5-Azacytidine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Azacytidine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Azacytidine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.135411
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0864769
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0801456
TPM3 tropomyosin 3 0.0726595
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0662017
JMJD1C jumonji domain containing 1C 0.0562067
MCL1 myeloid cell leukemia 1 0.0540443
EEF2 eukaryotic translation elongation factor 2 0.0477315
ERRFI1 ERBB receptor feedback inhibitor 1 0.0468814
AKAP12 A kinase (PRKA) anchor protein 12 0.0438387
XPOT exportin, tRNA 0.0423907
CSNK1A1 casein kinase 1, alpha 1 0.0418175
ZCCHC7 zinc finger, CCHC domain containing 7 0.0406074
RAB7A RAB7A, member RAS oncogene family 0.0405429
BIRC6 baculoviral IAP repeat containing 6 0.0397995
AFF4 AF4/FMR2 family, member 4 0.0396159
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0395894
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0395793
ADAM17 ADAM metallopeptidase domain 17 0.0383084
SFPQ splicing factor proline/glutamine-rich 0.0377446
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0376686
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0373286
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367913
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0366413
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0357373
ZFC3H1 zinc finger, C3H1-type containing 0.0354916
CCNL1 cyclin L1 0.0347004
IPO7 importin 7 0.0346753
COPA coatomer protein complex, subunit alpha 0.0345497
SESN2 sestrin 2 0.0342842
CSDE1 cold shock domain containing E1, RNA-binding 0.0342177
GARS1 glycyl-tRNA synthetase 1 0.0330763
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0329012
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0327957
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.030861
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0303366
MYH9 myosin, heavy chain 9, non-muscle 0.0300392
PFDN2 prefoldin subunit 2 0.0285896
BRD4 bromodomain containing 4 0.0283597
NCKAP1 NCK-associated protein 1 0.028329
NUP58 nucleoporin 58 0.028279
CLTC clathrin, heavy chain (Hc) 0.027928
ATF6 activating transcription factor 6 0.0278004
EIF4B eukaryotic translation initiation factor 4B 0.0273662
PCBP2 poly(rC) binding protein 2 0.0268436
RPL41 ribosomal protein L41 0.0265711
SRRM2 serine/arginine repetitive matrix 2 0.0263682
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0259583
ANKRD36 ankyrin repeat domain 36 0.0254344
SND1 staphylococcal nuclease and tudor domain containing 1 0.0253942
ZNF638 zinc finger protein 638 0.0249638
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0249505
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0247671
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0247046
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246077
CUL3 cullin 3 0.0245587
DENR density-regulated protein 0.0243343
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0239125
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0238613
EXT1 exostosin glycosyltransferase 1 0.0235957
MSN moesin 0.0235691
ENO1 enolase 1, (alpha) 0.0234143
ZZZ3 zinc finger, ZZ-type containing 3 0.0234053
NOTCH2 notch 2 0.0233875
KDM2A lysine (K)-specific demethylase 2A 0.0233511
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0232695
SMAP1 small ArfGAP 1 0.0228458
WNK1 WNK lysine deficient protein kinase 1 0.0225199
JAK1 Janus kinase 1 0.0225079
RSF1 remodeling and spacing factor 1 0.0222737
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.0222722
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0222684
UBC ubiquitin C 0.0217879
PPME1 protein phosphatase methylesterase 1 0.0217388
SARS1 seryl-tRNA synthetase 1 0.0214425
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0211665
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0211565
WSB1 WD repeat and SOCS box containing 1 0.021109
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0210011
ANO6 anoctamin 6 0.0209918
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0207007
GIGYF2 GRB10 interacting GYF protein 2 0.0203627
ITSN2 intersectin 2 0.0201733
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0199394
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.019926
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0198697
PREPL prolyl endopeptidase-like 0.0198302
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.019823
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0196511
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0196194
TLN1 talin 1 0.0196062
USP47 ubiquitin specific peptidase 47 0.0194764
VMP1 vacuole membrane protein 1 0.0194415
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0194389
PRPF8 pre-mRNA processing factor 8 0.0193554
BZW1 basic leucine zipper and W2 domains 1 0.0193406
RB1CC1 RB1-inducible coiled-coil 1 0.0192386
