5-Azacytidine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Azacytidine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Azacytidine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.193992
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.168432
DST dystonin 0.135541
EZR ezrin 0.107772
CANX calnexin 0.0986383
SLC38A2 solute carrier family 38, member 2 0.0873891
RAI1 retinoic acid induced 1 0.0851443
MACF1 microtubule-actin crosslinking factor 1 0.081772
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0783911
DLG1 discs, large homolog 1 (Drosophila) 0.0763073
CD44 CD44 molecule (Indian blood group) 0.0753785
CALR calreticulin 0.0744238
ARHGAP5 Rho GTPase activating protein 5 0.0636982
APP amyloid beta (A4) precursor protein 0.0610046
EFNA5 ephrin-A5 0.0607528
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0590515
LDHA lactate dehydrogenase A 0.0583442
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0575659
HDAC9 histone deacetylase 9 0.0575383
ENO1 enolase 1, (alpha) 0.0569307
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0569191
EHBP1 EH domain binding protein 1 0.0524615
RUNX1 runt-related transcription factor 1 0.0522048
EEF2 eukaryotic translation elongation factor 2 0.051133
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0496822
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0489292
PLK2 polo-like kinase 2 0.0479999
MYOF myoferlin 0.04732
PSD3 pleckstrin and Sec7 domain containing 3 0.0471772
ERRFI1 ERBB receptor feedback inhibitor 1 0.0468458
TSC22D1 TSC22 domain family, member 1 0.0453892
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0449067
EPHA4 EPH receptor A4 0.0449006
AFF4 AF4/FMR2 family, member 4 0.0437211
SRRM2 serine/arginine repetitive matrix 2 0.0425672
FMNL2 formin-like 2 0.0417901
CAPRIN2 caprin family member 2 0.0417734
MBNL2 muscleblind-like splicing regulator 2 0.0413751
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0413433
RPS3 ribosomal protein S3 0.0405287
ADAM10 ADAM metallopeptidase domain 10 0.0404916
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0393441
DOCK11 dedicator of cytokinesis 11 0.037918
SLK STE20-like kinase 0.0377035
USP9X ubiquitin specific peptidase 9, X-linked 0.0371687
ANGPTL4 angiopoietin-like 4 0.0361002
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0347742
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0346745
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0342869
MYH9 myosin, heavy chain 9, non-muscle 0.0340598
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0337991
RPL4 ribosomal protein L4 0.0336888
ANKRD36 ankyrin repeat domain 36 0.0331959
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0328025
YEATS2 YEATS domain containing 2 0.0325675
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0319386
PKM pyruvate kinase, muscle 0.0316246
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0313803
PYGL phosphorylase, glycogen, liver 0.0312278
PHF3 PHD finger protein 3 0.0310464
PGK1 phosphoglycerate kinase 1 0.0297858
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0296218
BZW1 basic leucine zipper and W2 domains 1 0.0295044
MAP4 microtubule-associated protein 4 0.0289854
ZNF217 zinc finger protein 217 0.0284353
TPM3 tropomyosin 3 0.0280604
TPR translocated promoter region, nuclear basket protein 0.0279317
RPL41 ribosomal protein L41 0.0279241
CXCL8 chemokine (C-X-C motif) ligand 8 0.0275783
VMP1 vacuole membrane protein 1 0.0274932
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0274896
KLF6 Kruppel-like factor 6 0.0274856
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0274272
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0273697
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0271299
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0270452
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0268865
SET SET nuclear proto-oncogene 0.0266645
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0264446
ESYT2 extended synaptotagmin-like protein 2 0.0263825
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0262073
SQSTM1 sequestosome 1 0.0261528
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.025944
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0258513
TTC3 tetratricopeptide repeat domain 3 0.0258445
JUN jun proto-oncogene 0.025699
PODXL podocalyxin-like 0.025668
NGLY1 N-glycanase 1 0.0255308
BCAR3 breast cancer anti-estrogen resistance 3 0.0253433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0249141
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0244253
DPYSL2 dihydropyrimidinase-like 2 0.0242717
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0242354
SGK1 serum/glucocorticoid regulated kinase 1 0.02421
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0240484
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0235696
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0234099
