5-Azacytidine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Azacytidine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Azacytidine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.152096
DSPP dentin sialophosphoprotein 0.135332
TXNIP thioredoxin interacting protein 0.122578
SPTBN1 spectrin, beta, non-erythrocytic 1 0.100042
AREG amphiregulin 0.0862198
ENO1 enolase 1, (alpha) 0.078432
SRRM2 serine/arginine repetitive matrix 2 0.0779104
LDHA lactate dehydrogenase A 0.0738088
ASPH aspartate beta-hydroxylase 0.0722573
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0702919
MACF1 microtubule-actin crosslinking factor 1 0.06765
RPS3 ribosomal protein S3 0.0669215
EREG epiregulin 0.0644013
CALR calreticulin 0.0641148
EEF2 eukaryotic translation elongation factor 2 0.0636586
TMSB4X thymosin beta 4, X-linked 0.062907
FAT1 FAT atypical cadherin 1 0.0625602
EZR ezrin 0.0623482
ATF4 activating transcription factor 4 0.0613384
DSCAM Down syndrome cell adhesion molecule 0.0608226
EIF1 eukaryotic translation initiation factor 1 0.060672
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0602606
SLC38A2 solute carrier family 38, member 2 0.0601044
SAMD4A sterile alpha motif domain containing 4A 0.0600836
PRRC2C proline-rich coiled-coil 2C 0.0592947
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0568649
EXT1 exostosin glycosyltransferase 1 0.0542834
CD164 CD164 molecule, sialomucin 0.0541588
ANKRD11 ankyrin repeat domain 11 0.0530871
PKM pyruvate kinase, muscle 0.0514587
ERRFI1 ERBB receptor feedback inhibitor 1 0.051142
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0490798
KLF5 Kruppel-like factor 5 (intestinal) 0.048359
GOLGB1 golgin B1 0.0473003
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0466073
DDIT4 DNA-damage-inducible transcript 4 0.0464993
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0457614
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0444785
RPL4 ribosomal protein L4 0.0442864
RPL41 ribosomal protein L41 0.043614
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0430292
GARS1 glycyl-tRNA synthetase 1 0.0418154
JUN jun proto-oncogene 0.0415839
NEBL nebulette 0.0410635
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0408987
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0408328
XPOT exportin, tRNA 0.0404205
RPS12 ribosomal protein S12 0.0400898
MYH9 myosin, heavy chain 9, non-muscle 0.0398574
EIF4B eukaryotic translation initiation factor 4B 0.0395893
MBNL2 muscleblind-like splicing regulator 2 0.0390481
SLK STE20-like kinase 0.0388555
VMP1 vacuole membrane protein 1 0.0387994
TPM3 tropomyosin 3 0.038363
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0382544
YTHDC1 YTH domain containing 1 0.0380437
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0378038
MYO1E myosin IE 0.0375839
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0372847
FNBP4 formin binding protein 4 0.0372578
S100P S100 calcium binding protein P 0.0371494
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0365119
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0362646
ITGA6 integrin, alpha 6 0.0355908
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0353635
KLF6 Kruppel-like factor 6 0.0343448
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0341474
AKAP9 A kinase (PRKA) anchor protein 9 0.0341312
SRRM1 serine/arginine repetitive matrix 1 0.0338283
ZFAND3 zinc finger, AN1-type domain 3 0.0333866
BZW1 basic leucine zipper and W2 domains 1 0.0330218
FTL ferritin, light polypeptide 0.032699
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0324542
KRT18 keratin 18, type I 0.032401
SQSTM1 sequestosome 1 0.0322202
IARS1 isoleucyl-tRNA synthetase 1 0.0319936
RPL26 ribosomal protein L26 0.0315453
ATXN1 ataxin 1 0.0315331
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0315049
TPR translocated promoter region, nuclear basket protein 0.0314434
APP amyloid beta (A4) precursor protein 0.0312069
CSNK1A1 casein kinase 1, alpha 1 0.0308829
ZBTB20 zinc finger and BTB domain containing 20 0.0308283
TMF1 TATA element modulatory factor 1 0.03035
HSPA8 heat shock 70kDa protein 8 0.0303219
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0299844
JMJD1C jumonji domain containing 1C 0.0299214
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0298985
TTC3 tetratricopeptide repeat domain 3 0.0298627
MYO5B myosin VB 0.0298573
PARD3B par-3 family cell polarity regulator beta 0.0295407
RPL12 ribosomal protein L12 0.0292992
NARS1 asparaginyl-tRNA synthetase 1 0.029248
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0289523
MT2A metallothionein 2A 0.0284813
TARS1 threonyl-tRNA synthetase 1 0.0279525
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.027904
RNF145 ring finger protein 145 0.0278435
AFF4 AF4/FMR2 family, member 4 0.0277285
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0275845

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146265
NPSR1 neuropeptide S receptor 1 -0.130866
