein 0.0297663
PKM pyruvate kinase, muscle 0.0293392
XPO1 exportin 1 0.0285228
ANLN anillin, actin binding protein 0.0273072
KDM6A lysine (K)-specific demethylase 6A 0.0271659
VCL vinculin 0.0269118
ITCH itchy E3 ubiquitin protein ligase 0.0265644
TGM2 transglutaminase 2 0.0262366
NUP58 nucleoporin 58 0.0261266
COG6 component of oligomeric golgi complex 6 0.0253742
VMP1 vacuole membrane protein 1 0.025152
ANXA1 annexin A1 0.0251041
SH3PXD2A SH3 and PX domains 2A 0.0246689
ADM adrenomedullin 0.0244424
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0244173
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0241226
NRIP1 nuclear receptor interacting protein 1 0.0237438
NAV2 neuron navigator 2 0.0236154
RNF145 ring finger protein 145 0.0235487
LUZP1 leucine zipper protein 1 0.0232608
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.022825
MTSS1 metastasis suppressor 1 0.0226128
SPAG9 sperm associated antigen 9 0.0221978
KIF16B kinesin family member 16B 0.0220149
RERE arginine-glutamic acid dipeptide (RE) repeats 0.021939
HELZ helicase with zinc finger 0.0219256
UBA6 ubiquitin-like modifier activating enzyme 6 0.0214761
MBNL1 muscleblind-like splicing regulator 1 0.0209493
PLS3 plastin 3 0.0206669
CUL4B cullin 4B 0.0204685
USP9X ubiquitin specific peptidase 9, X-linked 0.0202779
SPTBN1 spectrin, beta, non-erythrocytic 1 0.020277
TMSB4X thymosin beta 4, X-linked 0.0201796
RAB6A RAB6A, member RAS oncogene family 0.0200658
CTNND1 catenin (cadherin-associated protein), delta 1 0.0200561
ZSWIM6 zinc finger, SWIM-type containing 6 0.0198922
ANO6 anoctamin 6 0.0197802
UBAP2 ubiquitin associated protein 2 0.0196971
CCNL1 cyclin L1 0.0196468
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0196093
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.0195002
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0194471
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0192245
MATR3 matrin 3 0.0189811
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0189449
RPL3 ribosomal protein L3 0.0187971
LIFR leukemia inhibitory factor receptor alpha 0.0187905
SRRM2 serine/arginine repetitive matrix 2 0.0187876
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0186224
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0185195
INTS6 integrator complex subunit 6 0.0184412
AKAP9 A kinase (PRKA) anchor protein 9 0.0184396
BARX2 BARX homeobox 2 0.0183365
TMF1 TATA element modulatory factor 1 0.0183242
CDC73 cell division cycle 73 0.0183191
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0182725
DIAPH1 diaphanous-related formin 1 0.0180112
CD47 CD47 molecule 0.0179712
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0178566
TRA2A transformer 2 alpha homolog (Drosophila) 0.0178101
LMO7 LIM domain 7 0.0177923
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0176574
COPA coatomer protein complex, subunit alpha 0.0176318
KDM4C lysine (K)-specific demethylase 4C 0.0176068
SFPQ splicing factor proline/glutamine-rich 0.0175765
CD46 CD46 molecule, complement regulatory protein 0.0175659
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0174896
ECT2 epithelial cell transforming 2 0.0174436
JAG1 jagged 1 0.0174373

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.341482
TIMP3 TIMP metallopeptidase inhibitor 3 -0.316982
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.200893
DPYD dihydropyrimidine dehydrogenase -0.140547
FLNB filamin B, beta -0.133817
AHNAK AHNAK nucleoprotein -0.116872
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110699
SULF1 sulfatase 1 -0.0799944
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0733826
NDRG1 N-myc downstream regulated 1 -0.0647165
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0644423
EMP1 epithelial membrane protein 1 -0.0643673
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0622874
ITGA6 integrin, alpha 6 -0.0622291
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0616902
MECOM MDS1 and EVI1 complex locus -0.0608307
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0567547
TMSB10 thymosin beta 10 -0.0526575
ZMYND8 zinc finger, MYND-type containing 8 -0.0496805
