5637 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000905
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Genes

265 gene knockdowns changing fitness of 5637 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
PRL prolactin 18.3318
TMEM40 transmembrane protein 40 15.4416
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 11.7345
NUP210 nucleoporin 210kDa 11.5531
CLDN14 claudin 14 10.6397
RETNLB resistin like beta 8.96837
MKRN2 makorin ring finger protein 2 8.06295
CAMK1G calcium/calmodulin-dependent protein kinase IG 7.95981
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 7.85322
MYO1B myosin IB 7.50204
THUMPD3 THUMP domain containing 3 7.03055
CNTROB centrobin, centrosomal BRCA2 interacting protein 6.44796
CGGBP1 CGG triplet repeat binding protein 1 6.33809
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 6.31157
PPARG peroxisome proliferator-activated receptor gamma 6.29845
LHFPL4 lipoma HMGIC fusion partner-like 4 5.95094
SOX4 SRY (sex determining region Y)-box 4 5.74128
CYLD cylindromatosis (turban tumor syndrome) 5.60885
PCDHGB2 protocadherin gamma subfamily B, 2 5.47968
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 5.41226
TMEM208 transmembrane protein 208 5.19585
CALCR calcitonin receptor 5.11726
KLF7 Kruppel-like factor 7 (ubiquitous) 5.08415
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 5.06418
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 5.05114
PLA2G4E phospholipase A2, group IVE 5.0429
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 5.01173
TRPM2 transient receptor potential cation channel, subfamily M, member 2 4.99056
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 4.84494
GPR19 G protein-coupled receptor 19 4.81047
ZBTB4 zinc finger and BTB domain containing 4 4.75218
AXIN1 axin 1 4.74883
MKRN2OS MKRN2 opposite strand 4.73389
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 4.56667
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 4.55663
MYO9B myosin IXB 4.54028
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 4.52703
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 4.51815
HCRTR2 hypocretin (orexin) receptor 2 4.50884
ZNF106 zinc finger protein 106 4.4558
FBXL17 F-box and leucine-rich repeat protein 17 4.42315
CDV3 CDV3 homolog (mouse) 4.09983
KIF20B kinesin family member 20B 4.08002
ERI1 exoribonuclease 1 4.05295
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 4.03015
OR4N5 olfactory receptor, family 4, subfamily N, member 5 4.00897
STAP1 signal transducing adaptor family member 1 3.9645
EIF2A eukaryotic translation initiation factor 2A, 65kDa 3.9526
WNT7A wingless-type MMTV integration site family, member 7A 3.90875
SORT1 sortilin 1 3.87487
INAVA innate immunity activator 3.86245
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 3.79718
GRK2 G protein-coupled receptor kinase 2 3.78462
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 3.7565
CSPG4 chondroitin sulfate proteoglycan 4 3.75382
FUZ fuzzy planar cell polarity protein 3.68432
KCNIP3 Kv channel interacting protein 3, calsenilin 3.68178
RUSC1 RUN and SH3 domain containing 1 3.61752
TMEM203 transmembrane protein 203 3.61296
KIF2A kinesin heavy chain member 2A 3.60379
HDAC11 histone deacetylase 11 3.59181
CCL14 chemokine (C-C motif) ligand 14 3.58523
CPNE9 copine family member IX 3.56924
GRHL2 grainyhead-like 2 (Drosophila) 3.53681
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 3.50939
CHST10 carbohydrate sulfotransferase 10 3.49424
SBF2 SET binding factor 2 3.48063
BTC betacellulin 3.47017
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.46093
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 3.45985
TMEM54 transmembrane protein 54 3.45959
FAM212B family with sequence similarity 212, member B 3.45622
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 3.44427
MACO1 macoilin 1 3.42548
GFRA2 GDNF family receptor alpha 2 3.42289
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 3.41452
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 3.40063
SLC22A25 solute carrier family 22, member 25 3.38632
ADGRL3 adhesion G protein-coupled receptor L3 3.34884
OIT3 oncoprotein induced transcript 3 3.32578
RAB35 RAB35, member RAS oncogene family 3.30893
SYCP1 synaptonemal complex protein 1 3.29895
MAPK14 mitogen-activated protein kinase 14 3.29419
TRAF4 TNF receptor-associated factor 4 3.29116
LEMD3 LEM domain containing 3 3.25657
