5-Fluorouracil_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Fluorouracil perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Fluorouracil_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.279414
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.160134
TRIO trio Rho guanine nucleotide exchange factor 0.152962
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.147824
DLG1 discs, large homolog 1 (Drosophila) 0.1322
SLC39A11 solute carrier family 39, member 11 0.102704
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0901983
PLAT plasminogen activator, tissue 0.084327
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0765931
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0738941
FNIP1 folliculin interacting protein 1 0.0715237
DST dystonin 0.06758
ELL2 elongation factor, RNA polymerase II, 2 0.0660548
FLNB filamin B, beta 0.0625165
CDH13 cadherin 13 0.0610735
SETD5 SET domain containing 5 0.0576562
ABI3BP ABI family, member 3 (NESH) binding protein 0.0560907
PBX3 pre-B-cell leukemia homeobox 3 0.056085
SBF2 SET binding factor 2 0.0554341
NAV2 neuron navigator 2 0.0552562
MYADM myeloid-associated differentiation marker 0.052876
ERRFI1 ERBB receptor feedback inhibitor 1 0.0503329
MSI2 musashi RNA-binding protein 2 0.0485583
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0479181
EGFR epidermal growth factor receptor 0.0477084
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0472008
CD109 CD109 molecule 0.04627
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0455923
AHNAK AHNAK nucleoprotein 0.0448426
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0440366
ZEB1 zinc finger E-box binding homeobox 1 0.0419659
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0417436
BACE2 beta-site APP-cleaving enzyme 2 0.0401766
MSN moesin 0.0398811
COPA coatomer protein complex, subunit alpha 0.0395539
LOXL2 lysyl oxidase-like 2 0.0393122
FNDC3B fibronectin type III domain containing 3B 0.038685
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0383037
IQGAP1 IQ motif containing GTPase activating protein 1 0.0381433
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0380868
MYOF myoferlin 0.0378196
MAP4 microtubule-associated protein 4 0.0376176
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0371855
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0367361
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0364564
HELZ helicase with zinc finger 0.0357311
MBNL2 muscleblind-like splicing regulator 2 0.0357181
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0356484
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0354326
RAB1A RAB1A, member RAS oncogene family 0.0352171
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0351457
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0347552
TAOK1 TAO kinase 1 0.034587
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.034553
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0345475
PGK1 phosphoglycerate kinase 1 0.034189
ITCH itchy E3 ubiquitin protein ligase 0.0335135
FAM219A family with sequence similarity 219, member A 0.0330287
MACF1 microtubule-actin crosslinking factor 1 0.0327773
OPTN optineurin 0.0327513
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0320974
LRRC49 leucine rich repeat containing 49 0.0320116
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0319588
N4BP2L2 NEDD4 binding protein 2-like 2 0.0316627
ACBD3 acyl-CoA binding domain containing 3 0.0314216
ADAM17 ADAM metallopeptidase domain 17 0.0314168
DENND1A DENN/MADD domain containing 1A 0.0311417
CYLD cylindromatosis (turban tumor syndrome) 0.0310908
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0310515
ANXA1 annexin A1 0.0308798
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0308048
ARFGEF3 ARFGEF family member 3 0.0306525
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0306364
ESYT2 extended synaptotagmin-like protein 2 0.0303864
KMT2E lysine (K)-specific methyltransferase 2E 0.0303572
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0300882
ZCCHC7 zinc finger, CCHC domain containing 7 0.0299234
NBAS neuroblastoma amplified sequence 0.0299231
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0299163
SUCO SUN domain containing ossification factor 0.0297824
SEPTIN2 septin 2 0.0296557
MMP12 matrix metallopeptidase 12 0.0296392
FAM107B family with sequence similarity 107, member B 0.0295493
SP3 Sp3 transcription factor 0.0289255
AUTS2 autism susceptibility candidate 2 0.0288388
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0288342
RB1CC1 RB1-inducible coiled-coil 1 0.0286068
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0286011
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0283952
FRMD5 FERM domain containing 5 0.0282845
STK10 serine/threonine kinase 10 0.028265
SYTL3 synaptotagmin-like 3 0.0279344
ZMYND8 zinc finger, MYND-type containing 8 0.0276859
RAB10 RAB10, member RAS oncogene family 0.0274975
LIMS1 LIM and senescent cell antigen-like domains 1 0.0274928
