5-Fluorouracil_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Fluorouracil perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Fluorouracil_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.105759
TIMP3 TIMP metallopeptidase inhibitor 3 0.100037
MEF2A myocyte enhancer factor 2A 0.0977777
NAMPT nicotinamide phosphoribosyltransferase 0.0863166
KIAA1217 KIAA1217 0.0722357
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0696338
AHNAK AHNAK nucleoprotein 0.0682112
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0672117
MYOF myoferlin 0.0660334
FLNB filamin B, beta 0.0638588
ITGA6 integrin, alpha 6 0.0623979
FNIP1 folliculin interacting protein 1 0.0614013
STC1 stanniocalcin 1 0.0609287
PSD3 pleckstrin and Sec7 domain containing 3 0.0595508
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0560883
SULF1 sulfatase 1 0.0534966
EZR ezrin 0.0534758
NRIP1 nuclear receptor interacting protein 1 0.0534652
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0524143
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0520124
ITCH itchy E3 ubiquitin protein ligase 0.0506015
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0502125
TRIO trio Rho guanine nucleotide exchange factor 0.0482482
ESYT2 extended synaptotagmin-like protein 2 0.0479932
MBNL2 muscleblind-like splicing regulator 2 0.0472888
PRELID2 PRELI domain containing 2 0.0466659
PGK1 phosphoglycerate kinase 1 0.0454473
APLP2 amyloid beta (A4) precursor-like protein 2 0.0454263
RIN2 Ras and Rab interactor 2 0.0452469
EMP1 epithelial membrane protein 1 0.0448915
ENO1 enolase 1, (alpha) 0.0445085
CUL4B cullin 4B 0.0444873
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0443721
DLG1 discs, large homolog 1 (Drosophila) 0.0431274
COL17A1 collagen, type XVII, alpha 1 0.0430366
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0411393
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0405851
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0401982
CD44 CD44 molecule (Indian blood group) 0.0401251
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0398903
TMSB4X thymosin beta 4, X-linked 0.0397262
OGA O-GlcNAcase 0.0391222
BIRC6 baculoviral IAP repeat containing 6 0.0389807
LMO7 LIM domain 7 0.0378353
NDRG1 N-myc downstream regulated 1 0.037803
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0374635
LIFR leukemia inhibitory factor receptor alpha 0.0372208
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0369297
ANLN anillin, actin binding protein 0.0367647
SBF2 SET binding factor 2 0.0365291
SEC31A SEC31 homolog A (S. cerevisiae) 0.035977
ANKH ANKH inorganic pyrophosphate transport regulator 0.0358754
BLCAP bladder cancer associated protein 0.0354108
NAV2 neuron navigator 2 0.0347876
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0345641
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0342386
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0341788
ARHGAP5 Rho GTPase activating protein 5 0.0339275
ASPH aspartate beta-hydroxylase 0.0338665
AFAP1 actin filament associated protein 1 0.0337838
PPARG peroxisome proliferator-activated receptor gamma 0.0336178
SMAD3 SMAD family member 3 0.0330638
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0323273
HLA-E major histocompatibility complex, class I, E 0.0321489
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0319796
FNDC3B fibronectin type III domain containing 3B 0.0318929
RNF19B ring finger protein 19B 0.0318679
AKAP13 A kinase (PRKA) anchor protein 13 0.0316335
DOCK5 dedicator of cytokinesis 5 0.0316084
MACF1 microtubule-actin crosslinking factor 1 0.0314086
ADAM10 ADAM metallopeptidase domain 10 0.031205
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0311617
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.030903
EXT1 exostosin glycosyltransferase 1 0.0308139
PHF20 PHD finger protein 20 0.0307456
RAI14 retinoic acid induced 14 0.0305611
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0304807
PRRC2C proline-rich coiled-coil 2C 0.0304263
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0303749
SLK STE20-like kinase 0.0302493
RSF1 remodeling and spacing factor 1 0.0301197
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0301082
PHF21A PHD finger protein 21A 0.0300564
ANKRD33B ankyrin repeat domain 33B 0.0299425
COPB1 coatomer protein complex, subunit beta 1 0.0296935
RICTOR RPTOR independent companion of MTOR, complex 2 0.0296348
TM4SF1 transmembrane 4 L six family member 1 0.0295468
SDC4 syndecan 4 0.0293536
KIF16B kinesin family member 16B 0.0293078
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0292938
WASL Wiskott-Aldrich syndrome-like 0.0292588
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0290155
PODXL podocalyxin-like 0.0289968
SERINC3 serine incorporator 3 0.0289477
COG5 component of oligomeric golgi complex 5 0.0288067
LMAN1 lectin, mannose-binding, 1 0.0287103
