8-Hydroxyquinoline_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SVIL supervillin 0.0822652
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0814001
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.079711
ERRFI1 ERBB receptor feedback inhibitor 1 0.0641968
FNDC3B fibronectin type III domain containing 3B 0.0604388
FN1 fibronectin 1 0.0578416
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0559989
JMJD1C jumonji domain containing 1C 0.0506028
SAMD4A sterile alpha motif domain containing 4A 0.0486625
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0446942
CRY1 cryptochrome circadian clock 1 0.0376247
DDIT4 DNA-damage-inducible transcript 4 0.0374077
PCBP2 poly(rC) binding protein 2 0.0351377
PAWR PRKC, apoptosis, WT1, regulator 0.0349357
TNS1 tensin 1 0.0333415
SPTBN1 spectrin, beta, non-erythrocytic 1 0.033302
LCOR ligand dependent nuclear receptor corepressor 0.0330143
GCLC glutamate-cysteine ligase, catalytic subunit 0.0328996
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0328523
ELL2 elongation factor, RNA polymerase II, 2 0.0324592
MBNL2 muscleblind-like splicing regulator 2 0.0322178
GK glycerol kinase 0.029993
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0286021
MBNL1 muscleblind-like splicing regulator 1 0.0283805
NUP58 nucleoporin 58 0.0277932
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0274933
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0266231
MYO6 myosin VI 0.0257851
ESYT2 extended synaptotagmin-like protein 2 0.0249116
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0248258
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0247501
ARHGAP26 Rho GTPase activating protein 26 0.0244984
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0239976
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0238652
SOS1 son of sevenless homolog 1 (Drosophila) 0.0238531
PABPC1 poly(A) binding protein, cytoplasmic 1 0.023249
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0227893
SYNE1 spectrin repeat containing, nuclear envelope 1 0.022782
RAI14 retinoic acid induced 14 0.0226023
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0224466
SIK3 SIK family kinase 3 0.0224089
TXNRD1 thioredoxin reductase 1 0.0222406
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0216778
VMP1 vacuole membrane protein 1 0.0216602
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0215638
MCL1 myeloid cell leukemia 1 0.0214978
TCIM transcriptional and immune response regulator 0.021472
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0210739
MYO1B myosin IB 0.0203526
ARL5B ADP-ribosylation factor-like 5B 0.0203279
ATRN attractin 0.0202102
RPS18 ribosomal protein S18 0.0200992
ZEB1 zinc finger E-box binding homeobox 1 0.0200157
RPL3 ribosomal protein L3 0.0199528
DTNA dystrobrevin, alpha 0.0199187
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0198294
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0196634
AHR aryl hydrocarbon receptor 0.0196023
SNX9 sorting nexin 9 0.0195212
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0193936
LRMDA leucine rich melanocyte differentiation associated 0.0193796
FTH1 ferritin, heavy polypeptide 1 0.0193594
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0192677
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0190281
ARHGAP21 Rho GTPase activating protein 21 0.0188895
RAD51B RAD51 paralog B 0.0187699
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0186018
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0184702
MALRD1 MAM and LDL receptor class A domain containing 1 0.0183753
PCGF5 polycomb group ring finger 5 0.0183306
TLE4 transducin-like enhancer of split 4 0.018279
TF transferrin 0.0182739
QKI QKI, KH domain containing, RNA binding 0.0182259
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0181516
SKIL SKI-like proto-oncogene 0.0179819
INSIG2 insulin induced gene 2 0.0177835
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0177743
CARD16 caspase recruitment domain family, member 16 0.0176838
DENND4A DENN/MADD domain containing 4A 0.0174178
EIF4B eukaryotic translation initiation factor 4B 0.0173167
FBXO42 F-box protein 42 0.0170768
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0169899
ATF3 activating transcription factor 3 0.0169519
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0169431
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0163949
WWC2 WW and C2 domain containing 2 0.0163578
RUNX1 runt-related transcription factor 1 0.0163279
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0161726
KMT2C lysine (K)-specific methyltransferase 2C 0.0160784
AAK1 AP2 associated kinase 1 0.0160776
PTK2 protein tyrosine kinase 2 0.0159982
TPD52 tumor protein D52 0.0159129
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0157862
DOCK5 dedicator of cytokinesis 5 0.0157415
FAM13A family with sequence similarity 13, member A 0.0157191
