8-Hydroxyquinoline_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.137866
INTS6 integrator complex subunit 6 0.116237
LMO7 LIM domain 7 0.0997872
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0829149
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0742551
EXT1 exostosin glycosyltransferase 1 0.0617016
SMAD3 SMAD family member 3 0.0556567
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0540395
ANXA2 annexin A2 0.0531875
GCLC glutamate-cysteine ligase, catalytic subunit 0.0490854
GMDS GDP-mannose 4,6-dehydratase 0.0461401
RNF213 ring finger protein 213 0.0441676
EPSTI1 epithelial stromal interaction 1 (breast) 0.042634
SPTBN1 spectrin, beta, non-erythrocytic 1 0.039649
ARHGAP26 Rho GTPase activating protein 26 0.0393527
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.037008
PLSCR2 phospholipid scramblase 2 0.0368158
ZSWIM6 zinc finger, SWIM-type containing 6 0.0361949
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0339566
EFNB2 ephrin-B2 0.0336666
LPP LIM domain containing preferred translocation partner in lipoma 0.0326338
VMP1 vacuole membrane protein 1 0.0319714
ASPH aspartate beta-hydroxylase 0.0317992
RSAD2 radical S-adenosyl methionine domain containing 2 0.0311697
TOX3 TOX high mobility group box family member 3 0.0307526
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0306869
ANKRD10 ankyrin repeat domain 10 0.0306312
BTBD9 BTB (POZ) domain containing 9 0.0301388
PRKCA protein kinase C, alpha 0.0298723
FNDC3B fibronectin type III domain containing 3B 0.0294389
VCL vinculin 0.0293744
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0288127
DSCAM Down syndrome cell adhesion molecule 0.0287346
CATSPERB catsper channel auxiliary subunit beta 0.0284353
RIGI RNA sensor RIG-I 0.0280927
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0267112
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0265468
TRIO trio Rho guanine nucleotide exchange factor 0.0262634
MYO1E myosin IE 0.0253084
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0250197
EZR ezrin 0.0246755
SHB Src homology 2 domain containing adaptor protein B 0.0236361
RAD51B RAD51 paralog B 0.0234722
FNIP2 folliculin interacting protein 2 0.0232768
TUFT1 tuftelin 1 0.0229969
AKAP13 A kinase (PRKA) anchor protein 13 0.0223181
SP100 SP100 nuclear antigen 0.0221988
POF1B premature ovarian failure, 1B 0.0216542
PLSCR1 phospholipid scramblase 1 0.0216519
PDLIM5 PDZ and LIM domain 5 0.0214761
ZBTB20 zinc finger and BTB domain containing 20 0.0213789
STS steroid sulfatase (microsomal), isozyme S 0.0211652
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0211455
PHF3 PHD finger protein 3 0.0208679
SQSTM1 sequestosome 1 0.0206696
DST dystonin 0.0204759
TSHZ2 teashirt zinc finger homeobox 2 0.020375
NABP1 nucleic acid binding protein 1 0.020259
CTBP2 C-terminal binding protein 2 0.020181
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0191691
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0184784
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0184434
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0183055
KYNU kynureninase 0.018229
DUSP10 dual specificity phosphatase 10 0.0180271
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0178802
ITGA6 integrin, alpha 6 0.0174042
N4BP2L2 NEDD4 binding protein 2-like 2 0.0173731
NCKAP5 NCK-associated protein 5 0.0173112
ATXN1 ataxin 1 0.0171205
GK glycerol kinase 0.0170871
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0170309
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0170223
RDH10 retinol dehydrogenase 10 (all-trans) 0.0169224
KIAA1217 KIAA1217 0.0168876
MSI2 musashi RNA-binding protein 2 0.0168356
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0168211
ERRFI1 ERBB receptor feedback inhibitor 1 0.0165204
LURAP1L leucine rich adaptor protein 1-like 0.0164944
UBAP2 ubiquitin associated protein 2 0.0162085
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0161883
MED13 mediator complex subunit 13 0.0160241
HOMER1 homer scaffolding protein 1 0.0159554
MX1 MX dynamin-like GTPase 1 0.0159147
LAMA4 laminin, alpha 4 0.0158488
EFNA5 ephrin-A5 0.0158189
PRKCE protein kinase C, epsilon 0.0157426
SAMD12 sterile alpha motif domain containing 12 0.0156292
TM4SF19 transmembrane 4 L six family member 19 0.0155228
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0153469
AREG amphiregulin 0.0153382
PADI1 peptidyl arginine deiminase, type I 0.0150327
MAML2 mastermind-like 2 (Drosophila) 0.014997
MCU mitochondrial calcium uniporter 0.0146994
CEMIP2 cell migration inducing hyaluronidase 2 0.0146181
SERINC5 serine incorporator 5 0.0146066
AFF1 AF4/FMR2 family, member 1 0.0145893
PRELID2 PRELI domain containing 2 0.0144085
USP53 ubiquitin specific peptidase 53 0.0143481
HKDC1 hexokinase domain containing 1 0.0141403