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0285768
CAV1 caveolin 1, caveolae protein, 22kDa 0.0284981
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0282645
YAP1 Yes-associated protein 1 0.0278089

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.161744
TMSB10 thymosin beta 10 -0.108692
RPS8 ribosomal protein S8 -0.0873044
RPLP2 ribosomal protein, large, P2 -0.082876
RPS6 ribosomal protein S6 -0.0808865
RPS21 ribosomal protein S21 -0.071544
POTEF POTE ankyrin domain family, member F -0.0676035
RPLP1 ribosomal protein, large, P1 -0.0664455
PTMA prothymosin, alpha -0.0633608
RPS3 ribosomal protein S3 -0.0632153
S100A10 S100 calcium binding protein A10 -0.0628821
MT2A metallothionein 2A -0.0619502
PDLIM5 PDZ and LIM domain 5 -0.0579579
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0550467
LOC112694756 uncharaterized LOC112694756 -0.0539486
RPL11 ribosomal protein L11 -0.0536939
RPL23 ribosomal protein L23 -0.0507513
RPS19 ribosomal protein S19 -0.049554
EGR1 early growth response 1 -0.0484332
RPS13 ribosomal protein S13 -0.0479992
RPS25 ribosomal protein S25 -0.0469237
RPL8 ribosomal protein L8 -0.0464182
RPL12 ribosomal protein L12 -0.0458534
LAMA5 laminin, alpha 5 -0.0457417
FTL ferritin, light polypeptide -0.0442087
FTH1 ferritin, heavy polypeptide 1 -0.0429003
YBX1 Y box binding protein 1 -0.0405034
RPS27 ribosomal protein S27 -0.040139
IFI6 interferon, alpha-inducible protein 6 -0.0401076
RPL36 ribosomal protein L36 -0.0392744
RPL28 ribosomal protein L28 -0.039221
MT1X metallothionein 1X -0.0392005
HSPG2 heparan sulfate proteoglycan 2 -0.038571
RPS23 ribosomal protein S23 -0.0380197
RPS2 ribosomal protein S2 -0.0373973
S100A9 S100 calcium binding protein A9 -0.0364968
RPL37A ribosomal protein L37a -0.0363911
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.035812
RPL35A ribosomal protein L35a -0.0355025
IFITM3 interferon induced transmembrane protein 3 -0.0346189
INTS6 integrator complex subunit 6 -0.0342059
RACK1 receptor for activated C kinase 1 -0.0336863
RPS14 ribosomal protein S14 -0.0335625
P4HB prolyl 4-hydroxylase, beta polypeptide -0.03325
ANO1 anoctamin 1, calcium activated chloride channel -0.0329543
AOPEP aminopeptidase O (putative) -0.0326363
RPS20 ribosomal protein S20 -0.0323293
MORF4L2 mortality factor 4 like 2 -0.0321998
RPS12 ribosomal protein S12 -0.0320641
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0319694
RPL37 ribosomal protein L37 -0.0310527
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0309765
CYB5R3 cytochrome b5 reductase 3 -0.0309478
VCL vinculin -0.0308291
RPS11 ribosomal protein S11 -0.0304243
TOP2A topoisomerase (DNA) II alpha 170kDa -0.028239
RPS16 ribosomal protein S16 -0.0282172
TPT1 tumor protein, translationally-controlled 1 -0.0279767
RPL26 ribosomal protein L26 -0.0278537
RPL30 ribosomal protein L30 -0.027527
ANXA1 annexin A1 -0.0274177
RPS29 ribosomal protein S29 -0.0272698
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0267306
RPL36A ribosomal protein L36a -0.0264016
IARS1 isoleucyl-tRNA synthetase 1 -0.0262238
RPS27A ribosomal protein S27a -0.0259067
SRRM2 serine/arginine repetitive matrix 2 -0.025682
ATP5F1E ATP synthase F1 subunit epsilon -0.0254064
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0253757
RPL34 ribosomal protein L34 -0.0253693
S100A2 S100 calcium binding protein A2 -0.0250243
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0249545
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0247727
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0245724
RPL21 ribosomal protein L21 -0.0244595
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0238435
DHFR dihydrofolate reductase -0.0237297
IFI27 interferon, alpha-inducible protein 27 -0.0236898
RPS5 ribosomal protein S5 -0.023484
RPL19 ribosomal protein L19 -0.0230378
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0228948
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0226998
RPS17 ribosomal protein S17 -0.0223271
CSTB cystatin B (stefin B) -0.0219198
RAB2A RAB2A, member RAS oncogene family -0.0219169
RAB7A RAB7A, member RAS oncogene family -0.0216524
PICALM phosphatidylinositol binding clathrin assembly protein -0.0215977
IFITM1 interferon induced transmembrane protein 1 -0.0215874
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0215626
GUK1 guanylate kinase 1 -0.0215597
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.021485
USP15 ubiquitin specific peptidase 15 -0.0211033
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0209209
RPL32 ribosomal protein L32 -0.020884
SQSTM1 sequestosome 1 -0.0208838
DOCK4 dedicator of cytokinesis 4 -0.0207847
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0204766
CNRIP1 cannabinoid receptor interacting protein 1 -0.0203469
RPL10A ribosomal protein L10a -0.0202421
S100A11 S100 calcium binding protein A11 -0.020164