5-Azacytidine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Azacytidine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Azacytidine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.154222
CXCL8 chemokine (C-X-C motif) ligand 8 0.118711
CANX calnexin 0.113004
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.111261
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0937952
TPR translocated promoter region, nuclear basket protein 0.065018
NAMPT nicotinamide phosphoribosyltransferase 0.0614909
CALR calreticulin 0.059194
STC2 stanniocalcin 2 0.0574118
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0534215
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0527443
TMSB4X thymosin beta 4, X-linked 0.0520015
AHR aryl hydrocarbon receptor 0.0518249
FTH1 ferritin, heavy polypeptide 1 0.0482845
ENO1 enolase 1, (alpha) 0.0481828
PTMA prothymosin, alpha 0.0464348
SOD2 superoxide dismutase 2, mitochondrial 0.045192
FN1 fibronectin 1 0.0432731
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0417016
RNF145 ring finger protein 145 0.0412704
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0410331
BHLHE40 basic helix-loop-helix family, member e40 0.0402006
SQSTM1 sequestosome 1 0.0400163
PKM pyruvate kinase, muscle 0.0398946
TRIO trio Rho guanine nucleotide exchange factor 0.039123
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0383037
SPAG9 sperm associated antigen 9 0.0381938
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368846
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0359495
RAI14 retinoic acid induced 14 0.035786
FNDC3B fibronectin type III domain containing 3B 0.0356235
SEC31A SEC31 homolog A (S. cerevisiae) 0.0355283
HILPDA hypoxia inducible lipid droplet-associated 0.0354107
NRG1 neuregulin 1 0.0351388
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0343492
AFDN afadin, adherens junction formation factor 0.0339445
SEC23A Sec23 homolog A (S. cerevisiae) 0.0338822
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0329261
CD109 CD109 molecule 0.0326054
OSBPL8 oxysterol binding protein-like 8 0.0320423
COPA coatomer protein complex, subunit alpha 0.0316065
ERRFI1 ERBB receptor feedback inhibitor 1 0.0312247
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0311447
ITGA1 integrin, alpha 1 0.031086
MYH9 myosin, heavy chain 9, non-muscle 0.030927
BZW1 basic leucine zipper and W2 domains 1 0.030671
CDC73 cell division cycle 73 0.0304523
WAC WW domain containing adaptor with coiled-coil 0.0299485
FAM13A family with sequence similarity 13, member A 0.0297775
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0297083
CTBP2 C-terminal binding protein 2 0.0293683
AFF4 AF4/FMR2 family, member 4 0.0285762
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0277713
KDM3A lysine (K)-specific demethylase 3A 0.0274438
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.027404
LCORL ligand dependent nuclear receptor corepressor-like 0.0270453
EPS8 epidermal growth factor receptor pathway substrate 8 0.02683
KMT2C lysine (K)-specific methyltransferase 2C 0.0267325
APP amyloid beta (A4) precursor protein 0.0266635
NAP1L1 nucleosome assembly protein 1-like 1 0.0264957
NUP58 nucleoporin 58 0.0263682
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0263617
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0263381
DST dystonin 0.026316
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0260876
EXT1 exostosin glycosyltransferase 1 0.0260599
DDIT4 DNA-damage-inducible transcript 4 0.0254923
CADM1 cell adhesion molecule 1 0.0253998
NEK7 NIMA-related kinase 7 0.0253342
ETNK1 ethanolamine kinase 1 0.0251768
ARHGAP35 Rho GTPase activating protein 35 0.0249344
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024829
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0240803
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0240307
INSIG2 insulin induced gene 2 0.0238026
PRRC2C proline-rich coiled-coil 2C 0.0236434
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0236278
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.023594
PICALM phosphatidylinositol binding clathrin assembly protein 0.0235479
HBP1 HMG-box transcription factor 1 0.0232303
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0230315
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0229694
PLIN2 perilipin 2 0.0228874
TXNIP thioredoxin interacting protein 0.0228133
HMGB3 high mobility group box 3 0.022718
EIF3H eukaryotic translation initiation factor 3, subunit H 0.022708
RLF rearranged L-myc fusion 0.0226987
TPM3 tropomyosin 3 0.0226713
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.022638
MRPS6 mitochondrial ribosomal protein S6 0.022434
HDLBP high density lipoprotein binding protein 0.022421
DENND5B DENN/MADD domain containing 5B 0.022242
GPBP1 GC-rich promoter binding protein 1 0.0222189
RPL41 ribosomal protein L41 0.0218278
RAB8B RAB8B, member RAS oncogene family 0.0216406
