786-0 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description This line was derived from a primary clear cell adenocarcinoma. The karyotype is hypertriploid; Y was present in 60% the cells examined. The cells display both microvilli and desmosomes, and can be grown in soft agar. The cells produce a PTH like peptides that is identical to peptides produced by breast and lung tumors. (Experimental Factor Ontology, EFO_0005707)
Similar Terms
Downloads & Tools

Genes

291 genes with high or low expression in 786-0 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
PRDM8 PR domain containing 8 3.12182
MRPL44 mitochondrial ribosomal protein L44 2.90896
HKDC1 hexokinase domain containing 1 2.68271
ZNF80 zinc finger protein 80 2.45835
SIX5 SIX homeobox 5 2.38422
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.34944
KLHL1 kelch-like family member 1 2.34813
SRY sex determining region Y 2.23395
MPPED1 metallophosphoesterase domain containing 1 2.22248
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.18151
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 2.1305
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.11865
ANXA7 annexin A7 2.06955
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.0323
ETV3 ets variant 3 1.9718
LOC157562 uncharacterized LOC157562 1.96716
BBS7 Bardet-Biedl syndrome 7 1.96449
ACTL7A actin-like 7A 1.96347
SCAND2P SCAN domain containing 2 pseudogene 1.93679
ARG2 arginase 2 1.93162
EMC1 ER membrane protein complex subunit 1 1.90991
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 1.89344
CSN1S1 casein alpha s1 1.883
TIAM2 T-cell lymphoma invasion and metastasis 2 1.88258
KRT36 keratin 36, type I 1.88178
CRHBP corticotropin releasing hormone binding protein 1.87578
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 1.87206
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.85897
GEM GTP binding protein overexpressed in skeletal muscle 1.83331
SCTR secretin receptor 1.83146
EIF5A2 eukaryotic translation initiation factor 5A2 1.82634
OR1A1 olfactory receptor, family 1, subfamily A, member 1 1.81989
UBA6 ubiquitin-like modifier activating enzyme 6 1.81591
FBXO28 F-box protein 28 1.80491
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 1.80358
TMSB4Y thymosin beta 4, Y-linked 1.7977
TPMT thiopurine S-methyltransferase 1.77726
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1 1.7751
MYL1 myosin, light chain 1, alkali; skeletal, fast 1.77261
ARF1P1 ADP-ribosylation factor 1 pseudogene 1 1.74803
PDE10A phosphodiesterase 10A 1.74788
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 1.74533
STX8 syntaxin 8 1.74525
AARS alanyl-tRNA synthetase 1.73903
PFKP phosphofructokinase, platelet 1.73497
ITPKA inositol-trisphosphate 3-kinase A 1.72119
LBP lipopolysaccharide binding protein 1.72065
MAP3K10 mitogen-activated protein kinase kinase kinase 10 1.71709
AMHR2 anti-Mullerian hormone receptor, type II 1.70829
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 1.69331
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 1.68778
KIF1BP KIF1 binding protein 1.68006
ASCL3 achaete-scute family bHLH transcription factor 3 1.67098
APOL2 apolipoprotein L, 2 1.67064
PLIN2 perilipin 2 1.66889
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.66085
CTSD cathepsin D 1.65907
MYH11 myosin, heavy chain 11, smooth muscle 1.65655
HOXA2 homeobox A2 1.65095
ZFAND1 zinc finger, AN1-type domain 1 1.64155
SARDH sarcosine dehydrogenase 1.63856
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 1.63627
HPCAL1 hippocalcin-like 1 1.62447
HABP4 hyaluronan binding protein 4 1.623
PTPN14 protein tyrosine phosphatase, non-receptor type 14 1.61755
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene) 1.60986
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.60769
GCM1 glial cells missing homolog 1 (Drosophila) 1.6073
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 1.60094
KRT37 keratin 37, type I 1.6009
ANGPTL3 angiopoietin-like 3 1.59714
ACHE acetylcholinesterase (Yt blood group) 1.58439
DUSP21 dual specificity phosphatase 21 1.5841
MMP19 matrix metallopeptidase 19 1.57975
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.57639
MYCT1 myc target 1 1.57127
HNF4G hepatocyte nuclear factor 4, gamma 1.5629
CCSER2 coiled-coil serine-rich protein 2 1.55719
BMPR1B bone morphogenetic protein receptor, type IB 1.55174
LATS1 large tumor suppressor kinase 1 1.55172
TPSG1 tryptase gamma 1 1.54631
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 1.5426
LRRC6 leucine rich repeat containing 6 1.53958
COMMD8 COMM domain containing 8 1.53806
IL18R1 interleukin 18 receptor 1 1.53732
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.53622
RRAGA Ras-related GTP binding A 1.53346
RB1CC1 RB1-inducible coiled-coil 1 1.52732
CTSZ cathepsin Z 1.52606
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 1.52383
NFIL3 nuclear factor, interleukin 3 regulated 1.52283
DKFZP434A062 uncharacterized LOC26102 1.52233
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 1.52159
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 1.5178