SLC35F3 solute carrier family 35, member F3 -0.0489486
SAMD9 sterile alpha motif domain containing 9 -0.0453913
CAV1 caveolin 1, caveolae protein, 22kDa -0.044482
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0441077
NAMPT nicotinamide phosphoribosyltransferase -0.0438024
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0436125
FOXP1 forkhead box P1 -0.043585
RABGAP1L RAB GTPase activating protein 1-like -0.0433564
ALCAM activated leukocyte cell adhesion molecule -0.0403999
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0395018
ZEB1 zinc finger E-box binding homeobox 1 -0.0390977
NRG1 neuregulin 1 -0.0380552
DOCK9 dedicator of cytokinesis 9 -0.0377933
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0368406
PRSS23 protease, serine, 23 -0.0359013
ABI3BP ABI family, member 3 (NESH) binding protein -0.0355829
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0352522
GNAS GNAS complex locus -0.0349836
GRB10 growth factor receptor-bound protein 10 -0.0345013
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0344996
BCL2L1 BCL2-like 1 -0.0337281
HM13 histocompatibility (minor) 13 -0.0337197
EGFR epidermal growth factor receptor -0.0334516
PALLD palladin, cytoskeletal associated protein -0.0328956
LOC112694756 uncharaterized LOC112694756 -0.0325128
S100A10 S100 calcium binding protein A10 -0.0313601
DGKH diacylglycerol kinase, eta -0.0311124
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0309925
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0308737
EXOC6B exocyst complex component 6B -0.0308003
CDK6 cyclin-dependent kinase 6 -0.0298227
DOCK5 dedicator of cytokinesis 5 -0.0288951
BLCAP bladder cancer associated protein -0.0286078
PLAT plasminogen activator, tissue -0.0285995
CAPN2 calpain 2, (m/II) large subunit -0.028597
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0284736
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0280453
DPYSL2 dihydropyrimidinase-like 2 -0.0279694
NEK7 NIMA-related kinase 7 -0.0279329
SULF2 sulfatase 2 -0.0276499
ANO1 anoctamin 1, calcium activated chloride channel -0.0274547
NRCAM neuronal cell adhesion molecule -0.0270427
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0268484
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0267171
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0260327
HSPG2 heparan sulfate proteoglycan 2 -0.0260118
DLG1 discs, large homolog 1 (Drosophila) -0.0256752
RASAL2 RAS protein activator like 2 -0.025635
UTRN utrophin -0.0253761
IGF2 insulin-like growth factor 2 -0.0251792
ARHGAP29 Rho GTPase activating protein 29 -0.0249708
AGMO alkylglycerol monooxygenase -0.0247774
GARS1 glycyl-tRNA synthetase 1 -0.024724
TXNRD1 thioredoxin reductase 1 -0.0246832
CAVIN1 caveolae associated protein 1 -0.0246795
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0245194
THSD4 thrombospondin, type I, domain containing 4 -0.0243693
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0241089
OXR1 oxidation resistance 1 -0.0241086
FOXO1 forkhead box O1 -0.0239805
TTC28 tetratricopeptide repeat domain 28 -0.0236433
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0235715
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0235644
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0233047
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0231985
COL4A5 collagen, type IV, alpha 5 -0.0231819
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0231645
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0227105
PTMA prothymosin, alpha -0.022677
RPS21 ribosomal protein S21 -0.0225322
ITGB4 integrin, beta 4 -0.0224593
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0223986
LAMC2 laminin, gamma 2 -0.0222587
S100A11 S100 calcium binding protein A11 -0.0220746
EXT1 exostosin glycosyltransferase 1 -0.0220498
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0220162
HMGA2 high mobility group AT-hook 2 -0.0218145
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0216878
IFI16 interferon, gamma-inducible protein 16 -0.0213877
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0210424
H1-0 H1.0 linker histone -0.0208833