8-Hydroxyquinoline_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0817999
SLC35F3 solute carrier family 35, member F3 0.0778283
MTSS1 metastasis suppressor 1 0.0728776
INTS6 integrator complex subunit 6 0.0624396
LMO7 LIM domain 7 0.0564353
RAI14 retinoic acid induced 14 0.0544026
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0513469
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0484129
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0481986
PDLIM5 PDZ and LIM domain 5 0.0457473
DPYD dihydropyrimidine dehydrogenase 0.04551
EXT1 exostosin glycosyltransferase 1 0.0433692
PLS3 plastin 3 0.0433354
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0427959
ABI3BP ABI family, member 3 (NESH) binding protein 0.042069
RNF217 ring finger protein 217 0.0418581
NAV2 neuron navigator 2 0.0400721
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0394388
HMGA2 high mobility group AT-hook 2 0.0385222
ESYT2 extended synaptotagmin-like protein 2 0.0359138
ANO1 anoctamin 1, calcium activated chloride channel 0.0357553
NRIP1 nuclear receptor interacting protein 1 0.0356105
GRB10 growth factor receptor-bound protein 10 0.0352724
PTK2 protein tyrosine kinase 2 0.0342664
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0335826
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0328012
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0317374
ANXA1 annexin A1 0.0314398
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0302912
ZCCHC7 zinc finger, CCHC domain containing 7 0.0293202
ALCAM activated leukocyte cell adhesion molecule 0.0285117
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.028503
AKAP13 A kinase (PRKA) anchor protein 13 0.0283318
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0270483
DOK5 docking protein 5 0.0263995
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0236358
CALB1 calbindin 1, 28kDa 0.0231546
LAMC2 laminin, gamma 2 0.0230176
FRMD6 FERM domain containing 6 0.022772
RASAL2 RAS protein activator like 2 0.0224457
ZEB1 zinc finger E-box binding homeobox 1 0.0224326
N4BP2L2 NEDD4 binding protein 2-like 2 0.0223021
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0216542
VEGFA vascular endothelial growth factor A 0.0214056
PEAK1 pseudopodium-enriched atypical kinase 1 0.0210614
FNIP1 folliculin interacting protein 1 0.0205889
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0204092
FAM107B family with sequence similarity 107, member B 0.0201734
HDAC9 histone deacetylase 9 0.0201107
ARHGAP24 Rho GTPase activating protein 24 0.0198762
SPIRE1 spire-type actin nucleation factor 1 0.0196272
RAD51B RAD51 paralog B 0.0195412
EFNA5 ephrin-A5 0.0194109
CDK6 cyclin-dependent kinase 6 0.0193847
BACE2 beta-site APP-cleaving enzyme 2 0.0192964
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.019293
PICALM phosphatidylinositol binding clathrin assembly protein 0.0190608
ANKRD28 ankyrin repeat domain 28 0.0186321
CTBP2 C-terminal binding protein 2 0.0182141
ZSWIM6 zinc finger, SWIM-type containing 6 0.0182006
CSMD2 CUB and Sushi multiple domains 2 0.0181022
MEGF6 multiple EGF-like-domains 6 0.0179308
PPARG peroxisome proliferator-activated receptor gamma 0.0175475
RABGAP1L RAB GTPase activating protein 1-like 0.0174761
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0174602
CUX1 cut-like homeobox 1 0.0173432
ARHGAP21 Rho GTPase activating protein 21 0.017317
FNDC3B fibronectin type III domain containing 3B 0.0172763
THSD4 thrombospondin, type I, domain containing 4 0.0171782
LRP1B low density lipoprotein receptor-related protein 1B 0.0171678
SOX5 SRY (sex determining region Y)-box 5 0.0169858
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0167474
FBXO11 F-box protein 11 0.0163366
ABLIM3 actin binding LIM protein family, member 3 0.0163364
NPAS2 neuronal PAS domain protein 2 0.0161939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0161159
KDM4C lysine (K)-specific demethylase 4C 0.0160428
NEBL nebulette 0.0159712
PTPRG protein tyrosine phosphatase, receptor type, G 0.0159318
UTRN utrophin 0.0158506
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0158363
SDCCAG8 serologically defined colon cancer antigen 8 0.0158001
FTH1 ferritin, heavy polypeptide 1 0.0155368
KLF12 Kruppel-like factor 12 0.0155108
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0154304
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0151973
ERBIN erbb2 interacting protein 0.015183
MAML3 mastermind-like 3 (Drosophila) 0.0150189
IRAK2 interleukin-1 receptor-associated kinase 2 0.014981
PDE4D phosphodiesterase 4D, cAMP-specific 0.0148955
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0147603
SSH2 slingshot protein phosphatase 2 0.0147207
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0147143
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0146847
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0146439