RAB1A RAB1A, member RAS oncogene family 0.0216156
GOLT1B golgi transport 1B 0.0213572
VMP1 vacuole membrane protein 1 0.0212192
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0211832
CD164 CD164 molecule, sialomucin 0.0210258

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.599188
MT2A metallothionein 2A -0.136224
NDRG1 N-myc downstream regulated 1 -0.078888
VIM vimentin -0.0755123
TMSB10 thymosin beta 10 -0.0579012
FTL ferritin, light polypeptide -0.0560708
MAP1B microtubule-associated protein 1B -0.0490211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0470387
HMGA1 high mobility group AT-hook 1 -0.045485
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0445905
RPLP1 ribosomal protein, large, P1 -0.0433408
RPL9 ribosomal protein L9 -0.0410685
RPS23 ribosomal protein S23 -0.038236
S100A10 S100 calcium binding protein A10 -0.0382317
RPS6 ribosomal protein S6 -0.0377026
RPL28 ribosomal protein L28 -0.0348784
RPS15 ribosomal protein S15 -0.0329526
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0329316
SMYD3 SET and MYND domain containing 3 -0.0319809
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0319062
RPS29 ribosomal protein S29 -0.0318649
ATP5F1B ATP synthase F1 subunit beta -0.0315293
RPLP2 ribosomal protein, large, P2 -0.0303067
RPS19 ribosomal protein S19 -0.0299844
RPS11 ribosomal protein S11 -0.0294298
HLA-B major histocompatibility complex, class I, B -0.0288957
ENO2 enolase 2 (gamma, neuronal) -0.0282808
TXNRD1 thioredoxin reductase 1 -0.0278436
RPS25 ribosomal protein S25 -0.0274394
RPS24 ribosomal protein S24 -0.0270478
RPS16 ribosomal protein S16 -0.0269908
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0268348
POTEF POTE ankyrin domain family, member F -0.0267688
RPL23 ribosomal protein L23 -0.0258748
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0256887
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0247189
RPLP0 ribosomal protein, large, P0 -0.0245507
RPS5 ribosomal protein S5 -0.0223898
FOSL1 FOS-like antigen 1 -0.0222261
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0221071
RPS8 ribosomal protein S8 -0.0215809
PELO pelota homolog (Drosophila) -0.021427
ZMYND8 zinc finger, MYND-type containing 8 -0.0210341
S100A6 S100 calcium binding protein A6 -0.0209559
GCC2 GRIP and coiled-coil domain containing 2 -0.0209002
CDCP1 CUB domain containing protein 1 -0.0202606
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0200897
RPL32 ribosomal protein L32 -0.0198329
RPL7A ribosomal protein L7a -0.0198196
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0194849
RTN4 reticulon 4 -0.0193396
RPL38 ribosomal protein L38 -0.0190609
TUBB4B tubulin, beta 4B class IVb -0.0190046
RPL36A ribosomal protein L36a -0.0188418
PLAUR plasminogen activator, urokinase receptor -0.0185287
ACTG1 actin gamma 1 -0.0184397
EIF1 eukaryotic translation initiation factor 1 -0.0179517
RPL21 ribosomal protein L21 -0.0179487
OSMR oncostatin M receptor -0.0178853
AREG amphiregulin -0.0177372
ATN1 atrophin 1 -0.0174667
RPL8 ribosomal protein L8 -0.0172768
RPS21 ribosomal protein S21 -0.0172283
RPL19 ribosomal protein L19 -0.017036
TPT1 tumor protein, translationally-controlled 1 -0.0169349
NAV2 neuron navigator 2 -0.0168747
FOXP1 forkhead box P1 -0.0168241
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0167976
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0165923
PDE4D phosphodiesterase 4D, cAMP-specific -0.0165171
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0164135
TUBA1C tubulin, alpha 1c -0.0161553
ETV1 ets variant 1 -0.0160605
NALF1 NALCN channel auxiliary factor 1 -0.0160258
VEZT vezatin, adherens junctions transmembrane protein -0.016023
NDUFA4 NDUFA4, mitochondrial complex associated -0.0155513
ITGB5 integrin, beta 5 -0.01554
RPL31 ribosomal protein L31 -0.015525
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0151081
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0150068
IER3 immediate early response 3 -0.0149625
EGR1 early growth response 1 -0.0149411
ATP5F1E ATP synthase F1 subunit epsilon -0.0149202
CCND1 cyclin D1 -0.0148916
DUSP5 dual specificity phosphatase 5 -0.0148485
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0147043
MBD5 methyl-CpG binding domain protein 5 -0.0146344
ANKRD28 ankyrin repeat domain 28 -0.0144698
RPS10 ribosomal protein S10 -0.0144455
RPL35A ribosomal protein L35a -0.0144224
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0143094
FNBP1 formin binding protein 1 -0.0140906
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0139573
RPS14 ribosomal protein S14 -0.0138994
RPL7 ribosomal protein L7 -0.0138801
ZBTB20 zinc finger and BTB domain containing 20 -0.0138296
LY6E lymphocyte antigen 6 complex, locus E -0.0138156
ATP5MG ATP synthase membrane subunit g -0.0138014
IFI27 interferon, alpha-inducible protein 27 -0.0137456
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0137122