5-Fluorouracil_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Fluorouracil perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Fluorouracil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.141149
AKAP12 A kinase (PRKA) anchor protein 12 0.135289
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0963987
GRAMD1B GRAM domain containing 1B 0.0846395
ERRFI1 ERBB receptor feedback inhibitor 1 0.0777797
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0642817
RAD51B RAD51 paralog B 0.0605154
KDM2A lysine (K)-specific demethylase 2A 0.0586131
ANO6 anoctamin 6 0.0507565
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0497315
EXOC4 exocyst complex component 4 0.0487934
JMJD1C jumonji domain containing 1C 0.0485681
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0449064
TRIO trio Rho guanine nucleotide exchange factor 0.0425532
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0418702
ELL2 elongation factor, RNA polymerase II, 2 0.041624
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0411216
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0408593
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0402133
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0393362
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.037501
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0373634
CSNK1A1 casein kinase 1, alpha 1 0.036554
MYPN myopalladin 0.035848
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.035448
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0352348
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0349549
RTN4 reticulon 4 0.0343229
PDE4D phosphodiesterase 4D, cAMP-specific 0.0341245
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0340085
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0334028
STC1 stanniocalcin 1 0.0333212
GPHN gephyrin 0.0332263
EIF4B eukaryotic translation initiation factor 4B 0.03291
TPM3 tropomyosin 3 0.032628
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0317864
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0317643
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0315566
BIRC2 baculoviral IAP repeat containing 2 0.0313951
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0308652
TNRC6B trinucleotide repeat containing 6B 0.0306349
BCAS3 breast carcinoma amplified sequence 3 0.03018
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.030058
OSMR oncostatin M receptor 0.0300143
TAS2R14 taste receptor, type 2, member 14 0.0298306
NCAPD2 non-SMC condensin I complex, subunit D2 0.0293358
NIPBL Nipped-B homolog (Drosophila) 0.0293317
XPO1 exportin 1 0.0290585
MKI67 marker of proliferation Ki-67 0.0289411
TM4SF1 transmembrane 4 L six family member 1 0.0283098
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0281882
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0277847
ZBTB20 zinc finger and BTB domain containing 20 0.0271062
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0268545
PTK2 protein tyrosine kinase 2 0.0267652
PGK1 phosphoglycerate kinase 1 0.0262248
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0260221
TBC1D5 TBC1 domain family, member 5 0.02597
FER fer (fps/fes related) tyrosine kinase 0.0258605
NFE2L2 nuclear factor, erythroid 2-like 2 0.0257994
EML4 echinoderm microtubule associated protein like 4 0.025793
RUSC2 RUN and SH3 domain containing 2 0.0256547
MARCHF4 membrane associated ring-CH-type finger 4 0.0256282
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0254813
NF1 neurofibromin 1 0.0254089
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0251012
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0249392
BMAL2 basic helix-loop-helix ARNT like 2 0.0245575
LATS2 large tumor suppressor kinase 2 0.0245092
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0244182
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0243566
RASAL2 RAS protein activator like 2 0.0241646
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0241365
SINHCAF SIN3-HDAC complex associated factor 0.0240518
SENP6 SUMO1/sentrin specific peptidase 6 0.0239943
NCOR1 nuclear receptor corepressor 1 0.0239613
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0235436
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0232124
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0231488
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0231436
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0230644
ZNF292 zinc finger protein 292 0.0226047
BRWD1 bromodomain and WD repeat domain containing 1 0.0225656
MMP12 matrix metallopeptidase 12 0.0225155
TRIP12 thyroid hormone receptor interactor 12 0.0223222
ITCH itchy E3 ubiquitin protein ligase 0.0220085
AHNAK AHNAK nucleoprotein 0.0219552
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0216373
FBXL17 F-box and leucine-rich repeat protein 17 0.0214951
SBF2 SET binding factor 2 0.0214141
ANKRD36 ankyrin repeat domain 36 0.0213701
