5-Azacytidine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Azacytidine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Azacytidine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.088084
CD44 CD44 molecule (Indian blood group) 0.06952
BHLHE40 basic helix-loop-helix family, member e40 0.0646916
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0572435
ANKRD11 ankyrin repeat domain 11 0.0561286
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0549204
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0533283
RBM39 RNA binding motif protein 39 0.0504981
MEF2A myocyte enhancer factor 2A 0.0487537
TRIO trio Rho guanine nucleotide exchange factor 0.0487329
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0481241
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0473691
AKAP12 A kinase (PRKA) anchor protein 12 0.0472688
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0456773
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0423069
ARB2A ARB2 cotranscriptional regulator A 0.0412823
TRA2A transformer 2 alpha homolog (Drosophila) 0.0410921
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0400488
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0392402
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0386308
ARHGAP5 Rho GTPase activating protein 5 0.0375911
NUP58 nucleoporin 58 0.0374235
CUL3 cullin 3 0.0371853
VMP1 vacuole membrane protein 1 0.0368787
RPL11 ribosomal protein L11 0.0364912
MATR3 matrin 3 0.0358788
NAP1L1 nucleosome assembly protein 1-like 1 0.0357312
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0354918
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0354458
MT2A metallothionein 2A 0.0353126
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0352174
KDM3A lysine (K)-specific demethylase 3A 0.0351225
NAMPT nicotinamide phosphoribosyltransferase 0.0348957
TPR translocated promoter region, nuclear basket protein 0.0346053
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0344374
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0334692
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0333412
ZNF638 zinc finger protein 638 0.0331702
ZNF292 zinc finger protein 292 0.0329177
NFE2L1 nuclear factor, erythroid 2-like 1 0.0321915
IGF2R insulin-like growth factor 2 receptor 0.03181
RPL12 ribosomal protein L12 0.0317635
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.03165
FAM13A family with sequence similarity 13, member A 0.0314514
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0313616
BIRC2 baculoviral IAP repeat containing 2 0.0312973
COL6A2 collagen, type VI, alpha 2 0.0312352
SAMD9 sterile alpha motif domain containing 9 0.0310977
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0309388
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0305934
JMJD1C jumonji domain containing 1C 0.0303844
MT1X metallothionein 1X 0.0301791
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0293407
RAB6A RAB6A, member RAS oncogene family 0.0293106
EXT1 exostosin glycosyltransferase 1 0.0292532
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0290661
RTN4 reticulon 4 0.0290425
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0288301
ADM adrenomedullin 0.0286656
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0285015
PRRC2C proline-rich coiled-coil 2C 0.0283026
RAB2A RAB2A, member RAS oncogene family 0.0282129
MT1E metallothionein 1E 0.0280456
TBCA tubulin folding cofactor A 0.0279978
WNK1 WNK lysine deficient protein kinase 1 0.0278972
CHMP4B charged multivesicular body protein 4B 0.0277939
RBM25 RNA binding motif protein 25 0.0276213
POM121C POM121 transmembrane nucleoporin C 0.0276155
SQSTM1 sequestosome 1 0.0276144
EIF1 eukaryotic translation initiation factor 1 0.0275695
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0275501
AFF4 AF4/FMR2 family, member 4 0.0275469
WNT5A wingless-type MMTV integration site family, member 5A 0.0274902
PTMA prothymosin, alpha 0.0272814
SUCO SUN domain containing ossification factor 0.0272416
DST dystonin 0.027126
OGA O-GlcNAcase 0.026972
SPAG9 sperm associated antigen 9 0.0269629
NGLY1 N-glycanase 1 0.0267669
USP9X ubiquitin specific peptidase 9, X-linked 0.0264587
SERINC1 serine incorporator 1 0.0263816
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0263097
MED13L mediator complex subunit 13-like 0.0259504
VCAM1 vascular cell adhesion molecule 1 0.0257388
RAB8B RAB8B, member RAS oncogene family 0.0256854
ANXA5 annexin A5 0.0256723
ACVR1 activin A receptor, type I 0.0256721
RPL34 ribosomal protein L34 0.0254745
ACER3 alkaline ceramidase 3 0.0253941
EIF5 eukaryotic translation initiation factor 5 0.0253696
EPS8 epidermal growth factor receptor pathway substrate 8 0.0253648
SAMD4A sterile alpha motif domain containing 4A 0.0252254
PUM2 pumilio RNA-binding family member 2 0.0251242
WDR20 WD repeat domain 20 0.025076
TMSB4X thymosin beta 4, X-linked 0.0250539
FUBP1 far upstream element (FUSE) binding protein 1 0.0249713
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0249168