RAB20 RAB20, member RAS oncogene family 3.25413
CYB5R4 cytochrome b5 reductase 4 3.20621
ZNF169 zinc finger protein 169 3.20436
SCML4 sex comb on midleg-like 4 (Drosophila) 3.20206
GPX2 glutathione peroxidase 2 3.16954
OR1Q1 olfactory receptor, family 1, subfamily Q, member 1 3.16115
CEP135 centrosomal protein 135kDa 3.13387
MOXD1 monooxygenase, DBH-like 1 3.10783
PCDHAC2 protocadherin alpha subfamily C, 2 3.10566
PDZK1 PDZ domain containing 1 3.09222
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 3.07876
RNH1 ribonuclease/angiogenin inhibitor 1 3.07251
JAG1 jagged 1 3.02467
L3MBTL3 l(3)mbt-like 3 (Drosophila) 3.02268
ERICH5 glutamate-rich 5 3.00925
CPNE2 copine II 3.00891
OR10V1 olfactory receptor, family 10, subfamily V, member 1 3.00699
PCDHB4 protocadherin beta 4 3.00463
ASTL astacin-like metallo-endopeptidase (M12 family) 3.00161
SCGB1D2 secretoglobin, family 1D, member 2 2.99233
PLA2G4F phospholipase A2, group IVF 2.98324
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 2.97524
MYO5A myosin VA (heavy chain 12, myoxin) 2.95803
ICK intestinal cell (MAK-like) kinase 2.91873
DIAPH1 diaphanous-related formin 1 2.9098
AARSD1 alanyl-tRNA synthetase domain containing 1 2.89583
TNRC6B trinucleotide repeat containing 6B 2.86219
TYRO3 TYRO3 protein tyrosine kinase 2.85937
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J 2.85823
FBXO11 F-box protein 11 2.8435
SAXO1 stabilizer of axonemal microtubules 1 2.84132
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.83745
SH3BP1 SH3-domain binding protein 1 2.83552
RNF25 ring finger protein 25 2.82976
CENPQ centromere protein Q 2.81817
KLF10 Kruppel-like factor 10 2.80348
KRT78 keratin 78, type II 2.77053
UNC45A unc-45 homolog A (C. elegans) 2.75883
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 2.74244
FSIP1 fibrous sheath interacting protein 1 2.73298
RUNX1 runt-related transcription factor 1 2.72774
TMEM87A transmembrane protein 87A 2.72119
CATSPER2 cation channel, sperm associated 2 2.70553
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.70265
PCDH9 protocadherin 9 2.70066
MED23 mediator complex subunit 23 2.69719
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.69414
LGALS9C lectin, galactoside-binding, soluble, 9C 2.69134
IL17RE interleukin 17 receptor E 2.69121
NPAS4 neuronal PAS domain protein 4 2.69101
TMEM252 transmembrane protein 252 2.67539
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.66424
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.65735
DOCK9 dedicator of cytokinesis 9 2.65053
IL1F10 interleukin 1 family, member 10 (theta) 2.64367
FCRL3 Fc receptor-like 3 2.63277
C12ORF65 chromosome 12 open reading frame 65 2.63247
LARP7 La ribonucleoprotein domain family, member 7 2.62777
ZIM2 zinc finger, imprinted 2 2.61036
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.61033
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.59282
ARNT aryl hydrocarbon receptor nuclear translocator 2.58827
SOX9 SRY (sex determining region Y)-box 9 2.58634
H3F3B H3 histone, family 3B (H3.3B) 2.57932
WBP4 WW domain binding protein 4 2.56814
CES1 carboxylesterase 1 2.56789
CEP43 centrosomal protein 43 2.56515
EXOC7 exocyst complex component 7 2.56392
GBP5 guanylate binding protein 5 2.56158
CFAP410 cilia and flagella associated protein 410 2.54509
OR6S1 olfactory receptor, family 6, subfamily S, member 1 2.54445
PCBP3 poly(rC) binding protein 3 2.54134
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.53727
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.4986
GRK7 G protein-coupled receptor kinase 7 2.46645
IGFBP6 insulin-like growth factor binding protein 6 2.45965
FAM114A1 family with sequence similarity 114, member A1 2.44646
RILPL2 Rab interacting lysosomal protein-like 2 2.44036
FAM219A family with sequence similarity 219, member A 2.4398
SPG11 spastic paraplegia 11 (autosomal recessive) 2.4316
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.42498
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.42195
MYH11 myosin, heavy chain 11, smooth muscle 2.41586
PRDM14 PR domain containing 14 2.41237
MARK2 MAP/microtubule affinity-regulating kinase 2 2.41017
RBM45 RNA binding motif protein 45 2.40659
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.39244
PAQR6 progestin and adipoQ receptor family member VI 2.38837
GOLGA8M golgin A8 family, member M 2.38333
RNF2 ring finger protein 2 2.37177
