8-Hydroxyquinoline_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description 8-Hydroxyquinoline perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the 8-Hydroxyquinoline_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A 0.0436823
FAT1 FAT atypical cadherin 1 0.0388858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0364896
CEMIP cell migration inducing protein, hyaluronan binding 0.0302339
MBNL1 muscleblind-like splicing regulator 1 0.0296292
PKM pyruvate kinase, muscle 0.0274922
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0262337
PLEC plectin 0.0248492
ZSWIM6 zinc finger, SWIM-type containing 6 0.0243426
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.024279
MYH9 myosin, heavy chain 9, non-muscle 0.0240902
INTS6 integrator complex subunit 6 0.023862
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0237032
TPM3 tropomyosin 3 0.0233162
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0231514
CALR calreticulin 0.0229104
VCL vinculin 0.0228381
APLP2 amyloid beta (A4) precursor-like protein 2 0.0221437
EXT1 exostosin glycosyltransferase 1 0.0214985
RPS18 ribosomal protein S18 0.0209323
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0195762
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0194317
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0182602
RPS12 ribosomal protein S12 0.0173314
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0173132
VEGFA vascular endothelial growth factor A 0.0166432
PDLIM5 PDZ and LIM domain 5 0.0162188
ERRFI1 ERBB receptor feedback inhibitor 1 0.0159719
EGFR epidermal growth factor receptor 0.0159524
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0159431
MYO1E myosin IE 0.015616
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0155736
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0153693
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.015303
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0145108
RPL3 ribosomal protein L3 0.0144801
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0136775
MARCHF3 membrane associated ring-CH-type finger 3 0.0136568
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0134829
EEF1G eukaryotic translation elongation factor 1 gamma 0.0130524
MCL1 myeloid cell leukemia 1 0.0130338
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0129165
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0125055
F3 coagulation factor III (thromboplastin, tissue factor) 0.0121023
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0120617
PSD3 pleckstrin and Sec7 domain containing 3 0.0119427
MPRIP myosin phosphatase Rho interacting protein 0.0118073
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0117787
MRPS6 mitochondrial ribosomal protein S6 0.0117523
TPM4 tropomyosin 4 0.011734
SEPTIN9 septin 9 0.0116464
SIK3 SIK family kinase 3 0.0115979
NCOR2 nuclear receptor corepressor 2 0.0112937
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0112615
FBXO11 F-box protein 11 0.0112467
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.011201
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0110652
FAM120A family with sequence similarity 120A 0.0110111
NRXN3 neurexin 3 0.0107085
HSPA8 heat shock 70kDa protein 8 0.0106001
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0103561
RNF217 ring finger protein 217 0.010355
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0103415
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0102439
SFPQ splicing factor proline/glutamine-rich 0.0102307
TRAPPC9 trafficking protein particle complex 9 0.0101543
RPS2 ribosomal protein S2 0.00987963
ABR active BCR-related 0.00984593
WWOX WW domain containing oxidoreductase 0.00980873
JARID2 jumonji, AT rich interactive domain 2 0.00979762
RPS26 ribosomal protein S26 0.00962773
SMAD3 SMAD family member 3 0.00951248
UNC13B unc-13 homolog B (C. elegans) 0.00947648
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00943017
PRR5L proline rich 5 like 0.00932818
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00930135
TTC19 tetratricopeptide repeat domain 19 0.00927384
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0092363
STPG4 sperm-tail PG-rich repeat containing 4 0.00905886
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00901007
CATSPERB catsper channel auxiliary subunit beta 0.00896329
TPM1 tropomyosin 1 (alpha) 0.0088488
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00883262
FLNA filamin A, alpha 0.00854584
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.00850386
PDIA4 protein disulfide isomerase family A, member 4 0.00842234
RYBP RING1 and YY1 binding protein 0.00835413
SQSTM1 sequestosome 1 0.00826557
NCEH1 neutral cholesterol ester hydrolase 1 0.00816532
CAPRIN2 caprin family member 2 0.00811395
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00809718
CANX calnexin 0.00805122
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00794392
MYO18A myosin XVIIIA 0.0079221
