| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 5-Fluorouracil perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the 5-Fluorouracil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.130727 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0633541 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0626873 |
| AREG | amphiregulin | 0.0573608 |
| VMP1 | vacuole membrane protein 1 | 0.0498458 |
| MMP12 | matrix metallopeptidase 12 | 0.0496411 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0393946 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0388209 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0380551 |
| EDN1 | endothelin 1 | 0.0365551 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0353216 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0339982 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.033631 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0329936 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0310096 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0295413 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0273226 |
| CPOX | coproporphyrinogen oxidase | 0.027177 |
| EPHA6 | EPH receptor A6 | 0.0267524 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0264455 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0262508 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0261939 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0261276 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0260471 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0249977 |
| ANXA1 | annexin A1 | 0.0245917 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0241485 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0238216 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.023639 |
| NEBL | nebulette | 0.0234819 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0228737 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0225325 |
| KIF5B | kinesin family member 5B | 0.0224702 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0218698 |
| OXR1 | oxidation resistance 1 | 0.0216119 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0215419 |
| IL6ST | interleukin 6 signal transducer | 0.0212795 |
| TMEM47 | transmembrane protein 47 | 0.0202666 |
| JMJD1C | jumonji domain containing 1C | 0.0199441 |
| NKTR | natural killer cell triggering receptor | 0.0195428 |
| CLDND1 | claudin domain containing 1 | 0.0194616 |
| CCNG1 | cyclin G1 | 0.0193318 |
| HELB | helicase (DNA) B | 0.0192204 |
| CEP70 | centrosomal protein 70kDa | 0.0191404 |
| CPSF6 | cleavage and polyadenylation specific factor 6, 68kDa | 0.0190189 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0187829 |
| ATP11B | ATPase, class VI, type 11B | 0.0186603 |
| ZNF217 | zinc finger protein 217 | 0.0186048 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0185742 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0183642 |
| MEMO1 | mediator of cell motility 1 | 0.0182683 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0180696 |
| PRKCI | protein kinase C, iota | 0.0173506 |
| TMEM41B | transmembrane protein 41B | 0.017328 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.0173027 |
| PGK1 | phosphoglycerate kinase 1 | 0.0171844 |
| SSH2 | slingshot protein phosphatase 2 | 0.016993 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0169032 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0167886 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0166299 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0164447 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0162932 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0162416 |
| RPL4 | ribosomal protein L4 | 0.0162085 |
| ABI2 | abl-interactor 2 | 0.0161563 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.0156772 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0156003 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0155687 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0154422 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0154072 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0152606 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0152322 |
| TFCP2 | transcription factor CP2 | 0.0151519 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0150778 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.0150332 |
| EPHA5 | EPH receptor A5 | 0.015011 |
| TMEM39A | transmembrane protein 39A | 0.0149842 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0149653 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0149173 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0148725 |
| ZNF292 | zinc finger protein 292 | 0.0145868 |
| RYK | receptor-like tyrosine kinase | 0.0144909 |
| CENPF | centromere protein F, 350/400kDa | 0.0144683 |
| PHF21A | PHD finger protein 21A | 0.0144586 |
| RPLP0 | ribosomal protein, large, P0 | 0.0144424 |
| ETNK1 | ethanolamine kinase 1 | 0.0143409 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0143204 |
| PRR11 | proline rich 11 | 0.0142316 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0142038 |
| SERINC5 | serine incorporator 5 | 0.014145 |
| AHR | aryl hydrocarbon receptor | 0.0141225 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0141186 |
| TXNRD1 | thioredoxin reductase 1 | 0.0139279 |
| ENAH | enabled homolog (Drosophila) | 0.013875 |
| IPMK | inositol polyphosphate multikinase | 0.0138382 |
| SNX14 | sorting nexin 14 | 0.0137843 |