HBP1 HMG-box transcription factor 1 0.024906
XPO6 exportin 6 0.0248678
ZMIZ1 zinc finger, MIZ-type containing 1 0.0248201

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.28
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.200249
TGFBI transforming growth factor, beta-induced, 68kDa -0.170044
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.166725
F3 coagulation factor III (thromboplastin, tissue factor) -0.133715
NDRG1 N-myc downstream regulated 1 -0.12373
COL1A2 collagen, type I, alpha 2 -0.116786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105722
COL6A3 collagen, type VI, alpha 3 -0.102372
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0984396
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0946795
HLA-B major histocompatibility complex, class I, B -0.0875626
PDIA3 protein disulfide isomerase family A, member 3 -0.0831179
CALU calumenin -0.0799247
FN1 fibronectin 1 -0.0791553
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0783309
LOX lysyl oxidase -0.0781764
CDK13 cyclin-dependent kinase 13 -0.0770537
COL1A1 collagen, type I, alpha 1 -0.07294
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0698965
LOXL2 lysyl oxidase-like 2 -0.068011
VIM vimentin -0.0679155
ZMYND8 zinc finger, MYND-type containing 8 -0.0668981
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0663775
COL5A1 collagen, type V, alpha 1 -0.0655029
PDIA6 protein disulfide isomerase family A, member 6 -0.0642352
IL6 interleukin 6 -0.0642223
B2M beta-2-microglobulin -0.0641488
EGFR epidermal growth factor receptor -0.0637322
POTEF POTE ankyrin domain family, member F -0.0636536
HMGA2 high mobility group AT-hook 2 -0.0627769
TMSB10 thymosin beta 10 -0.0622149
TENT5A terminal nucleotidyltransferase 5A -0.0610783
HLA-C major histocompatibility complex, class I, C -0.0606648
MAP1B microtubule-associated protein 1B -0.0577966
COL6A1 collagen, type VI, alpha 1 -0.0574837
LMAN1 lectin, mannose-binding, 1 -0.0549288
TMEM165 transmembrane protein 165 -0.052735
CDH13 cadherin 13 -0.0519863
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0511102
MYADM myeloid-associated differentiation marker -0.0510097
STC1 stanniocalcin 1 -0.0505992
NRXN3 neurexin 3 -0.0492052
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0490445
GOLGA4 golgin A4 -0.0479691
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0474967
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0473624
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0468724
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.046836
AHNAK AHNAK nucleoprotein -0.0464504
CCNI cyclin I -0.0460557
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0441431
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0438942
MON2 MON2 homolog (S. cerevisiae) -0.0435914
PRKCA protein kinase C, alpha -0.0433819
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0426535
TNS3 tensin 3 -0.0423101
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0422536
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0417984
LDHA lactate dehydrogenase A -0.0408595
MSN moesin -0.0396964
CMIP c-Maf inducing protein -0.0382823
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0380011
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0379914
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0378941
ACTG1 actin gamma 1 -0.0368812
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0363561
IARS1 isoleucyl-tRNA synthetase 1 -0.0362492
FNIP1 folliculin interacting protein 1 -0.0360443
KAZN kazrin, periplakin interacting protein -0.0359307
LAMB1 laminin, beta 1 -0.0347844
COL5A2 collagen, type V, alpha 2 -0.0340816
DSTN destrin (actin depolymerizing factor) -0.0339441
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0335797
CA12 carbonic anhydrase XII -0.0334975
PRRC1 proline-rich coiled-coil 1 -0.0331089
UBC ubiquitin C -0.0330616
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0329801
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0329743
RRBP1 ribosome binding protein 1 -0.0329528
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0325001
FNDC3B fibronectin type III domain containing 3B -0.0312203
DPYD dihydropyrimidine dehydrogenase -0.0309671
VEGFA vascular endothelial growth factor A -0.0307158
PRSS23 protease, serine, 23 -0.0305493
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0299123
TTC3 tetratricopeptide repeat domain 3 -0.029603
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0289996
SERINC3 serine incorporator 3 -0.0289762
YIPF5 Yip1 domain family, member 5 -0.0289572
H3-3B H3.3 histone B -0.0285877
ANKRD28 ankyrin repeat domain 28 -0.0278072
KRIT1 KRIT1, ankyrin repeat containing -0.027744
HDLBP high density lipoprotein binding protein -0.02774
TAGLN2 transgelin 2 -0.0276644
NBAS neuroblastoma amplified sequence -0.0274303
NUCB2 nucleobindin 2 -0.0272764
NCOR2 nuclear receptor corepressor 2 -0.0272762
KDM5B lysine (K)-specific demethylase 5B -0.0272674
COPA coatomer protein complex, subunit alpha -0.027034