LOXL2 lysyl oxidase-like 2 0.0232107
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.023123
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0230725

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.517796
MT2A metallothionein 2A -0.109726
FTL ferritin, light polypeptide -0.0680543
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0673978
HMGA1 high mobility group AT-hook 1 -0.0638667
TMSB10 thymosin beta 10 -0.0592883
POTEF POTE ankyrin domain family, member F -0.0572002
LOC112694756 uncharaterized LOC112694756 -0.0540622
HLA-B major histocompatibility complex, class I, B -0.0538063
EGR1 early growth response 1 -0.0524459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0513597
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0439579
RAB7A RAB7A, member RAS oncogene family -0.0422223
RPL28 ribosomal protein L28 -0.0409071
RPS6 ribosomal protein S6 -0.0407864
SRGN serglycin -0.0406478
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0375475
WARS1 tryptophanyl-tRNA synthetase 1 -0.0363563
RPS23 ribosomal protein S23 -0.0358761
MT1E metallothionein 1E -0.0353534
KMT2E lysine (K)-specific methyltransferase 2E -0.034673
ZFAND3 zinc finger, AN1-type domain 3 -0.0336644
RPS19 ribosomal protein S19 -0.0333995
BRD2 bromodomain containing 2 -0.0326972
RPS8 ribosomal protein S8 -0.0325806
ACTG1 actin gamma 1 -0.032339
SEPTIN7 septin 7 -0.0318249
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.031754
RPS10 ribosomal protein S10 -0.0314557
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0314203
S100A10 S100 calcium binding protein A10 -0.0312299
RPS15 ribosomal protein S15 -0.0307848
GCLM glutamate-cysteine ligase, modifier subunit -0.0304798
IARS1 isoleucyl-tRNA synthetase 1 -0.0303495
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0299746
PUM2 pumilio RNA-binding family member 2 -0.0289193
TM4SF1 transmembrane 4 L six family member 1 -0.0286819
NDRG1 N-myc downstream regulated 1 -0.0283739
ZNF207 zinc finger protein 207 -0.0275617
TPT1 tumor protein, translationally-controlled 1 -0.0273491
RPS16 ribosomal protein S16 -0.0270684
PDIA3 protein disulfide isomerase family A, member 3 -0.0266792
DEK DEK proto-oncogene -0.0264951
PNISR PNN-interacting serine/arginine-rich protein -0.0263944
ANKRD11 ankyrin repeat domain 11 -0.0263409
WAC WW domain containing adaptor with coiled-coil -0.0263095
PTMA prothymosin, alpha -0.025788
TSC22D2 TSC22 domain family, member 2 -0.0248866
RTN4 reticulon 4 -0.0246264
RPLP2 ribosomal protein, large, P2 -0.0244698
TUBB4B tubulin, beta 4B class IVb -0.0243916
GNAS GNAS complex locus -0.0243449
S100A9 S100 calcium binding protein A9 -0.0241979
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0238069
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0237043
RPL36 ribosomal protein L36 -0.0236447
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0236399
ATP5F1B ATP synthase F1 subunit beta -0.0234014
FOSL1 FOS-like antigen 1 -0.0229169
B2M beta-2-microglobulin -0.0228629
RPS25 ribosomal protein S25 -0.022856
RPLP1 ribosomal protein, large, P1 -0.0228159
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0225396
RPS29 ribosomal protein S29 -0.0221579
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0218426
RPS5 ribosomal protein S5 -0.0216799
RPL38 ribosomal protein L38 -0.0216134
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0214646
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0213829
MYADM myeloid-associated differentiation marker -0.0211427
RPL36A ribosomal protein L36a -0.0206082
UBE2B ubiquitin-conjugating enzyme E2B -0.0203321
SRPK2 SRSF protein kinase 2 -0.0202602
RPL9 ribosomal protein L9 -0.0202508
RPL21 ribosomal protein L21 -0.0202201
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0202177
BRWD1 bromodomain and WD repeat domain containing 1 -0.0201511
TUBA1B tubulin, alpha 1b -0.0201354
SRSF3 serine/arginine-rich splicing factor 3 -0.0200075
PFN1 profilin 1 -0.019866
RPL11 ribosomal protein L11 -0.0198418
EMP1 epithelial membrane protein 1 -0.0198316
BSG basigin (Ok blood group) -0.0194647
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0193324
SESN2 sestrin 2 -0.0193135
CDCP1 CUB domain containing protein 1 -0.0191893
ARID4B AT rich interactive domain 4B (RBP1-like) -0.019184
UBC ubiquitin C -0.0190225
RPL8 ribosomal protein L8 -0.0190046
SETX senataxin -0.0189694
FERMT1 fermitin family member 1 -0.0189301
MARCHF6 membrane associated ring-CH-type finger 6 -0.0188787
RBM27 RNA binding motif protein 27 -0.018802
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0187851
RPS21 ribosomal protein S21 -0.0187452
ENO2 enolase 2 (gamma, neuronal) -0.0186899
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0185789
RPL19 ribosomal protein L19 -0.018489
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0183301
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0183205