GJB4 gap junction protein, beta 4, 30.3kDa 1.51485
SYNJ2 synaptojanin 2 1.51428
SCGB1D1 secretoglobin, family 1D, member 1 1.50595
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.50474
GP2 glycoprotein 2 (zymogen granule membrane) 1.49935
IRS4 insulin receptor substrate 4 1.49902
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 1.49565
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 1.49267
VEGFA vascular endothelial growth factor A 1.4915
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 1.48742
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 1.48661
USP25 ubiquitin specific peptidase 25 1.48532
NEK4 NIMA-related kinase 4 1.48451
TCEA1 transcription elongation factor A (SII), 1 1.4758
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 1.47573
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.47509
MYO1E myosin IE 1.47172
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 1.47109
TTC4 tetratricopeptide repeat domain 4 1.46552
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 1.45219
DAD1 defender against cell death 1 1.45192
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 1.44823
FRYL FRY-like 1.44572
REM1 RAS (RAD and GEM)-like GTP-binding 1 1.44292
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 1.44177
PGGT1B protein geranylgeranyltransferase type I, beta subunit 1.4404
TSC22D4 TSC22 domain family, member 4 1.43973
OR6A2 olfactory receptor, family 6, subfamily A, member 2 1.43942
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.43226
CHRDL1 chordin-like 1 1.42955
OGFRL1 opioid growth factor receptor-like 1 1.42914
RAB23 RAB23, member RAS oncogene family 1.4272
VSIG4 V-set and immunoglobulin domain containing 4 1.42064
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3 1.42009
DSCR3 Down syndrome critical region 3 1.41645

low expression

Symbol Name Standardized Value
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.53725
RAD9A RAD9 homolog A (S. pombe) -3.53724
MOSPD3 motile sperm domain containing 3 -3.5349
TMC5 transmembrane channel-like 5 -3.5273
TTLL4 tubulin tyrosine ligase-like family member 4 -3.39263
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.94533
COX7C cytochrome c oxidase subunit VIIc -2.94118
ITPKC inositol-trisphosphate 3-kinase C -2.90753
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.89181
ANKRD6 ankyrin repeat domain 6 -2.84771
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) -2.84624
GMPPA GDP-mannose pyrophosphorylase A -2.80119
ARF3 ADP-ribosylation factor 3 -2.79518
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.75441
UBTF upstream binding transcription factor, RNA polymerase I -2.65897
RHBDD3 rhomboid domain containing 3 -2.63895
SAV1 salvador family WW domain containing protein 1 -2.63139
ADCK3 aarF domain containing kinase 3 -2.61152
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.60116
STXBP6 syntaxin binding protein 6 (amisyn) -2.49394
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -2.4923
ADAM5 ADAM metallopeptidase domain 5 (pseudogene) -2.47752
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.46614
TNPO1 transportin 1 -2.45856
STX5 syntaxin 5 -2.42161
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.37519
PDCL phosducin-like -2.31931
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.30095
MAPK12 mitogen-activated protein kinase 12 -2.27039
LDB1 LIM domain binding 1 -2.17288
DES desmin -2.1631
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.16153
CCDC25 coiled-coil domain containing 25 -2.15945
TMF1 TATA element modulatory factor 1 -2.12287
EIF3K eukaryotic translation initiation factor 3, subunit K -2.11782
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -2.11773
SNRPA small nuclear ribonucleoprotein polypeptide A -2.10565
PHGDH phosphoglycerate dehydrogenase -2.0853
DCAF11 DDB1 and CUL4 associated factor 11 -2.08171
RBM23 RNA binding motif protein 23 -2.06529
TRAF3IP2 TRAF3 interacting protein 2 -2.0332
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -2.03093
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -2.01927
NR4A1 nuclear receptor subfamily 4, group A, member 1 -2.01496
EDC3 enhancer of mRNA decapping 3 -2.00893
CHERP calcium homeostasis endoplasmic reticulum protein -1.99653
DENND4A DENN/MADD domain containing 4A -1.99071
ZGPAT zinc finger, CCCH-type with G patch domain -1.98758
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -1.97857
PLP1 proteolipid protein 1 -1.97789
BTG2 BTG family, member 2 -1.97579
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -1.96401
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -1.95489
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -1.91349
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -1.90964
DBP D site of albumin promoter (albumin D-box) binding protein -1.90687
TTI1 TELO2 interacting protein 1 -1.89318
ALDOC aldolase C, fructose-bisphosphate -1.88974
HIST3H2A histone cluster 3, H2a -1.88672
GMIP GEM interacting protein -1.88102
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -1.87733