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0145906
COL5A1 collagen, type V, alpha 1 0.0145293
CDK13 cyclin-dependent kinase 13 0.0144878
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0143972
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0143278

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.154042
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.151336
B2M beta-2-microglobulin -0.127141
TIMP3 TIMP metallopeptidase inhibitor 3 -0.105672
TMSB10 thymosin beta 10 -0.104523
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102809
MT2A metallothionein 2A -0.088362
AHNAK AHNAK nucleoprotein -0.0851162
PTMA prothymosin, alpha -0.083901
RPS21 ribosomal protein S21 -0.0785024
BCL2L1 BCL2-like 1 -0.075666
FOXO1 forkhead box O1 -0.0753824
ENO1 enolase 1, (alpha) -0.0746294
LDHA lactate dehydrogenase A -0.0743155
HLA-B major histocompatibility complex, class I, B -0.0704125
KRT17 keratin 17, type I -0.0703742
IFITM1 interferon induced transmembrane protein 1 -0.068408
IFITM3 interferon induced transmembrane protein 3 -0.068115
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0648232
TMSB4X thymosin beta 4, X-linked -0.0644263
RPLP2 ribosomal protein, large, P2 -0.0629029
NAMPT nicotinamide phosphoribosyltransferase -0.0611857
CLU clusterin -0.0593112
LMNA lamin A/C -0.058672
TPT1 tumor protein, translationally-controlled 1 -0.0584352
PGK1 phosphoglycerate kinase 1 -0.0581971
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0563401
RPL11 ribosomal protein L11 -0.0538007
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.052824
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0521264
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.051451
H1-0 H1.0 linker histone -0.0503929
NEK7 NIMA-related kinase 7 -0.050321
RPS19 ribosomal protein S19 -0.0499634
OSMR oncostatin M receptor -0.0497133
PLAT plasminogen activator, tissue -0.049346
RPS6 ribosomal protein S6 -0.0491082
S100A10 S100 calcium binding protein A10 -0.0487667
RPLP1 ribosomal protein, large, P1 -0.048125
IFI6 interferon, alpha-inducible protein 6 -0.0476083
ZNFX1 zinc finger, NFX1-type containing 1 -0.0467749
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.046699
EMP1 epithelial membrane protein 1 -0.0463807
PLEC plectin -0.0452905
ANXA2 annexin A2 -0.044551
YBX3 Y box binding protein 3 -0.0443965
LOC112694756 uncharaterized LOC112694756 -0.0442397
CAV1 caveolin 1, caveolae protein, 22kDa -0.0439098
RPS12 ribosomal protein S12 -0.041432
S100A6 S100 calcium binding protein A6 -0.0412395
CUL4B cullin 4B -0.041155
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0408195
S100A9 S100 calcium binding protein A9 -0.040718
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0399923
NRG1 neuregulin 1 -0.0399588
OGA O-GlcNAcase -0.0391046
GNAS GNAS complex locus -0.0389676
HLA-E major histocompatibility complex, class I, E -0.0387959
SAMD9 sterile alpha motif domain containing 9 -0.0386019
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.038169
RPS8 ribosomal protein S8 -0.0380366
CD44 CD44 molecule (Indian blood group) -0.0380352
ANKRD33B ankyrin repeat domain 33B -0.0379967
MYH9 myosin, heavy chain 9, non-muscle -0.0378751
RPS3 ribosomal protein S3 -0.0374292
RPL37 ribosomal protein L37 -0.0371793
ACTN4 actinin, alpha 4 -0.0369708
PRRC2C proline-rich coiled-coil 2C -0.0368027
STC1 stanniocalcin 1 -0.0362233
CAVIN1 caveolae associated protein 1 -0.0361252
RPS13 ribosomal protein S13 -0.0360393
RPL23 ribosomal protein L23 -0.0359555
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0352299
RPS24 ribosomal protein S24 -0.0346509
RPL12 ribosomal protein L12 -0.034231
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0341341
SERINC3 serine incorporator 3 -0.0340466
WSB1 WD repeat and SOCS box containing 1 -0.0328559
EPHA2 EPH receptor A2 -0.0323269
IFI27 interferon, alpha-inducible protein 27 -0.0319746
PODXL podocalyxin-like -0.0319566
ITGA6 integrin, alpha 6 -0.0314643
PKM pyruvate kinase, muscle -0.0312889
RIN2 Ras and Rab interactor 2 -0.0311219
RACK1 receptor for activated C kinase 1 -0.0309836
CANX calnexin -0.030885
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0307952
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0307702
FN1 fibronectin 1 -0.0307252
SLC45A4 solute carrier family 45, member 4 -0.0299715
HLA-A major histocompatibility complex, class I, A -0.0299671
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0294513
TPX2 TPX2, microtubule-associated -0.0293394
S100A4 S100 calcium binding protein A4 -0.0293313
TXNRD1 thioredoxin reductase 1 -0.0292887
KRT14 keratin 14, type I -0.0289644
PDLIM1 PDZ and LIM domain 1 -0.0288393
ANLN anillin, actin binding protein -0.0285501
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0283136
CNRIP1 cannabinoid receptor interacting protein 1 -0.0279514