MARCHF7 membrane associated ring-CH-type finger 7 0.0212647
TTC17 tetratricopeptide repeat domain 17 0.0211995
KMT2A lysine (K)-specific methyltransferase 2A 0.0211564
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0210356
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0209074
YBX3 Y box binding protein 3 0.0207756
SNX27 sorting nexin family member 27 0.0205458
THSD4 thrombospondin, type I, domain containing 4 0.020495
DARS1 aspartyl-tRNA synthetase 1 0.0203005

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230155
TMSB10 thymosin beta 10 -0.138794
PTMA prothymosin, alpha -0.112642
RPL35A ribosomal protein L35a -0.0861427
RPLP1 ribosomal protein, large, P1 -0.0772481
RPL37A ribosomal protein L37a -0.0734948
RPS8 ribosomal protein S8 -0.0720144
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0683112
RPS19 ribosomal protein S19 -0.0616657
RPL23 ribosomal protein L23 -0.0612994
RPS29 ribosomal protein S29 -0.0596205
RPS27 ribosomal protein S27 -0.0582269
RPS21 ribosomal protein S21 -0.056267
VIM vimentin -0.0517226
RPL26 ribosomal protein L26 -0.0496348
RPS15 ribosomal protein S15 -0.0493227
EGR1 early growth response 1 -0.0488409
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0468239
RPL34 ribosomal protein L34 -0.0452196
MT2A metallothionein 2A -0.0446898
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0425335
RPS10 ribosomal protein S10 -0.041783
RPLP2 ribosomal protein, large, P2 -0.0396109
RPL37 ribosomal protein L37 -0.0391072
YBX1 Y box binding protein 1 -0.0385021
RPL36 ribosomal protein L36 -0.0383068
RPL31 ribosomal protein L31 -0.0373085
RPL38 ribosomal protein L38 -0.037163
FTL ferritin, light polypeptide -0.0369271
RPS6 ribosomal protein S6 -0.036812
RPS3 ribosomal protein S3 -0.036771
RPS12 ribosomal protein S12 -0.0365925
PFN1 profilin 1 -0.0351709
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0344249
RPL27 ribosomal protein L27 -0.0334967
NAP1L1 nucleosome assembly protein 1-like 1 -0.0334048
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.033077
RPS23 ribosomal protein S23 -0.0325855
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.032242
RPL8 ribosomal protein L8 -0.0321589
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0320153
RACK1 receptor for activated C kinase 1 -0.0314937
PDE10A phosphodiesterase 10A -0.0312765
TPM2 tropomyosin 2 (beta) -0.0307323
RPL12 ribosomal protein L12 -0.0305522
RPL28 ribosomal protein L28 -0.0303611
RPL9 ribosomal protein L9 -0.0301207
RPL19 ribosomal protein L19 -0.029768
ATP5F1E ATP synthase F1 subunit epsilon -0.0293047
PCBP2 poly(rC) binding protein 2 -0.0290443
RBM39 RNA binding motif protein 39 -0.0287831
RPLP0 ribosomal protein, large, P0 -0.0287819
RPL13A ribosomal protein L13a -0.0287457
RPL35 ribosomal protein L35 -0.0286502
EIF1 eukaryotic translation initiation factor 1 -0.0281533
GPX4 glutathione peroxidase 4 -0.0276132
RPS20 ribosomal protein S20 -0.0273
MYL12B myosin, light chain 12B, regulatory -0.0267129
RPL32 ribosomal protein L32 -0.0266718
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0266127
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0264683
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.026457
RPL5 ribosomal protein L5 -0.0261503
RPL11 ribosomal protein L11 -0.025986
RPS25 ribosomal protein S25 -0.0258479
RPS4X ribosomal protein S4, X-linked -0.0252915
FUS FUS RNA binding protein -0.0251255
RPS16 ribosomal protein S16 -0.0249141
HMGB1 high mobility group box 1 -0.0241229
RPS17 ribosomal protein S17 -0.0235457
TPT1 tumor protein, translationally-controlled 1 -0.0233693
HLA-B major histocompatibility complex, class I, B -0.0231622
GSTP1 glutathione S-transferase pi 1 -0.0230319
RPL36A ribosomal protein L36a -0.0229721
IER3 immediate early response 3 -0.0226986
POTEF POTE ankyrin domain family, member F -0.0224699
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0220113
SEPTIN2 septin 2 -0.0218788
CAVIN1 caveolae associated protein 1 -0.0209549
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0208388
AEBP2 AE binding protein 2 -0.0206862
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0206581
RPS27A ribosomal protein S27a -0.0204491
S100A10 S100 calcium binding protein A10 -0.0201447
CALR calreticulin -0.0201431
SSB Sjogren syndrome antigen B (autoantigen La) -0.0201242
ACTG1 actin gamma 1 -0.0198118
GOLGA4 golgin A4 -0.0196059
LDHB lactate dehydrogenase B -0.019526
RPS14 ribosomal protein S14 -0.019377
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0191879
RPS13 ribosomal protein S13 -0.0188933
EIF5B eukaryotic translation initiation factor 5B -0.0185823
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0185158
RPS5 ribosomal protein S5 -0.0184527
EEF1G eukaryotic translation elongation factor 1 gamma -0.0183701
S100A11 S100 calcium binding protein A11 -0.0182898
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0182442
RPL18 ribosomal protein L18 -0.0182404
RPS11 ribosomal protein S11 -0.0180805