TPM4 tropomyosin 4 0.0272998
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0272733
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0271386
CLIP2 CAP-GLY domain containing linker protein 2 0.0267537
PFKP phosphofructokinase, platelet 0.0265276

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.205254
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114413
LOX lysyl oxidase -0.109391
MT2A metallothionein 2A -0.109203
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0893106
HLA-B major histocompatibility complex, class I, B -0.0792123
THBS2 thrombospondin 2 -0.0791689
S100A10 S100 calcium binding protein A10 -0.0746008
FBN1 fibrillin 1 -0.0726399
IFITM3 interferon induced transmembrane protein 3 -0.0677647
GLIS3 GLIS family zinc finger 3 -0.0630713
COL1A2 collagen, type I, alpha 2 -0.0555356
MEIS2 Meis homeobox 2 -0.0537769
PODXL podocalyxin-like -0.0511247
HLA-C major histocompatibility complex, class I, C -0.0507541
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0495304
LOC112694756 uncharaterized LOC112694756 -0.0486304
RRBP1 ribosome binding protein 1 -0.0462173
MARCKS myristoylated alanine-rich protein kinase C substrate -0.045129
RPL23 ribosomal protein L23 -0.0440895
COL8A1 collagen, type VIII, alpha 1 -0.0432111
IGFBP3 insulin-like growth factor binding protein 3 -0.0430345
LMNA lamin A/C -0.0407183
RPL28 ribosomal protein L28 -0.0402792
IFITM1 interferon induced transmembrane protein 1 -0.0399124
RIGI RNA sensor RIG-I -0.0395352
SMC4 structural maintenance of chromosomes 4 -0.0386883
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0357631
MX2 MX dynamin-like GTPase 2 -0.0353167
FTH1 ferritin, heavy polypeptide 1 -0.0350864
CAVIN1 caveolae associated protein 1 -0.0338843
FLNA filamin A, alpha -0.0327456
ANXA2 annexin A2 -0.0326551
LGALS1 lectin, galactoside-binding, soluble, 1 -0.031917
RPL26 ribosomal protein L26 -0.0318335
MT1X metallothionein 1X -0.0314492
PMP22 peripheral myelin protein 22 -0.0310573
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0310132
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0308069
GSE1 Gse1 coiled-coil protein -0.0297607
RPL34 ribosomal protein L34 -0.0297001
RPL35A ribosomal protein L35a -0.0288325
RPL36 ribosomal protein L36 -0.0288228
POTEF POTE ankyrin domain family, member F -0.0285387
PLSCR1 phospholipid scramblase 1 -0.0276598
GUK1 guanylate kinase 1 -0.0273169
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0264965
COL3A1 collagen, type III, alpha 1 -0.026302
HMGB2 high mobility group box 2 -0.0259365
NDRG1 N-myc downstream regulated 1 -0.025696
RAD21 RAD21 homolog (S. pombe) -0.0255893
SAMD9 sterile alpha motif domain containing 9 -0.0255758
MPRIP myosin phosphatase Rho interacting protein -0.0251002
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0249292
RPL19 ribosomal protein L19 -0.02484
IER3 immediate early response 3 -0.0247327
IFI44 interferon-induced protein 44 -0.0244493
B2M beta-2-microglobulin -0.0243256
RPS24 ribosomal protein S24 -0.0236395
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0233414
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0231685
GNAS GNAS complex locus -0.0231381
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0230895
RPS19 ribosomal protein S19 -0.0230299
COL5A2 collagen, type V, alpha 2 -0.0227973
ACTG1 actin gamma 1 -0.0224836
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0224422
TRABD2B TraB domain containing 2B -0.0223874
RPS6 ribosomal protein S6 -0.0223496
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0222986
ARF1 ADP-ribosylation factor 1 -0.0218519
NPR2 natriuretic peptide receptor 2 -0.0217266
RPS3 ribosomal protein S3 -0.0216734
MKI67 marker of proliferation Ki-67 -0.0216126
KIF5B kinesin family member 5B -0.0214231
PARD3 par-3 family cell polarity regulator -0.0209432
RACK1 receptor for activated C kinase 1 -0.0208624
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0207257
GDI2 GDP dissociation inhibitor 2 -0.0206405
ANLN anillin, actin binding protein -0.0204936
MAP1B microtubule-associated protein 1B -0.0203164
TDO2 tryptophan 2,3-dioxygenase -0.020285
TUBB4B tubulin, beta 4B class IVb -0.0202551
EXT1 exostosin glycosyltransferase 1 -0.0202405
IFI16 interferon, gamma-inducible protein 16 -0.0202352
HMGB1 high mobility group box 1 -0.0201933
FTL ferritin, light polypeptide -0.0201442
S100A9 S100 calcium binding protein A9 -0.0201008
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0199313
LMO7 LIM domain 7 -0.0199031
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.019818
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.0198114
RPLP2 ribosomal protein, large, P2 -0.0197764
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.01961
VAV2 vav 2 guanine nucleotide exchange factor -0.0195121
ISG15 ISG15 ubiquitin-like modifier -0.0194432
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0194394
SOD1 superoxide dismutase 1, soluble -0.019439
VCL vinculin -0.0194296
ACTN4 actinin, alpha 4 -0.0193458