RBM23 RNA binding motif protein 23 2.3688
SCARF2 scavenger receptor class F, member 2 2.36279
OLFML3 olfactomedin-like 3 2.35036
TMEM217 transmembrane protein 217 2.34757
TGIF1 TGFB-induced factor homeobox 1 2.34328
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.33935
AANAT aralkylamine N-acetyltransferase 2.3379
SPICE1 spindle and centriole associated protein 1 2.33684
RGSL1 regulator of G-protein signaling like 1 2.33387
LPPR4 lipid phosphate phosphatase-related protein type 4 2.32435
CLSTN2 calsyntenin 2 2.32427
OTOA otoancorin 2.31707
METTL5 methyltransferase like 5 2.30723
IMPG2 interphotoreceptor matrix proteoglycan 2 2.29798
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.2961
FLT3 fms-related tyrosine kinase 3 2.29222
IQSEC1 IQ motif and Sec7 domain 1 2.28795
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.28618
IRF2BP2 interferon regulatory factor 2 binding protein 2 2.2793
LCE4A late cornified envelope 4A 2.26369
IRS2 insulin receptor substrate 2 2.26277
PRCP prolylcarboxypeptidase (angiotensinase C) 2.26209
ANKRD52 ankyrin repeat domain 52 2.26122
APC adenomatous polyposis coli 2.251
UGCG UDP-glucose ceramide glucosyltransferase 2.25055
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.24555
CMIP c-Maf inducing protein 2.24125
SFR1 SWI5-dependent recombination repair 1 2.24042
IL1B interleukin 1, beta 2.24023
BRPF1 bromodomain and PHD finger containing, 1 2.23521
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 2.23316
SORBS3 sorbin and SH3 domain containing 3 2.22521
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 2.2235
OR5AU1 olfactory receptor, family 5, subfamily AU, member 1 2.22093
PCM1 pericentriolar material 1 2.21558
PLD6 phospholipase D family, member 6 2.21219
BARHL2 BarH-like homeobox 2 2.21219
MPV17 MpV17 mitochondrial inner membrane protein 2.21175
KDM4E lysine (K)-specific demethylase 4E 2.20119
TRHR thyrotropin-releasing hormone receptor 2.2001
IL21R interleukin 21 receptor 2.2
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 2.19897
SPTBN2 spectrin, beta, non-erythrocytic 2 2.19873
SLC38A7 solute carrier family 38, member 7 2.1958
FLII flightless I homolog (Drosophila) 2.19539
SCAF4 SR-related CTD-associated factor 4 2.19396
LBP lipopolysaccharide binding protein 2.17873
TSC22D1 TSC22 domain family, member 1 2.17807
PPP1R35 protein phosphatase 1, regulatory subunit 35 2.17068
COG7 component of oligomeric golgi complex 7 2.16986
WDR19 WD repeat domain 19 2.16303
MYO1A myosin IA 2.16091
HFE2 hemochromatosis type 2 (juvenile) 2.16026
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.15731
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.15624
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.15589
CCDC85B coiled-coil domain containing 85B 2.15415
SAMD4B sterile alpha motif domain containing 4B 2.15381
FBLN2 fibulin 2 2.14773
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 2.1447
NOTCH4 notch 4 2.14392
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.14089
GPR15 G protein-coupled receptor 15 2.13661
MRPL2 mitochondrial ribosomal protein L2 2.13212
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.13091
DAP death-associated protein 2.12909
DOCK5 dedicator of cytokinesis 5 2.12327
ZSCAN25 zinc finger and SCAN domain containing 25 2.11736
LRRC37B leucine rich repeat containing 37B 2.11429
PM20D1 peptidase M20 domain containing 1 2.11035
CCP110 centriolar coiled coil protein 110kDa 2.10133
KCTD19 potassium channel tetramerization domain containing 19 2.09981
WBP1L WW domain binding protein 1-like 2.09563
YAP1 Yes-associated protein 1 2.08696
WRAP53 WD repeat containing, antisense to TP53 2.07285
MIX23 mitochondrial matrix import factor 23 2.06794
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.066
METTL15 methyltransferase like 15 2.06073
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.05946
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.05519
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.05263
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 2.05071
CPXCR1 CPX chromosome region, candidate 1 2.05004
KIAA1211L KIAA1211-like 2.03914
IFNA21 interferon, alpha 21 2.03862
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 2.03656
JADE3 jade family PHD finger 3 2.02871
SMYD5 SMYD family member 5 2.01727
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.00563
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.00495