5-Fluorouracil_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Fluorouracil perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the 5-Fluorouracil_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0989279
AKAP12 A kinase (PRKA) anchor protein 12 0.0982733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0737372
HELZ helicase with zinc finger 0.0599113
FAM13A family with sequence similarity 13, member A 0.0533366
DPH6 diphthamine biosynthesis 6 0.0505392
ERRFI1 ERBB receptor feedback inhibitor 1 0.0456195
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0416023
MAP1B microtubule-associated protein 1B 0.0375687
MEF2A myocyte enhancer factor 2A 0.0364624
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0353162
KMT2C lysine (K)-specific methyltransferase 2C 0.0351984
STARD4 StAR-related lipid transfer (START) domain containing 4 0.035165
GOLGA4 golgin A4 0.0351132
APP amyloid beta (A4) precursor protein 0.0345882
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0345245
LIMCH1 LIM and calponin homology domains 1 0.0335263
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0335177
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0327922
USP34 ubiquitin specific peptidase 34 0.0315359
DSCAM Down syndrome cell adhesion molecule 0.03129
ZNF292 zinc finger protein 292 0.0309365
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0289647
KDM6A lysine (K)-specific demethylase 6A 0.0286268
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.027002
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0269671
MXI1 MAX interactor 1, dimerization protein 0.0269215
RNF145 ring finger protein 145 0.0266568
BCLAF1 BCL2-associated transcription factor 1 0.0266375
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0263934
ENO1 enolase 1, (alpha) 0.0263715
UBC ubiquitin C 0.0259322
SETD5 SET domain containing 5 0.0259243
NFE2L1 nuclear factor, erythroid 2-like 1 0.0256905
WAC WW domain containing adaptor with coiled-coil 0.025679
NEK7 NIMA-related kinase 7 0.0246934
SBNO1 strawberry notch homolog 1 (Drosophila) 0.024566
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0244122
DST dystonin 0.0243793
ANLN anillin, actin binding protein 0.0241342
RAB2A RAB2A, member RAS oncogene family 0.0240523
YTHDC1 YTH domain containing 1 0.0239859
SUMO2 small ubiquitin-like modifier 2 0.0239326
UBA6 ubiquitin-like modifier activating enzyme 6 0.0239291
UBA2 ubiquitin-like modifier activating enzyme 2 0.0238787
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.023866
SSBP2 single-stranded DNA binding protein 2 0.0238564
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0231222
ITPRID2 ITPR interacting domain containing 2 0.0230451
INSIG2 insulin induced gene 2 0.0228704
ANKRD17 ankyrin repeat domain 17 0.0225605
GPBP1 GC-rich promoter binding protein 1 0.0225576
SBF2 SET binding factor 2 0.0224578
MED13 mediator complex subunit 13 0.0224345
XPO1 exportin 1 0.0218854
BIRC6 baculoviral IAP repeat containing 6 0.0218182
COPA coatomer protein complex, subunit alpha 0.0217883
ETNK1 ethanolamine kinase 1 0.0217181
BBX bobby sox homolog (Drosophila) 0.0216117
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0215975
RSL1D1 ribosomal L1 domain containing 1 0.0215613
NCKAP1 NCK-associated protein 1 0.021518
SRPK2 SRSF protein kinase 2 0.0214777
PCM1 pericentriolar material 1 0.0214618
PSD3 pleckstrin and Sec7 domain containing 3 0.0214311
SUCO SUN domain containing ossification factor 0.0213588
USP37 ubiquitin specific peptidase 37 0.0212143
SPAG9 sperm associated antigen 9 0.0207208
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.02072
SCAF11 SR-related CTD-associated factor 11 0.0207106
PHF3 PHD finger protein 3 0.0206697
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0203707
TNRC6A trinucleotide repeat containing 6A 0.0202763
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0201417
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0200427
TNIP1 TNFAIP3 interacting protein 1 0.0198777
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0197731
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0196061
NAMPT nicotinamide phosphoribosyltransferase 0.019525
SOX9 SRY (sex determining region Y)-box 9 0.019484
TOP1 topoisomerase (DNA) I 0.0194823
SERBP1 SERPINE1 mRNA binding protein 1 0.0194812
SRP54 signal recognition particle 54kDa 0.019363
FBXL20 F-box and leucine-rich repeat protein 20 0.0193392
PTK2 protein tyrosine kinase 2 0.0191481
STRN3 striatin, calmodulin binding protein 3 0.0191442
CENPF centromere protein F, 350/400kDa 0.0189474
MON2 MON2 homolog (S. cerevisiae) 0.0189076
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0187566
DGKH diacylglycerol kinase, eta 0.0186477
FNIP1 folliculin interacting protein 1 0.0186046
OXSR1 oxidative stress responsive 1 0.0185277
ESYT2 extended synaptotagmin-like protein 2 0.0184287
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0184102
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0183597