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -1.8718
GALT galactose-1-phosphate uridylyltransferase -1.86362
EGLN2 egl-9 family hypoxia-inducible factor 2 -1.86328
TSSC1 tumor suppressing subtransferable candidate 1 -1.85489
MBD4 methyl-CpG binding domain protein 4 -1.83319
ZNF688 zinc finger protein 688 -1.8259
ARMC6 armadillo repeat containing 6 -1.81803
UBOX5 U-box domain containing 5 -1.81046
IL23A interleukin 23, alpha subunit p19 -1.80338
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -1.79576
HNRNPL heterogeneous nuclear ribonucleoprotein L -1.79274
SRSF9 serine/arginine-rich splicing factor 9 -1.78943
HCFC2 host cell factor C2 -1.78127
TRIM32 tripartite motif containing 32 -1.77363
ZBTB3 zinc finger and BTB domain containing 3 -1.77354
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -1.76869
RPL7A ribosomal protein L7a -1.74338
ZDHHC24 zinc finger, DHHC-type containing 24 -1.73847
FRY furry homolog (Drosophila) -1.73143
JAM3 junctional adhesion molecule 3 -1.72809
VDAC3 voltage-dependent anion channel 3 -1.72628
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -1.72542
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -1.70422
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit -1.70255
NDRG3 NDRG family member 3 -1.69874
IGHD immunoglobulin heavy constant delta -1.69513
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -1.68711
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -1.67878
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -1.6787
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -1.67672
SCIN scinderin -1.6597
KIAA1456 KIAA1456 -1.6496
CNPY2 canopy FGF signaling regulator 2 -1.64803
DPY19L1P1 DPY19L1 pseudogene 1 -1.6465
DNAI2 dynein, axonemal, intermediate chain 2 -1.64281
FUZ fuzzy planar cell polarity protein -1.64095
MSRA methionine sulfoxide reductase A -1.64046
IFT74 intraflagellar transport 74 -1.63545
RNF122 ring finger protein 122 -1.63533
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -1.63397
METTL9 methyltransferase like 9 -1.63233
FLJ21369 uncharacterized protein FLJ21369 -1.62631
GAREM GRB2 associated, regulator of MAPK1 -1.61709
CS citrate synthase -1.61459
LGALS4 lectin, galactoside-binding, soluble, 4 -1.61404
NUP214 nucleoporin 214kDa -1.61375
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -1.6029
GPR153 G protein-coupled receptor 153 -1.60056
SRRM2 serine/arginine repetitive matrix 2 -1.59941
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -1.59669
PANK4 pantothenate kinase 4 -1.59076
RFX3 regulatory factor X, 3 (influences HLA class II expression) -1.58823
PRDM10 PR domain containing 10 -1.58573
TECR trans-2,3-enoyl-CoA reductase -1.58567
TIAM1 T-cell lymphoma invasion and metastasis 1 -1.5834
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -1.583
AGO4 argonaute RISC catalytic component 4 -1.57995
DCXR dicarbonyl/L-xylulose reductase -1.56495
BPTF bromodomain PHD finger transcription factor -1.56309
ELL3 elongation factor RNA polymerase II-like 3 -1.55554
BRAP BRCA1 associated protein -1.54499
SRRT serrate, RNA effector molecule -1.54461
CEP250 centrosomal protein 250kDa -1.53568
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -1.52157
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -1.52108
KIAA0922 KIAA0922 -1.52019
DAXX death-domain associated protein -1.52008
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -1.51693
OSBPL1A oxysterol binding protein-like 1A -1.51571
KIAA1217 KIAA1217 -1.51279
MVK mevalonate kinase -1.50722
MON1B MON1 secretory trafficking family member B -1.50297
LUC7L3 LUC7-like 3 (S. cerevisiae) -1.49518
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene -1.49114
NPHP1 nephronophthisis 1 (juvenile) -1.48875
CA11 carbonic anhydrase XI -1.4788
FASN fatty acid synthase -1.47706
CNOT2 CCR4-NOT transcription complex, subunit 2 -1.47651
RAE1 ribonucleic acid export 1 -1.47634
UBL4A ubiquitin-like 4A -1.47604
TMEM104 transmembrane protein 104 -1.47503
RSRC1 arginine/serine-rich coiled-coil 1 -1.46692
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -1.46573
CHMP7 charged multivesicular body protein 7 -1.46445
PPIE peptidylprolyl isomerase E (cyclophilin E) -1.45704
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -1.45628
SERGEF secretion regulating guanine nucleotide exchange factor -1.44816
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase -1.44787
GORASP1 golgi reassembly stacking protein 1, 65kDa -1.44315
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -1.4399
RPS23 ribosomal protein S23 -1.4391
MADD MAP-kinase activating death domain -1.43748
MTG1 mitochondrial ribosome-associated GTPase 1 -1.43332
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -1.43215
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -1.42978
RNF44 ring finger protein 44 -1.42938
FDPS farnesyl diphosphate synthase -1.42824
FBL fibrillarin -1.42385
AHDC1 AT hook, DNA binding motif, containing 1 -1.4227
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -1.42203
CCND3 cyclin D3 -1.41991