| NLN | neurolysin (metallopeptidase M3 family) | 0.0137332 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0135844 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.0135802 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0134954 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.13608 |
| NLGN1 | neuroligin 1 | -0.119423 |
| TMSB10 | thymosin beta 10 | -0.116252 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.108776 |
| HMGA2 | high mobility group AT-hook 2 | -0.0944335 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0907641 |
| PTMA | prothymosin, alpha | -0.0882779 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0814891 |
| RPL23 | ribosomal protein L23 | -0.0789791 |
| ACTG1 | actin gamma 1 | -0.074385 |
| DST | dystonin | -0.0673379 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0671316 |
| YAP1 | Yes-associated protein 1 | -0.063477 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0620917 |
| RPS8 | ribosomal protein S8 | -0.0607989 |
| FTL | ferritin, light polypeptide | -0.0603023 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0592361 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0587516 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0561415 |
| RPLP1 | ribosomal protein, large, P1 | -0.0535627 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0517542 |
| RPL35A | ribosomal protein L35a | -0.0517079 |
| RBM39 | RNA binding motif protein 39 | -0.0513443 |
| RASAL2 | RAS protein activator like 2 | -0.0505236 |
| BCHE | butyrylcholinesterase | -0.0497459 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0494888 |
| RPS6 | ribosomal protein S6 | -0.0481029 |
| RPS19 | ribosomal protein S19 | -0.0475796 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0472249 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0458273 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0452529 |
| EHBP1 | EH domain binding protein 1 | -0.0447979 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0442227 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0436591 |
| RPL12 | ribosomal protein L12 | -0.0431909 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0430445 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0427884 |
| RPL36 | ribosomal protein L36 | -0.042353 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0421809 |
| RPS27A | ribosomal protein S27a | -0.0420718 |
| MGAT4C | MGAT4 family, member C | -0.0417097 |
| ADIPOR2 | adiponectin receptor 2 | -0.0411318 |
| RPLP2 | ribosomal protein, large, P2 | -0.0408715 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0407531 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0405906 |
| TGM2 | transglutaminase 2 | -0.0395727 |
| RPL19 | ribosomal protein L19 | -0.0393818 |
| PCDH7 | protocadherin 7 | -0.0388848 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0386122 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0381797 |
| RPL26 | ribosomal protein L26 | -0.0380219 |
| MYL12B | myosin, light chain 12B, regulatory | -0.037949 |
| ZNF804A | zinc finger protein 804A | -0.0379338 |
| TPI1 | triosephosphate isomerase 1 | -0.0362683 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0356244 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0352454 |
| RACK1 | receptor for activated C kinase 1 | -0.0347391 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.03461 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0341048 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0339605 |
| RPL37 | ribosomal protein L37 | -0.0338652 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0334241 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0332722 |
| RPS12 | ribosomal protein S12 | -0.0332059 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0328903 |
| LDHB | lactate dehydrogenase B | -0.0327824 |
| RPL38 | ribosomal protein L38 | -0.0323442 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.032313 |
| CALR | calreticulin | -0.0323018 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0316037 |
| NHSL1 | NHS-like 1 | -0.0306461 |
| EGR1 | early growth response 1 | -0.0304821 |
| RPS29 | ribosomal protein S29 | -0.0303734 |
| RPL9 | ribosomal protein L9 | -0.0303288 |
| LMO7 | LIM domain 7 | -0.0302122 |
| HMGB1 | high mobility group box 1 | -0.0299798 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0299753 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.029957 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0298077 |
| CUX1 | cut-like homeobox 1 | -0.0294884 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0294784 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0294641 |
| GNAS | GNAS complex locus | -0.029452 |
| PCBP2 | poly(rC) binding protein 2 | -0.0293517 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.029302 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0292117 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0289846 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0289148 |
| TMEM131 | transmembrane protein 131 | -0.0289077 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.028789 |
| RPL5 | ribosomal protein L5 | -0.0286984 |
| PARD3 | par-3 family cell polarity regulator | -0.0286749 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0286031 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0286025 |
| YBX3 | Y box binding protein 3 | -0.0281631 |
| NAV3 | neuron navigator 3 | -0.0279915 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0276767 |
| S100A10 | S100 calcium binding protein A10 | -0.0276069 |
| TPM4 | tropomyosin 4 | -0.0275582 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0273157 |