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.107552
PTMA prothymosin, alpha -0.107247
CEMIP cell migration inducing protein, hyaluronan binding -0.0961134
GPHN gephyrin -0.0912626
NDRG1 N-myc downstream regulated 1 -0.0859546
TNS4 tensin 4 -0.0812348
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0808323
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0805856
GMDS GDP-mannose 4,6-dehydratase -0.076599
NALF1 NALCN channel auxiliary factor 1 -0.0675383
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0583218
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0547617
HMGA1 high mobility group AT-hook 1 -0.0527247
RNF43 ring finger protein 43 -0.0513802
ALCAM activated leukocyte cell adhesion molecule -0.048276
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0453868
PDIA3 protein disulfide isomerase family A, member 3 -0.0416603
CD46 CD46 molecule, complement regulatory protein -0.0410391
PPARG peroxisome proliferator-activated receptor gamma -0.0396538
ATP5F1B ATP synthase F1 subunit beta -0.0391752
ITGB4 integrin, beta 4 -0.0375295
FHIT fragile histidine triad -0.0372416
LOC112694756 uncharaterized LOC112694756 -0.0359407
ARHGAP32 Rho GTPase activating protein 32 -0.0358027
PTBP3 polypyrimidine tract binding protein 3 -0.0355612
MED13L mediator complex subunit 13-like -0.0352757
NRXN3 neurexin 3 -0.0348043
PDE4D phosphodiesterase 4D, cAMP-specific -0.0343512
PTPRE protein tyrosine phosphatase, receptor type, E -0.0342167
HMGB1 high mobility group box 1 -0.0336033
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0329637
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0325991
ACTN4 actinin, alpha 4 -0.0325326
MAML2 mastermind-like 2 (Drosophila) -0.0316221
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0309139
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0307544
MON2 MON2 homolog (S. cerevisiae) -0.0304414
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0301058
PTPRR protein tyrosine phosphatase, receptor type, R -0.0297597
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0285884
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0282768
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0278339
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0276227
MUC17 mucin 17, cell surface associated -0.0272426
INSIG1 insulin induced gene 1 -0.0268956
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0267719
GNAS GNAS complex locus -0.026606
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.0264463
FOSL1 FOS-like antigen 1 -0.0263658
TUBB4B tubulin, beta 4B class IVb -0.0258936
ARHGAP26 Rho GTPase activating protein 26 -0.0255272
ZNRF3 zinc and ring finger 3 -0.025278
FNDC3B fibronectin type III domain containing 3B -0.0251783
AGR2 anterior gradient 2 -0.025178
TRIM2 tripartite motif containing 2 -0.0250842
NFIA nuclear factor I/A -0.0250803
PRELID2 PRELI domain containing 2 -0.0248618
RPS24 ribosomal protein S24 -0.024567
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.024403
EPHB2 EPH receptor B2 -0.0243004
ABLIM1 actin binding LIM protein 1 -0.0240115
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0237382
SPIDR scaffolding protein involved in DNA repair -0.0236378
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0234083
POTEF POTE ankyrin domain family, member F -0.0231809
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0231297
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0230888
RAD51B RAD51 paralog B -0.0230289
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0228283
TFG TRK-fused gene -0.0227033
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.022683
KDM4C lysine (K)-specific demethylase 4C -0.0223444
SAMD5 sterile alpha motif domain containing 5 -0.0223081
TMEM123 transmembrane protein 123 -0.0220851
FOXP1 forkhead box P1 -0.0220013
KLF3 Kruppel-like factor 3 (basic) -0.021888
MARCHF6 membrane associated ring-CH-type finger 6 -0.021852
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0218002
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0217169
DLG1 discs, large homolog 1 (Drosophila) -0.0215174
DENND1A DENN/MADD domain containing 1A -0.0214945
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0213705
FTH1 ferritin, heavy polypeptide 1 -0.0213075
DSTN destrin (actin depolymerizing factor) -0.0212612
AGRN agrin -0.0210203
PCDHB16 protocadherin beta 16 -0.0209348
ESYT2 extended synaptotagmin-like protein 2 -0.0208742
TUBA1B tubulin, alpha 1b -0.0206874
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0206813
S100A10 S100 calcium binding protein A10 -0.0205462
SERINC5 serine incorporator 5 -0.0205422
SLC35F3 solute carrier family 35, member F3 -0.0203665
TRIM24 tripartite motif containing 24 -0.0203023
GPA33 glycoprotein A33 (transmembrane) -0.0202489
RPL21 ribosomal protein L21 -0.0202236
CD44 CD44 molecule (Indian blood group) -0.0200677
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0197465