BCLAF1 BCL2-associated transcription factor 1 0.0190009
KDM7A lysine (K)-specific demethylase 7A 0.0187747
RPL3 ribosomal protein L3 0.0185272

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195937
PTMA prothymosin, alpha -0.0955702
TMSB10 thymosin beta 10 -0.0941538
GRAMD1B GRAM domain containing 1B -0.0844065
PDE4D phosphodiesterase 4D, cAMP-specific -0.065089
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0633018
GNAS GNAS complex locus -0.0600041
THSD4 thrombospondin, type I, domain containing 4 -0.0564877
YBX3 Y box binding protein 3 -0.0537496
AHNAK AHNAK nucleoprotein -0.0518263
RPL35A ribosomal protein L35a -0.0459558
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0432528
TRIO trio Rho guanine nucleotide exchange factor -0.0428153
RPL12 ribosomal protein L12 -0.0407207
RPLP1 ribosomal protein, large, P1 -0.0384868
NCOA7 nuclear receptor coactivator 7 -0.0382503
VIM vimentin -0.0381306
RPL23 ribosomal protein L23 -0.0380016
RAD51B RAD51 paralog B -0.0377194
RPS19 ribosomal protein S19 -0.0367928
IGF1R insulin-like growth factor 1 receptor -0.0366754
PDE10A phosphodiesterase 10A -0.036442
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0364379
ACTG1 actin gamma 1 -0.0360934
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0351043
ANKRD28 ankyrin repeat domain 28 -0.0350638
RPS8 ribosomal protein S8 -0.0346258
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0340822
TFPI2 tissue factor pathway inhibitor 2 -0.03381
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0323761
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0320556
ADGRG6 adhesion G protein-coupled receptor G6 -0.0320511
FTL ferritin, light polypeptide -0.0320395
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0318356
RPS21 ribosomal protein S21 -0.0318125
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0315365
SMAD3 SMAD family member 3 -0.0313732
BASP1 brain abundant, membrane attached signal protein 1 -0.0312793
HMGA2 high mobility group AT-hook 2 -0.0308348
FCHSD2 FCH and double SH3 domains 2 -0.0308248
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0304815
ZMYND8 zinc finger, MYND-type containing 8 -0.0298811
SSH2 slingshot protein phosphatase 2 -0.0298646
FNDC3B fibronectin type III domain containing 3B -0.0296851
RPL38 ribosomal protein L38 -0.0282336
RPL19 ribosomal protein L19 -0.0276506
PFN1 profilin 1 -0.0266168
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0263491
TMEM165 transmembrane protein 165 -0.0262125
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0254864
VCL vinculin -0.0252937
KRT18 keratin 18, type I -0.0252071
EML4 echinoderm microtubule associated protein like 4 -0.0251311
RPL34 ribosomal protein L34 -0.0251269
RACK1 receptor for activated C kinase 1 -0.025036
RBM39 RNA binding motif protein 39 -0.0246517
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.024574
RPL5 ribosomal protein L5 -0.0244953
BMP5 bone morphogenetic protein 5 -0.0242476
RPL11 ribosomal protein L11 -0.0242201
MT2A metallothionein 2A -0.0241287
RPL13A ribosomal protein L13a -0.024096
RPL32 ribosomal protein L32 -0.0238061
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.02352
RPS29 ribosomal protein S29 -0.0234915
SMYD3 SET and MYND domain containing 3 -0.0234654
NCOR1 nuclear receptor corepressor 1 -0.0232547
ARB2A ARB2 cotranscriptional regulator A -0.0230497
NFIA nuclear factor I/A -0.0230453
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0230232
RIMS2 regulating synaptic membrane exocytosis 2 -0.0229874
ETV6 ets variant 6 -0.0227433
RPS27 ribosomal protein S27 -0.022548
TAS2R14 taste receptor, type 2, member 14 -0.0225174
RPL36 ribosomal protein L36 -0.0224945
RRM2 ribonucleotide reductase M2 -0.0223553
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.022351
EXOC4 exocyst complex component 4 -0.0222663
NAP1L1 nucleosome assembly protein 1-like 1 -0.0222468
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0217846
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0217657
RPL31 ribosomal protein L31 -0.0216189
MED13L mediator complex subunit 13-like -0.0215855
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0214625
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0214547
CCND1 cyclin D1 -0.0214365
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0213965
SENP6 SUMO1/sentrin specific peptidase 6 -0.021368
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0210074
RPL26 ribosomal protein L26 -0.0208292
DENND1A DENN/MADD domain containing 1A -0.0206241
H1-0 H1.0 linker histone -0.0205696
PGK1 phosphoglycerate kinase 1 -0.0205695
UBB ubiquitin B -0.0205403
PNISR PNN-interacting serine/arginine-rich protein -0.0203993
RPL18 ribosomal protein L18 -0.0202211
ATXN1 ataxin 1 -0.0202081
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0201983
TPI1 triosephosphate isomerase 1 -0.0201975
IFIH1 interferon induced with helicase C domain 1 -0.0201707