| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/667490 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in 6-Mercaptopurine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| F13A1 | coagulation factor XIII, A1 polypeptide | 2.02 |
| S100A4 | S100 calcium binding protein A4 | 1.68 |
| IFT74 | intraflagellar transport 74 | 1.68 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 1.48 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 1.36 |
| PTMA | prothymosin, alpha | 1.22 |
| CSTB | cystatin B (stefin B) | 1.17 |
| RWDD1 | RWD domain containing 1 | 1.05 |
| PTMS | parathymosin | 1.02 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.99 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 0.96 |
| POLK | polymerase (DNA directed) kappa | 0.96 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.92 |
| KIAA0556 | KIAA0556 | 0.89 |
| RPL36AL | ribosomal protein L36a-like | 0.88 |
| CYCS | cytochrome c, somatic | 0.88 |
| CNPY2 | canopy FGF signaling regulator 2 | 0.86 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.83 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.82 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.82 |
| UBC | ubiquitin C | 0.81 |
| H2AZ1 | H2A.Z variant histone 1 | 0.81 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.81 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.8 |
| TIPRL | TOR signaling pathway regulator | 0.8 |
| ACTN1 | actinin, alpha 1 | 0.78 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.77 |
| RPS20 | ribosomal protein S20 | 0.77 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 0.76 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.76 |
| SUMO2 | small ubiquitin-like modifier 2 | 0.75 |
| ZNF428 | zinc finger protein 428 | 0.73 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.72 |
| CDC34 | cell division cycle 34 | 0.72 |
| SKA3 | spindle and kinetochore associated complex subunit 3 | 0.71 |
| NES | nestin | 0.69 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | 0.69 |
| STMN2 | stathmin 2 | 0.69 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.69 |
| TUBA1A | tubulin, alpha 1a | 0.67 |
| ERICH5 | glutamate-rich 5 | 0.67 |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.67 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.66 |
| FXN | frataxin | 0.66 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.65 |
| RPL10A | ribosomal protein L10a | 0.64 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.64 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.63 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.63 |
| ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 | 0.63 |
| ANXA3 | annexin A3 | 0.62 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.62 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | 0.61 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | 0.61 |
| ACTG1 | actin gamma 1 | 0.6 |
| NABP2 | nucleic acid binding protein 2 | 0.6 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.6 |
| RAN | RAN, member RAS oncogene family | 0.59 |
| MT2A | metallothionein 2A | 0.59 |
| TMEM205 | transmembrane protein 205 | 0.59 |
| DUSP6 | dual specificity phosphatase 6 | 0.58 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | 0.58 |
| GTSF1 | gametocyte specific factor 1 | 0.57 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.57 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.57 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.57 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | 0.56 |
| FAM160A1 | family with sequence similarity 160, member A1 | 0.56 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.56 |
| CALR | calreticulin | 0.55 |
| BOLA2 | bolA family member 2 | 0.55 |
| POTEI | POTE ankyrin domain family, member I | 0.55 |
| RPS10 | ribosomal protein S10 | 0.55 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.54 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.54 |
| TAGLN2 | transgelin 2 | 0.54 |
| PPT1 | palmitoyl-protein thioesterase 1 | 0.53 |
| S100A11 | S100 calcium binding protein A11 | 0.53 |
| CLDND1 | claudin domain containing 1 | 0.53 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.52 |
| MRPL57 | mitochondrial ribosomal protein L57 | 0.52 |
| SSRP1 | structure specific recognition protein 1 | 0.52 |
| RPL26 | ribosomal protein L26 | 0.52 |
| CNTNAP1 | contactin associated protein 1 | 0.51 |
| AAGAB | alpha- and gamma-adaptin binding protein | 0.51 |
| SYAP1 | synapse associated protein 1 | 0.5 |
| RPL18A | ribosomal protein L18a | 0.5 |
| CALU | calumenin | 0.5 |
| CCDC158 | coiled-coil domain containing 158 | 0.5 |
| MIEF2 | mitochondrial elongation factor 2 | 0.5 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.5 |
| SPTBN4 | spectrin, beta, non-erythrocytic 4 | 0.5 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 0.49 |
| FEN1 | flap structure-specific endonuclease 1 | 0.49 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | 0.49 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.49 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.49 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.48 |
