5-Fluorouracil_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Fluorouracil perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Fluorouracil_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.162617
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.107773
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0971969
RAI1 retinoic acid induced 1 0.088214
VIM vimentin 0.0855957
HDAC9 histone deacetylase 9 0.0748932
PSD3 pleckstrin and Sec7 domain containing 3 0.0658783
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0617721
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0588031
ENO1 enolase 1, (alpha) 0.0582221
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0571608
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0563976
TM4SF1 transmembrane 4 L six family member 1 0.0562509
DST dystonin 0.0546931
CENPF centromere protein F, 350/400kDa 0.0541416
FNIP1 folliculin interacting protein 1 0.0537349
MKI67 marker of proliferation Ki-67 0.052546
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0504761
ANGPTL4 angiopoietin-like 4 0.0475338
SLC38A2 solute carrier family 38, member 2 0.0465145
TSC22D1 TSC22 domain family, member 1 0.0403632
UBC ubiquitin C 0.0389609
EHBP1 EH domain binding protein 1 0.0380325
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0373186
ARHGAP5 Rho GTPase activating protein 5 0.0365961
MINDY2 MINDY lysine 48 deubiquitinase 2 0.036083
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0360186
ESYT2 extended synaptotagmin-like protein 2 0.0358488
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0356283
USP34 ubiquitin specific peptidase 34 0.0354798
CDK19 cyclin-dependent kinase 19 0.0354575
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351004
CSMD3 CUB and Sushi multiple domains 3 0.0341269
TAOK1 TAO kinase 1 0.033246
PRELID2 PRELI domain containing 2 0.0324383
EREG epiregulin 0.0316656
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0311291
YEATS2 YEATS domain containing 2 0.0308558
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0305532
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0293814
ATM ATM serine/threonine kinase 0.0285235
CAPRIN2 caprin family member 2 0.0284918
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0282583
MBD5 methyl-CpG binding domain protein 5 0.0280024
PDIA4 protein disulfide isomerase family A, member 4 0.0280006
ZMYND8 zinc finger, MYND-type containing 8 0.0279488
CSNK1A1 casein kinase 1, alpha 1 0.027925
ADAM10 ADAM metallopeptidase domain 10 0.0274886
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.027309
PGK1 phosphoglycerate kinase 1 0.0270726
ENO2 enolase 2 (gamma, neuronal) 0.0268416
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0254746
TPM3 tropomyosin 3 0.0252974
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0250686
APLP2 amyloid beta (A4) precursor-like protein 2 0.0249611
LDHA lactate dehydrogenase A 0.0246801
EXOC4 exocyst complex component 4 0.0244454
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0242977
TXNRD1 thioredoxin reductase 1 0.0236717
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.023454
MBNL2 muscleblind-like splicing regulator 2 0.0234425
TPX2 TPX2, microtubule-associated 0.0231042
APOLD1 apolipoprotein L domain containing 1 0.0229277
BPTF bromodomain PHD finger transcription factor 0.0228757
PDE4D phosphodiesterase 4D, cAMP-specific 0.0228224
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.022295
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0221196
DARS1 aspartyl-tRNA synthetase 1 0.0218626
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0218479
KMT2E lysine (K)-specific methyltransferase 2E 0.0217293
DPYSL2 dihydropyrimidinase-like 2 0.0215129
PATJ PATJ crumbs cell polarity complex component 0.021305
TBC1D5 TBC1 domain family, member 5 0.0211711
SPATS2L spermatogenesis associated, serine-rich 2-like 0.021129
STXBP1 syntaxin binding protein 1 0.0209632
TTC3 tetratricopeptide repeat domain 3 0.0208697
BIRC2 baculoviral IAP repeat containing 2 0.020783
ANKRD36 ankyrin repeat domain 36 0.0207353
CLTC clathrin, heavy chain (Hc) 0.0202345
SDCCAG8 serologically defined colon cancer antigen 8 0.0202288
NCAPD2 non-SMC condensin I complex, subunit D2 0.020214
PLK2 polo-like kinase 2 0.0200785
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0200473
KDM4C lysine (K)-specific demethylase 4C 0.0200348
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0199452
CKAP5 cytoskeleton associated protein 5 0.0199348
ZEB1 zinc finger E-box binding homeobox 1 0.0198635
AHNAK AHNAK nucleoprotein 0.0193168
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0191114
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0189986
OFD1 oral-facial-digital syndrome 1 0.0188601
CKAP2 cytoskeleton associated protein 2 0.018809
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0187221
PYGL phosphorylase, glycogen, liver 0.0187035
