5-Fluorouracil_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 5-Fluorouracil perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 5-Fluorouracil_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0842423
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0723104
TPX2 TPX2, microtubule-associated 0.0718604
GOLGA4 golgin A4 0.0708633
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.070503
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0684477
IARS1 isoleucyl-tRNA synthetase 1 0.0673175
ERRFI1 ERBB receptor feedback inhibitor 1 0.0613486
CALU calumenin 0.0542491
RPL4 ribosomal protein L4 0.0480478
SNX14 sorting nexin 14 0.0461955
RPLP0 ribosomal protein, large, P0 0.0433343
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0424023
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0419161
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0414865
SET SET nuclear proto-oncogene 0.040856
AKAP10 A kinase (PRKA) anchor protein 10 0.0408321
TMEM263 transmembrane protein 263 0.0404409
SEC24A SEC24 family member A 0.040279
H3-3B H3.3 histone B 0.0400853
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0397801
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.039631
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.039489
UBC ubiquitin C 0.0392434
OGA O-GlcNAcase 0.0387194
URI1 URI1, prefoldin-like chaperone 0.0385054
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0382087
KLHL24 kelch-like family member 24 0.0377969
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0376428
GOLT1B golgi transport 1B 0.037641
SQSTM1 sequestosome 1 0.0374745
UBE2B ubiquitin-conjugating enzyme E2B 0.0373892
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0372698
TOP1 topoisomerase (DNA) I 0.036854
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.036772
FAM168A family with sequence similarity 168, member A 0.0361864
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0358866
SEC23A Sec23 homolog A (S. cerevisiae) 0.0356236
IFRD1 interferon-related developmental regulator 1 0.0353901
FNIP1 folliculin interacting protein 1 0.0351558
LOC102724023 ES1 protein homolog, mitochondrial 0.0349882
AKAP9 A kinase (PRKA) anchor protein 9 0.0346976
GPBP1 GC-rich promoter binding protein 1 0.0343648
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0341176
VEZT vezatin, adherens junctions transmembrane protein 0.0339889
HIPK3 homeodomain interacting protein kinase 3 0.0339591
SETD5 SET domain containing 5 0.0333983
ARL13B ADP-ribosylation factor-like 13B 0.0328965
TSC22D2 TSC22 domain family, member 2 0.0328951
UBE2H ubiquitin-conjugating enzyme E2H 0.0328577
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.032728
NF1 neurofibromin 1 0.0324616
UBE3D ubiquitin protein ligase E3D 0.0324554
RAB1A RAB1A, member RAS oncogene family 0.0322941
CKAP2 cytoskeleton associated protein 2 0.0321947
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0320074
RBM25 RNA binding motif protein 25 0.0318977
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0317532
OXR1 oxidation resistance 1 0.0317209
TM4SF1 transmembrane 4 L six family member 1 0.0315438
WAC WW domain containing adaptor with coiled-coil 0.0313906
USP47 ubiquitin specific peptidase 47 0.0308965
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0307516
DTNA dystrobrevin, alpha 0.0306701
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0303773
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0302794
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0301488
HBS1L HBS1-like translational GTPase 0.0299934
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0299592
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0299381
YBX3 Y box binding protein 3 0.0298008
GGNBP2 gametogenetin binding protein 2 0.0295402
BRD8 bromodomain containing 8 0.02948
CEP70 centrosomal protein 70kDa 0.0290017
MCTP1 multiple C2 domains, transmembrane 1 0.0290013
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0288936
SPAG9 sperm associated antigen 9 0.0288224
KIF5B kinesin family member 5B 0.028423
TNRC6B trinucleotide repeat containing 6B 0.0281627
SERF2 small EDRK-rich factor 2 0.028124
ARHGAP26 Rho GTPase activating protein 26 0.0280868
HP1BP3 heterochromatin protein 1, binding protein 3 0.0279786
GADD45B growth arrest and DNA-damage-inducible, beta 0.0279158
NXN nucleoredoxin 0.0278961
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0278596
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0278422
FBXO34 F-box protein 34 0.0278011
SLTM SAFB-like, transcription modulator 0.0277943
SMC4 structural maintenance of chromosomes 4 0.0277535
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0276559
MEF2A myocyte enhancer factor 2A 0.0275342
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0275064
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0274424
UBXN7 UBX domain protein 7 0.027103
GOLGB1 golgin B1 0.0268781
KIAA1958 KIAA1958 0.02676
FAM114A1 family with sequence similarity 114, member A1 0.0267226
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0266813
STK38 serine/threonine kinase 38 0.0262406
PDE7A phosphodiesterase 7A 0.0261027

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.104569