CCNL1 cyclin L1 0.0156894
FNIP1 folliculin interacting protein 1 0.0156798
USP37 ubiquitin specific peptidase 37 0.0156753
TMX4 thioredoxin-related transmembrane protein 4 0.0156684
BBX bobby sox homolog (Drosophila) 0.0156431

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.248098
AKAP12 A kinase (PRKA) anchor protein 12 -0.238871
MT2A metallothionein 2A -0.183834
TPT1 tumor protein, translationally-controlled 1 -0.16726
TMSB10 thymosin beta 10 -0.135268
TIMP1 TIMP metallopeptidase inhibitor 1 -0.12451
APOA2 apolipoprotein A-II -0.114315
TM4SF1 transmembrane 4 L six family member 1 -0.0916424
ENO1 enolase 1, (alpha) -0.0878849
GPC3 glypican 3 -0.087703
RPL35A ribosomal protein L35a -0.0824811
RPL11 ribosomal protein L11 -0.0717058
RPS24 ribosomal protein S24 -0.0680112
FTL ferritin, light polypeptide -0.0679907
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0658934
RPL37A ribosomal protein L37a -0.0620294
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0619835
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0616771
RPS12 ribosomal protein S12 -0.0599874
RPL23 ribosomal protein L23 -0.0597619
IFI6 interferon, alpha-inducible protein 6 -0.0559851
CP ceruloplasmin (ferroxidase) -0.0549394
RPS8 ribosomal protein S8 -0.0522361
RPS6 ribosomal protein S6 -0.0515437
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0508378
RPS3 ribosomal protein S3 -0.0503351
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0501125
PTPRF protein tyrosine phosphatase, receptor type, F -0.0494558
APOE apolipoprotein E -0.049059
SLC38A2 solute carrier family 38, member 2 -0.04886
RPS19 ribosomal protein S19 -0.0464092
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0463298
PTMA prothymosin, alpha -0.0455629
ZMYND8 zinc finger, MYND-type containing 8 -0.0446471
B2M beta-2-microglobulin -0.0443293
RPLP2 ribosomal protein, large, P2 -0.0438254
RPL34 ribosomal protein L34 -0.0435568
GNAS GNAS complex locus -0.0399477
APOB apolipoprotein B -0.0394715
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0387103
RPS27A ribosomal protein S27a -0.0386649
RRBP1 ribosome binding protein 1 -0.0385685
ACTN4 actinin, alpha 4 -0.0377014
RPL31 ribosomal protein L31 -0.0369183
RPS21 ribosomal protein S21 -0.03631
HMGA1 high mobility group AT-hook 1 -0.0361583
WSB1 WD repeat and SOCS box containing 1 -0.0360469
AMBP alpha-1-microglobulin/bikunin precursor -0.0358857
NAP1L1 nucleosome assembly protein 1-like 1 -0.0357623
RPLP1 ribosomal protein, large, P1 -0.0355111
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0354523
RPL26 ribosomal protein L26 -0.0353958
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0353868
ISG15 ISG15 ubiquitin-like modifier -0.0347942
RPL9 ribosomal protein L9 -0.0344582
FRMD5 FERM domain containing 5 -0.0343963
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0341087
H1-0 H1.0 linker histone -0.0332392
KPNB1 karyopherin (importin) beta 1 -0.0328736
IER3 immediate early response 3 -0.0325871
DST dystonin -0.0325783
DLC1 DLC1 Rho GTPase activating protein -0.0321498
NPR2 natriuretic peptide receptor 2 -0.0315755
RPL37 ribosomal protein L37 -0.0315305
ARHGAP5 Rho GTPase activating protein 5 -0.0313517
RPLP0 ribosomal protein, large, P0 -0.0313096
SOX4 SRY (sex determining region Y)-box 4 -0.0311177
ACTG1 actin gamma 1 -0.0309604
EXT1 exostosin glycosyltransferase 1 -0.0307271
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0306805
RPL12 ribosomal protein L12 -0.0301937
APOA1 apolipoprotein A-I -0.0295466
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0290077
EIF5B eukaryotic translation initiation factor 5B -0.0285587
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0281339
RACK1 receptor for activated C kinase 1 -0.0276938
ZFHX3 zinc finger homeobox 3 -0.0276773
RPL36 ribosomal protein L36 -0.0275899
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0275589
HLA-A major histocompatibility complex, class I, A -0.0275172
RPS25 ribosomal protein S25 -0.0275136
VCL vinculin -0.027447
NPAS2 neuronal PAS domain protein 2 -0.0274008
KRT18 keratin 18, type I -0.027362
TRIM26 tripartite motif containing 26 -0.0270396
SDC4 syndecan 4 -0.0270135
SPATS2L spermatogenesis associated, serine-rich 2-like -0.026745
IFITM1 interferon induced transmembrane protein 1 -0.0267251
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0265795
S100A6 S100 calcium binding protein A6 -0.0264475
RPL36A ribosomal protein L36a -0.0264402
RPS11 ribosomal protein S11 -0.0263671
CD63 CD63 molecule -0.0263474
PERP PERP, TP53 apoptosis effector -0.0262465
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0256751
RNF213 ring finger protein 213 -0.0254861
PGK1 phosphoglycerate kinase 1 -0.0254687
RPL32 ribosomal protein L32 -0.0251854
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0250347
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0247814