| C1QBP | complement component 1, q subcomponent binding protein | 0.48 |
| CCDC88A | coiled-coil domain containing 88A | 0.48 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PER2 | period circadian clock 2 | -2.32 |
| PIP | prolactin-induced protein | -1.07 |
| TSPAN3 | tetraspanin 3 | -1.07 |
| CD63 | CD63 molecule | -0.93 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.88 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.85 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.82 |
| CRIPT | cysteine-rich PDZ-binding protein | -0.79 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.75 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | -0.74 |
| LYST | lysosomal trafficking regulator | -0.7 |
| MYO3A | myosin IIIA | -0.69 |
| PRNP | prion protein | -0.68 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -0.68 |
| COL1A1 | collagen, type I, alpha 1 | -0.66 |
| IFT54 | intraflagellar transport 54 | -0.61 |
| SCARB1 | scavenger receptor class B, member 1 | -0.59 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.59 |
| FGA | fibrinogen alpha chain | -0.58 |
| TP73 | tumor protein p73 | -0.58 |
| PLPP2 | phospholipid phosphatase 2 | -0.57 |
| FN1 | fibronectin 1 | -0.56 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | -0.56 |
| CSNK1A1L | casein kinase 1, alpha 1-like | -0.56 |
| ATXN2 | ataxin 2 | -0.55 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.54 |
| SESN1 | sestrin 1 | -0.54 |
| CERCAM | cerebral endothelial cell adhesion molecule | -0.53 |
| CRIP2 | cysteine-rich protein 2 | -0.53 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.52 |
| ZBED1 | zinc finger, BED-type containing 1 | -0.51 |
| RPS29 | ribosomal protein S29 | -0.51 |
| HFE | hemochromatosis | -0.5 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.5 |
| SIMC1 | SUMO-interacting motifs containing 1 | -0.5 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.49 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | -0.49 |
| CHKB | choline kinase beta | -0.48 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.47 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | -0.47 |
| CCDC28A | coiled-coil domain containing 28A | -0.47 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.46 |
| CDK18 | cyclin-dependent kinase 18 | -0.46 |
| AMOTL2 | angiomotin like 2 | -0.45 |
| SERINC1 | serine incorporator 1 | -0.45 |
| CLK1 | CDC-like kinase 1 | -0.45 |
| KIAA1109 | KIAA1109 | -0.45 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.44 |
| FAR1 | fatty acyl CoA reductase 1 | -0.44 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.44 |
| CERK | ceramide kinase | -0.44 |
| PLEK | pleckstrin | -0.44 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | -0.43 |
| APOB | apolipoprotein B | -0.43 |
| BCDIN3D | BCDIN3 domain containing | -0.42 |
| STK17A | serine/threonine kinase 17a | -0.42 |
| DAPK1 | death-associated protein kinase 1 | -0.42 |
| FGB | fibrinogen beta chain | -0.42 |
| DOCK10 | dedicator of cytokinesis 10 | -0.42 |
| MT1E | metallothionein 1E | -0.42 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | -0.42 |
| MKRN1 | makorin ring finger protein 1 | -0.42 |
| LMF2 | lipase maturation factor 2 | -0.41 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.41 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -0.41 |
| MOCS1 | molybdenum cofactor synthesis 1 | -0.41 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.41 |
| SP140 | SP140 nuclear body protein | -0.41 |
| PRKCG | protein kinase C, gamma | -0.41 |
| SLC38A7 | solute carrier family 38, member 7 | -0.4 |
| TRAF3 | TNF receptor-associated factor 3 | -0.4 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -0.4 |
| GAB1 | GRB2-associated binding protein 1 | -0.4 |
| NAIF1 | nuclear apoptosis inducing factor 1 | -0.4 |
| AREG | amphiregulin | -0.39 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.39 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.39 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.39 |
| PAH | phenylalanine hydroxylase | -0.38 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.38 |
| GLDC | glycine dehydrogenase (decarboxylating) | -0.38 |
| SON | SON DNA binding protein | -0.38 |
| ATP13A3 | ATPase type 13A3 | -0.38 |
| SPATA2 | spermatogenesis associated 2 | -0.38 |
| THBS1 | thrombospondin 1 | -0.38 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.38 |
| LAMA3 | laminin, alpha 3 | -0.38 |
| NCOA4 | nuclear receptor coactivator 4 | -0.37 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.37 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.37 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | -0.37 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.37 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.37 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.36 |
| RGN | regucalcin | -0.36 |
| SYPL1 | synaptophysin-like 1 | -0.36 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.35 |
| FAM104A | family with sequence similarity 104, member A | -0.35 |
| F2 | coagulation factor II (thrombin) | -0.35 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.35 |
