5253409-844 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the 5253409-844 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
AHCYL2 adenosylhomocysteinase-like 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AREG amphiregulin
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATF3 activating transcription factor 3
BAGE B melanoma antigen
CACTIN cactin, spliceosome C complex subunit
CACYBP calcyclin binding protein
CES2 carboxylesterase 2
CLCN6 chloride channel, voltage-sensitive 6
CLSTN2 calsyntenin 2
CRELD1 cysteine-rich with EGF-like domains 1
CRYAB crystallin, alpha B
CSNK1G1 casein kinase 1, gamma 1
CSRP2 cysteine and glycine-rich protein 2
CST6 cystatin E/M
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EGR1 early growth response 1
EIF5A2 eukaryotic translation initiation factor 5A2
ENGASE endo-beta-N-acetylglucosaminidase
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FAM50B family with sequence similarity 50, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GOSR2 golgi SNAP receptor complex member 2
HBEGF heparin-binding EGF-like growth factor
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
INHBE inhibin, beta E
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IPO8 importin 8
IQCK IQ motif containing K
IRF6 interferon regulatory factor 6
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LTB4R leukotriene B4 receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MBTPS2 membrane-bound transcription factor peptidase, site 2
MLX MLX, MAX dimerization protein
MYO1E myosin IE
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OSMR oncostatin M receptor
PDLIM7 PDZ and LIM domain 7 (enigma)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPT2 palmitoyl-protein thioesterase 2
RAB11B RAB11B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RANBP1 RAN binding protein 1
RNF24 ring finger protein 24
RSL1D1 ribosomal L1 domain containing 1
RUFY3 RUN and FYVE domain containing 3
S100A2 S100 calcium binding protein A2
SAMD4A sterile alpha motif domain containing 4A
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SIAH1 siah E3 ubiquitin protein ligase 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM63A transmembrane protein 63A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TWF1 twinfilin actin binding protein 1
UBOX5 U-box domain containing 5
UBQLN4 ubiquilin 4
USP27X ubiquitin specific peptidase 27, X-linked
VIPR1 vasoactive intestinal peptide receptor 1
VLDLR very low density lipoprotein receptor
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC6 armadillo repeat containing 6
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BBS10 Bardet-Biedl syndrome 10
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
BTF3P12 basic transcription factor 3 pseudogene 12
C22ORF29 chromosome 22 open reading frame 29
CABP2 calcium binding protein 2
CCDC85C coiled-coil domain containing 85C
CGREF1 cell growth regulator with EF-hand domain 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIDEC cell death-inducing DFFA-like effector c
CINP cyclin-dependent kinase 2 interacting protein
COL4A5 collagen, type IV, alpha 5
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRLF1 cytokine receptor-like factor 1
CXORF56 chromosome X open reading frame 56
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FAM63A family with sequence similarity 63, member A
FGF23 fibroblast growth factor 23
FILIP1L filamin A interacting protein 1-like
FMO4 flavin containing monooxygenase 4
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
IRF2BP1 interferon regulatory factor 2 binding protein 1
JAK2 Janus kinase 2
KAT2A K(lysine) acetyltransferase 2A
KRT15 keratin 15, type I
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRRC37A2 leucine rich repeat containing 37, member A2
MANEA mannosidase, endo-alpha
MAP1S microtubule-associated protein 1S
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MCPH1 microcephalin 1
MFAP2 microfibrillar-associated protein 2
MRPL44 mitochondrial ribosomal protein L44
MT1H metallothionein 1H
MXD3 MAX dimerization protein 3
MYO19 myosin XIX
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NPY1R neuropeptide Y receptor Y1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZK1 PDZ domain containing 1
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTDSS2 phosphatidylserine synthase 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB23 RAB23, member RAS oncogene family
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF123 ring finger protein 123
RNF170 ring finger protein 170
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SNX15 sorting nexin 15
SP1 Sp1 transcription factor
SPON2 spondin 2, extracellular matrix protein
SREK1IP1 SREK1-interacting protein 1
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TCTN2 tectonic family member 2
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM254 transmembrane protein 254
TRIM5 tripartite motif containing 5
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VGF VGF nerve growth factor inducible
WDR4 WD repeat domain 4
XYLT2 xylosyltransferase II
ZC3H3 zinc finger CCCH-type containing 3
ZNF141 zinc finger protein 141
ZNF211 zinc finger protein 211
ZNF250 zinc finger protein 250
ZNF268 zinc finger protein 268
ZNF551 zinc finger protein 551
ZNF552 zinc finger protein 552
ZNF574 zinc finger protein 574
ZNF665 zinc finger protein 665
ZNF74 zinc finger protein 74
ZNF813 zinc finger protein 813
ZNF85 zinc finger protein 85
ZSCAN31 zinc finger and SCAN domain containing 31