ZNF638 zinc finger protein 638 0.0186145
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0185513
TXNIP thioredoxin interacting protein 0.018222
RTN4 reticulon 4 0.0181267
NPAS2 neuronal PAS domain protein 2 0.0180621
MYH9 myosin, heavy chain 9, non-muscle 0.0178501

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.210899
TMSB10 thymosin beta 10 -0.181262
PTMA prothymosin, alpha -0.133529
RPL35A ribosomal protein L35a -0.0998934
RPL23 ribosomal protein L23 -0.0672132
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0641247
FTL ferritin, light polypeptide -0.0614951
WSB1 WD repeat and SOCS box containing 1 -0.0546664
RPL12 ribosomal protein L12 -0.0537935
RPLP1 ribosomal protein, large, P1 -0.0510044
RPS19 ribosomal protein S19 -0.0489973
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0484869
RPS8 ribosomal protein S8 -0.0474424
RBM39 RNA binding motif protein 39 -0.044898
RPL36 ribosomal protein L36 -0.0431376
HLA-B major histocompatibility complex, class I, B -0.0429324
RPS6 ribosomal protein S6 -0.0418621
RAB7A RAB7A, member RAS oncogene family -0.0406562
GNAS GNAS complex locus -0.040633
RPL38 ribosomal protein L38 -0.0398357
FUS FUS RNA binding protein -0.0386185
TRA2A transformer 2 alpha homolog (Drosophila) -0.0377672
KLF6 Kruppel-like factor 6 -0.0363131
RPL35 ribosomal protein L35 -0.035156
TPT1 tumor protein, translationally-controlled 1 -0.0350106
RPLP2 ribosomal protein, large, P2 -0.0328928
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0325665
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0322963
RPS24 ribosomal protein S24 -0.0321175
RPL28 ribosomal protein L28 -0.0309733
FTH1 ferritin, heavy polypeptide 1 -0.0307871
RPS29 ribosomal protein S29 -0.0306317
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0304486
ANKRD11 ankyrin repeat domain 11 -0.0298977
MT2A metallothionein 2A -0.0298811
RPL34 ribosomal protein L34 -0.0296236
CAVIN1 caveolae associated protein 1 -0.0293148
NAMPT nicotinamide phosphoribosyltransferase -0.0290319
LOC112694756 uncharaterized LOC112694756 -0.0288446
RPL37 ribosomal protein L37 -0.0286002
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0284101
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0280356
HMGB1 high mobility group box 1 -0.0276914
ACTG1 actin gamma 1 -0.0275682
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0275449
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0274058
S100A10 S100 calcium binding protein A10 -0.0269075
KDM3A lysine (K)-specific demethylase 3A -0.0268099
ZFAND3 zinc finger, AN1-type domain 3 -0.0265791
NPR2 natriuretic peptide receptor 2 -0.0265715
TFRC transferrin receptor -0.0254777
RPS12 ribosomal protein S12 -0.0254588
SEPTIN7 septin 7 -0.0253125
RPS2 ribosomal protein S2 -0.0251137
WDR43 WD repeat domain 43 -0.0250501
POTEF POTE ankyrin domain family, member F -0.0250491
RPS14 ribosomal protein S14 -0.0245447
MT1X metallothionein 1X -0.0243702
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0242908
IARS1 isoleucyl-tRNA synthetase 1 -0.0242873
RPS28 ribosomal protein S28 -0.0241767
RPL36A ribosomal protein L36a -0.0240647
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0235507
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0235338
ANXA2 annexin A2 -0.023311
RPS10 ribosomal protein S10 -0.0233031
RPS20 ribosomal protein S20 -0.023053
GARS1 glycyl-tRNA synthetase 1 -0.0228863
RPL37A ribosomal protein L37a -0.022811
RPL26 ribosomal protein L26 -0.0225912
RPS23 ribosomal protein S23 -0.0221573
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0218486
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0212501
RPL13A ribosomal protein L13a -0.021142
EIF4A1 eukaryotic translation initiation factor 4A1 -0.020852
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0206922
TOP1 topoisomerase (DNA) I -0.0206744
PRRC2C proline-rich coiled-coil 2C -0.0206635
TMSB4X thymosin beta 4, X-linked -0.0203873
FBXO11 F-box protein 11 -0.0202885
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.020089
TRIO trio Rho guanine nucleotide exchange factor -0.0200845
KCMF1 potassium channel modulatory factor 1 -0.0198873
OLA1 Obg-like ATPase 1 -0.0196388
UBE3C ubiquitin protein ligase E3C -0.019546
SLC38A1 solute carrier family 38, member 1 -0.0193503
MARCHF6 membrane associated ring-CH-type finger 6 -0.019273
YBX1 Y box binding protein 1 -0.0191616
RPL31 ribosomal protein L31 -0.0190289
MORF4L2 mortality factor 4 like 2 -0.0190258
SRSF7 serine/arginine-rich splicing factor 7 -0.0189724
RBM25 RNA binding motif protein 25 -0.0187746
CDC73 cell division cycle 73 -0.0187104
RPS21 ribosomal protein S21 -0.0186645
ISG15 ISG15 ubiquitin-like modifier -0.0184598
RPL27 ribosomal protein L27 -0.0183572
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0182602
RPL5 ribosomal protein L5 -0.0182331
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0180907
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0180117