FNDC3B fibronectin type III domain containing 3B -0.096719
LOC112694756 uncharaterized LOC112694756 -0.0888704
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0802796
CD44 CD44 molecule (Indian blood group) -0.0777427
NT5E 5'-nucleotidase, ecto (CD73) -0.0706858
SMAD3 SMAD family member 3 -0.0612746
PRKCA protein kinase C, alpha -0.0589753
RIGI RNA sensor RIG-I -0.0585913
NDRG1 N-myc downstream regulated 1 -0.0584684
ANKRD11 ankyrin repeat domain 11 -0.0577359
SDC4 syndecan 4 -0.0538955
DST dystonin -0.0538756
RAD51B RAD51 paralog B -0.0527934
IGFBP3 insulin-like growth factor binding protein 3 -0.0513439
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0503449
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0485925
MT2A metallothionein 2A -0.0465115
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0460402
ATXN1 ataxin 1 -0.0458002
PICALM phosphatidylinositol binding clathrin assembly protein -0.0457854
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0445593
ZBTB20 zinc finger and BTB domain containing 20 -0.0433572
ANXA2 annexin A2 -0.042829
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0421013
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0419762
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.041849
HMGA2 high mobility group AT-hook 2 -0.0417865
LDHA lactate dehydrogenase A -0.0417609
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0413893
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0412227
SMYD3 SET and MYND domain containing 3 -0.0409196
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0404376
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0396466
MAP1B microtubule-associated protein 1B -0.0395997
MBD5 methyl-CpG binding domain protein 5 -0.0389766
DNER delta/notch-like EGF repeat containing -0.0383775
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0383565
RNF213 ring finger protein 213 -0.0380329
SVIL supervillin -0.0379807
TPT1 tumor protein, translationally-controlled 1 -0.0360469
PARD3 par-3 family cell polarity regulator -0.0360133
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0359808
FMNL2 formin-like 2 -0.0351637
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0347884
AHNAK AHNAK nucleoprotein -0.0347684
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0346379
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0344547
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0344079
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0344049
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0342666
WWTR1 WW domain containing transcription regulator 1 -0.0339726
DLG1 discs, large homolog 1 (Drosophila) -0.0339192
ANGPTL4 angiopoietin-like 4 -0.0339055
DPYD dihydropyrimidine dehydrogenase -0.0330202
ASXL1 additional sex combs like transcriptional regulator 1 -0.0328363
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0323675
OASL 2'-5'-oligoadenylate synthetase-like -0.0318307
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.031825
SUN1 Sad1 and UNC84 domain containing 1 -0.031748
NALCN sodium leak channel, non selective -0.0311827
DSCAM Down syndrome cell adhesion molecule -0.0308612
MSN moesin -0.0307012
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0306976
FLNB filamin B, beta -0.0306403
KLHL5 kelch-like family member 5 -0.0303921
LPP LIM domain containing preferred translocation partner in lipoma -0.0300385
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0296711
ELL2 elongation factor, RNA polymerase II, 2 -0.0294246
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0292441
OSMR oncostatin M receptor -0.0290822
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0288746
RPL35 ribosomal protein L35 -0.0287929
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0286612
ANO6 anoctamin 6 -0.028304
FBXL17 F-box and leucine-rich repeat protein 17 -0.0282403
S100A10 S100 calcium binding protein A10 -0.0281746
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0280723
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0280423
MARCHF6 membrane associated ring-CH-type finger 6 -0.028033
THSD4 thrombospondin, type I, domain containing 4 -0.027578
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0275555
BZW1 basic leucine zipper and W2 domains 1 -0.0266706
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0265862
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0265226
NCEH1 neutral cholesterol ester hydrolase 1 -0.0263859
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0260694
FBXL2 F-box and leucine-rich repeat protein 2 -0.0260666
RPL30 ribosomal protein L30 -0.0259492
ANKRD28 ankyrin repeat domain 28 -0.0257078
ZFR zinc finger RNA binding protein -0.0251418
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0251073
DNAAF9 dynein axonemal assembly factor 9 -0.0250714
TUBB4B tubulin, beta 4B class IVb -0.0250004
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0249529
ACTG1 actin gamma 1 -0.0249123
IFIH1 interferon induced with helicase C domain 1 -0.024884
CFDP1 craniofacial development protein 1 -0.0246696
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0246401
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.024527