| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | 5-Fluorouracil perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the 5-Fluorouracil_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.26031 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.126248 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.097299 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0941937 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0910336 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0907396 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0866567 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0857117 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0809015 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0772998 |
| DSPP | dentin sialophosphoprotein | 0.0677558 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0619518 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0594377 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0565746 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0558425 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0554234 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0539001 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0527519 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0509894 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0501912 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0446245 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0436443 |
| RPS3 | ribosomal protein S3 | 0.043609 |
| ENO1 | enolase 1, (alpha) | 0.0429305 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0409072 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0396994 |
| PLIN2 | perilipin 2 | 0.0381244 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0379927 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0370087 |
| LDHA | lactate dehydrogenase A | 0.036991 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0361385 |
| RTN4 | reticulon 4 | 0.0358521 |
| RPL3 | ribosomal protein L3 | 0.0346188 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0341576 |
| ASPH | aspartate beta-hydroxylase | 0.0338379 |
| CPE | carboxypeptidase E | 0.0336914 |
| RPL4 | ribosomal protein L4 | 0.0328682 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0326208 |
| NOL4L | nucleolar protein 4-like | 0.0323568 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0318635 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0318059 |
| JMJD1C | jumonji domain containing 1C | 0.0309104 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0308233 |
| VMP1 | vacuole membrane protein 1 | 0.0303914 |
| FLNB | filamin B, beta | 0.0302599 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0298538 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0296622 |
| ARFGEF3 | ARFGEF family member 3 | 0.0287862 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0286334 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0285908 |
| VEGFA | vascular endothelial growth factor A | 0.0284329 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0283976 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.028183 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0281756 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0278334 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0277934 |
| WAPL | WAPL cohesin release factor | 0.0271539 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0271403 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0268029 |
| PCGF5 | polycomb group ring finger 5 | 0.026733 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0266369 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0266301 |
| NDRG1 | N-myc downstream regulated 1 | 0.0261957 |
| AFDN | afadin, adherens junction formation factor | 0.0255619 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0254411 |
| WWC2 | WW and C2 domain containing 2 | 0.0252542 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.02479 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0247757 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0242769 |
| MICU1 | mitochondrial calcium uptake 1 | 0.0240875 |
| YTHDC1 | YTH domain containing 1 | 0.023933 |
| ZNF292 | zinc finger protein 292 | 0.0236486 |
| FNIP1 | folliculin interacting protein 1 | 0.0233989 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0233153 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0232949 |
| SPOPL | speckle-type POZ protein-like | 0.0232399 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0232396 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0231214 |
| PDE8A | phosphodiesterase 8A | 0.0230678 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0227287 |
| NCKAP1 | NCK-associated protein 1 | 0.0222827 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.0222593 |
| CD109 | CD109 molecule | 0.0222474 |
| USP47 | ubiquitin specific peptidase 47 | 0.0221075 |
| FOXN3 | forkhead box N3 | 0.0220014 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0218839 |
| EFNA1 | ephrin-A1 | 0.0217178 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0214865 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.021389 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.021299 |
| FAM219A | family with sequence similarity 219, member A | 0.0212807 |
| CFB | complement factor B | 0.0212454 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0212207 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0210712 |
| SLC35F5 | solute carrier family 35, member F5 | 0.021011 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.021009 |
| ZNF395 | zinc finger protein 395 | 0.0209946 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0209346 |
| PRELID2 | PRELI domain containing 2 | 0.0209234 |
| RPLP0 | ribosomal protein, large, P0 | 0.0207028 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.33599 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.126634 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0994962 |
| FN1 | fibronectin 1 | -0.0986183 |
| MT2A | metallothionein 2A | -0.0923316 |
| APOB | apolipoprotein B | -0.0909074 |
| PTCHD4 | patched domain containing 4 | -0.080819 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0753612 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0727712 |
| RPL35A | ribosomal protein L35a | -0.0629789 |
| GPC6 | glypican 6 | -0.0604537 |
| RPS24 | ribosomal protein S24 | -0.0601053 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0587565 |
| APOA2 | apolipoprotein A-II | -0.056877 |
| RPL34 | ribosomal protein L34 | -0.0522007 |
| RPL23 | ribosomal protein L23 | -0.0512696 |
| APOA1 | apolipoprotein A-I | -0.0504863 |
| ENAH | enabled homolog (Drosophila) | -0.0498135 |
| FRMD5 | FERM domain containing 5 | -0.0476908 |
| FTL | ferritin, light polypeptide | -0.0459166 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0456591 |
| GPC3 | glypican 3 | -0.0425523 |
| TMSB10 | thymosin beta 10 | -0.0424078 |
| KLHL5 | kelch-like family member 5 | -0.0423399 |
| TMEM123 | transmembrane protein 123 | -0.0413883 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0396451 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0395985 |
| TCF12 | transcription factor 12 | -0.0392784 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0392639 |
| GNAS | GNAS complex locus | -0.038221 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0376384 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0375808 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0373782 |
| A2M | alpha-2-macroglobulin | -0.0372787 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0371041 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0365894 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0365227 |
| BCL2L1 | BCL2-like 1 | -0.0356563 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.035209 |
| RPS19 | ribosomal protein S19 | -0.0351632 |
| FAM107B | family with sequence similarity 107, member B | -0.0348696 |
| RBM39 | RNA binding motif protein 39 | -0.0332175 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0330377 |
| RPS20 | ribosomal protein S20 | -0.0327885 |
| RPL31 | ribosomal protein L31 | -0.0325891 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0322955 |
| RRBP1 | ribosome binding protein 1 | -0.0309646 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0309324 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0303906 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0299914 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0296673 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0292019 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0289884 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0285714 |
| RNF213 | ring finger protein 213 | -0.0284799 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0281586 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0281304 |
| RBM33 | RNA binding motif protein 33 | -0.0280109 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0278268 |
| FUS | FUS RNA binding protein | -0.0277838 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0276213 |
| RPS6 | ribosomal protein S6 | -0.0272544 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0270342 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0269991 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0268981 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0267908 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0265751 |
| OLA1 | Obg-like ATPase 1 | -0.0264977 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.02648 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0256615 |
| RPL11 | ribosomal protein L11 | -0.0256233 |
| NHSL1 | NHS-like 1 | -0.0255832 |
| CCND1 | cyclin D1 | -0.0255532 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0253778 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0252793 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0252342 |
| TPM4 | tropomyosin 4 | -0.0246433 |
| RASA2 | RAS p21 protein activator 2 | -0.0245082 |
| LAMA4 | laminin, alpha 4 | -0.0243841 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0243214 |
| GPHN | gephyrin | -0.0241908 |
| AHR | aryl hydrocarbon receptor | -0.0241516 |
| ITGAV | integrin, alpha V | -0.0241464 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0241338 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0241333 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0239806 |
| RSF1 | remodeling and spacing factor 1 | -0.0237624 |
| IER3 | immediate early response 3 | -0.0235088 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0232377 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.0228936 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.02286 |
| RPL9 | ribosomal protein L9 | -0.0227423 |
| WTAP | Wilms tumor 1 associated protein | -0.0223626 |
| CP | ceruloplasmin (ferroxidase) | -0.0220266 |
| RPL28 | ribosomal protein L28 | -0.0218364 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0218092 |
| AOPEP | aminopeptidase O (putative) | -0.02179 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0216941 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0216772 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0216527 |
