6-bromoindirubin-3'-oxime-7048 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the 6-bromoindirubin-3'-oxime-7048 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALPK1 alpha-kinase 1
AQP3 aquaporin 3 (Gill blood group)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BICD1 bicaudal D homolog 1 (Drosophila)
C7ORF43 chromosome 7 open reading frame 43
CAPN5 calpain 5
CD52 CD52 molecule
CD82 CD82 molecule
CDC14A cell division cycle 14A
CLDN14 claudin 14
CREB3L1 cAMP responsive element binding protein 3-like 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND2D DENN/MADD domain containing 2D
DMPK dystrophia myotonica-protein kinase
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOHH deoxyhypusine hydroxylase/monooxygenase
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF1 eukaryotic translation initiation factor 1
ELF4 E74-like factor 4 (ets domain transcription factor)
FAM13A family with sequence similarity 13, member A
FBXL15 F-box and leucine-rich repeat protein 15
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPATCH4 G patch domain containing 4
HIST1H3I histone cluster 1, H3i
IDI2-AS1 IDI2 antisense RNA 1
IL24 interleukin 24
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCTD13 potassium channel tetramerization domain containing 13
KDM4C lysine (K)-specific demethylase 4C
KHK ketohexokinase (fructokinase)
KLHL22 kelch-like family member 22
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LIN7B lin-7 homolog B (C. elegans)
LOC100294391 uncharacterized LOC100294391
MAST3 microtubule associated serine/threonine kinase 3
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
METTL5 methyltransferase like 5
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
N4BP1 NEDD4 binding protein 1
NCAPH2 non-SMC condensin II complex, subunit H2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NID2 nidogen 2 (osteonidogen)
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUP88 nucleoporin 88kDa
OLFML2B olfactomedin-like 2B
PCGF3 polycomb group ring finger 3
PDCD6 programmed cell death 6
PEX26 peroxisomal biogenesis factor 26
PEX5 peroxisomal biogenesis factor 5
PGPEP1 pyroglutamyl-peptidase I
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAC1 placenta-specific 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRB1 proline-rich protein BstNI subfamily 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRR3 proline rich 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REPS1 RALBP1 associated Eps domain containing 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF24 ring finger protein 24
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
SAMD4A sterile alpha motif domain containing 4A
SCAPER S-phase cyclin A-associated protein in the ER
SCG5 secretogranin V
SGSM2 small G protein signaling modulator 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLMO1 slowmo homolog 1 (Drosophila)
SMIM8 small integral membrane protein 8
SNW1 SNW domain containing 1
TMEM183A transmembrane protein 183A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOP3B topoisomerase (DNA) III beta
TRABD TraB domain containing
TTLL4 tubulin tyrosine ligase-like family member 4
TUBA4B tubulin, alpha 4b
UBXN1 UBX domain protein 1
USP27X ubiquitin specific peptidase 27, X-linked
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VIPR1 vasoactive intestinal peptide receptor 1
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF43 zinc finger protein 43
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABT1 activator of basal transcription 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANG angiogenin, ribonuclease, RNase A family, 5
ANKFY1 ankyrin repeat and FYVE domain containing 1
APH1B APH1B gamma secretase subunit
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C14ORF93 chromosome 14 open reading frame 93
C1R complement component 1, r subcomponent
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC106 coiled-coil domain containing 106
CCDC7 coiled-coil domain containing 7
CCNA1 cyclin A1
CDIP1 cell death-inducing p53 target 1
CENPJ centromere protein J
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLEC4E C-type lectin domain family 4, member E
CNGB3 cyclic nucleotide gated channel beta 3
CORO1A coronin, actin binding protein, 1A
CSRNP3 cysteine-serine-rich nuclear protein 3
CTGF connective tissue growth factor
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DLK2 delta-like 2 homolog (Drosophila)
DNAH7 dynein, axonemal, heavy chain 7
DSCAM Down syndrome cell adhesion molecule
EDIL3 EGF-like repeats and discoidin I-like domains 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP3 elongator acetyltransferase complex subunit 3
F2R coagulation factor II (thrombin) receptor
FAM102A family with sequence similarity 102, member A
FAM131B family with sequence similarity 131, member B
FAM46C family with sequence similarity 46, member C
FAM50B family with sequence similarity 50, member B
FAM86C1 family with sequence similarity 86, member C1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FUZ fuzzy planar cell polarity protein
FZD4 frizzled class receptor 4
FZD8 frizzled class receptor 8
GBP2 guanylate binding protein 2, interferon-inducible
GBX2 gastrulation brain homeobox 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GPR157 G protein-coupled receptor 157
GPR3 G protein-coupled receptor 3
GRB7 growth factor receptor-bound protein 7
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST2H2AA3 histone cluster 2, H2aa3
HYI hydroxypyruvate isomerase (putative)
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL17RB interleukin 17 receptor B
IL7 interleukin 7
IRAK4 interleukin-1 receptor-associated kinase 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLHL25 kelch-like family member 25
LIPG lipase, endothelial
LMAN1 lectin, mannose-binding, 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCTP1 multiple C2 domains, transmembrane 1
MFSD6 major facilitator superfamily domain containing 6
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MILR1 mast cell immunoglobulin-like receptor 1
MN1 meningioma (disrupted in balanced translocation) 1
NOL12 nucleolar protein 12
NT5C 5', 3'-nucleotidase, cytosolic
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PER3 period circadian clock 3
PLD3 phospholipase D family, member 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRAME preferentially expressed antigen in melanoma
RAP1GAP2 RAP1 GTPase activating protein 2
RNASE4 ribonuclease, RNase A family, 4
RNF122 ring finger protein 122
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RRAS related RAS viral (r-ras) oncogene homolog
RUNX1-IT1 RUNX1 intronic transcript 1
SAYSD1 SAYSVFN motif domain containing 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SGK2 serum/glucocorticoid regulated kinase 2
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SYT17 synaptotagmin XVII
TMEM53 transmembrane protein 53
TRAIP TRAF interacting protein
TUBA3C tubulin, alpha 3c
UEVLD UEV and lactate/malate dehyrogenase domains
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YIPF5 Yip1 domain family, member 5
ZNF215 zinc finger protein 215
ZNF33B zinc finger protein 33B
ZNF639 zinc finger protein 639