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.125184
TPT1 tumor protein, translationally-controlled 1 -0.0858404
LCN2 lipocalin 2 -0.0738614
HLA-B major histocompatibility complex, class I, B -0.0677141
PTMA prothymosin, alpha -0.0671982
IFI6 interferon, alpha-inducible protein 6 -0.0594684
RPL35A ribosomal protein L35a -0.0417052
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0413318
TMSB10 thymosin beta 10 -0.0388034
FTL ferritin, light polypeptide -0.0332048
LOC102724023 ES1 protein homolog, mitochondrial -0.0331848
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0325447
RPS6 ribosomal protein S6 -0.0315462
IFI27 interferon, alpha-inducible protein 27 -0.0297813
RPL23 ribosomal protein L23 -0.0284335
C6ORF132 chromosome 6 open reading frame 132 -0.0265614
HLA-A major histocompatibility complex, class I, A -0.0263055
EIF1 eukaryotic translation initiation factor 1 -0.0253657
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0253307
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0250377
RPS19 ribosomal protein S19 -0.0222882
RPL7L1 ribosomal protein L7-like 1 -0.0218026
RPLP1 ribosomal protein, large, P1 -0.0215055
RPL19 ribosomal protein L19 -0.021385
RPL26 ribosomal protein L26 -0.0207718
RPL37A ribosomal protein L37a -0.0206951
RPS3 ribosomal protein S3 -0.0201696
CALR calreticulin -0.0201469
RPL34 ribosomal protein L34 -0.0199926
RPS27 ribosomal protein S27 -0.0197408
PRRC2C proline-rich coiled-coil 2C -0.0196014
MT2A metallothionein 2A -0.019492
ZMYND8 zinc finger, MYND-type containing 8 -0.0194693
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0191505
TXNIP thioredoxin interacting protein -0.0190986
MACC1 metastasis associated in colon cancer 1 -0.0190576
RPS8 ribosomal protein S8 -0.0186558
MPHOSPH8 M-phase phosphoprotein 8 -0.0186404
EGR1 early growth response 1 -0.0185896
TPM4 tropomyosin 4 -0.0182497
NDRG1 N-myc downstream regulated 1 -0.0181713
RPL12 ribosomal protein L12 -0.0181289
HLA-C major histocompatibility complex, class I, C -0.0178067
LYZ lysozyme -0.0177409
RPS12 ribosomal protein S12 -0.0176394
IFITM3 interferon induced transmembrane protein 3 -0.0174796
S100A6 S100 calcium binding protein A6 -0.0170969
RPL11 ribosomal protein L11 -0.0170401
RPL31 ribosomal protein L31 -0.0169963
RPL37 ribosomal protein L37 -0.0169306
CANX calnexin -0.0163224
UQCRB ubiquinol-cytochrome c reductase binding protein -0.015564
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0154927
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0153633
SLC38A1 solute carrier family 38, member 1 -0.0151382
PDIA3 protein disulfide isomerase family A, member 3 -0.0150842
SERF2 small EDRK-rich factor 2 -0.0148403
DSTN destrin (actin depolymerizing factor) -0.0148154
CST3 cystatin C -0.0141958
RPL9 ribosomal protein L9 -0.0140136
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0140106
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0139603
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0138438
RPL35 ribosomal protein L35 -0.013741
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0136775
S100A9 S100 calcium binding protein A9 -0.0136304
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.013488
SRRM2 serine/arginine repetitive matrix 2 -0.0134677
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0133608
HLA-E major histocompatibility complex, class I, E -0.0133342
GOLGA4 golgin A4 -0.0133243
RNF149 ring finger protein 149 -0.0132919
TOP2A topoisomerase (DNA) II alpha 170kDa -0.013052
ISG15 ISG15 ubiquitin-like modifier -0.0130499
EPCAM epithelial cell adhesion molecule -0.0130079
SET SET nuclear proto-oncogene -0.0129249
RPS24 ribosomal protein S24 -0.012814
RPLP2 ribosomal protein, large, P2 -0.0127865
RPL36A ribosomal protein L36a -0.012524
RPS17 ribosomal protein S17 -0.0124615
RPS13 ribosomal protein S13 -0.0124408
RACK1 receptor for activated C kinase 1 -0.0124048
TPI1 triosephosphate isomerase 1 -0.0122684
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0121967
NPEPPS aminopeptidase puromycin sensitive -0.0121941
AKAP9 A kinase (PRKA) anchor protein 9 -0.011798
KRT19 keratin 19, type I -0.0117947
RPS29 ribosomal protein S29 -0.0117685
POTEF POTE ankyrin domain family, member F -0.011647
KPNB1 karyopherin (importin) beta 1 -0.0116144
RHOBTB3 Rho-related BTB domain containing 3 -0.011599
WDR45B WD repeat domain 45B -0.0114496
DIAPH3 diaphanous-related formin 3 -0.0113487
H1-0 H1.0 linker histone -0.0113476
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0113105
BCLAF1 BCL2-associated transcription factor 1 -0.0112774
BMP4 bone morphogenetic protein 4 -0.0112436
RPL30 ribosomal protein L30 -0.0111716
POMP proteasome maturation protein -0.0111292
CSTB cystatin B (stefin B) -0.0111271