ADGRV1 adhesion G protein-coupled receptor V1 0.00787776
SAMD4A sterile alpha motif domain containing 4A 0.00784246
ARGLU1 arginine and glutamate rich 1 0.00783811
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00780114
OSBPL10 oxysterol binding protein-like 10 0.00778672
IFRD1 interferon-related developmental regulator 1 0.00777654

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17859
TMSB10 thymosin beta 10 -0.133082
TPT1 tumor protein, translationally-controlled 1 -0.117654
NPSR1 neuropeptide S receptor 1 -0.103253
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.087409
PTMA prothymosin, alpha -0.0836095
RPL34 ribosomal protein L34 -0.063217
RPS6 ribosomal protein S6 -0.0584517
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0556415
EPCAM epithelial cell adhesion molecule -0.0541702
ACTG1 actin gamma 1 -0.0510071
RPLP0 ribosomal protein, large, P0 -0.0498394
RPL35A ribosomal protein L35a -0.0486722
S100A6 S100 calcium binding protein A6 -0.0450981
ANXA2 annexin A2 -0.0428616
RPS21 ribosomal protein S21 -0.0409245
H1-0 H1.0 linker histone -0.040572
GOLGA4 golgin A4 -0.0402091
GCC2 GRIP and coiled-coil domain containing 2 -0.0390433
RPL12 ribosomal protein L12 -0.038961
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0387273
GPHN gephyrin -0.0378636
EIF1 eukaryotic translation initiation factor 1 -0.0362287
PTPRR protein tyrosine phosphatase, receptor type, R -0.0360875
RPS24 ribosomal protein S24 -0.0354538
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0350842
DSG2 desmoglein 2 -0.0346586
ITGA6 integrin, alpha 6 -0.0336801
HMGB1 high mobility group box 1 -0.0331258
ALCAM activated leukocyte cell adhesion molecule -0.0330217
RPL8 ribosomal protein L8 -0.0324615
S100A10 S100 calcium binding protein A10 -0.0322255
RPS8 ribosomal protein S8 -0.0317336
NCOR1 nuclear receptor corepressor 1 -0.0312135
KRT18 keratin 18, type I -0.0311731
RPL11 ribosomal protein L11 -0.0310375
DEK DEK proto-oncogene -0.0297512
RPLP1 ribosomal protein, large, P1 -0.0293724
RPL19 ribosomal protein L19 -0.0293397
RPL26 ribosomal protein L26 -0.0288162
TFF3 trefoil factor 3 (intestinal) -0.0287621
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0286557
SNX9 sorting nexin 9 -0.0285306
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0283041
PNISR PNN-interacting serine/arginine-rich protein -0.0282066
PERP PERP, TP53 apoptosis effector -0.0280572
PIGR polymeric immunoglobulin receptor -0.0278971
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0278637
ZNF292 zinc finger protein 292 -0.0278523
SBF2 SET binding factor 2 -0.0278021
RPLP2 ribosomal protein, large, P2 -0.0273412
CD2AP CD2-associated protein -0.0271592
RPS19 ribosomal protein S19 -0.0269466
FERMT1 fermitin family member 1 -0.0266593
RAB1A RAB1A, member RAS oncogene family -0.0264295
PPARG peroxisome proliferator-activated receptor gamma -0.0258625
MYL12B myosin, light chain 12B, regulatory -0.0258549
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.025816
KIF5B kinesin family member 5B -0.0256951
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0255862
RPS23 ribosomal protein S23 -0.0255595
LAMA4 laminin, alpha 4 -0.0251363
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0249702
THOC2 THO complex 2 -0.0246189
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0246053
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0244189
TFF1 trefoil factor 1 -0.024274
KDM3A lysine (K)-specific demethylase 3A -0.024151
CLTC clathrin, heavy chain (Hc) -0.0240969
RPL5 ribosomal protein L5 -0.0238839
TNS4 tensin 4 -0.0237587
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0235185
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0234108
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0232917
TXNIP thioredoxin interacting protein -0.0232497
RBM25 RNA binding motif protein 25 -0.023242
NFIA nuclear factor I/A -0.0231058
DLG1 discs, large homolog 1 (Drosophila) -0.0228754
TPI1 triosephosphate isomerase 1 -0.0226521
NDRG1 N-myc downstream regulated 1 -0.022644
ANTXR2 anthrax toxin receptor 2 -0.0224665
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0224331
RPL32 ribosomal protein L32 -0.0224109
KRT19 keratin 19, type I -0.0222352
NALF1 NALCN channel auxiliary factor 1 -0.0222154
CCNI cyclin I -0.0220704
ARHGAP32 Rho GTPase activating protein 32 -0.0220254
RBM39 RNA binding motif protein 39 -0.0219475
HMGA1 high mobility group AT-hook 1 -0.0217585
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0216895
LMNA lamin A/C -0.0215204
ATP5F1B ATP synthase F1 subunit beta -0.0214688
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0213815
RPS13 ribosomal protein S13 -0.0213656
KLK10 kallikrein-related peptidase 10 -0.021145
RSL1D1 ribosomal L1 domain containing 1 -0.0211214
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0209079
ESYT2 extended synaptotagmin-like protein 2 -0.0208793
CBX3 chromobox homolog 3 -0.0208499
ARHGAP5 Rho GTPase activating protein 5 -0.0208019