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.0183531
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0183491
TNRC6B trinucleotide repeat containing 6B 0.0183263
LIMS1 LIM and senescent cell antigen-like domains 1 0.0182982
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0182791

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.248872
LSAMP limbic system-associated membrane protein -0.13819
NALF1 NALCN channel auxiliary factor 1 -0.116201
RPL23 ribosomal protein L23 -0.101771
RPL38 ribosomal protein L38 -0.0760406
RPL35A ribosomal protein L35a -0.0746261
COL1A1 collagen, type I, alpha 1 -0.0722947
ACTG1 actin gamma 1 -0.0673164
RPLP1 ribosomal protein, large, P1 -0.0628484
PTPRD protein tyrosine phosphatase, receptor type, D -0.0592382
VCL vinculin -0.0557714
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0534997
THSD4 thrombospondin, type I, domain containing 4 -0.0523901
SMYD3 SET and MYND domain containing 3 -0.0491048
PTMA prothymosin, alpha -0.0466595
TLE4 transducin-like enhancer of split 4 -0.0459743
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0458876
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0454261
RPL34 ribosomal protein L34 -0.0434643
RAD51B RAD51 paralog B -0.0431322
TRIB2 tribbles pseudokinase 2 -0.0428633
TMSB10 thymosin beta 10 -0.0415538
SLIT2 slit homolog 2 (Drosophila) -0.0405818
MBD5 methyl-CpG binding domain protein 5 -0.0388409
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0381932
RPS24 ribosomal protein S24 -0.0378693
RPL37A ribosomal protein L37a -0.0372848
EIF1 eukaryotic translation initiation factor 1 -0.0371582
RPL27 ribosomal protein L27 -0.036398
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0361946
RPS6 ribosomal protein S6 -0.0360256
SYT1 synaptotagmin I -0.0345281
RPS12 ribosomal protein S12 -0.0341657
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0340897
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.033855
TRIO trio Rho guanine nucleotide exchange factor -0.0335006
RPL19 ribosomal protein L19 -0.0329819
UNC5C unc-5 homolog C (C. elegans) -0.0323803
PDZRN3 PDZ domain containing ring finger 3 -0.0321686
RNF213 ring finger protein 213 -0.03205
FMN1 formin 1 -0.0315936
RPL9 ribosomal protein L9 -0.0313604
ZNF804A zinc finger protein 804A -0.0310705
DNAH14 dynein, axonemal, heavy chain 14 -0.0306423
RPS27 ribosomal protein S27 -0.0306146
EXT1 exostosin glycosyltransferase 1 -0.0305327
ATXN1 ataxin 1 -0.0300698
RPS19 ribosomal protein S19 -0.0299707
TCF12 transcription factor 12 -0.0298312
CADM2 cell adhesion molecule 2 -0.0289003
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0286916
RPS13 ribosomal protein S13 -0.0286099
TPM1 tropomyosin 1 (alpha) -0.0277992
RPL32 ribosomal protein L32 -0.027766
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0277472
TPT1 tumor protein, translationally-controlled 1 -0.0276698
S100A9 S100 calcium binding protein A9 -0.0272217
TBX2 T-box 2 -0.0270875
NREP neuronal regeneration related protein -0.0269638
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0268378
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0266281
RPL7 ribosomal protein L7 -0.0262153
RIGI RNA sensor RIG-I -0.0257364
COL4A6 collagen, type IV, alpha 6 -0.024853
MX2 MX dynamin-like GTPase 2 -0.0239737
RNF150 ring finger protein 150 -0.0239631
NPAS2 neuronal PAS domain protein 2 -0.0239312
GSE1 Gse1 coiled-coil protein -0.0238457
RPL28 ribosomal protein L28 -0.0234744
RPS3 ribosomal protein S3 -0.0234167
MED13L mediator complex subunit 13-like -0.0233335
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.023249
NACA nascent polypeptide-associated complex alpha subunit -0.0230047
VIM vimentin -0.0228921
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0227094
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0227006
PRRC2C proline-rich coiled-coil 2C -0.0226699
KLF6 Kruppel-like factor 6 -0.0223012
FERMT2 fermitin family member 2 -0.0222784
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0222573
ADGRB3 adhesion G protein-coupled receptor B3 -0.0221312
SEPTIN9 septin 9 -0.0220429
WSB1 WD repeat and SOCS box containing 1 -0.0218696
MACF1 microtubule-actin crosslinking factor 1 -0.0216443
UBAP2 ubiquitin associated protein 2 -0.021364
GATA3 GATA binding protein 3 -0.021353
RPL36 ribosomal protein L36 -0.0213381
PABPN1 poly(A) binding protein, nuclear 1 -0.0212409
RPL31 ribosomal protein L31 -0.0212057
KLHL13 kelch-like family member 13 -0.0211869
LOC112694756 uncharaterized LOC112694756 -0.0211055
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0205222
PKM pyruvate kinase, muscle -0.0205047
FRMD4A FERM domain containing 4A -0.0203456
SOX4 SRY (sex determining region Y)-box 4 -0.0203173
EGR1 early growth response 1 -0.0202583
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0202288
ACTN1 actinin, alpha 1 -0.0202026
IGFBP3 insulin-like growth factor binding protein 3 -0.0201911
GNAS GNAS complex locus -0.0201785