| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11524901 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in 5-R-Rivaroxaban relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | 1.32 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.67 |
| IER2 | immediate early response 2 | 0.56 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.52 |
| DES | desmin | 0.52 |
| FBN3 | fibrillin 3 | 0.52 |
| FAM117A | family with sequence similarity 117, member A | 0.51 |
| CCNE2 | cyclin E2 | 0.51 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.5 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.5 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | 0.48 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 0.48 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.45 |
| SH2B3 | SH2B adaptor protein 3 | 0.44 |
| LYST | lysosomal trafficking regulator | 0.42 |
| KIAA1210 | KIAA1210 | 0.41 |
| TXNDC16 | thioredoxin domain containing 16 | 0.41 |
| ZNF174 | zinc finger protein 174 | 0.41 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.4 |
| RNF4 | ring finger protein 4 | 0.39 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.39 |
| CCDC88A | coiled-coil domain containing 88A | 0.38 |
| RAB40C | RAB40C, member RAS oncogene family | 0.38 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.38 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.38 |
| TRAIP | TRAF interacting protein | 0.38 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.37 |
| RARA | retinoic acid receptor, alpha | 0.35 |
| AKTIP | AKT interacting protein | 0.35 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.34 |
| SDC1 | syndecan 1 | 0.34 |
| TIGD5 | tigger transposable element derived 5 | 0.33 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.33 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.33 |
| KIF1B | kinesin family member 1B | 0.33 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.33 |
| MTF1 | metal-regulatory transcription factor 1 | 0.32 |
| TRAK2 | trafficking protein, kinesin binding 2 | 0.32 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.31 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.31 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.31 |
| STON2 | stonin 2 | 0.3 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.3 |
| SLC35B3 | solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 | 0.3 |
| CYTH3 | cytohesin 3 | 0.3 |
| PER2 | period circadian clock 2 | 0.3 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.3 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | 0.3 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | 0.3 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.3 |
| TATDN2 | TatD DNase domain containing 2 | 0.29 |
| SP4 | Sp4 transcription factor | 0.29 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.29 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.29 |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.29 |
| RGN | regucalcin | 0.29 |
| FAM133B | family with sequence similarity 133, member B | 0.28 |
| TRIM62 | tripartite motif containing 62 | 0.28 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | 0.28 |
| SPATA2 | spermatogenesis associated 2 | 0.28 |
| SLC25A39 | solute carrier family 25, member 39 | 0.28 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.28 |
| TRNP1 | TMF1-regulated nuclear protein 1 | 0.28 |
| JDP2 | Jun dimerization protein 2 | 0.28 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.28 |
| MINDY4 | MINDY lysine 48 deubiquitinase 4 | 0.28 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | 0.28 |
| MCOLN1 | mucolipin 1 | 0.27 |
| EFCAB14 | EF-hand calcium binding domain 14 | 0.27 |
| ZNF724 | zinc finger protein 724 | 0.27 |
| MBP | myelin basic protein | 0.27 |
| EAF2 | ELL associated factor 2 | 0.27 |
| KLHL5 | kelch-like family member 5 | 0.27 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.27 |
| RGS12 | regulator of G-protein signaling 12 | 0.27 |
| CCDC112 | coiled-coil domain containing 112 | 0.27 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.27 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.27 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | 0.27 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.26 |
| ZMYM6 | zinc finger, MYM-type 6 | 0.26 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | 0.26 |
| UBXN2B | UBX domain protein 2B | 0.26 |
| AXIN2 | axin 2 | 0.26 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.26 |
| PPP1R35 | protein phosphatase 1, regulatory subunit 35 | 0.26 |
| PUM1 | pumilio RNA-binding family member 1 | 0.26 |
| USP19 | ubiquitin specific peptidase 19 | 0.25 |
| MROH6 | maestro heat-like repeat family member 6 | 0.25 |
| HOXB9 | homeobox B9 | 0.25 |
| RAB24 | RAB24, member RAS oncogene family | 0.25 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.25 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.25 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.25 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | 0.25 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.25 |
| AHI1 | Abelson helper integration site 1 | 0.25 |
| NARF | nuclear prelamin A recognition factor | 0.25 |
| KIAA1143 | KIAA1143 | 0.25 |
| CCDC84 | coiled-coil domain containing 84 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CFAP57 | cilia and flagella associated protein 57 | -0.89 |
| FAM219B | family with sequence similarity 219, member B | -0.78 |
| CCDC150 | coiled-coil domain containing 150 | -0.77 |
| FBXO33 | F-box protein 33 | -0.76 |
| CLTA | clathrin, light chain A | -0.65 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.65 |
| ZBTB7B | zinc finger and BTB domain containing 7B | -0.64 |
| HSPA14 | heat shock 70kDa protein 14 | -0.63 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.6 |
| ZNF175 | zinc finger protein 175 | -0.59 |
| NCOR1 | nuclear receptor corepressor 1 | -0.56 |
| CYHR1 | cysteine/histidine-rich 1 | -0.52 |
| PKM | pyruvate kinase, muscle | -0.51 |
| MFAP3 | microfibrillar-associated protein 3 | -0.51 |
| TMC4 | transmembrane channel-like 4 | -0.5 |
| PRKD3 | protein kinase D3 | -0.49 |
| ZNF205 | zinc finger protein 205 | -0.49 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | -0.47 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.46 |
| FAM241B | family with sequence similarity 241 member B | -0.45 |
| HLA-B | major histocompatibility complex, class I, B | -0.44 |
| NABP1 | nucleic acid binding protein 1 | -0.43 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.42 |
| CALU | calumenin | -0.42 |
| ZMYM5 | zinc finger, MYM-type 5 | -0.41 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.4 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.39 |
| BAG4 | BCL2-associated athanogene 4 | -0.38 |
| DDTL | D-dopachrome tautomerase-like | -0.38 |
| ZFHX4 | zinc finger homeobox 4 | -0.38 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.38 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.37 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.37 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.36 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.36 |
| ATOX1 | antioxidant 1 copper chaperone | -0.34 |
| HSBP1 | heat shock factor binding protein 1 | -0.34 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.34 |
| RAD51D | RAD51 paralog D | -0.33 |
| KLK6 | kallikrein-related peptidase 6 | -0.33 |
| MXRA7 | matrix-remodelling associated 7 | -0.33 |
| PPP1R2B | PPP1R2 family member B | -0.33 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.33 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.33 |
| FBXW4 | F-box and WD repeat domain containing 4 | -0.32 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | -0.32 |
| RNF126 | ring finger protein 126 | -0.32 |
| ZNF623 | zinc finger protein 623 | -0.32 |
| NOTCH3 | notch 3 | -0.32 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.31 |
| ZNF564 | zinc finger protein 564 | -0.31 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -0.31 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.3 |
| TMEM14C | transmembrane protein 14C | -0.3 |
| C2ORF69 | chromosome 2 open reading frame 69 | -0.3 |
| CTSB | cathepsin B | -0.3 |
| PRR14 | proline rich 14 | -0.29 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.29 |
| ZNF675 | zinc finger protein 675 | -0.29 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -0.29 |
| PGRMC1 | progesterone receptor membrane component 1 | -0.29 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.29 |
| ZNF714 | zinc finger protein 714 | -0.28 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.28 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.28 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.28 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -0.28 |
| FZD2 | frizzled class receptor 2 | -0.28 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | -0.28 |
| SMIM26 | small integral membrane protein 26 | -0.27 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | -0.27 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.27 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.27 |
| MAP2 | microtubule-associated protein 2 | -0.27 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | -0.27 |
| TMSB10 | thymosin beta 10 | -0.27 |
| MGMT | O-6-methylguanine-DNA methyltransferase | -0.27 |
| CILP2 | cartilage intermediate layer protein 2 | -0.26 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.26 |
| PRNP | prion protein | -0.26 |
| RIC1 | RAB6A GEF complex partner 1 | -0.26 |
| PFDN1 | prefoldin subunit 1 | -0.26 |
| SELENOF | selenoprotein F | -0.26 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.26 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.26 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.26 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.26 |
| SLC38A2 | solute carrier family 38, member 2 | -0.25 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | -0.25 |
| CRAT | carnitine O-acetyltransferase | -0.25 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.25 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.25 |
| HYPK | huntingtin interacting protein K | -0.25 |
| TPP1 | tripeptidyl peptidase I | -0.25 |
| CAV2 | caveolin 2 | -0.25 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | -0.24 |
| ACTBL2 | actin, beta-like 2 | -0.24 |
| APOBEC3C | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | -0.24 |
| ADCY5 | adenylate cyclase 5 | -0.24 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.24 |
